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The map label for this gene is gltA

Identifier: 41406927

GI number: 41406927

Start: 845809

End: 847104

Strand: Direct

Name: gltA

Synonym: MAP0829

Alternate gene names: 41406927

Gene position: 845809-847104 (Clockwise)

Preceding gene: 41406926

Following gene: 41406934

Centisome position: 17.51

GC content: 65.35

Gene sequence:

>1296_bases
GTGGCCGACACCGACGACATCGCCACTTTGAAGTACCCGGGCGGGGAAACCGACCTGGAGATCGTCAGCGCCACCGAGGG
CGCCGACGGCATCGCGCTGGGTTCGCTGTTGTCCAAGACCGGCTACACCACCTTCGACAACGGCTTTGTCAACACCGCCT
CGTGCAAGAGCGCGATCACCTACATCGACGGCGACGCCGGCATCCTGCGTTACCGCGGCTACCCGATCGAGCAACTGGCC
GAGAAGTCGACCTTCCTCGAGGTGAGCTACCTGTTGATCTACGGCGAGCTGCCGGACAAGGACCAGCTGGCCGAGTTCAC
CAAGCGGATCCAGCTGCACACCATGCTGCACGAGGACCTGAAGCGGTTCTTCGACGGCTTCCCTCGCAACGCCCACCCGA
TGCCGGTGCTGTCCAGTGCCGTCAACGCGCTGTCCGCCTACTACCCCGATTCGCTGGACCCGATGGACACCGAGGACGTC
GAGCTGTCCACGATCCGGTTGCTGGCCAAGCTGCCGACCATCGCCGCGTACGCCTACAAGAAGTCGGTCGGCCAGCCCTT
CCTCTACCCGGACAACAAGCTGAGCCTGGTGGAGAACTTCCTGCGCATGACGTTCGGCCTGCCCGCCGAGCCGTACCAGG
CCGACCCCGAGGTGGTCCGCGCGCTGGACATGCTGCTGATCCTGCACGCCGACCACGAACAGAACTGCTCGACGTCGACG
GTCCGGCTGGTGGGGTCCTCCCAGGCCAACCTGTTCACCTCCATCTCCGGCGGCATCAACGCGCTGTGGGGGCCGCTGCA
CGGTGGGGCCAACCAGGCGGTGCTCGAGATGCTGGAGAAGATCCGCCAAAGCGACGACGACGTCAGCGAATTCGTGCGCA
AGGTGAAGAACCGCGAGGCCGGGGTGAAGCTGATGGGCTTCGGTCACCGGGTGTACAAGAACTACGACCCGCGGGCGCGC
ATCGTCAAGGAACAGGCCGACAAGATCCTGGCCAAGCTCGGCGGCGACGACGACCTGCTCGACATCGCCAAGCAACTCGA
AGAGGCCGCGCTGACCGACGAGTACTTCATCGAGCGCAAGCTGTACCCCAACGTCGACTTCTACACCGGCCTGATCTACC
GGGCGCTGGGCTTCCCGACCCGGATGTTCACCGTGCTGTTCGCGCTGGGGCGCCTGCCCGGCTGGATCGCGCACTGGCGC
GAGATGCACGACGAGGGCGACAGCAAGATCGGCCGCCCGCGCCAGATCTACACCGGCTACACCGAGCGCGACTACGTCAC
CATCGACGCCCGCTAG

Upstream 100 bases:

>100_bases
GACTCGACCCCGGGCAGGCGCCTCCTCGCCATAACGACTACCTTCAGCTGTAAGCACCTAGTCAGGGCAGCCATATCAGC
CAGAGCGCAAAGGGGTTCTC

Downstream 100 bases:

>100_bases
TTTTCCCGCTCACCGGGAGGACAGGGAGGACAGCACCGCCATCGCGGCGTTGTGGCCACCGATGCCCGACACCGCCCCGC
CGCGCCGGGCGCCCGAGCCG

Product: type II citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MADTDDIATLKYPGGETDLEIVSATEGADGIALGSLLSKTGYTTFDNGFVNTASCKSAITYIDGDAGILRYRGYPIEQLA
EKSTFLEVSYLLIYGELPDKDQLAEFTKRIQLHTMLHEDLKRFFDGFPRNAHPMPVLSSAVNALSAYYPDSLDPMDTEDV
ELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNKLSLVENFLRMTFGLPAEPYQADPEVVRALDMLLILHADHEQNCSTST
VRLVGSSQANLFTSISGGINALWGPLHGGANQAVLEMLEKIRQSDDDVSEFVRKVKNREAGVKLMGFGHRVYKNYDPRAR
IVKEQADKILAKLGGDDDLLDIAKQLEEAALTDEYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHWR
EMHDEGDSKIGRPRQIYTGYTERDYVTIDAR

Sequences:

>Translated_431_residues
MADTDDIATLKYPGGETDLEIVSATEGADGIALGSLLSKTGYTTFDNGFVNTASCKSAITYIDGDAGILRYRGYPIEQLA
EKSTFLEVSYLLIYGELPDKDQLAEFTKRIQLHTMLHEDLKRFFDGFPRNAHPMPVLSSAVNALSAYYPDSLDPMDTEDV
ELSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNKLSLVENFLRMTFGLPAEPYQADPEVVRALDMLLILHADHEQNCSTST
VRLVGSSQANLFTSISGGINALWGPLHGGANQAVLEMLEKIRQSDDDVSEFVRKVKNREAGVKLMGFGHRVYKNYDPRAR
IVKEQADKILAKLGGDDDLLDIAKQLEEAALTDEYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHWR
EMHDEGDSKIGRPRQIYTGYTERDYVTIDAR
>Mature_430_residues
ADTDDIATLKYPGGETDLEIVSATEGADGIALGSLLSKTGYTTFDNGFVNTASCKSAITYIDGDAGILRYRGYPIEQLAE
KSTFLEVSYLLIYGELPDKDQLAEFTKRIQLHTMLHEDLKRFFDGFPRNAHPMPVLSSAVNALSAYYPDSLDPMDTEDVE
LSTIRLLAKLPTIAAYAYKKSVGQPFLYPDNKLSLVENFLRMTFGLPAEPYQADPEVVRALDMLLILHADHEQNCSTSTV
RLVGSSQANLFTSISGGINALWGPLHGGANQAVLEMLEKIRQSDDDVSEFVRKVKNREAGVKLMGFGHRVYKNYDPRARI
VKEQADKILAKLGGDDDLLDIAKQLEEAALTDEYFIERKLYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHWRE
MHDEGDSKIGRPRQIYTGYTERDYVTIDAR

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=370, Percent_Identity=29.7297297297297, Blast_Score=122, Evalue=8e-28,
Organism=Escherichia coli, GI1786939, Length=427, Percent_Identity=54.5667447306792, Blast_Score=480, Evalue=1e-137,
Organism=Escherichia coli, GI1786527, Length=388, Percent_Identity=32.9896907216495, Blast_Score=199, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI17555174, Length=423, Percent_Identity=29.7872340425532, Blast_Score=128, Evalue=5e-30,
Organism=Saccharomyces cerevisiae, GI6319850, Length=326, Percent_Identity=28.2208588957055, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6324328, Length=361, Percent_Identity=27.4238227146814, Blast_Score=114, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6325257, Length=373, Percent_Identity=25.4691689008043, Blast_Score=91, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24640126, Length=391, Percent_Identity=28.6445012787724, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI24640124, Length=391, Percent_Identity=28.6445012787724, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI21356863, Length=332, Percent_Identity=28.3132530120482, Blast_Score=99, Evalue=5e-21,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48256; Mature: 48125

Theoretical pI: Translated: 4.88; Mature: 4.88

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADTDDIATLKYPGGETDLEIVSATEGADGIALGSLLSKTGYTTFDNGFVNTASCKSAIT
CCCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHEE
YIDGDAGILRYRGYPIEQLAEKSTFLEVSYLLIYGELPDKDQLAEFTKRIQLHTMLHEDL
EEECCCCEEEECCCCHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
KRFFDGFPRNAHPMPVLSSAVNALSAYYPDSLDPMDTEDVELSTIRLLAKLPTIAAYAYK
HHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KSVGQPFLYPDNKLSLVENFLRMTFGLPAEPYQADPEVVRALDMLLILHADHEQNCSTST
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCE
VRLVGSSQANLFTSISGGINALWGPLHGGANQAVLEMLEKIRQSDDDVSEFVRKVKNREA
EEEECCCCCCEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
GVKLMGFGHRVYKNYDPRARIVKEQADKILAKLGGDDDLLDIAKQLEEAALTDEYFIERK
CEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHH
LYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHWREMHDEGDSKIGRPRQIYTGY
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEECC
TERDYVTIDAR
CCCCEEEEECC
>Mature Secondary Structure 
ADTDDIATLKYPGGETDLEIVSATEGADGIALGSLLSKTGYTTFDNGFVNTASCKSAIT
CCCCCCEEEECCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHEE
YIDGDAGILRYRGYPIEQLAEKSTFLEVSYLLIYGELPDKDQLAEFTKRIQLHTMLHEDL
EEECCCCEEEECCCCHHHHHHHHHHHEEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
KRFFDGFPRNAHPMPVLSSAVNALSAYYPDSLDPMDTEDVELSTIRLLAKLPTIAAYAYK
HHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
KSVGQPFLYPDNKLSLVENFLRMTFGLPAEPYQADPEVVRALDMLLILHADHEQNCSTST
HHCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHEECCCCCCCCCCE
VRLVGSSQANLFTSISGGINALWGPLHGGANQAVLEMLEKIRQSDDDVSEFVRKVKNREA
EEEECCCCCCEEEECCCCHHHHCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
GVKLMGFGHRVYKNYDPRARIVKEQADKILAKLGGDDDLLDIAKQLEEAALTDEYFIERK
CEEEEECCHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCHHHHHHHH
LYPNVDFYTGLIYRALGFPTRMFTVLFALGRLPGWIAHWREMHDEGDSKIGRPRQIYTGY
CCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCEEEECC
TERDYVTIDAR
CCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]