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The map label for this gene is purE-2 [H]

Identifier: 39997404

GI number: 39997404

Start: 2523789

End: 2524340

Strand: Direct

Name: purE-2 [H]

Synonym: GSU2306

Alternate gene names: 39997404

Gene position: 2523789-2524340 (Clockwise)

Preceding gene: 39997403

Following gene: 39997405

Centisome position: 66.17

GC content: 66.67

Gene sequence:

>552_bases
ATGGAAAAAGTCGAAACATCGAGCGCACCCGGCACTCTCGCCGACCGCTCGCCGCTGGTGGGAATCCTGACCGGGAGCCC
CAATGATCTGCCCACGGTGGTGAAGGTGCGCGACACCCTGACCGAGCTCGGCATCCCGAGCGAGATCGTGGTGGCTTCGG
CCCACCGGACCCCCGACAAGGTCCTCGCCTACCTGGACCGGGCCCATAAGGAAGGGGTGCAGGTACTGATCGGCTGCGCC
GGCGTGGCCGCTCACCTGGCGGGTGTAATCGCCGGGCACACGAGATTGCCGGTCATCGGTTTGCCGCTCGGCAACGGCCC
CTTGTCAGGGATGGACAGCCTCCTCTCGACCGTGCAGATGCCCCCGGGCGTGCCGGTTGCCACGGTGGCCATCGACGGGA
GCCGCAATGCGGCCATGCTGGCGGCCCGCATTCTGGCCCTCAAGTACCCGGAGATTGACAAGGCCCTGGAAGAGGCGGCT
CGGAAGGAGCGGGAGCGCTACGACCTGACCGCCGATGAGGCCCTGGCAAAACTCACCTCGTGCGTCAAGTAA

Upstream 100 bases:

>100_bases
AAGCCCGCTGTCGAGGGCCACGATGAGTCAGCCTGGGCCGGAAATCGGCGCGTCGAGTTCATCCCCAAACGCTGATCAGC
CTATTCATAAGGAGCTAGCT

Downstream 100 bases:

>100_bases
TGAAGGAGAGAACGCGCGGCGCCCTTTCCCGGGCGCCGCGCCATGGAGGCACTATGAAGGACATCGAACGCTTCATCGCA
GGATTCCGCCGGTTCAGAGA

Product: phosphoribosylaminoimidazole carboxylase, catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase [H]

Number of amino acids: Translated: 183; Mature: 183

Protein sequence:

>183_residues
MEKVETSSAPGTLADRSPLVGILTGSPNDLPTVVKVRDTLTELGIPSEIVVASAHRTPDKVLAYLDRAHKEGVQVLIGCA
GVAAHLAGVIAGHTRLPVIGLPLGNGPLSGMDSLLSTVQMPPGVPVATVAIDGSRNAAMLAARILALKYPEIDKALEEAA
RKERERYDLTADEALAKLTSCVK

Sequences:

>Translated_183_residues
MEKVETSSAPGTLADRSPLVGILTGSPNDLPTVVKVRDTLTELGIPSEIVVASAHRTPDKVLAYLDRAHKEGVQVLIGCA
GVAAHLAGVIAGHTRLPVIGLPLGNGPLSGMDSLLSTVQMPPGVPVATVAIDGSRNAAMLAARILALKYPEIDKALEEAA
RKERERYDLTADEALAKLTSCVK
>Mature_183_residues
MEKVETSSAPGTLADRSPLVGILTGSPNDLPTVVKVRDTLTELGIPSEIVVASAHRTPDKVLAYLDRAHKEGVQVLIGCA
GVAAHLAGVIAGHTRLPVIGLPLGNGPLSGMDSLLSTVQMPPGVPVATVAIDGSRNAAMLAARILALKYPEIDKALEEAA
RKERERYDLTADEALAKLTSCVK

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) [H]

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family [H]

Homologues:

Organism=Escherichia coli, GI1786734, Length=110, Percent_Identity=46.3636363636364, Blast_Score=102, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324702, Length=149, Percent_Identity=47.6510067114094, Blast_Score=132, Evalue=5e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000031 [H]

Pfam domain/function: PF00731 AIRC [H]

EC number: =5.4.99.18 [H]

Molecular weight: Translated: 19073; Mature: 19073

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKVETSSAPGTLADRSPLVGILTGSPNDLPTVVKVRDTLTELGIPSEIVVASAHRTPDK
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHEEECCCCCHHH
VLAYLDRAHKEGVQVLIGCAGVAAHLAGVIAGHTRLPVIGLPLGNGPLSGMDSLLSTVQM
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHCC
PPGVPVATVAIDGSRNAAMLAARILALKYPEIDKALEEAARKERERYDLTADEALAKLTS
CCCCCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
CVK
HCC
>Mature Secondary Structure
MEKVETSSAPGTLADRSPLVGILTGSPNDLPTVVKVRDTLTELGIPSEIVVASAHRTPDK
CCCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHEEECCCCCHHH
VLAYLDRAHKEGVQVLIGCAGVAAHLAGVIAGHTRLPVIGLPLGNGPLSGMDSLLSTVQM
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCHHHHHHHHHHCC
PPGVPVATVAIDGSRNAAMLAARILALKYPEIDKALEEAARKERERYDLTADEALAKLTS
CCCCCEEEEEEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
CVK
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9679194 [H]