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The map label for this gene is purH

Identifier: 41407001

GI number: 41407001

Start: 931891

End: 933492

Strand: Direct

Name: purH

Synonym: MAP0903

Alternate gene names: 41407001

Gene position: 931891-933492 (Clockwise)

Preceding gene: 41407000

Following gene: 41407002

Centisome position: 19.29

GC content: 68.73

Gene sequence:

>1602_bases
ATGAAAGGCGACCAACCGATGAGCACCGACGACTGGCGGGAAAACGCCAAAAGGCCGATCCGTCGCGCCTTGATCAGCGT
GTACGACAAGACCGGTCTGGTCGAGCTCGCCCAGGGGCTGACCGAGGCGGGCGTCGAGATCGTCTCGACCGGTTCCACCG
CGAAGGTCATTGCCGAGAAAGGCATTCCGGTGACCCGGGTCGAGGTGCTGACCGGTTTCCCCGAAGTGCTCGACGGCCGG
GTCAAGACACTGCACCCGCGCGTGCACGCCGGACTGCTGGCGGATCTGCGCAAACCCGAACACGCCGCGGCGCTCGAGCA
ACTCGGCATCGCCGCCTTCGAGCTCGTCGTCGTCAACCTGTATCCGTTCACCGAAACCGTCGACTCCGGCGCCGGCATCG
ACGAATGCGTCGAACAGATCGACATCGGCGGCCCGTCGATGGTGCGGGCCGCCGCCAAGAACCACCCCAGCGTGGCAGTG
GTCGTCGACCCACTCGGCTACGACGGGGTGCTCGCGGCGGTGCGCCACGGCGGATTCACCCTCGCCGAGCGTAAAAGGCT
GGCGGCGTTGGCGTTTCAGCACACCGCCGACTACGACATCGCGGTGGCGACGTGGATGGAGTCGACGCTGGCCCCCGAAC
ATCCGCCGACCACCTTCCCGAAGTGGCTGGGCCGCAGCTGGCGCCGCTCGGCGATGCTGCGCTACGGCGAGAACCCGCAC
CAGCAGGCGTCGCTGTACAGCGACCCGGGTGCCTGGCCGGGCCTGGCGCAAGCCGAGCAGCTGCACGGAAAAGAGATGTC
CTACAACAACTTCACCGATGCGGACGCGGCCTGGCGGGCGGCCTTCGACCATGAACAAACGTGTGTGGCAATCATCAAGC
ACGCCAACCCATGTGGGATCGCGATCTCGTCGATATCGGTCGCCGACGCGCATCGCAAGGCCCACGAATGCGATCCGCTC
AGCGCGTTCGGCGGCGTCATCGCCGCCAACACCGAAGTCAGCGTCGAGATGGCCGAATACGTCAGCACCATCTTCACCGA
GGTGATCATCGCCCCCGCGTATCAGCCCGCCGCCCTGGAGATCCTGACCCGCAAGAAGAACATCCGGGTGCTGGTGGCGT
CCGAGCCGCTGACCGGCGGCACCGAACTGCGCCCGATCAGCGGCGGGCTGCTGGTGCAGCAGCGCGACGAACTCGACGCG
CACGGCGACAACCCGGCCAATTGGACGCTGGCCACCGGGGCACCCGCCGACCCGGCCACGCTGGCGGACCTGGTGTTCGC
GTGGCGGGTGTGCCGCGCCGTCAAATCGAATGCCATCGTGATCGCCGCCGGCGGCGCCACCATCGGCGTCGGCATGGGCC
AGGTGAACCGGGTCGACGCCGCCCGGCTGGCCGTCGAACGAGGCGGGGACCGGGTGCGCGGCGCGGTCGCGGCTTCGGAT
GCGTTCTTCCCGTTCCCCGACGGGCTCGAGACGCTCACCGGCGCCGGGGTGAAGGCCGTCGTGCACCCCGGCGGGTCGGT
GCGCGACGACGAGGTGACCGCGGCCGCCGCCAACGCCGGCATCACGCTGTATCTCACCGGGGCGCGTCACTTCGCCCACT
AG

Upstream 100 bases:

>100_bases
ACGAACGCATCAAAGTCACCGAACGCAAGCTGCTGGTGGATGTGGTGGCTGCGATCGCGACCGGCGGCCTGACCCTGGTC
GGGAGAAAAGCGACGATCGG

Downstream 100 bases:

>100_bases
CGATTGGCCGCGATGCCGGTGATGGGGGTCACAAACGCGTCGATTCTCAGTACGATGCGTTCGGGGGAGGACCCGACGGC
CCCTGCGAGTTTCCTCCTTT

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 533; Mature: 533

Protein sequence:

>533_residues
MKGDQPMSTDDWRENAKRPIRRALISVYDKTGLVELAQGLTEAGVEIVSTGSTAKVIAEKGIPVTRVEVLTGFPEVLDGR
VKTLHPRVHAGLLADLRKPEHAAALEQLGIAAFELVVVNLYPFTETVDSGAGIDECVEQIDIGGPSMVRAAAKNHPSVAV
VVDPLGYDGVLAAVRHGGFTLAERKRLAALAFQHTADYDIAVATWMESTLAPEHPPTTFPKWLGRSWRRSAMLRYGENPH
QQASLYSDPGAWPGLAQAEQLHGKEMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGIAISSISVADAHRKAHECDPL
SAFGGVIAANTEVSVEMAEYVSTIFTEVIIAPAYQPAALEILTRKKNIRVLVASEPLTGGTELRPISGGLLVQQRDELDA
HGDNPANWTLATGAPADPATLADLVFAWRVCRAVKSNAIVIAAGGATIGVGMGQVNRVDAARLAVERGGDRVRGAVAASD
AFFPFPDGLETLTGAGVKAVVHPGGSVRDDEVTAAAANAGITLYLTGARHFAH

Sequences:

>Translated_533_residues
MKGDQPMSTDDWRENAKRPIRRALISVYDKTGLVELAQGLTEAGVEIVSTGSTAKVIAEKGIPVTRVEVLTGFPEVLDGR
VKTLHPRVHAGLLADLRKPEHAAALEQLGIAAFELVVVNLYPFTETVDSGAGIDECVEQIDIGGPSMVRAAAKNHPSVAV
VVDPLGYDGVLAAVRHGGFTLAERKRLAALAFQHTADYDIAVATWMESTLAPEHPPTTFPKWLGRSWRRSAMLRYGENPH
QQASLYSDPGAWPGLAQAEQLHGKEMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGIAISSISVADAHRKAHECDPL
SAFGGVIAANTEVSVEMAEYVSTIFTEVIIAPAYQPAALEILTRKKNIRVLVASEPLTGGTELRPISGGLLVQQRDELDA
HGDNPANWTLATGAPADPATLADLVFAWRVCRAVKSNAIVIAAGGATIGVGMGQVNRVDAARLAVERGGDRVRGAVAASD
AFFPFPDGLETLTGAGVKAVVHPGGSVRDDEVTAAAANAGITLYLTGARHFAH
>Mature_533_residues
MKGDQPMSTDDWRENAKRPIRRALISVYDKTGLVELAQGLTEAGVEIVSTGSTAKVIAEKGIPVTRVEVLTGFPEVLDGR
VKTLHPRVHAGLLADLRKPEHAAALEQLGIAAFELVVVNLYPFTETVDSGAGIDECVEQIDIGGPSMVRAAAKNHPSVAV
VVDPLGYDGVLAAVRHGGFTLAERKRLAALAFQHTADYDIAVATWMESTLAPEHPPTTFPKWLGRSWRRSAMLRYGENPH
QQASLYSDPGAWPGLAQAEQLHGKEMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGIAISSISVADAHRKAHECDPL
SAFGGVIAANTEVSVEMAEYVSTIFTEVIIAPAYQPAALEILTRKKNIRVLVASEPLTGGTELRPISGGLLVQQRDELDA
HGDNPANWTLATGAPADPATLADLVFAWRVCRAVKSNAIVIAAGGATIGVGMGQVNRVDAARLAVERGGDRVRGAVAASD
AFFPFPDGLETLTGAGVKAVVHPGGSVRDDEVTAAAANAGITLYLTGARHFAH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=483, Percent_Identity=34.9896480331263, Blast_Score=224, Evalue=2e-58,
Organism=Escherichia coli, GI1790439, Length=532, Percent_Identity=45.8646616541353, Blast_Score=442, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI71985564, Length=476, Percent_Identity=34.0336134453782, Blast_Score=224, Evalue=7e-59,
Organism=Caenorhabditis elegans, GI71985574, Length=307, Percent_Identity=26.0586319218241, Blast_Score=76, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71985556, Length=143, Percent_Identity=37.0629370629371, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323056, Length=480, Percent_Identity=34.375, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6323768, Length=482, Percent_Identity=33.8174273858921, Blast_Score=222, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24649832, Length=476, Percent_Identity=33.8235294117647, Blast_Score=211, Evalue=1e-54,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 56546; Mature: 56546

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGDQPMSTDDWRENAKRPIRRALISVYDKTGLVELAQGLTEAGVEIVSTGSTAKVIAEK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHC
GIPVTRVEVLTGFPEVLDGRVKTLHPRVHAGLLADLRKPEHAAALEQLGIAAFELVVVNL
CCCEEEHHHHHCCHHHHCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHCHHEEEEEEEEE
YPFTETVDSGAGIDECVEQIDIGGPSMVRAAAKNHPSVAVVVDPLGYDGVLAAVRHGGFT
ECCHHHCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCC
LAERKRLAALAFQHTADYDIAVATWMESTLAPEHPPTTFPKWLGRSWRRSAMLRYGENPH
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHCHHHHHHHHHHCCCCCC
QQASLYSDPGAWPGLAQAEQLHGKEMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGI
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCE
AISSISVADAHRKAHECDPLSAFGGVIAANTEVSVEMAEYVSTIFTEVIIAPAYQPAALE
EEEEEEHHHHHHHHCCCCCHHHHCCEEEECCEEEHHHHHHHHHHHHHHHHCCCCCCHHHH
ILTRKKNIRVLVASEPLTGGTELRPISGGLLVQQRDELDAHGDNPANWTLATGAPADPAT
HHCCCCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCEEEECCCCCCHHH
LADLVFAWRVCRAVKSNAIVIAAGGATIGVGMGQVNRVDAARLAVERGGDRVRGAVAASD
HHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHCCCCHHEEEEEECC
AFFPFPDGLETLTGAGVKAVVHPGGSVRDDEVTAAAANAGITLYLTGARHFAH
CCCCCCCCHHHHCCCCEEEEECCCCCCCCCCHHHEECCCCEEEEEECCHHCCC
>Mature Secondary Structure
MKGDQPMSTDDWRENAKRPIRRALISVYDKTGLVELAQGLTEAGVEIVSTGSTAKVIAEK
CCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCEEEECCCCHHHHHHC
GIPVTRVEVLTGFPEVLDGRVKTLHPRVHAGLLADLRKPEHAAALEQLGIAAFELVVVNL
CCCEEEHHHHHCCHHHHCCCHHHCCCHHHHHHHHHHCCCHHHHHHHHHCHHEEEEEEEEE
YPFTETVDSGAGIDECVEQIDIGGPSMVRAAAKNHPSVAVVVDPLGYDGVLAAVRHGGFT
ECCHHHCCCCCCHHHHHHHHCCCCHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHCCCCC
LAERKRLAALAFQHTADYDIAVATWMESTLAPEHPPTTFPKWLGRSWRRSAMLRYGENPH
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCCCCHHHHCHHHHHHHHHHCCCCCC
QQASLYSDPGAWPGLAQAEQLHGKEMSYNNFTDADAAWRAAFDHEQTCVAIIKHANPCGI
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHCCCCCCE
AISSISVADAHRKAHECDPLSAFGGVIAANTEVSVEMAEYVSTIFTEVIIAPAYQPAALE
EEEEEEHHHHHHHHCCCCCHHHHCCEEEECCEEEHHHHHHHHHHHHHHHHCCCCCCHHHH
ILTRKKNIRVLVASEPLTGGTELRPISGGLLVQQRDELDAHGDNPANWTLATGAPADPAT
HHCCCCCEEEEEECCCCCCCCEEEECCCCEEEEECCCCCCCCCCCCCEEEECCCCCCHHH
LADLVFAWRVCRAVKSNAIVIAAGGATIGVGMGQVNRVDAARLAVERGGDRVRGAVAASD
HHHHHHHHHHHHHHCCCEEEEEECCCEEECCCCCCCHHHHHHHHHHCCCCHHEEEEEECC
AFFPFPDGLETLTGAGVKAVVHPGGSVRDDEVTAAAANAGITLYLTGARHFAH
CCCCCCCCHHHHCCCCEEEEECCCCCCCCCCHHHEECCCCEEEEEECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA