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The map label for this gene is pdhB [H]

Identifier: 39997749

GI number: 39997749

Start: 2925945

End: 2926907

Strand: Direct

Name: pdhB [H]

Synonym: GSU2655

Alternate gene names: 39997749

Gene position: 2925945-2926907 (Clockwise)

Preceding gene: 39997748

Following gene: 39997750

Centisome position: 76.71

GC content: 69.57

Gene sequence:

>963_bases
ATGCCCCAACTGAATATGGTCCAGGCAATAAACCTCGCCCTGCGGGAGGAGATGGCCCGGGACAACCGGCTGGTGGTCCT
CGGCGAGGACGTGGGCAGAGACGGCGGGGTGTTCCGGGTGACGGAGGGGCTGTTCGAGCAGTTCGGCGGGGACCGGGTCA
TGGACACTCCCCTGTCGGAATCGGCCATAGCCGGGGCGGCCATCGGCATGGCCGTTTGCGGCATGCGCCCCGTGGCGGAG
ATCCAGTTCATGGGGTTCATCTACGCCGCCTTCGACCAGCTCGTGGCCCACGCCGCACGCATCCGCACCCGGTCCCGGGG
CCGCTTCACCTGTCCGCTGGTTATCCGCACCCCCTATGGCGGCGGCATCAAGGCGCCGGAACTCCACGAGGAGAGTACCG
AGGCCCTGTTCTGCCACGTGCCGGGGCTCAAGGTGGTGGTCCCCTCGGGGCCCTACAGCGCCAAGGGGCTCCTGCTGGCC
GCCATCCGCGATCCGGATCCGGTGCTCTTCCTTGAGCCGACCCGCCTCTACCGGTTGGTGAAGGAGGAGGTACCCGAGGG
GGACTACACCCTGCCCCTGGGCACGGCCCGGATCGTCCGGCAGGGAGGCGCGGTGACCGTGGTCGCCTGGGGCAGCATGC
TCCAGCGGACCATCCAGGCCGTGGAGGGATACGATGCCGAGGTGATCGACCCCATGACCCTGGCTCCCTTTGACGGGGAG
ACGCTGCTGGCATCGGTGCGGAAAACCGGCCGGCTCGTCATCGTCCACGAGGCGCCGCTGACCTGCGGCCTGGGGGCCGA
AATCGCCGCCACCGTGGCGGAGGAGGCAATCCTCCACCTGCGGGGGCCGGTGGTGCGGGTGGCGGCCCCGGACGTCCCGG
TGCCCCTGGCCCGGCTCATGGACCGGTATCTGCCGTCGGTGGAGCGGATCCAGGCGGCCGTCAAGGAAGTGCTGACCTAC
TGA

Upstream 100 bases:

>100_bases
GCCGCCGGAGCCGGGGGAGATGTTCGCCTTCACCTGTGCGGAGTTGAGTCCGCGGCAGAGGCGGCAACAGGAAAACATCC
GCTAGAGGAGAGGTTGCTCC

Downstream 100 bases:

>100_bases
TCTGCGGAGAAAAGATCCCGCATAAATCACCGAGGGCCCAGACAAAGGGAAGGCGCCAGGAGCAGCGCTTGCGTTTCCAT
GAAATTCAGCCGGCGACGCT

Product: pyruvate dehydrogenase complex E1 component subunit beta

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MPQLNMVQAINLALREEMARDNRLVVLGEDVGRDGGVFRVTEGLFEQFGGDRVMDTPLSESAIAGAAIGMAVCGMRPVAE
IQFMGFIYAAFDQLVAHAARIRTRSRGRFTCPLVIRTPYGGGIKAPELHEESTEALFCHVPGLKVVVPSGPYSAKGLLLA
AIRDPDPVLFLEPTRLYRLVKEEVPEGDYTLPLGTARIVRQGGAVTVVAWGSMLQRTIQAVEGYDAEVIDPMTLAPFDGE
TLLASVRKTGRLVIVHEAPLTCGLGAEIAATVAEEAILHLRGPVVRVAAPDVPVPLARLMDRYLPSVERIQAAVKEVLTY

Sequences:

>Translated_320_residues
MPQLNMVQAINLALREEMARDNRLVVLGEDVGRDGGVFRVTEGLFEQFGGDRVMDTPLSESAIAGAAIGMAVCGMRPVAE
IQFMGFIYAAFDQLVAHAARIRTRSRGRFTCPLVIRTPYGGGIKAPELHEESTEALFCHVPGLKVVVPSGPYSAKGLLLA
AIRDPDPVLFLEPTRLYRLVKEEVPEGDYTLPLGTARIVRQGGAVTVVAWGSMLQRTIQAVEGYDAEVIDPMTLAPFDGE
TLLASVRKTGRLVIVHEAPLTCGLGAEIAATVAEEAILHLRGPVVRVAAPDVPVPLARLMDRYLPSVERIQAAVKEVLTY
>Mature_319_residues
PQLNMVQAINLALREEMARDNRLVVLGEDVGRDGGVFRVTEGLFEQFGGDRVMDTPLSESAIAGAAIGMAVCGMRPVAEI
QFMGFIYAAFDQLVAHAARIRTRSRGRFTCPLVIRTPYGGGIKAPELHEESTEALFCHVPGLKVVVPSGPYSAKGLLLAA
IRDPDPVLFLEPTRLYRLVKEEVPEGDYTLPLGTARIVRQGGAVTVVAWGSMLQRTIQAVEGYDAEVIDPMTLAPFDGET
LLASVRKTGRLVIVHEAPLTCGLGAEIAATVAEEAILHLRGPVVRVAAPDVPVPLARLMDRYLPSVERIQAAVKEVLTY

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=325, Percent_Identity=44, Blast_Score=271, Evalue=4e-73,
Organism=Homo sapiens, GI34101272, Length=325, Percent_Identity=44, Blast_Score=271, Evalue=4e-73,
Organism=Homo sapiens, GI156564403, Length=327, Percent_Identity=38.5321100917431, Blast_Score=215, Evalue=5e-56,
Organism=Homo sapiens, GI291084858, Length=327, Percent_Identity=37.6146788990826, Blast_Score=201, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17506935, Length=325, Percent_Identity=47.0769230769231, Blast_Score=276, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI17538422, Length=322, Percent_Identity=38.8198757763975, Blast_Score=222, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6319698, Length=323, Percent_Identity=37.7708978328173, Blast_Score=212, Evalue=6e-56,
Organism=Drosophila melanogaster, GI160714828, Length=325, Percent_Identity=43.6923076923077, Blast_Score=271, Evalue=4e-73,
Organism=Drosophila melanogaster, GI160714832, Length=325, Percent_Identity=43.6923076923077, Blast_Score=270, Evalue=7e-73,
Organism=Drosophila melanogaster, GI21358145, Length=326, Percent_Identity=38.0368098159509, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24650940, Length=326, Percent_Identity=38.0368098159509, Blast_Score=222, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24650943, Length=91, Percent_Identity=41.7582417582418, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24650945, Length=91, Percent_Identity=41.7582417582418, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 34578; Mature: 34447

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQLNMVQAINLALREEMARDNRLVVLGEDVGRDGGVFRVTEGLFEQFGGDRVMDTPLSE
CCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEHHHHHHHCCCCEEECCCCCH
SAIAGAAIGMAVCGMRPVAEIQFMGFIYAAFDQLVAHAARIRTRSRGRFTCPLVIRTPYG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCC
GGIKAPELHEESTEALFCHVPGLKVVVPSGPYSAKGLLLAAIRDPDPVLFLEPTRLYRLV
CCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCEEEEEECCCCCEEEECHHHHHHHH
KEEVPEGDYTLPLGTARIVRQGGAVTVVAWGSMLQRTIQAVEGYDAEVIDPMTLAPFDGE
HHHCCCCCEEECCCHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCEEECCCCCH
TLLASVRKTGRLVIVHEAPLTCGLGAEIAATVAEEAILHLRGPVVRVAAPDVPVPLARLM
HHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHH
DRYLPSVERIQAAVKEVLTY
HHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PQLNMVQAINLALREEMARDNRLVVLGEDVGRDGGVFRVTEGLFEQFGGDRVMDTPLSE
CCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEEEEHHHHHHHCCCCEEECCCCCH
SAIAGAAIGMAVCGMRPVAEIQFMGFIYAAFDQLVAHAARIRTRSRGRFTCPLVIRTPYG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCCC
GGIKAPELHEESTEALFCHVPGLKVVVPSGPYSAKGLLLAAIRDPDPVLFLEPTRLYRLV
CCCCCCCCCCCCCCEEEEECCCEEEEECCCCCCCCCEEEEEECCCCCEEEECHHHHHHHH
KEEVPEGDYTLPLGTARIVRQGGAVTVVAWGSMLQRTIQAVEGYDAEVIDPMTLAPFDGE
HHHCCCCCEEECCCHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCCEEECCCCCH
TLLASVRKTGRLVIVHEAPLTCGLGAEIAATVAEEAILHLRGPVVRVAAPDVPVPLARLM
HHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCHHHHHHH
DRYLPSVERIQAAVKEVLTY
HHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]