Click here to switch to the map view.

The map label for this gene is purN

Identifier: 41407000

GI number: 41407000

Start: 931265

End: 931894

Strand: Direct

Name: purN

Synonym: MAP0902

Alternate gene names: 41407000

Gene position: 931265-931894 (Clockwise)

Preceding gene: 41406999

Following gene: 41407001

Centisome position: 19.28

GC content: 67.94

Gene sequence:

>630_bases
GTGGTCGAACCGCTGCATGTGCCCCCCAATGCGCCGGCGCGGGTGGTGGTGCTGGCTTCGGGTACCGGATCGCTGCTCAG
CTCGCTGATCGACGCCGCCGTGGGCGACTACCCGGCCCGGGTGGTCGCGGTCGGCGCCGACCGCGACTGCCTGGCCACCC
AGATCGCCGCGGCCGCCTCCCTGCCCTCCTTCACCGTCCGGCTCGGCGACCACCCTGACCGCGCCGCCTGGGACGCCGCG
ATCACCGAGGCCACCGCCGCCCACTCGCCCGACCTGGTGGTATCCGCAGGGTTTATGAAAATTCTTGGGCCGCAATTTCT
TTCACGCTTCTACGGGCGGGTCATCAACACGCATCCGGCGCTGCTGCCAGCCTTCCCGGGCGCACATGGCGTGGCCGAAG
CGTTGGCCTACGGCGTGAAAGTCACAGGCTGTACGGTGCACCTGGTGGACGCCGGGACGGACACCGGGCCGATTTTGGCT
CAGCAATCCGTTCCGGTGCTCGACGGCGACGACGAACAGACGTTGCACGAACGCATCAAAGTCACCGAACGCAAGCTGCT
GGTGGATGTGGTGGCTGCGATCGCGACCGGCGGCCTGACCCTGGTCGGGAGAAAAGCGACGATCGGATGA

Upstream 100 bases:

>100_bases
CGGGCACTTCCCATGTGCCCCGCCGGCCCGGCGCGCCGGATTGTCGGGCTCCTCAGCGTGCCGTGACGGCACGCATCGTC
GCCCGACTAGGCTCGCCGAT

Downstream 100 bases:

>100_bases
AAGGCGACCAACCGATGAGCACCGACGACTGGCGGGAAAACGCCAAAAGGCCGATCCGTCGCGCCTTGATCAGCGTGTAC
GACAAGACCGGTCTGGTCGA

Product: phosphoribosylglycinamide formyltransferase

Products: NA

Alternate protein names: 5'-phosphoribosylglycinamide transformylase; GAR transformylase; GART [H]

Number of amino acids: Translated: 209; Mature: 209

Protein sequence:

>209_residues
MVEPLHVPPNAPARVVVLASGTGSLLSSLIDAAVGDYPARVVAVGADRDCLATQIAAAASLPSFTVRLGDHPDRAAWDAA
ITEATAAHSPDLVVSAGFMKILGPQFLSRFYGRVINTHPALLPAFPGAHGVAEALAYGVKVTGCTVHLVDAGTDTGPILA
QQSVPVLDGDDEQTLHERIKVTERKLLVDVVAAIATGGLTLVGRKATIG

Sequences:

>Translated_209_residues
MVEPLHVPPNAPARVVVLASGTGSLLSSLIDAAVGDYPARVVAVGADRDCLATQIAAAASLPSFTVRLGDHPDRAAWDAA
ITEATAAHSPDLVVSAGFMKILGPQFLSRFYGRVINTHPALLPAFPGAHGVAEALAYGVKVTGCTVHLVDAGTDTGPILA
QQSVPVLDGDDEQTLHERIKVTERKLLVDVVAAIATGGLTLVGRKATIG
>Mature_209_residues
MVEPLHVPPNAPARVVVLASGTGSLLSSLIDAAVGDYPARVVAVGADRDCLATQIAAAASLPSFTVRLGDHPDRAAWDAA
ITEATAAHSPDLVVSAGFMKILGPQFLSRFYGRVINTHPALLPAFPGAHGVAEALAYGVKVTGCTVHLVDAGTDTGPILA
QQSVPVLDGDDEQTLHERIKVTERKLLVDVVAAIATGGLTLVGRKATIG

Specific function: De novo purine biosynthesis; third step. [C]

COG id: COG0299

COG function: function code F; Folate-dependent phosphoribosylglycinamide formyltransferase PurN

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GART family [H]

Homologues:

Organism=Homo sapiens, GI4503915, Length=191, Percent_Identity=38.7434554973822, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI209869995, Length=191, Percent_Identity=38.7434554973822, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI209869993, Length=191, Percent_Identity=38.7434554973822, Blast_Score=126, Evalue=1e-29,
Organism=Escherichia coli, GI1788846, Length=190, Percent_Identity=35.7894736842105, Blast_Score=117, Evalue=4e-28,
Organism=Escherichia coli, GI1787483, Length=161, Percent_Identity=32.2981366459627, Blast_Score=89, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI17567511, Length=184, Percent_Identity=36.9565217391304, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI24582400, Length=188, Percent_Identity=40.9574468085106, Blast_Score=137, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002376
- InterPro:   IPR001555
- InterPro:   IPR004607 [H]

Pfam domain/function: PF00551 Formyl_trans_N [H]

EC number: =2.1.2.2 [H]

Molecular weight: Translated: 21479; Mature: 21479

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEPLHVPPNAPARVVVLASGTGSLLSSLIDAAVGDYPARVVAVGADRDCLATQIAAAAS
CCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHC
LPSFTVRLGDHPDRAAWDAAITEATAAHSPDLVVSAGFMKILGPQFLSRFYGRVINTHPA
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCCC
LLPAFPGAHGVAEALAYGVKVTGCTVHLVDAGTDTGPILAQQSVPVLDGDDEQTLHERIK
EECCCCCHHHHHHHHHHCEEEECEEEEEEECCCCCCCEEECCCCCCCCCCCHHHHHHHHH
VTERKLLVDVVAAIATGGLTLVGRKATIG
HHHHHHHHHHHHHHHCCCEEEEECCCCCC
>Mature Secondary Structure
MVEPLHVPPNAPARVVVLASGTGSLLSSLIDAAVGDYPARVVAVGADRDCLATQIAAAAS
CCCCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHC
LPSFTVRLGDHPDRAAWDAAITEATAAHSPDLVVSAGFMKILGPQFLSRFYGRVINTHPA
CCCEEEEECCCCCHHHHHHHHHHHHCCCCCCEEEEHHHHHHHCHHHHHHHHHHHHCCCCC
LLPAFPGAHGVAEALAYGVKVTGCTVHLVDAGTDTGPILAQQSVPVLDGDDEQTLHERIK
EECCCCCHHHHHHHHHHCEEEECEEEEEEECCCCCCCEEECCCCCCCCCCCHHHHHHHHH
VTERKLLVDVVAAIATGGLTLVGRKATIG
HHHHHHHHHHHHHHHCCCEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3036807; 9384377 [H]