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The map label for this gene is pdxH

Identifier: 41406926

GI number: 41406926

Start: 845011

End: 845673

Strand: Direct

Name: pdxH

Synonym: MAP0828

Alternate gene names: 41406926

Gene position: 845011-845673 (Clockwise)

Preceding gene: 41406923

Following gene: 41406927

Centisome position: 17.5

GC content: 69.98

Gene sequence:

>663_bases
GTGCCGGGACCAGCAGACGAGCACCTGCAGAGAATGCGTGTGGAATACGGATCGGTGGAAAAGGACGGCAGCCCGGATCT
GGACGTCGACTGGCTCGACGACGGCTGGGTTGCGTTGTTGCGCAAGTGGATCGACGACGCCGAGCGCGCCGGGGTGGCCG
AGCCCAACGCGATGGTGCTGGCCACCGTCACCCCCGACGGCAGACCGGCCAGCCGAACGGTGCTGTGCAAGAGCCTGGAC
GAGACGGGGATCACTTTTTTCACCAACTATGACTCGGCCAAGGCCGACGATCTGGCGGCGACGCCGTACGCCGCGGTGAC
GTTCCCGTGGTACCAGCTGGGCCGGCAGGTCCACCTGCGCGGGCCGGTGAGCAAAGTCACGGCCCAGGTCACCGAGGACT
ACTGGTCCAAGCGACCGCGCGGGTCGCAGCTGGGCGCCTGGGCGTCGCAGCAGTCCCGGCCGATCGCCTCCCGCGCGGCC
CTGCTGGAGCAGCTGGCGCAGGTGACGGCCCGCTTCGCCGACCACGAGCGGGTGCCGGTGCCGCCGGGCTGGGGCGGCTA
CCTCATCGCCGCCGACGTGGTGGAGTTCTGGCAGGGGCGGGAAAACCGGTTGCACAACCGCATCCGGGTCACCGGCGACC
GGGTGGAGCGTCTGCAGCCGTAG

Upstream 100 bases:

>100_bases
GGGACAAAGTTCTCGGGGACAACAGTCATGGGAAAATTCTCGCACCCCGCCCTGGGGCGGACGCTACCGGCCGGTAGCAA
GCGCCGGTAGCGTTGGCGCG

Downstream 100 bases:

>100_bases
CGCGCCGGGCCACTTGATCGATTGCGTGACCAGCGGACTCGACCCCGGGCAGGCGCCTCCTCGCCATAACGACTACCTTC
AGCTGTAAGCACCTAGTCAG

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 220; Mature: 219

Protein sequence:

>220_residues
MPGPADEHLQRMRVEYGSVEKDGSPDLDVDWLDDGWVALLRKWIDDAERAGVAEPNAMVLATVTPDGRPASRTVLCKSLD
ETGITFFTNYDSAKADDLAATPYAAVTFPWYQLGRQVHLRGPVSKVTAQVTEDYWSKRPRGSQLGAWASQQSRPIASRAA
LLEQLAQVTARFADHERVPVPPGWGGYLIAADVVEFWQGRENRLHNRIRVTGDRVERLQP

Sequences:

>Translated_220_residues
MPGPADEHLQRMRVEYGSVEKDGSPDLDVDWLDDGWVALLRKWIDDAERAGVAEPNAMVLATVTPDGRPASRTVLCKSLD
ETGITFFTNYDSAKADDLAATPYAAVTFPWYQLGRQVHLRGPVSKVTAQVTEDYWSKRPRGSQLGAWASQQSRPIASRAA
LLEQLAQVTARFADHERVPVPPGWGGYLIAADVVEFWQGRENRLHNRIRVTGDRVERLQP
>Mature_219_residues
PGPADEHLQRMRVEYGSVEKDGSPDLDVDWLDDGWVALLRKWIDDAERAGVAEPNAMVLATVTPDGRPASRTVLCKSLDE
TGITFFTNYDSAKADDLAATPYAAVTFPWYQLGRQVHLRGPVSKVTAQVTEDYWSKRPRGSQLGAWASQQSRPIASRAAL
LEQLAQVTARFADHERVPVPPGWGGYLIAADVVEFWQGRENRLHNRIRVTGDRVERLQP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=167, Percent_Identity=42.5149700598802, Blast_Score=145, Evalue=2e-35,
Organism=Escherichia coli, GI1787926, Length=188, Percent_Identity=38.2978723404255, Blast_Score=148, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17553712, Length=174, Percent_Identity=37.3563218390805, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6319509, Length=185, Percent_Identity=41.6216216216216, Blast_Score=137, Evalue=1e-33,
Organism=Drosophila melanogaster, GI45551845, Length=173, Percent_Identity=43.9306358381503, Blast_Score=150, Evalue=5e-37,
Organism=Drosophila melanogaster, GI24644901, Length=173, Percent_Identity=43.9306358381503, Blast_Score=150, Evalue=6e-37,
Organism=Drosophila melanogaster, GI24644903, Length=165, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_MYCPA (Q742K7)

Other databases:

- EMBL:   AE016958
- RefSeq:   NP_959762.1
- ProteinModelPortal:   Q742K7
- SMR:   Q742K7
- EnsemblBacteria:   EBMYCT00000036816
- GeneID:   2719515
- GenomeReviews:   AE016958_GR
- KEGG:   mpa:MAP0828
- NMPDR:   fig|262316.1.peg.828
- GeneTree:   EBGT00050000017296
- HOGENOM:   HBG327559
- OMA:   FTFFTNY
- ProtClustDB:   PRK05679
- BRENDA:   1.4.3.5
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 24551; Mature: 24420

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 72-72 BINDING 75-75 BINDING 77-77 BINDING 94-94 BINDING 134-134 BINDING 138-138 BINDING 142-142

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPGPADEHLQRMRVEYGSVEKDGSPDLDVDWLDDGWVALLRKWIDDAERAGVAEPNAMVL
CCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEE
ATVTPDGRPASRTVLCKSLDETGITFFTNYDSAKADDLAATPYAAVTFPWYQLGRQVHLR
EEECCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEECCHHHCCCEEEEC
GPVSKVTAQVTEDYWSKRPRGSQLGAWASQQSRPIASRAALLEQLAQVTARFADHERVPV
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PPGWGGYLIAADVVEFWQGRENRLHNRIRVTGDRVERLQP
CCCCCCHHHHHHHHHHHCCHHHHHHHHEEECHHHHHCCCC
>Mature Secondary Structure 
PGPADEHLQRMRVEYGSVEKDGSPDLDVDWLDDGWVALLRKWIDDAERAGVAEPNAMVL
CCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCCCEEE
ATVTPDGRPASRTVLCKSLDETGITFFTNYDSAKADDLAATPYAAVTFPWYQLGRQVHLR
EEECCCCCCCHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCEEECCHHHCCCEEEEC
GPVSKVTAQVTEDYWSKRPRGSQLGAWASQQSRPIASRAALLEQLAQVTARFADHERVPV
CCHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCC
PPGWGGYLIAADVVEFWQGRENRLHNRIRVTGDRVERLQP
CCCCCCHHHHHHHHHHHCCHHHHHHHHEEECHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA