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The map label for this gene is lpxH [H]

Identifier: 39997551

GI number: 39997551

Start: 2695266

End: 2695988

Strand: Direct

Name: lpxH [H]

Synonym: GSU2456

Alternate gene names: 39997551

Gene position: 2695266-2695988 (Clockwise)

Preceding gene: 39997534

Following gene: 39997554

Centisome position: 70.67

GC content: 66.8

Gene sequence:

>723_bases
ATGCGCGCAATCTTCATCGCCGACGCCCACCTGCGGCAGCCGGGGGACCGAAACTACCGGCTGCTCATGGAGTTCCTGGC
CGGGCTCCGGGGCAACGTCGACACCCTCTACATTCTCGGCGACCTCTTCGAGTTCTGGATCGGCTACGATCCGGTCCCCT
TCACCCACTACCTCCCCCTTCTCGACCGGCTGCGGGAGCTGGTCGACAGCGGGGTCCGGATCGAGTACTTCGAAGGGAAC
CACGACTTCCACATGGGGCCGTTTTTCACGGAGACGCTCAGGGCAACGGTCCACCCGGGCCCCGCCGTGATCGACATCCA
GGGGGAGCGGCTCTATCTCTGCCACGGGGACGAGGTCAACCGGAAGGACTATCCCTACCGGCTCCTGCGGTTCATCCTCC
ACAGCTCCCTGACGCGGGCGGCCACCCGCATCGTCCCCCCCGCCGTGACCTGCCGGATCGCCGTGGGCATGTCGCGGGAA
AGCCGCAAAAACCACGGCCGGCGCCGGCACCGCTGGGACTACGCCGCCATCCTCCGGGCCTTCGCCGCCGAGCGCTTCCG
GGAAGGATGCCGCGCAGTCGTCGCCGGACACTTCCACCAGCCGTTCATCGATCGCAACGACGACGGCACGGTCCTGCTCT
CCCTGGGCGACTGGCTCACCCACTACACCTACGGCGAATGGAGCGACGGCACCCTTTCGCTGAAGACCTACGGAACACCG
TAA

Upstream 100 bases:

>100_bases
CAGAGTATTTCAATGTCGCGCATGAATCCCATGTTCACCTTACGCCTCGCCCGCCTCAACGCGCCTTTACCTTTGGCGGC
CTTTCGATTATAGTGCCGCC

Downstream 100 bases:

>100_bases
CCCCGCCGCTAGACCCCGAACAGCGCCCGGTACTTTTTCACCCGCTCTTCCAGCGTCGGCGCCGCAATCCGGCGGCAGAT
CTCGTCGGGGCGGTACCCCC

Product: UDP-2,3-diacylglucosamine hydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 240; Mature: 240

Protein sequence:

>240_residues
MRAIFIADAHLRQPGDRNYRLLMEFLAGLRGNVDTLYILGDLFEFWIGYDPVPFTHYLPLLDRLRELVDSGVRIEYFEGN
HDFHMGPFFTETLRATVHPGPAVIDIQGERLYLCHGDEVNRKDYPYRLLRFILHSSLTRAATRIVPPAVTCRIAVGMSRE
SRKNHGRRRHRWDYAAILRAFAAERFREGCRAVVAGHFHQPFIDRNDDGTVLLSLGDWLTHYTYGEWSDGTLSLKTYGTP

Sequences:

>Translated_240_residues
MRAIFIADAHLRQPGDRNYRLLMEFLAGLRGNVDTLYILGDLFEFWIGYDPVPFTHYLPLLDRLRELVDSGVRIEYFEGN
HDFHMGPFFTETLRATVHPGPAVIDIQGERLYLCHGDEVNRKDYPYRLLRFILHSSLTRAATRIVPPAVTCRIAVGMSRE
SRKNHGRRRHRWDYAAILRAFAAERFREGCRAVVAGHFHQPFIDRNDDGTVLLSLGDWLTHYTYGEWSDGTLSLKTYGTP
>Mature_240_residues
MRAIFIADAHLRQPGDRNYRLLMEFLAGLRGNVDTLYILGDLFEFWIGYDPVPFTHYLPLLDRLRELVDSGVRIEYFEGN
HDFHMGPFFTETLRATVHPGPAVIDIQGERLYLCHGDEVNRKDYPYRLLRFILHSSLTRAATRIVPPAVTCRIAVGMSRE
SRKNHGRRRHRWDYAAILRAFAAERFREGCRAVVAGHFHQPFIDRNDDGTVLLSLGDWLTHYTYGEWSDGTLSLKTYGTP

Specific function: Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP [H]

COG id: COG2908

COG function: function code S; Uncharacterized protein conserved in bacteria

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxH family [H]

Homologues:

Organism=Escherichia coli, GI1786735, Length=225, Percent_Identity=30.6666666666667, Blast_Score=88, Evalue=6e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004843
- InterPro:   IPR010138 [H]

Pfam domain/function: PF00149 Metallophos [H]

EC number: 3.6.1.-

Molecular weight: Translated: 27767; Mature: 27767

Theoretical pI: Translated: 8.13; Mature: 8.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAIFIADAHLRQPGDRNYRLLMEFLAGLRGNVDTLYILGDLFEFWIGYDPVPFTHYLPL
CEEEEEECHHHCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCHHHHHHH
LDRLRELVDSGVRIEYFEGNHDFHMGPFFTETLRATVHPGPAVIDIQGERLYLCHGDEVN
HHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCC
RKDYPYRLLRFILHSSLTRAATRIVPPAVTCRIAVGMSRESRKNHGRRRHRWDYAAILRA
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCHHHHCHHHHHHHHH
FAAERFREGCRAVVAGHFHQPFIDRNDDGTVLLSLGDWLTHYTYGEWSDGTLSLKTYGTP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHCCCCCCCCCEEEEEECCCC
>Mature Secondary Structure
MRAIFIADAHLRQPGDRNYRLLMEFLAGLRGNVDTLYILGDLFEFWIGYDPVPFTHYLPL
CEEEEEECHHHCCCCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCHHHHHHH
LDRLRELVDSGVRIEYFEGNHDFHMGPFFTETLRATVHPGPAVIDIQGERLYLCHGDEVN
HHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCEEEEECCCEEEEEECCCCC
RKDYPYRLLRFILHSSLTRAATRIVPPAVTCRIAVGMSRESRKNHGRRRHRWDYAAILRA
CCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHCCHHHHCHHHHHHHHH
FAAERFREGCRAVVAGHFHQPFIDRNDDGTVLLSLGDWLTHYTYGEWSDGTLSLKTYGTP
HHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECHHHHHCCCCCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA