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The map label for this gene is adk

Identifier: 39997928

GI number: 39997928

Start: 3118533

End: 3119186

Strand: Reverse

Name: adk

Synonym: GSU2836

Alternate gene names: 39997928

Gene position: 3119186-3118533 (Counterclockwise)

Preceding gene: 39997929

Following gene: 39997927

Centisome position: 81.78

GC content: 54.59

Gene sequence:

>654_bases
ATGAATCTGGTGTTTCTCGGTCCGCCTGGTGCCGGCAAGGGGACGCAGGCAAACCTGTTAACTCGTACGTATGAAGTCCC
GCAGATTTCAACCGGCGAAATACTTCGCGCAGCCGTTAAGTCAAAGACCCCTATGGGGGTCAAGGCTAAAGAGTACATGG
ATCAGGGTGCACTCGTCCCTGACAGTGTCGTTGTCGGTATTGTAGAGGAGCGGCTAGCTTCGCCTGATTGTGCGTCCGGC
TTTATCCTTGACGGATTTCCCCGTACCGTTGCCCAGGCCGATGCACTCAAGCAGGTGCTTGGTGCGTTGGGTAAGCAGAT
AGAGCACGTCGTCTCGTTTGAAGTCGACAAGGGTGTGCTTCTGGAGCGTATCGTCGGTCGCAGGGTGTGCCGTGCATGCG
GACGGGCATTTCATGTCAAATTTGATCCACCCCTCGTTGACGGTGTCTGTGATGCGTGTGGTGGAGAGCTCTATCAGCGT
GATGACGACCGCGAAGACACCATGCGGCGTAGGCTTGAAGTTTATGATGAGCAGACAGCGCCCCTGAAATCATATTATGA
GGGTGAGAGGCTCCTGCGGAAAGTGAATGCTCTGGAGCCGATCGAAGATGTACAGCGTCAGATTGTGAAGCTTGTCGAGA
GTTGTAACGGGTGA

Upstream 100 bases:

>100_bases
GGCACAGATTGAATCCCATCTCATCACCCGAAGCTATGAGGGTTTTATGAAGGGTGTGCGGGTGCGGGGCGGGCGGTAAT
ACTGGCGTGGAGTGTGCTGC

Downstream 100 bases:

>100_bases
TCATACTCAAGTCACCTCGTGAAATTGAAAAGATGCGGGTGTCCGCCAGGATAGTCGCTGAAGTTCTTGAGATTCTCAAG
GCTTGCATTAGGCCGGGCGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MNLVFLGPPGAGKGTQANLLTRTYEVPQISTGEILRAAVKSKTPMGVKAKEYMDQGALVPDSVVVGIVEERLASPDCASG
FILDGFPRTVAQADALKQVLGALGKQIEHVVSFEVDKGVLLERIVGRRVCRACGRAFHVKFDPPLVDGVCDACGGELYQR
DDDREDTMRRRLEVYDEQTAPLKSYYEGERLLRKVNALEPIEDVQRQIVKLVESCNG

Sequences:

>Translated_217_residues
MNLVFLGPPGAGKGTQANLLTRTYEVPQISTGEILRAAVKSKTPMGVKAKEYMDQGALVPDSVVVGIVEERLASPDCASG
FILDGFPRTVAQADALKQVLGALGKQIEHVVSFEVDKGVLLERIVGRRVCRACGRAFHVKFDPPLVDGVCDACGGELYQR
DDDREDTMRRRLEVYDEQTAPLKSYYEGERLLRKVNALEPIEDVQRQIVKLVESCNG
>Mature_217_residues
MNLVFLGPPGAGKGTQANLLTRTYEVPQISTGEILRAAVKSKTPMGVKAKEYMDQGALVPDSVVVGIVEERLASPDCASG
FILDGFPRTVAQADALKQVLGALGKQIEHVVSFEVDKGVLLERIVGRRVCRACGRAFHVKFDPPLVDGVCDACGGELYQR
DDDREDTMRRRLEVYDEQTAPLKSYYEGERLLRKVNALEPIEDVQRQIVKLVESCNG

Specific function: This small ubiquitous enzyme is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=194, Percent_Identity=41.2371134020619, Blast_Score=158, Evalue=3e-39,
Organism=Homo sapiens, GI4502013, Length=194, Percent_Identity=41.2371134020619, Blast_Score=158, Evalue=3e-39,
Organism=Homo sapiens, GI19923437, Length=196, Percent_Identity=36.2244897959184, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI310110345, Length=196, Percent_Identity=31.6326530612245, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI53832003, Length=196, Percent_Identity=31.6326530612245, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI8051579, Length=196, Percent_Identity=31.6326530612245, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI53832001, Length=196, Percent_Identity=31.6326530612245, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI4502011, Length=209, Percent_Identity=29.6650717703349, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI22749187, Length=185, Percent_Identity=28.1081081081081, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI28144897, Length=222, Percent_Identity=29.7297297297297, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI28144899, Length=222, Percent_Identity=29.7297297297297, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI7706497, Length=213, Percent_Identity=22.5352112676056, Blast_Score=74, Evalue=1e-13,
Organism=Escherichia coli, GI1786680, Length=217, Percent_Identity=47.0046082949309, Blast_Score=204, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI17552384, Length=205, Percent_Identity=41.9512195121951, Blast_Score=169, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17567503, Length=204, Percent_Identity=30.8823529411765, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17537943, Length=188, Percent_Identity=32.4468085106383, Blast_Score=100, Evalue=7e-22,
Organism=Saccharomyces cerevisiae, GI6320432, Length=211, Percent_Identity=39.8104265402844, Blast_Score=172, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6321018, Length=185, Percent_Identity=38.3783783783784, Blast_Score=136, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6322828, Length=209, Percent_Identity=23.444976076555, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI22026816, Length=208, Percent_Identity=41.8269230769231, Blast_Score=173, Evalue=7e-44,
Organism=Drosophila melanogaster, GI17737899, Length=189, Percent_Identity=38.6243386243386, Blast_Score=139, Evalue=9e-34,
Organism=Drosophila melanogaster, GI24645822, Length=189, Percent_Identity=38.6243386243386, Blast_Score=139, Evalue=9e-34,
Organism=Drosophila melanogaster, GI17647141, Length=212, Percent_Identity=25, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24663208, Length=212, Percent_Identity=25, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221459597, Length=211, Percent_Identity=24.1706161137441, Blast_Score=74, Evalue=6e-14,
Organism=Drosophila melanogaster, GI21356893, Length=211, Percent_Identity=24.1706161137441, Blast_Score=74, Evalue=6e-14,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_GEOSL (Q749A8)

Other databases:

- EMBL:   AE017180
- RefSeq:   NP_953879.1
- ProteinModelPortal:   Q749A8
- SMR:   Q749A8
- GeneID:   2688728
- GenomeReviews:   AE017180_GR
- KEGG:   gsu:GSU2836
- NMPDR:   fig|243231.1.peg.2817
- TIGR:   GSU2836
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   GSUL243231:GSU_2836-MONOMER
- BRENDA:   2.7.4.3
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23834; Mature: 23834

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLVFLGPPGAGKGTQANLLTRTYEVPQISTGEILRAAVKSKTPMGVKAKEYMDQGALVP
CCEEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCC
DSVVVGIVEERLASPDCASGFILDGFPRTVAQADALKQVLGALGKQIEHVVSFEVDKGVL
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LERIVGRRVCRACGRAFHVKFDPPLVDGVCDACGGELYQRDDDREDTMRRRLEVYDEQTA
HHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCCCC
PLKSYYEGERLLRKVNALEPIEDVQRQIVKLVESCNG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNLVFLGPPGAGKGTQANLLTRTYEVPQISTGEILRAAVKSKTPMGVKAKEYMDQGALVP
CCEEEECCCCCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCC
DSVVVGIVEERLASPDCASGFILDGFPRTVAQADALKQVLGALGKQIEHVVSFEVDKGVL
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LERIVGRRVCRACGRAFHVKFDPPLVDGVCDACGGELYQRDDDREDTMRRRLEVYDEQTA
HHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHCCHHHCCCCCHHHHHHHHHHHHCCCCC
PLKSYYEGERLLRKVNALEPIEDVQRQIVKLVESCNG
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA