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The map label for this gene is pyrH [H]

Identifier: 38234085

GI number: 38234085

Start: 1529938

End: 1530747

Strand: Reverse

Name: pyrH [H]

Synonym: DIP1506

Alternate gene names: 38234085

Gene position: 1530747-1529938 (Counterclockwise)

Preceding gene: 38234086

Following gene: 38234084

Centisome position: 61.51

GC content: 49.51

Gene sequence:

>810_bases
ATGCGGTTTTCTAGTTGGACTAAAAATACCGTTACTGCGAGCAACACTATGGCCGAAAGGTCGGAGAGGCGACACACCAT
GACTGAAGGTGTCCAAAACGAACGTACTGGCTACAAGCGAGTAATGCTCAAACTCGGCGGTGAAATGTTCGGCGGTGGGG
CAGTGGGAATTGACCCTGACGTCGTCCAAAATGTTGCACGACAGATCGCCAGTGTTGCTCGTACCGGAGCGGAGATCGCT
GTAGTTATCGGAGGCGGTAATTTCTTCCGAGGTGCGCAGTTGCAACAGCGTGGTTTGGATCGTAATCGCTCAGACTACAT
GGGTATGTTGGGCACTGTTATGAACTGCTTGGCTCTGCAGGACTTCCTTGAACAAGAGGGCATTGATTGTCGTGTACAAA
CCGCCATCAATATGGCCCAGGTTGCTGAGCCATATTTGCCGCTTCGTGCAAAGCGACACCTGGAAAAGGGACGCGTGGTT
ATCTTTGGTGCAGGTATGGGTATGCCTTATTTCTCCACCGATACGACTGCAGCACAGCGTGCTCTAGAAATTGATTGTGA
AGTTCTTCTTATGGCTAAAGCCGTTGATGGAGTTTACGATGACGATCCTCGTACTAACCCAGATGCACAGTTGTTCCACC
AGATTACCCCTCGTGAAGTAATCGAAAAGGGTCTAAAAGTCGCAGATGCAACAGCATTTAGCCTGTGCATGGACAACAAG
ATGCCAATTTTGGTGTTCAACCTTCTCACAGAAGGTAATATCGCTCGTGCTGTCGCGGGTGAACAAATCGGTACTTTGGT
TCAATCCTGA

Upstream 100 bases:

>100_bases
TCGTGCACGGGCATTATTGTGTTATTTGGTGTTCCTTGTTAGTTGGTCGGGGTGTGAATAAGACAAGGTGGCAGATTAAC
GGTAGACTGTTATCCGATTT

Downstream 100 bases:

>100_bases
TAGATTAAGTGTGATCGAACGCTGCTATTGAGTGTTCCTTGACTTACCTAAAAACTGCAAAGGACAACATAATGATCGAT
GAGATCCTGTTTGAAGCTGA

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MRFSSWTKNTVTASNTMAERSERRHTMTEGVQNERTGYKRVMLKLGGEMFGGGAVGIDPDVVQNVARQIASVARTGAEIA
VVIGGGNFFRGAQLQQRGLDRNRSDYMGMLGTVMNCLALQDFLEQEGIDCRVQTAINMAQVAEPYLPLRAKRHLEKGRVV
IFGAGMGMPYFSTDTTAAQRALEIDCEVLLMAKAVDGVYDDDPRTNPDAQLFHQITPREVIEKGLKVADATAFSLCMDNK
MPILVFNLLTEGNIARAVAGEQIGTLVQS

Sequences:

>Translated_269_residues
MRFSSWTKNTVTASNTMAERSERRHTMTEGVQNERTGYKRVMLKLGGEMFGGGAVGIDPDVVQNVARQIASVARTGAEIA
VVIGGGNFFRGAQLQQRGLDRNRSDYMGMLGTVMNCLALQDFLEQEGIDCRVQTAINMAQVAEPYLPLRAKRHLEKGRVV
IFGAGMGMPYFSTDTTAAQRALEIDCEVLLMAKAVDGVYDDDPRTNPDAQLFHQITPREVIEKGLKVADATAFSLCMDNK
MPILVFNLLTEGNIARAVAGEQIGTLVQS
>Mature_269_residues
MRFSSWTKNTVTASNTMAERSERRHTMTEGVQNERTGYKRVMLKLGGEMFGGGAVGIDPDVVQNVARQIASVARTGAEIA
VVIGGGNFFRGAQLQQRGLDRNRSDYMGMLGTVMNCLALQDFLEQEGIDCRVQTAINMAQVAEPYLPLRAKRHLEKGRVV
IFGAGMGMPYFSTDTTAAQRALEIDCEVLLMAKAVDGVYDDDPRTNPDAQLFHQITPREVIEKGLKVADATAFSLCMDNK
MPILVFNLLTEGNIARAVAGEQIGTLVQS

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP [H]

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786367, Length=236, Percent_Identity=44.0677966101695, Blast_Score=199, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963 [H]

Pfam domain/function: PF00696 AA_kinase [H]

EC number: =2.7.4.22 [H]

Molecular weight: Translated: 29424; Mature: 29424

Theoretical pI: Translated: 6.28; Mature: 6.28

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
6.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFSSWTKNTVTASNTMAERSERRHTMTEGVQNERTGYKRVMLKLGGEMFGGGAVGIDPD
CCCCCCCCCCEECHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHCCCCCCCCCHH
VVQNVARQIASVARTGAEIAVVIGGGNFFRGAQLQQRGLDRNRSDYMGMLGTVMNCLALQ
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DFLEQEGIDCRVQTAINMAQVAEPYLPLRAKRHLEKGRVVIFGAGMGMPYFSTDTTAAQR
HHHHHCCCCEEHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHH
ALEIDCEVLLMAKAVDGVYDDDPRTNPDAQLFHQITPREVIEKGLKVADATAFSLCMDNK
HHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHCCC
MPILVFNLLTEGNIARAVAGEQIGTLVQS
CCEEEEEECCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRFSSWTKNTVTASNTMAERSERRHTMTEGVQNERTGYKRVMLKLGGEMFGGGAVGIDPD
CCCCCCCCCCEECHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCHHCCCCCCCCCHH
VVQNVARQIASVARTGAEIAVVIGGGNFFRGAQLQQRGLDRNRSDYMGMLGTVMNCLALQ
HHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DFLEQEGIDCRVQTAINMAQVAEPYLPLRAKRHLEKGRVVIFGAGMGMPYFSTDTTAAQR
HHHHHCCCCEEHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHH
ALEIDCEVLLMAKAVDGVYDDDPRTNPDAQLFHQITPREVIEKGLKVADATAFSLCMDNK
HHHCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCHHHHHHHCCCHHHHHHHHHHHCCC
MPILVFNLLTEGNIARAVAGEQIGTLVQS
CCEEEEEECCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910 [H]