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The map label for this gene is echA12_1

Identifier: 41406981

GI number: 41406981

Start: 909431

End: 910294

Strand: Direct

Name: echA12_1

Synonym: MAP0883

Alternate gene names: 41406981

Gene position: 909431-910294 (Clockwise)

Preceding gene: 41406979

Following gene: 41406986

Centisome position: 18.83

GC content: 67.48

Gene sequence:

>864_bases
ATGCGTGCATGCTATGCTGGGTCGTTGAACTGCCGCGGTGTCGCTTACGGTTCACCTATGCCCGCAGTGGAATTCGCGAC
CCTCGACGACGACATCGCCTGCATCACCCTGAACCGCCCCGAACGCCTCAACGCCATCGACGGCTCGCTGATCGACGGTG
TCCACGAGGCCCTGGACATGCTGGACAACGGTGACCACCGGGTGGCGGTCCTCACCGGCGCGGGCCGGGGATTCTGTGCC
GGTGCCGATCTGAGCGGTACCGGCCGGCCGTGGACGCGGAACAAGCCGACCACCCCGGCGTTCAAGGTCAACTACGACGC
CCAGGTCCGGCTGGCCAGCCTGTACACCCGGATCTACGAGCTCGATATCCCGGTGATCGCCGCGGTCAACGGCGTCGCCG
TCGGCGGCGGGCTGGCGTTCGCGTTGGTCAGCGATATCCGGGTGGGCTCGGAGCAGGCCCGGTTCGGTTCGGTGTTCATC
AAGGCCGGCTTCTCGTCGATGGACATGGGCACCAGCTACCTGCTGCCTAAAATCGTCGGCGCCGGGGTGGCCCGCGAGCT
GATGCTCACCGGCCGCATCATCGACGCGGCCGAGGCCTATCGCATCAGGCTGGTGCACGAGGTTGTCGCGCCCGATCAGC
TGATGCCCGCCGCGCTGCGGTTGGCCCGCTCGATCGCCGAGAACAACGCTTATGGCGTGTGGCAGACCAAGATCGGGCTC
AACGCGGCGCTGGACGCGCCCAGCCTGCGCCACGCCATCGAGCTGGAGAACCGCACCCAGATCCTGTCCGGTTTCACCAA
CAACCCGGCCGAGGCCGCCCTGGCACACCGGGAGAAGCGAGCGCCGAGGTGGGACCCCCTGTAA

Upstream 100 bases:

>100_bases
CCGCGGACGCCGGGTCGCGGCCGCGCGCGCGGCGGCGACCATGGTCGCGGTGGCGCCGACGCTGCTGGCCAGGTTCCAGG
TATCACCCTCGCTGCGTGTC

Downstream 100 bases:

>100_bases
AGCGCTGTGACGCTTGGGGTTTGGCGACGTCCGGTCAGACCTTCGCGATCACGTTCTCGGCGAACATCTCCAGATTGCGG
ATCTTGGTGTCCAGCGGCTC

Product: EchA12_1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 287; Mature: 287

Protein sequence:

>287_residues
MRACYAGSLNCRGVAYGSPMPAVEFATLDDDIACITLNRPERLNAIDGSLIDGVHEALDMLDNGDHRVAVLTGAGRGFCA
GADLSGTGRPWTRNKPTTPAFKVNYDAQVRLASLYTRIYELDIPVIAAVNGVAVGGGLAFALVSDIRVGSEQARFGSVFI
KAGFSSMDMGTSYLLPKIVGAGVARELMLTGRIIDAAEAYRIRLVHEVVAPDQLMPAALRLARSIAENNAYGVWQTKIGL
NAALDAPSLRHAIELENRTQILSGFTNNPAEAALAHREKRAPRWDPL

Sequences:

>Translated_287_residues
MRACYAGSLNCRGVAYGSPMPAVEFATLDDDIACITLNRPERLNAIDGSLIDGVHEALDMLDNGDHRVAVLTGAGRGFCA
GADLSGTGRPWTRNKPTTPAFKVNYDAQVRLASLYTRIYELDIPVIAAVNGVAVGGGLAFALVSDIRVGSEQARFGSVFI
KAGFSSMDMGTSYLLPKIVGAGVARELMLTGRIIDAAEAYRIRLVHEVVAPDQLMPAALRLARSIAENNAYGVWQTKIGL
NAALDAPSLRHAIELENRTQILSGFTNNPAEAALAHREKRAPRWDPL
>Mature_287_residues
MRACYAGSLNCRGVAYGSPMPAVEFATLDDDIACITLNRPERLNAIDGSLIDGVHEALDMLDNGDHRVAVLTGAGRGFCA
GADLSGTGRPWTRNKPTTPAFKVNYDAQVRLASLYTRIYELDIPVIAAVNGVAVGGGLAFALVSDIRVGSEQARFGSVFI
KAGFSSMDMGTSYLLPKIVGAGVARELMLTGRIIDAAEAYRIRLVHEVVAPDQLMPAALRLARSIAENNAYGVWQTKIGL
NAALDAPSLRHAIELENRTQILSGFTNNPAEAALAHREKRAPRWDPL

Specific function: Could possibly oxidize fatty acids using specific components [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=254, Percent_Identity=31.496062992126, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI45643119, Length=214, Percent_Identity=30.3738317757009, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI260275230, Length=214, Percent_Identity=30.3738317757009, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI260274832, Length=214, Percent_Identity=30.3738317757009, Blast_Score=75, Evalue=5e-14,
Organism=Homo sapiens, GI70995211, Length=212, Percent_Identity=32.5471698113208, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI68989263, Length=207, Percent_Identity=30.4347826086957, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI4502327, Length=261, Percent_Identity=29.1187739463602, Blast_Score=73, Evalue=4e-13,
Organism=Homo sapiens, GI31542718, Length=258, Percent_Identity=26.7441860465116, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1787660, Length=262, Percent_Identity=34.3511450381679, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI221142681, Length=266, Percent_Identity=33.0827067669173, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787659, Length=257, Percent_Identity=30.7392996108949, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1788597, Length=262, Percent_Identity=29.0076335877863, Blast_Score=85, Evalue=5e-18,
Organism=Escherichia coli, GI1788682, Length=200, Percent_Identity=31, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1790281, Length=199, Percent_Identity=28.643216080402, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17554946, Length=276, Percent_Identity=31.8840579710145, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI25145438, Length=256, Percent_Identity=35.15625, Blast_Score=111, Evalue=3e-25,
Organism=Caenorhabditis elegans, GI17540714, Length=215, Percent_Identity=33.0232558139535, Blast_Score=91, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17560910, Length=201, Percent_Identity=29.8507462686567, Blast_Score=88, Evalue=6e-18,
Organism=Caenorhabditis elegans, GI17534483, Length=283, Percent_Identity=27.5618374558304, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17535521, Length=215, Percent_Identity=27.906976744186, Blast_Score=71, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6320241, Length=209, Percent_Identity=28.2296650717703, Blast_Score=81, Evalue=2e-16,
Organism=Drosophila melanogaster, GI20129971, Length=265, Percent_Identity=30.9433962264151, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653477, Length=265, Percent_Identity=30.9433962264151, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24653139, Length=261, Percent_Identity=32.9501915708812, Blast_Score=105, Evalue=5e-23,
Organism=Drosophila melanogaster, GI19920382, Length=245, Percent_Identity=31.8367346938775, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21357171, Length=201, Percent_Identity=31.8407960199005, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24650670, Length=212, Percent_Identity=33.4905660377358, Blast_Score=81, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.2.1.17 [H]

Molecular weight: Translated: 30747; Mature: 30747

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRACYAGSLNCRGVAYGSPMPAVEFATLDDDIACITLNRPERLNAIDGSLIDGVHEALDM
CCCEECCCCCCCEEECCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
LDNGDHRVAVLTGAGRGFCAGADLSGTGRPWTRNKPTTPAFKVNYDAQVRLASLYTRIYE
HCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEHHHHHHHHHHH
LDIPVIAAVNGVAVGGGLAFALVSDIRVGSEQARFGSVFIKAGFSSMDMGTSYLLPKIVG
CCCCCEEEECCEEECCHHHHHHHHHHHCCCCHHHHCEEEEEECCCCCCCCHHHHHHHHHH
AGVARELMLTGRIIDAAEAYRIRLVHEVVAPDQLMPAALRLARSIAENNAYGVWQTKIGL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECCC
NAALDAPSLRHAIELENRTQILSGFTNNPAEAALAHREKRAPRWDPL
CEECCCCHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRACYAGSLNCRGVAYGSPMPAVEFATLDDDIACITLNRPERLNAIDGSLIDGVHEALDM
CCCEECCCCCCCEEECCCCCCCEEEEECCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHH
LDNGDHRVAVLTGAGRGFCAGADLSGTGRPWTRNKPTTPAFKVNYDAQVRLASLYTRIYE
HCCCCCEEEEEEECCCCEEECCCCCCCCCCCCCCCCCCCEEEECCCCEEHHHHHHHHHHH
LDIPVIAAVNGVAVGGGLAFALVSDIRVGSEQARFGSVFIKAGFSSMDMGTSYLLPKIVG
CCCCCEEEECCEEECCHHHHHHHHHHHCCCCHHHHCEEEEEECCCCCCCCHHHHHHHHHH
AGVARELMLTGRIIDAAEAYRIRLVHEVVAPDQLMPAALRLARSIAENNAYGVWQTKIGL
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECCC
NAALDAPSLRHAIELENRTQILSGFTNNPAEAALAHREKRAPRWDPL
CEECCCCHHHHHHHHCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]