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The map label for this gene is thrS

Identifier: 38233973

GI number: 38233973

Start: 1404545

End: 1406608

Strand: Reverse

Name: thrS

Synonym: DIP1388

Alternate gene names: 38233973

Gene position: 1406608-1404545 (Counterclockwise)

Preceding gene: 38233974

Following gene: 38233972

Centisome position: 56.52

GC content: 48.59

Gene sequence:

>2064_bases
ATGGCACATCTCATTGAGGCAGCCCCCAACCCCCACCAGCCTTTCGTCGTGACTGCAGGCGTTGCGGTCGGCGCTGCTAT
GCGGGAACTGGAGCTACCTAATAAAGGTCCTGAAGCGATCGTTTGTGTAAAGGATAGTGAAGGCACACTGCGTGATCTGT
CTTTTGTGCCTGAGCAAGATAGTAAGTTCACTCCAGTTCCTGCTAATACTGAAGATGGACGTACAGTCATCCGCCACTCG
TGTACTCACGTGTTGGCTCAAGCCGTGCAAGCAGAATTCCCAGGAACAAAGTTGGGCATTGGTCCAGCGATTGAAAATGG
CTTTTACTATGACTTTGATGTTGCAGAGCCTTTCACTCCGGAAGATCTTCAAAAGCTTGAAAAACGAATGAAGAAAATCG
TCAAGCAAGGGCAAAAATTTGAGCGTCGAATTTTCGCATCGGTTGCCGAGGCTGAAGAAGCTCTAAAGAACGAGCCTTAT
AAGCTTGAGCTGATTCGCGATAAAGGAAACGTTGATCCAGGCTCGGATGAGGCTACAGAGATTGGCGCTGGTGATCTCAC
AGGCTATTACAACGTTAACCCACGTACAGGTGAAGTGGATTGGTACGATCTGTGCCGCGGACCGCATGTTCCGACAACCA
AGTACATTCCAGCATTTGCTTTGACACGATCGTCAGCAGCATATTGGCGTGGCGATCAATCTCTAGCAGGTTTGCAGCGC
ATTTATGGCACCGCGTGGGAGTCTAAAGAAGCGCTTGAAGAATACCAGCTGATGATGGCCGAGGCTGAAAAGCGCGACCA
TCGTCGTCTAGGTGCAGAGCTTGACTTGTTCAGCTTCCCAGATGAAATCGGATCTGGTTTTCCGGTGTTCCACCCCAATG
GAGGAATTGTTCGTCTAGAGATGGAGGAACATTCTCGCCGTCGTCATATCAACGCAGGATATTCCTTTGTTAATACCCCG
CACATCACCAAAGGTGATCTGTTCAAGAAATCGGGTCACCTAGATTTCTATGCTGATGGCATGTTCCCTCCTATGCAGCT
TGATGGTGAGGTTGACGAGGAAGGAAACGTCGTAAAGCAGGCTCAGGACTACTATGCAAAGCCTATGAACTGCCCGATGC
ACAACCTCATCTTCGCATCGCGTGGTCGGTCTTACCGTGAGCTTCCTCTGCGCCTCTTTGAGTTCGGTACGGTTTACCGT
TATGAAAAATCTGGCGTAATCCACGGACTTACTCGTGCACGTGGTTTTACCCAAGATGATGCTCACATTTACTGTACTGA
GGATCAACTTGAGCAAGAGCTCACATCAGTACTCGATTTCATTATTTCGCTTCTTCGTGACTACGGCTTGGATGACTTTT
ATCTTGAGCTTTCCACCAAGGATCCGAACAAGTTCGTTGGTTCTGATGAAATTTGGGAAAAATCTACATCGATTCTGCAG
CGGGTAGCAACTAAATCTGGTCTAGAACTGGTTCCGGATCCTGCTGGAGCAGCATTCTATGGGCCGAAGATATCGGTACA
GGCTCGAGACGCTATCGGTAGAACTTGGCAAATGTCGACAGTTCAGCTTGACTTCAATCTCCCAGAGCGATTCAACTTGG
AATACACATCTTCTGATGGTTCTAAGAAGCGTCCCATCATGATTCACCGTGCGTTGTTTGGCTCAATCGAGCGATTCTTT
GGTGTCTTGCTGGAGCATTATGCCGGTGCATTCCCAGCGTGGTTGGCTCCTCACCAAGTAATTGGTATTCCAGTGGCAGA
TTCCTTCTCTGAGCATTTGGAGAAAGTTACAGGGATGCTTCGTGACAATGGCGTTCGCGCGAGCGTGGATACTTCTGACG
ATCGTATGCAGAAAAAGATTCGAAATCATACGACCGGTAAGGTTCCATTTATGCTCCTTGCAGGTGCGCGCGATGTTGAA
GCTAATGCGGTGAGCTTCCGTTTCCTCGATGGCACACAGATTAATGGGGTTCCTGTTGATAAAGCTATCGGCGTGATCAC
GCAGTGGATCTCTTCGCGAAATAACAAACAGCCAAGCGAAGAAACTGTGAAAAAACTGGTGTAA

Upstream 100 bases:

>100_bases
TTACTATTTTGATGAGTGAAAATCGAGCTATTGTCGGAACGTTTGAGCGTCCAGGTATGACGTTTAAACATGAGCGCAAG
TAAGGAGCGCATTTTTTTAA

Downstream 100 bases:

>100_bases
TACCCGTTGCTTTGCATGGTTATGGATTAACCCACGATGTATTCAACATGTACATCGTGGGTTAATCCCCTCATTGTGTG
CATAAACGAAGTACGGTGTA

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS

Number of amino acids: Translated: 687; Mature: 686

Protein sequence:

>687_residues
MAHLIEAAPNPHQPFVVTAGVAVGAAMRELELPNKGPEAIVCVKDSEGTLRDLSFVPEQDSKFTPVPANTEDGRTVIRHS
CTHVLAQAVQAEFPGTKLGIGPAIENGFYYDFDVAEPFTPEDLQKLEKRMKKIVKQGQKFERRIFASVAEAEEALKNEPY
KLELIRDKGNVDPGSDEATEIGAGDLTGYYNVNPRTGEVDWYDLCRGPHVPTTKYIPAFALTRSSAAYWRGDQSLAGLQR
IYGTAWESKEALEEYQLMMAEAEKRDHRRLGAELDLFSFPDEIGSGFPVFHPNGGIVRLEMEEHSRRRHINAGYSFVNTP
HITKGDLFKKSGHLDFYADGMFPPMQLDGEVDEEGNVVKQAQDYYAKPMNCPMHNLIFASRGRSYRELPLRLFEFGTVYR
YEKSGVIHGLTRARGFTQDDAHIYCTEDQLEQELTSVLDFIISLLRDYGLDDFYLELSTKDPNKFVGSDEIWEKSTSILQ
RVATKSGLELVPDPAGAAFYGPKISVQARDAIGRTWQMSTVQLDFNLPERFNLEYTSSDGSKKRPIMIHRALFGSIERFF
GVLLEHYAGAFPAWLAPHQVIGIPVADSFSEHLEKVTGMLRDNGVRASVDTSDDRMQKKIRNHTTGKVPFMLLAGARDVE
ANAVSFRFLDGTQINGVPVDKAIGVITQWISSRNNKQPSEETVKKLV

Sequences:

>Translated_687_residues
MAHLIEAAPNPHQPFVVTAGVAVGAAMRELELPNKGPEAIVCVKDSEGTLRDLSFVPEQDSKFTPVPANTEDGRTVIRHS
CTHVLAQAVQAEFPGTKLGIGPAIENGFYYDFDVAEPFTPEDLQKLEKRMKKIVKQGQKFERRIFASVAEAEEALKNEPY
KLELIRDKGNVDPGSDEATEIGAGDLTGYYNVNPRTGEVDWYDLCRGPHVPTTKYIPAFALTRSSAAYWRGDQSLAGLQR
IYGTAWESKEALEEYQLMMAEAEKRDHRRLGAELDLFSFPDEIGSGFPVFHPNGGIVRLEMEEHSRRRHINAGYSFVNTP
HITKGDLFKKSGHLDFYADGMFPPMQLDGEVDEEGNVVKQAQDYYAKPMNCPMHNLIFASRGRSYRELPLRLFEFGTVYR
YEKSGVIHGLTRARGFTQDDAHIYCTEDQLEQELTSVLDFIISLLRDYGLDDFYLELSTKDPNKFVGSDEIWEKSTSILQ
RVATKSGLELVPDPAGAAFYGPKISVQARDAIGRTWQMSTVQLDFNLPERFNLEYTSSDGSKKRPIMIHRALFGSIERFF
GVLLEHYAGAFPAWLAPHQVIGIPVADSFSEHLEKVTGMLRDNGVRASVDTSDDRMQKKIRNHTTGKVPFMLLAGARDVE
ANAVSFRFLDGTQINGVPVDKAIGVITQWISSRNNKQPSEETVKKLV
>Mature_686_residues
AHLIEAAPNPHQPFVVTAGVAVGAAMRELELPNKGPEAIVCVKDSEGTLRDLSFVPEQDSKFTPVPANTEDGRTVIRHSC
THVLAQAVQAEFPGTKLGIGPAIENGFYYDFDVAEPFTPEDLQKLEKRMKKIVKQGQKFERRIFASVAEAEEALKNEPYK
LELIRDKGNVDPGSDEATEIGAGDLTGYYNVNPRTGEVDWYDLCRGPHVPTTKYIPAFALTRSSAAYWRGDQSLAGLQRI
YGTAWESKEALEEYQLMMAEAEKRDHRRLGAELDLFSFPDEIGSGFPVFHPNGGIVRLEMEEHSRRRHINAGYSFVNTPH
ITKGDLFKKSGHLDFYADGMFPPMQLDGEVDEEGNVVKQAQDYYAKPMNCPMHNLIFASRGRSYRELPLRLFEFGTVYRY
EKSGVIHGLTRARGFTQDDAHIYCTEDQLEQELTSVLDFIISLLRDYGLDDFYLELSTKDPNKFVGSDEIWEKSTSILQR
VATKSGLELVPDPAGAAFYGPKISVQARDAIGRTWQMSTVQLDFNLPERFNLEYTSSDGSKKRPIMIHRALFGSIERFFG
VLLEHYAGAFPAWLAPHQVIGIPVADSFSEHLEKVTGMLRDNGVRASVDTSDDRMQKKIRNHTTGKVPFMLLAGARDVEA
NAVSFRFLDGTQINGVPVDKAIGVITQWISSRNNKQPSEETVKKLV

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI38570111, Length=637, Percent_Identity=36.1067503924647, Blast_Score=382, Evalue=1e-106,
Organism=Homo sapiens, GI38202255, Length=671, Percent_Identity=34.575260804769, Blast_Score=381, Evalue=1e-106,
Organism=Homo sapiens, GI20070344, Length=639, Percent_Identity=35.6807511737089, Blast_Score=353, Evalue=4e-97,
Organism=Escherichia coli, GI1788013, Length=635, Percent_Identity=38.4251968503937, Blast_Score=469, Evalue=1e-133,
Organism=Caenorhabditis elegans, GI71984192, Length=637, Percent_Identity=34.5368916797488, Blast_Score=375, Evalue=1e-104,
Organism=Caenorhabditis elegans, GI71984184, Length=637, Percent_Identity=34.5368916797488, Blast_Score=375, Evalue=1e-104,
Organism=Saccharomyces cerevisiae, GI6322112, Length=637, Percent_Identity=36.1067503924647, Blast_Score=381, Evalue=1e-106,
Organism=Saccharomyces cerevisiae, GI6322654, Length=400, Percent_Identity=34.25, Blast_Score=241, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24583839, Length=661, Percent_Identity=33.8880484114977, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24583842, Length=661, Percent_Identity=33.8880484114977, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI28574141, Length=661, Percent_Identity=33.8880484114977, Blast_Score=386, Evalue=1e-107,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYT_CORDI (Q6NGW2)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939740.1
- ProteinModelPortal:   Q6NGW2
- SMR:   Q6NGW2
- GeneID:   2649919
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1388
- NMPDR:   fig|257309.1.peg.1331
- HOGENOM:   HBG352811
- OMA:   TAKDPEC
- ProtClustDB:   PRK12305
- BioCyc:   CDIP257309:DIP1388-MONOMER
- BRENDA:   6.1.1.3
- GO:   GO:0005737
- HAMAP:   MF_00184_B
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947
- Gene3D:   G3DSA:3.40.50.800
- PRINTS:   PR01047
- SMART:   SM00863
- TIGRFAMs:   TIGR00418

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD; SSF52954 Anticodon_bd; SSF55186 Thr/Ala-tRNA-synth_IIc_edit

EC number: =6.1.1.3

Molecular weight: Translated: 76973; Mature: 76842

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAHLIEAAPNPHQPFVVTAGVAVGAAMRELELPNKGPEAIVCVKDSEGTLRDLSFVPEQD
CCCCCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHCCCCCCC
SKFTPVPANTEDGRTVIRHSCTHVLAQAVQAEFPGTKLGIGPAIENGFYYDFDVAEPFTP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEEECCCCCCCH
EDLQKLEKRMKKIVKQGQKFERRIFASVAEAEEALKNEPYKLELIRDKGNVDPGSDEATE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHC
IGAGDLTGYYNVNPRTGEVDWYDLCRGPHVPTTKYIPAFALTRSSAAYWRGDQSLAGLQR
CCCCCCCEEEECCCCCCCCCHHHHHCCCCCCCCCCCCHHEEECCCCHHCCCCHHHHHHHH
IYGTAWESKEALEEYQLMMAEAEKRDHRRLGAELDLFSFPDEIGSGFPVFHPNGGIVRLE
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHCCCCCEECCCCCEEEEE
MEEHSRRRHINAGYSFVNTPHITKGDLFKKSGHLDFYADGMFPPMQLDGEVDEEGNVVKQ
EHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCCCCCCCCCCCCCCHHHH
AQDYYAKPMNCPMHNLIFASRGRSYRELPLRLFEFGTVYRYEKSGVIHGLTRARGFTQDD
HHHHHCCCCCCCHHHHEEHHCCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCCC
AHIYCTEDQLEQELTSVLDFIISLLRDYGLDDFYLELSTKDPNKFVGSDEIWEKSTSILQ
CEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHH
RVATKSGLELVPDPAGAAFYGPKISVQARDAIGRTWQMSTVQLDFNLPERFNLEYTSSDG
HHHHHCCCEECCCCCCCCEECCEEEEEEHHHCCCEEEEEEEEEEECCCCCCCEEEECCCC
SKKRPIMIHRALFGSIERFFGVLLEHYAGAFPAWLAPHQVIGIPVADSFSEHLEKVTGML
CCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCEEEEECCHHHHHHHHHHHHHHH
RDNGVRASVDTSDDRMQKKIRNHTTGKVPFMLLAGARDVEANAVSFRFLDGTQINGVPVD
HCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEEECCCEECCCCHH
KAIGVITQWISSRNNKQPSEETVKKLV
HHHHHHHHHHHCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
AHLIEAAPNPHQPFVVTAGVAVGAAMRELELPNKGPEAIVCVKDSEGTLRDLSFVPEQD
CCCCCCCCCCCCCEEEECCHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHCCCCCCC
SKFTPVPANTEDGRTVIRHSCTHVLAQAVQAEFPGTKLGIGPAIENGFYYDFDVAEPFTP
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCEEEEECCCCCCCH
EDLQKLEKRMKKIVKQGQKFERRIFASVAEAEEALKNEPYKLELIRDKGNVDPGSDEATE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHC
IGAGDLTGYYNVNPRTGEVDWYDLCRGPHVPTTKYIPAFALTRSSAAYWRGDQSLAGLQR
CCCCCCCEEEECCCCCCCCCHHHHHCCCCCCCCCCCCHHEEECCCCHHCCCCHHHHHHHH
IYGTAWESKEALEEYQLMMAEAEKRDHRRLGAELDLFSFPDEIGSGFPVFHPNGGIVRLE
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHCCCCCEECCCCCEEEEE
MEEHSRRRHINAGYSFVNTPHITKGDLFKKSGHLDFYADGMFPPMQLDGEVDEEGNVVKQ
EHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCEEEECCCCCCCCCCCCCCCCCCHHHH
AQDYYAKPMNCPMHNLIFASRGRSYRELPLRLFEFGTVYRYEKSGVIHGLTRARGFTQDD
HHHHHCCCCCCCHHHHEEHHCCCCHHHHHHHHHHHCCEEEEECCCCCHHHHHHCCCCCCC
AHIYCTEDQLEQELTSVLDFIISLLRDYGLDDFYLELSTKDPNKFVGSDEIWEKSTSILQ
CEEEECHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHH
RVATKSGLELVPDPAGAAFYGPKISVQARDAIGRTWQMSTVQLDFNLPERFNLEYTSSDG
HHHHHCCCEECCCCCCCCEECCEEEEEEHHHCCCEEEEEEEEEEECCCCCCCEEEECCCC
SKKRPIMIHRALFGSIERFFGVLLEHYAGAFPAWLAPHQVIGIPVADSFSEHLEKVTGML
CCCCCEEEHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCEEEEECCHHHHHHHHHHHHHHH
RDNGVRASVDTSDDRMQKKIRNHTTGKVPFMLLAGARDVEANAVSFRFLDGTQINGVPVD
HCCCEEEECCCCHHHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEEEECCCEECCCCHH
KAIGVITQWISSRNNKQPSEETVKKLV
HHHHHHHHHHHCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14602910