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The map label for this gene is czcC [H]

Identifier: 39996432

GI number: 39996432

Start: 1454915

End: 1456396

Strand: Direct

Name: czcC [H]

Synonym: GSU1330

Alternate gene names: 39996432

Gene position: 1454915-1456396 (Clockwise)

Preceding gene: 39996431

Following gene: 39996433

Centisome position: 38.15

GC content: 65.52

Gene sequence:

>1482_bases
ATGCCGGAATCCATTGGCCCGTCATTGCGCAAGCTCGTTACGGGTCTATACTTTTCGCAGAATATTCTCCGCTGCTGTGG
AATATTCTTCACCGCCCGGCGGTCAGCTACGATGCGCCGCACGGACTTTCAACCGGTTACGGCATGGCACGGCCTGTGTA
ATGCCGATCTGAGACCCTATCCAGAGGTACCGGAGACTGAAATGATCACTTGCATCCTGAGGACCCTTCTCGCATCGGCG
GTTTGCGTCCTGCTCCTTGCCGGCCCGGCCCGGTCCGGAGATGCTCCGGCCGGGGAGGATCTGAACTCCCTGGTGAGCCG
CGCCCTTGCCGTCAACCCGGAGCTCAAGGCTTCCGAGGCCCGGTGGGAGATGTTCCGCAACCGCGTGGCCCAGGCCGGCG
CCCTGGCCGACCCCATGCTCATGTTCAAGCTCCAGAACTTTCTCCTGCGCGATCCCCTGGACAGCCGGCGGGACCCCATG
AGCCAGCGGGTGATCGGCATCTCCCAGGAGCTTCCCTTCTGGGGCAAGCGCGCCCTGAAGACCGAGATCGCCGACCGGGA
GGCCGAGGCCCTCAGGTGGCAGGTGGAGGAGCGCAAGCTGGAGCTGGCCCGCATGGTCAAGGAGACCTGGTACCAGCTCT
ACCTGGTTGATCGGGAGCTGGATATCGTGGAACGCAACATCCGGGTGATGGACGACTTCGTCACCCTGGCCGAAACCCGT
TACTCGGTGGGGCAGGGGGCCCAGCAGGACGTGTTCAAGGGACAGGTGGAGCGTTCCCGGATGCTCGACATGCAGATCGC
CCTCGCGCAGCAGCGCACGAGCCTCCAGGCCACCCTCAACACCCTCCTCTTCAGGCCGGCCGAGACCCCGGTGGGGCGCG
TGCCGGACCTGGAGATCCGCCCCATTTCCCTCTCAGCCGCCGAGTTGCGTGCCCTGGCCGAGGAGAACCGTCCCCAGTTC
AGGAGCGTGCGGGCCCAGTTGGAAAAGGGGGCGGCAGGGCACCGGCTGGCCGGCCTGGAATCATTCCCGGACGTGACCCT
CTCCCTTGAGTACATGCAGCGGGACCCCTCCATGGATGAGCGGGGGTACGACATGTACTCGGTGGGGCTCACCTTCAATC
TGCCGGTGCAGCGGGAGCGCCGCCGCGCCATGGCCCGGGAGTCCGTGGCCGAGACGGACATGGCCCGGGCCGAGCTGAAC
ACCCTGAACAATGCCATTGCCTTGGGCATCGCCGACAGCCTGGCCCGGCTGGAACGCAGCGAAAAACTGGCGCAGCTCTA
CCGCACGGGGATTATCCCCCAGGCCGAGCAGTCGCTGGAATCGGCCACCATCGGCTACCGGGTGGGGAAGGTCGATTTCC
TCTCCCTGCTGGACGCCCGGGTTACGGTCTTCAATTACGAACGCCAGTACTACGAGGCCCTGGCCGAGCACGGCATGCGC
CGGGCCCAGCTGGAGGCGCTGGTGGGGAGGGAACTGGAGTGA

Upstream 100 bases:

>100_bases
CCGCTGGGCCGCCGGCAATTTCGAGCCGTCGGCAATTCCGACCGCGGCCGCCCCCTTTCACGCTTCCCCCTGAAACCCGC
CGTTTCCATCCCTTGATGTC

Downstream 100 bases:

>100_bases
GCCGCCATCGCGAGGGATATGCCATGTTGTTCACGAGAAGGATCATGCTGCCGCTGGTGGCGCTTCTGCTGGCCCTGGTC
GCTGCTGGCTGCCAGAAGCA

Product: metal ion efflux outer membrane protein family protein

Products: NA

Alternate protein names: Cation efflux system protein CzcC [H]

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MPESIGPSLRKLVTGLYFSQNILRCCGIFFTARRSATMRRTDFQPVTAWHGLCNADLRPYPEVPETEMITCILRTLLASA
VCVLLLAGPARSGDAPAGEDLNSLVSRALAVNPELKASEARWEMFRNRVAQAGALADPMLMFKLQNFLLRDPLDSRRDPM
SQRVIGISQELPFWGKRALKTEIADREAEALRWQVEERKLELARMVKETWYQLYLVDRELDIVERNIRVMDDFVTLAETR
YSVGQGAQQDVFKGQVERSRMLDMQIALAQQRTSLQATLNTLLFRPAETPVGRVPDLEIRPISLSAAELRALAEENRPQF
RSVRAQLEKGAAGHRLAGLESFPDVTLSLEYMQRDPSMDERGYDMYSVGLTFNLPVQRERRRAMARESVAETDMARAELN
TLNNAIALGIADSLARLERSEKLAQLYRTGIIPQAEQSLESATIGYRVGKVDFLSLLDARVTVFNYERQYYEALAEHGMR
RAQLEALVGRELE

Sequences:

>Translated_493_residues
MPESIGPSLRKLVTGLYFSQNILRCCGIFFTARRSATMRRTDFQPVTAWHGLCNADLRPYPEVPETEMITCILRTLLASA
VCVLLLAGPARSGDAPAGEDLNSLVSRALAVNPELKASEARWEMFRNRVAQAGALADPMLMFKLQNFLLRDPLDSRRDPM
SQRVIGISQELPFWGKRALKTEIADREAEALRWQVEERKLELARMVKETWYQLYLVDRELDIVERNIRVMDDFVTLAETR
YSVGQGAQQDVFKGQVERSRMLDMQIALAQQRTSLQATLNTLLFRPAETPVGRVPDLEIRPISLSAAELRALAEENRPQF
RSVRAQLEKGAAGHRLAGLESFPDVTLSLEYMQRDPSMDERGYDMYSVGLTFNLPVQRERRRAMARESVAETDMARAELN
TLNNAIALGIADSLARLERSEKLAQLYRTGIIPQAEQSLESATIGYRVGKVDFLSLLDARVTVFNYERQYYEALAEHGMR
RAQLEALVGRELE
>Mature_492_residues
PESIGPSLRKLVTGLYFSQNILRCCGIFFTARRSATMRRTDFQPVTAWHGLCNADLRPYPEVPETEMITCILRTLLASAV
CVLLLAGPARSGDAPAGEDLNSLVSRALAVNPELKASEARWEMFRNRVAQAGALADPMLMFKLQNFLLRDPLDSRRDPMS
QRVIGISQELPFWGKRALKTEIADREAEALRWQVEERKLELARMVKETWYQLYLVDRELDIVERNIRVMDDFVTLAETRY
SVGQGAQQDVFKGQVERSRMLDMQIALAQQRTSLQATLNTLLFRPAETPVGRVPDLEIRPISLSAAELRALAEENRPQFR
SVRAQLEKGAAGHRLAGLESFPDVTLSLEYMQRDPSMDERGYDMYSVGLTFNLPVQRERRRAMARESVAETDMARAELNT
LNNAIALGIADSLARLERSEKLAQLYRTGIIPQAEQSLESATIGYRVGKVDFLSLLDARVTVFNYERQYYEALAEHGMRR
AQLEALVGRELE

Specific function: CzcC protein appears to modify the specificity of the system, perhaps by acting on the CzcB protein. When the CzcC protein is added to CzcA and CzcB, the efflux system gains specificity for cadmium and cobalt [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 55847; Mature: 55716

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPESIGPSLRKLVTGLYFSQNILRCCGIFFTARRSATMRRTDFQPVTAWHGLCNADLRPY
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHCCCCCCCC
PEVPETEMITCILRTLLASAVCVLLLAGPARSGDAPAGEDLNSLVSRALAVNPELKASEA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHH
RWEMFRNRVAQAGALADPMLMFKLQNFLLRDPLDSRRDPMSQRVIGISQELPFWGKRALK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHCCCCCCCHHHHHHHH
TEIADREAEALRWQVEERKLELARMVKETWYQLYLVDRELDIVERNIRVMDDFVTLAETR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHH
YSVGQGAQQDVFKGQVERSRMLDMQIALAQQRTSLQATLNTLLFRPAETPVGRVPDLEIR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
PISLSAAELRALAEENRPQFRSVRAQLEKGAAGHRLAGLESFPDVTLSLEYMQRDPSMDE
EECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHCCCCCCC
RGYDMYSVGLTFNLPVQRERRRAMARESVAETDMARAELNTLNNAIALGIADSLARLERS
CCCEEEEECEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLAQLYRTGIIPQAEQSLESATIGYRVGKVDFLSLLDARVTVFNYERQYYEALAEHGMR
HHHHHHHHHCCCCHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
RAQLEALVGRELE
HHHHHHHHCCCCC
>Mature Secondary Structure 
PESIGPSLRKLVTGLYFSQNILRCCGIFFTARRSATMRRTDFQPVTAWHGLCNADLRPY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHCCCCCCCC
PEVPETEMITCILRTLLASAVCVLLLAGPARSGDAPAGEDLNSLVSRALAVNPELKASEA
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHH
RWEMFRNRVAQAGALADPMLMFKLQNFLLRDPLDSRRDPMSQRVIGISQELPFWGKRALK
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHCCCHHHHHHCCCCCCCHHHHHHHH
TEIADREAEALRWQVEERKLELARMVKETWYQLYLVDRELDIVERNIRVMDDFVTLAETR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHHHHHHH
YSVGQGAQQDVFKGQVERSRMLDMQIALAQQRTSLQATLNTLLFRPAETPVGRVPDLEIR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEE
PISLSAAELRALAEENRPQFRSVRAQLEKGAAGHRLAGLESFPDVTLSLEYMQRDPSMDE
EECCCHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEHHHHHCCCCCCC
RGYDMYSVGLTFNLPVQRERRRAMARESVAETDMARAELNTLNNAIALGIADSLARLERS
CCCEEEEECEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EKLAQLYRTGIIPQAEQSLESATIGYRVGKVDFLSLLDARVTVFNYERQYYEALAEHGMR
HHHHHHHHHCCCCHHHHHHHHHHHHHEECHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
RAQLEALVGRELE
HHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2678100; 7766206 [H]