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The map label for this gene is map [H]

Identifier: 39997927

GI number: 39997927

Start: 3117790

End: 3118536

Strand: Reverse

Name: map [H]

Synonym: GSU2835

Alternate gene names: 39997927

Gene position: 3118536-3117790 (Counterclockwise)

Preceding gene: 39997928

Following gene: 39997926

Centisome position: 81.76

GC content: 53.41

Gene sequence:

>747_bases
GTGATCATACTCAAGTCACCTCGTGAAATTGAAAAGATGCGGGTGTCCGCCAGGATAGTCGCTGAAGTTCTTGAGATTCT
CAAGGCTTGCATTAGGCCGGGCGTAACCACTCTGGAGCTCAACGAGCTGGCCGAGCTTGAGGCGAAGAAGCGCAAGGCGC
GACCGGCATTCAAGGGTTATAACGGTTTTCCCTATTCGCTCTGTTGTTCGGTTAACGAGCAGGTTGTTCACGGTATGCCG
AATAGCCGGGAGTTGGTCGAGGGTGACATAATCAGCCTCGATTTTGGTGTTGTTGTTGACGGGTTTTATGGCGATGCAGC
CGTTACCGTTCCCGTCGGAAGGGTAAAGCCCGGTGTGCTTGATCTCCTTGCCGTAACCGAAGAGTCGCTTTGTCGGGCGG
TTGAGGCATCAGTAGTCGGCAACCGGCTTTCGGATATATCGCACGCAGTGCAAAGCTTTGTTGAGGAACGCGGCTATTCT
GTTGTGCGCGAATTCGTTGGACACGGCATTGGTAAAAATCTTCACGAAAGCCCCCAGGTGCCCAACTTCGGAGAGCCGGG
GCGCGGCGTGAAGCTCAAGGCCGGGATGGTACTGGCCATCGAGCCGATGATCAACGAAAAGGGGCATCAAGTTAAAATCC
TCAGTGATGGATGGACCGCAGTCACCTGTGACAAGGGCATGTCGGCTCACTTTGAGCATACAGTGGCAATTACGGAGAAT
GGTCCGGATATACTGAGCAAGTTATAG

Upstream 100 bases:

>100_bases
CATATTATGAGGGTGAGAGGCTCCTGCGGAAAGTGAATGCTCTGGAGCCGATCGAAGATGTACAGCGTCAGATTGTGAAG
CTTGTCGAGAGTTGTAACGG

Downstream 100 bases:

>100_bases
CACCAGCGAAGCACGCGAAAGGAAATGTCTATGAAAGTCAGGGCATCCGTAAAAAAGATTTGCGACAAGTGCAAAATTGT
TAAACGCAAGGGTGTTGTGC

Product: methionine aminopeptidase, type I

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MIILKSPREIEKMRVSARIVAEVLEILKACIRPGVTTLELNELAELEAKKRKARPAFKGYNGFPYSLCCSVNEQVVHGMP
NSRELVEGDIISLDFGVVVDGFYGDAAVTVPVGRVKPGVLDLLAVTEESLCRAVEASVVGNRLSDISHAVQSFVEERGYS
VVREFVGHGIGKNLHESPQVPNFGEPGRGVKLKAGMVLAIEPMINEKGHQVKILSDGWTAVTCDKGMSAHFEHTVAITEN
GPDILSKL

Sequences:

>Translated_248_residues
MIILKSPREIEKMRVSARIVAEVLEILKACIRPGVTTLELNELAELEAKKRKARPAFKGYNGFPYSLCCSVNEQVVHGMP
NSRELVEGDIISLDFGVVVDGFYGDAAVTVPVGRVKPGVLDLLAVTEESLCRAVEASVVGNRLSDISHAVQSFVEERGYS
VVREFVGHGIGKNLHESPQVPNFGEPGRGVKLKAGMVLAIEPMINEKGHQVKILSDGWTAVTCDKGMSAHFEHTVAITEN
GPDILSKL
>Mature_248_residues
MIILKSPREIEKMRVSARIVAEVLEILKACIRPGVTTLELNELAELEAKKRKARPAFKGYNGFPYSLCCSVNEQVVHGMP
NSRELVEGDIISLDFGVVVDGFYGDAAVTVPVGRVKPGVLDLLAVTEESLCRAVEASVVGNRLSDISHAVQSFVEERGYS
VVREFVGHGIGKNLHESPQVPNFGEPGRGVKLKAGMVLAIEPMINEKGHQVKILSDGWTAVTCDKGMSAHFEHTVAITEN
GPDILSKL

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=247, Percent_Identity=40.4858299595142, Blast_Score=191, Evalue=5e-49,
Organism=Homo sapiens, GI40385867, Length=247, Percent_Identity=35.2226720647773, Blast_Score=157, Evalue=7e-39,
Organism=Homo sapiens, GI11559925, Length=264, Percent_Identity=23.4848484848485, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI1786364, Length=249, Percent_Identity=42.9718875502008, Blast_Score=209, Evalue=1e-55,
Organism=Escherichia coli, GI1788728, Length=214, Percent_Identity=24.2990654205607, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71996291, Length=241, Percent_Identity=38.1742738589212, Blast_Score=153, Evalue=8e-38,
Organism=Saccharomyces cerevisiae, GI6323273, Length=239, Percent_Identity=38.0753138075314, Blast_Score=171, Evalue=1e-43,
Organism=Drosophila melanogaster, GI21355531, Length=239, Percent_Identity=38.4937238493724, Blast_Score=168, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24583427, Length=246, Percent_Identity=34.1463414634146, Blast_Score=162, Evalue=1e-40,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 26901; Mature: 26901

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILKSPREIEKMRVSARIVAEVLEILKACIRPGVTTLELNELAELEAKKRKARPAFKGY
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCCCC
NGFPYSLCCSVNEQVVHGMPNSRELVEGDIISLDFGVVVDGFYGDAAVTVPVGRVKPGVL
CCCCCEEEECCCHHHHCCCCCCCCHHCCCEEEEECCEEEECCCCCEEEEEECCCCCCCHH
DLLAVTEESLCRAVEASVVGNRLSDISHAVQSFVEERGYSVVREFVGHGIGKNLHESPQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PNFGEPGRGVKLKAGMVLAIEPMINEKGHQVKILSDGWTAVTCDKGMSAHFEHTVAITEN
CCCCCCCCCEEEECCEEEEEECCCCCCCCEEEEEECCCEEEEECCCCCCCCEEEEEEECC
GPDILSKL
CHHHHHCC
>Mature Secondary Structure
MIILKSPREIEKMRVSARIVAEVLEILKACIRPGVTTLELNELAELEAKKRKARPAFKGY
CEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHCCCCCCCC
NGFPYSLCCSVNEQVVHGMPNSRELVEGDIISLDFGVVVDGFYGDAAVTVPVGRVKPGVL
CCCCCEEEECCCHHHHCCCCCCCCHHCCCEEEEECCEEEECCCCCEEEEEECCCCCCCHH
DLLAVTEESLCRAVEASVVGNRLSDISHAVQSFVEERGYSVVREFVGHGIGKNLHESPQV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
PNFGEPGRGVKLKAGMVLAIEPMINEKGHQVKILSDGWTAVTCDKGMSAHFEHTVAITEN
CCCCCCCCCEEEECCEEEEEECCCCCCCCEEEEEECCCEEEEECCCCCCCCEEEEEEECC
GPDILSKL
CHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10192928; 11058132 [H]