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The map label for this gene is pdhA [H]

Identifier: 39997748

GI number: 39997748

Start: 2924871

End: 2925929

Strand: Direct

Name: pdhA [H]

Synonym: GSU2654

Alternate gene names: 39997748

Gene position: 2924871-2925929 (Clockwise)

Preceding gene: 39997747

Following gene: 39997749

Centisome position: 76.68

GC content: 68.46

Gene sequence:

>1059_bases
ATGCCCGAAACAACGATTCAGACATTCGGCGTCCGGCGTCTTGAGATCATCGCTGCGGACGGCACGGCGGACGAGGCGCT
TCTTCCCGACCTTTCGGGCGACCAGCTGCGGCGGCTCCACTACCTGATGCTCCTGACCCGCACCTTTGACCGCCGCGCCC
TGGCGCTCCAGCGGGAAGGCAGAATCGGCACCTATCCCTCGGTGCTTGGCCAGGAGGCGGCCCAGGTGGGGAGCGCCTTC
GCCCTTCAGCCAAGCGACTGGGTCTTTCCCTCCTTCCGGGAGATGGGCGCCCACCTCACCCTCGGCTACCCGGTCCACCA
GCTCTTCCAGTACTGGGGCGGCGACGAGCGGGGGCTGCGTACCCCGGACGGCATGAACCTCTTTCCCATCTGCGTTTCCG
TGGGGACCCACATCCCCCATGCCGCAGGGGCGGCGCTGGCGGCCAGGGCCAGGGGCGACCGGTCGGCCGTGGCGGCCTAC
TTCGGCGACGGCGCCACCTCCAAGGGGGACTTTCACGAAGGGTTCAACCTGGCCGGCGCCCTGAAGTTGCCGGTGGTCTT
CATCTGCCAGAACAACCAGTGGGCCATTTCGGTGCCCCTGGCGGCCCAGACCGCTGCCCCGACCCTGGCCCAGAAGGCGC
TGGCCTACGGTTTCGAGGGCATCCAGGTGGACGGCAACGACGTGCTGGCCGTATTCCGCGCCACGGGCGAGGCCCTGGTC
AGGGCCCGCGACGGGGGAGGCCCCACCTTCATCGAATGCCTCACCTACCGCATGGCCGACCACACCACCGCCGACGATGC
GAGCCGCTATCGTCCCCCGGCTGATGTGGAGGCGTGGCGCGACCGGGACCCCCTGCTCCGCTTCGAGCGGTTCCTGGCAA
AGCGCGGCCTCTGGAACGGGGATTACGGAGCCGAGGTACAGGCAAAGGCCGAGGGAGAGATCGACGAAGCGGTACGGCGC
TACGAATCGGTGCCGCCGCCGGAGCCGGGGGAGATGTTCGCCTTCACCTGTGCGGAGTTGAGTCCGCGGCAGAGGCGGCA
ACAGGAAAACATCCGCTAG

Upstream 100 bases:

>100_bases
GCTCTGGTATCCTTGCTCGTAAACCGGCGATGACGGCCGGGCCGCGACGCCATCAAAGCCCGTGCCTGCACAACATCATC
AACCTGAACGAGGGTGTCCC

Downstream 100 bases:

>100_bases
AGGAGAGGTTGCTCCATGCCCCAACTGAATATGGTCCAGGCAATAAACCTCGCCCTGCGGGAGGAGATGGCCCGGGACAA
CCGGCTGGTGGTCCTCGGCG

Product: pyruvate dehydrogenase complex E1 component subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MPETTIQTFGVRRLEIIAADGTADEALLPDLSGDQLRRLHYLMLLTRTFDRRALALQREGRIGTYPSVLGQEAAQVGSAF
ALQPSDWVFPSFREMGAHLTLGYPVHQLFQYWGGDERGLRTPDGMNLFPICVSVGTHIPHAAGAALAARARGDRSAVAAY
FGDGATSKGDFHEGFNLAGALKLPVVFICQNNQWAISVPLAAQTAAPTLAQKALAYGFEGIQVDGNDVLAVFRATGEALV
RARDGGGPTFIECLTYRMADHTTADDASRYRPPADVEAWRDRDPLLRFERFLAKRGLWNGDYGAEVQAKAEGEIDEAVRR
YESVPPPEPGEMFAFTCAELSPRQRRQQENIR

Sequences:

>Translated_352_residues
MPETTIQTFGVRRLEIIAADGTADEALLPDLSGDQLRRLHYLMLLTRTFDRRALALQREGRIGTYPSVLGQEAAQVGSAF
ALQPSDWVFPSFREMGAHLTLGYPVHQLFQYWGGDERGLRTPDGMNLFPICVSVGTHIPHAAGAALAARARGDRSAVAAY
FGDGATSKGDFHEGFNLAGALKLPVVFICQNNQWAISVPLAAQTAAPTLAQKALAYGFEGIQVDGNDVLAVFRATGEALV
RARDGGGPTFIECLTYRMADHTTADDASRYRPPADVEAWRDRDPLLRFERFLAKRGLWNGDYGAEVQAKAEGEIDEAVRR
YESVPPPEPGEMFAFTCAELSPRQRRQQENIR
>Mature_351_residues
PETTIQTFGVRRLEIIAADGTADEALLPDLSGDQLRRLHYLMLLTRTFDRRALALQREGRIGTYPSVLGQEAAQVGSAFA
LQPSDWVFPSFREMGAHLTLGYPVHQLFQYWGGDERGLRTPDGMNLFPICVSVGTHIPHAAGAALAARARGDRSAVAAYF
GDGATSKGDFHEGFNLAGALKLPVVFICQNNQWAISVPLAAQTAAPTLAQKALAYGFEGIQVDGNDVLAVFRATGEALVR
ARDGGGPTFIECLTYRMADHTTADDASRYRPPADVEAWRDRDPLLRFERFLAKRGLWNGDYGAEVQAKAEGEIDEAVRRY
ESVPPPEPGEMFAFTCAELSPRQRRQQENIR

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=334, Percent_Identity=36.5269461077844, Blast_Score=202, Evalue=4e-52,
Organism=Homo sapiens, GI258645172, Length=334, Percent_Identity=36.5269461077844, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI4885543, Length=304, Percent_Identity=30.2631578947368, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI4505685, Length=304, Percent_Identity=27.3026315789474, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI291084742, Length=304, Percent_Identity=27.3026315789474, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI291084744, Length=272, Percent_Identity=28.6764705882353, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI291084757, Length=298, Percent_Identity=25.1677852348993, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI86563355, Length=365, Percent_Identity=33.972602739726, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI86563357, Length=365, Percent_Identity=33.972602739726, Blast_Score=208, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17536047, Length=297, Percent_Identity=30.3030303030303, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI32564172, Length=297, Percent_Identity=30.3030303030303, Blast_Score=110, Evalue=8e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=316, Percent_Identity=29.746835443038, Blast_Score=117, Evalue=2e-27,
Organism=Drosophila melanogaster, GI21355903, Length=338, Percent_Identity=31.9526627218935, Blast_Score=174, Evalue=6e-44,
Organism=Drosophila melanogaster, GI24639740, Length=327, Percent_Identity=29.9694189602446, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24639744, Length=327, Percent_Identity=29.9694189602446, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI28571106, Length=327, Percent_Identity=29.9694189602446, Blast_Score=122, Evalue=3e-28,
Organism=Drosophila melanogaster, GI24639746, Length=256, Percent_Identity=31.25, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24639748, Length=300, Percent_Identity=27, Blast_Score=104, Evalue=8e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 38654; Mature: 38523

Theoretical pI: Translated: 5.68; Mature: 5.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPETTIQTFGVRRLEIIAADGTADEALLPDLSGDQLRRLHYLMLLTRTFDRRALALQREG
CCCCCHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RIGTYPSVLGQEAAQVGSAFALQPSDWVFPSFREMGAHLTLGYPVHQLFQYWGGDERGLR
CCCCCHHHHHHHHHHHCCEEEECCCCCCCCCHHHCCCEEEECCCHHHHHHHHCCCCCCCC
TPDGMNLFPICVSVGTHIPHAAGAALAARARGDRSAVAAYFGDGATSKGDFHEGFNLAGA
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCEE
LKLPVVFICQNNQWAISVPLAAQTAAPTLAQKALAYGFEGIQVDGNDVLAVFRATGEALV
EECCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECCCCEEE
RARDGGGPTFIECLTYRMADHTTADDASRYRPPADVEAWRDRDPLLRFERFLAKRGLWNG
EECCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCC
DYGAEVQAKAEGEIDEAVRRYESVPPPEPGEMFAFTCAELSPRQRRQQENIR
CCCCEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHCCC
>Mature Secondary Structure 
PETTIQTFGVRRLEIIAADGTADEALLPDLSGDQLRRLHYLMLLTRTFDRRALALQREG
CCCCHHHCCCEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCC
RIGTYPSVLGQEAAQVGSAFALQPSDWVFPSFREMGAHLTLGYPVHQLFQYWGGDERGLR
CCCCCHHHHHHHHHHHCCEEEECCCCCCCCCHHHCCCEEEECCCHHHHHHHHCCCCCCCC
TPDGMNLFPICVSVGTHIPHAAGAALAARARGDRSAVAAYFGDGATSKGDFHEGFNLAGA
CCCCCCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCCCCCCEE
LKLPVVFICQNNQWAISVPLAAQTAAPTLAQKALAYGFEGIQVDGNDVLAVFRATGEALV
EECCEEEEEECCCEEEEECCCHHHHHHHHHHHHHHHCCCCEEECCCCEEEEEECCCCEEE
RARDGGGPTFIECLTYRMADHTTADDASRYRPPADVEAWRDRDPLLRFERFLAKRGLWNG
EECCCCCCHHHHHHHHHHHCCCCCCCHHHCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCC
DYGAEVQAKAEGEIDEAVRRYESVPPPEPGEMFAFTCAELSPRQRRQQENIR
CCCCEEEECCCCCHHHHHHHHHCCCCCCCCCEEEEEHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674 [H]