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The map label for this gene is cusB [H]

Identifier: 39996433

GI number: 39996433

Start: 1456420

End: 1457775

Strand: Direct

Name: cusB [H]

Synonym: GSU1331

Alternate gene names: 39996433

Gene position: 1456420-1457775 (Clockwise)

Preceding gene: 39996432

Following gene: 39996434

Centisome position: 38.18

GC content: 65.34

Gene sequence:

>1356_bases
ATGTTGTTCACGAGAAGGATCATGCTGCCGCTGGTGGCGCTTCTGCTGGCCCTGGTCGCTGCTGGCTGCCAGAAGCAGGG
GGCCGAAGCCCCCAAAGGGGACGGCCACGACCACGCCGCCGAGGCCAAGGTCGAGTACACCTGCCCCATGCACCCCTTCA
TCATCAAGGACAAGCCCGGATCATGTCCTATCTGCGGCATGGACCTGGTGAAGAAGGTCGCCGGAGCCGGCGCCGACGCC
AAGGAACTGGAGAAGCTCGCCCAGGTAGCCATCCCCACCACCCAGATGGTGATGGCCAACGTGGCGACCCAGCCCGTGAC
GGCCAAAAGCCTCCAGAAGGAGATCACCGCCACGGGGATCGTGGCCTACGACCAGCGGCGCCAGGCCAAGGTAACCGCCT
GGGTGGCGGGGCGGATCGATCGGCTCAACGTCAACGCGGTCGGCGACTTCGTCTCCAGGGGACGGCCGGTGGCGGAACTC
TATTCGCCCGACCTGGTCTCGGCCCAGCAAGAGTATCTCCTGGCCCTCAAGAGCCGCGACCGGCTCAAGGACTCTCCCAT
CGCCTCCATCTCCCAGGGGGGAGAGGGGCTCGTGGCTTCCGCTCGGCAGCGGCTCCTGCTCATGGGAGTGAAGGAACAGC
AGATCGCCGGTCTGGAAAAGGCGGGACAGCCCAACATCAAGCTCCCCGTCTATACCCCCCTCTCCGGCGTGGTGATCGAA
AAGATCGCCATCGAAGGGCAGTACGTGAACATGGGCGATCCCCTCTTCACCATCGCCGACCTCTCCACGGTCTGGGTCGA
GGCCGAGATCTACGAGAGCGACGTCTCCTTCGTCAAGGTGGGGCAGCGGGTCGAGGTGACTTCTGCCTCGTGGCCGGGCA
AGACCTTTGCGGGGCGCATCTCCCTGGTCTATCCGTTCCTCGATCCCAAGACTCGGACCATCAAGGCCCGGATCGAGCTC
TCCAACCCTGGGCTGAAGCTGAAGCCCGACATGTTCGTCAACGCCGCCATCAAGATGCCCCTGGGCTCGGCCGTTGTCGT
CCCCGCTGCGGCGGTGATGGATACCGGAACCCGGCAGGTGGTCTGGGTGCAGGTGAAGGAGGGGACCTTCCAGCCCCGCG
ACGTGAAGGTGGGGGCGAGGGTCGGCGACGAGGTGCAGGTACTCTCGGGGCTGACGGCGGGCGAAGTGATCGCCTCCTCC
GGCGCGTACCTCATCGACTCGGAATCGCAGTTGCGGGGCGGCTCCGGCACGGGCCACGAAGGGATGCCCGGCATGGAAAA
GGAAGGGGTGAAACCGGCCCCGGCCGCGCCTCCCGCCAAGAAGAACGACATGGGCATGGATGACATGAAGATGTGA

Upstream 100 bases:

>100_bases
AGTACTACGAGGCCCTGGCCGAGCACGGCATGCGCCGGGCCCAGCTGGAGGCGCTGGTGGGGAGGGAACTGGAGTGAGCC
GCCATCGCGAGGGATATGCC

Downstream 100 bases:

>100_bases
TGGAGCCGTCATGATCGAGAAAATCATCGAATATTCGGCCCGCAACCGGGTCATCATCCTCATGCTTTTTGCCCTGGTCA
TCGGCTGGGGGATCTGGGCC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MLFTRRIMLPLVALLLALVAAGCQKQGAEAPKGDGHDHAAEAKVEYTCPMHPFIIKDKPGSCPICGMDLVKKVAGAGADA
KELEKLAQVAIPTTQMVMANVATQPVTAKSLQKEITATGIVAYDQRRQAKVTAWVAGRIDRLNVNAVGDFVSRGRPVAEL
YSPDLVSAQQEYLLALKSRDRLKDSPIASISQGGEGLVASARQRLLLMGVKEQQIAGLEKAGQPNIKLPVYTPLSGVVIE
KIAIEGQYVNMGDPLFTIADLSTVWVEAEIYESDVSFVKVGQRVEVTSASWPGKTFAGRISLVYPFLDPKTRTIKARIEL
SNPGLKLKPDMFVNAAIKMPLGSAVVVPAAAVMDTGTRQVVWVQVKEGTFQPRDVKVGARVGDEVQVLSGLTAGEVIASS
GAYLIDSESQLRGGSGTGHEGMPGMEKEGVKPAPAAPPAKKNDMGMDDMKM

Sequences:

>Translated_451_residues
MLFTRRIMLPLVALLLALVAAGCQKQGAEAPKGDGHDHAAEAKVEYTCPMHPFIIKDKPGSCPICGMDLVKKVAGAGADA
KELEKLAQVAIPTTQMVMANVATQPVTAKSLQKEITATGIVAYDQRRQAKVTAWVAGRIDRLNVNAVGDFVSRGRPVAEL
YSPDLVSAQQEYLLALKSRDRLKDSPIASISQGGEGLVASARQRLLLMGVKEQQIAGLEKAGQPNIKLPVYTPLSGVVIE
KIAIEGQYVNMGDPLFTIADLSTVWVEAEIYESDVSFVKVGQRVEVTSASWPGKTFAGRISLVYPFLDPKTRTIKARIEL
SNPGLKLKPDMFVNAAIKMPLGSAVVVPAAAVMDTGTRQVVWVQVKEGTFQPRDVKVGARVGDEVQVLSGLTAGEVIASS
GAYLIDSESQLRGGSGTGHEGMPGMEKEGVKPAPAAPPAKKNDMGMDDMKM
>Mature_451_residues
MLFTRRIMLPLVALLLALVAAGCQKQGAEAPKGDGHDHAAEAKVEYTCPMHPFIIKDKPGSCPICGMDLVKKVAGAGADA
KELEKLAQVAIPTTQMVMANVATQPVTAKSLQKEITATGIVAYDQRRQAKVTAWVAGRIDRLNVNAVGDFVSRGRPVAEL
YSPDLVSAQQEYLLALKSRDRLKDSPIASISQGGEGLVASARQRLLLMGVKEQQIAGLEKAGQPNIKLPVYTPLSGVVIE
KIAIEGQYVNMGDPLFTIADLSTVWVEAEIYESDVSFVKVGQRVEVTSASWPGKTFAGRISLVYPFLDPKTRTIKARIEL
SNPGLKLKPDMFVNAAIKMPLGSAVVVPAAAVMDTGTRQVVWVQVKEGTFQPRDVKVGARVGDEVQVLSGLTAGEVIASS
GAYLIDSESQLRGGSGTGHEGMPGMEKEGVKPAPAAPPAKKNDMGMDDMKM

Specific function: Part of a cation efflux system that mediates resistance to copper and silver [H]

COG id: COG0845

COG function: function code M; Membrane-fusion protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1786787, Length=397, Percent_Identity=31.2342569269521, Blast_Score=145, Evalue=7e-36,
Organism=Escherichia coli, GI87081796, Length=318, Percent_Identity=25.4716981132075, Blast_Score=70, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 48083; Mature: 48083

Theoretical pI: Translated: 8.80; Mature: 8.80

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLFTRRIMLPLVALLLALVAAGCQKQGAEAPKGDGHDHAAEAKVEYTCPMHPFIIKDKPG
CCCHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCC
SCPICGMDLVKKVAGAGADAKELEKLAQVAIPTTQMVMANVATQPVTAKSLQKEITATGI
CCCEECHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHEE
VAYDQRRQAKVTAWVAGRIDRLNVNAVGDFVSRGRPVAELYSPDLVSAQQEYLLALKSRD
EEECCCCCEEEEEEEECCCEEEECHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHH
RLKDSPIASISQGGEGLVASARQRLLLMGVKEQQIAGLEKAGQPNIKLPVYTPLSGVVIE
CCCCCCCHHHHCCCCHHHHHHHHHEEEECCCHHHHHCHHHCCCCCEEEEEECCCCCCEEE
KIAIEGQYVNMGDPLFTIADLSTVWVEAEIYESDVSFVKVGQRVEVTSASWPGKTFAGRI
EEEECCEEEECCCCEEEEECCEEEEEEEEEECCCCHHHHCCCEEEEECCCCCCCCEECEE
SLVYPFLDPKTRTIKARIELSNPGLKLKPDMFVNAAIKMPLGSAVVVPAAAVMDTGTRQV
EEEEECCCCCCEEEEEEEEECCCCCEECCCCEEEEEEECCCCCEEHHHHHHHHCCCCCEE
VWVQVKEGTFQPRDVKVGARVGDEVQVLSGLTAGEVIASSGAYLIDSESQLRGGSGTGHE
EEEEEECCCCCCCCEEECCCCCCHHHHHHCCCHHHHHHCCCCEEEECHHHCCCCCCCCCC
GMPGMEKEGVKPAPAAPPAKKNDMGMDDMKM
CCCCCHHCCCCCCCCCCCCCCCCCCCHHCCC
>Mature Secondary Structure
MLFTRRIMLPLVALLLALVAAGCQKQGAEAPKGDGHDHAAEAKVEYTCPMHPFIIKDKPG
CCCHHHHHHHHHHHHHHHHHHCHHHCCCCCCCCCCCCCCCCCEEEEECCCCCEEEECCCC
SCPICGMDLVKKVAGAGADAKELEKLAQVAIPTTQMVMANVATQPVTAKSLQKEITATGI
CCCEECHHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHEE
VAYDQRRQAKVTAWVAGRIDRLNVNAVGDFVSRGRPVAELYSPDLVSAQQEYLLALKSRD
EEECCCCCEEEEEEEECCCEEEECHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHH
RLKDSPIASISQGGEGLVASARQRLLLMGVKEQQIAGLEKAGQPNIKLPVYTPLSGVVIE
CCCCCCCHHHHCCCCHHHHHHHHHEEEECCCHHHHHCHHHCCCCCEEEEEECCCCCCEEE
KIAIEGQYVNMGDPLFTIADLSTVWVEAEIYESDVSFVKVGQRVEVTSASWPGKTFAGRI
EEEECCEEEECCCCEEEEECCEEEEEEEEEECCCCHHHHCCCEEEEECCCCCCCCEECEE
SLVYPFLDPKTRTIKARIELSNPGLKLKPDMFVNAAIKMPLGSAVVVPAAAVMDTGTRQV
EEEEECCCCCCEEEEEEEEECCCCCEECCCCEEEEEEECCCCCEEHHHHHHHHCCCCCEE
VWVQVKEGTFQPRDVKVGARVGDEVQVLSGLTAGEVIASSGAYLIDSESQLRGGSGTGHE
EEEEEECCCCCCCCEEECCCCCCHHHHHHCCCHHHHHHCCCCEEEECHHHCCCCCCCCCC
GMPGMEKEGVKPAPAAPPAKKNDMGMDDMKM
CCCCCHHCCCCCCCCCCCCCCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]