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The map label for this gene is ruvC

Identifier: 38233962

GI number: 38233962

Start: 1394694

End: 1395185

Strand: Reverse

Name: ruvC

Synonym: DIP1377

Alternate gene names: 38233962

Gene position: 1395185-1394694 (Counterclockwise)

Preceding gene: 38233963

Following gene: 38233961

Centisome position: 56.06

GC content: 52.64

Gene sequence:

>492_bases
ATGGGAATCGACCCCGGTCTGACGCGCTGTGGATTATCGGTGGTTCAGGCTGGAAAAGGTCGAAGCGTTATACCCGTAGC
CGTCGGGGTGGTGCGTACGCCGCCTCATGCTGAGTTGTCACAACGATTGTTAGAATTGAGTGAAGCGGTAAATAGCTGGA
TCGACGAGTATCAACCTGATGTCGTTGCCATCGAGAGAATTTTTGAGCGCGGAAATGTGTCCACGGTGATGAATACCGCC
CACGGAGTAGGAGTGCTTGTTCTTGCAGCAGCGCAACGCGGCCTACCAGTGCATATGTACACACCTAGCGAGGTGAAAAA
GGCAATTTCGGGTAATGGTCGAGCCGACAAAAAACAGATGACGGCCATGATTACAAGAATTCTTGGGTTGGTGGAAGCGC
CCAAACCGGCTGATGCGGCCGATGCTCTTGCTCTAGCGGTATGCCATTGTTGGCGAGCTCCAATGCTAGCGATACATAAC
TCCCAGAGATAG

Upstream 100 bases:

>100_bases
GTGTCAATGGTTTTACAGATATGTTCGCAACCAATTCACTAGATAAGGCACTATGACCATCACGCATCGTCCTCAACACT
CCGTTGTAGGCTTAAGGATC

Downstream 100 bases:

>100_bases
CCCGTAACAATAGATATTTAGAAAAAGGGGTATATGAAGTGATTGTTTCTCTGAGAGGTACAGTCGAATCGATCGGTTTA
GGTAGCGCTGTAATCGAATG

Product: Holliday junction resolvase

Products: NA

Alternate protein names: Holliday junction nuclease ruvC; Holliday junction resolvase ruvC

Number of amino acids: Translated: 163; Mature: 162

Protein sequence:

>163_residues
MGIDPGLTRCGLSVVQAGKGRSVIPVAVGVVRTPPHAELSQRLLELSEAVNSWIDEYQPDVVAIERIFERGNVSTVMNTA
HGVGVLVLAAAQRGLPVHMYTPSEVKKAISGNGRADKKQMTAMITRILGLVEAPKPADAADALALAVCHCWRAPMLAIHN
SQR

Sequences:

>Translated_163_residues
MGIDPGLTRCGLSVVQAGKGRSVIPVAVGVVRTPPHAELSQRLLELSEAVNSWIDEYQPDVVAIERIFERGNVSTVMNTA
HGVGVLVLAAAQRGLPVHMYTPSEVKKAISGNGRADKKQMTAMITRILGLVEAPKPADAADALALAVCHCWRAPMLAIHN
SQR
>Mature_162_residues
GIDPGLTRCGLSVVQAGKGRSVIPVAVGVVRTPPHAELSQRLLELSEAVNSWIDEYQPDVVAIERIFERGNVSTVMNTAH
GVGVLVLAAAQRGLPVHMYTPSEVKKAISGNGRADKKQMTAMITRILGLVEAPKPADAADALALAVCHCWRAPMLAIHNS
QR

Specific function: Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leav

COG id: COG0817

COG function: function code L; Holliday junction resolvasome, endonuclease subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ruvC family

Homologues:

Organism=Escherichia coli, GI1788170, Length=135, Percent_Identity=32.5925925925926, Blast_Score=72, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RUVC_CORDI (Q6NGX3)

Other databases:

- EMBL:   BX248358
- RefSeq:   NP_939729.1
- ProteinModelPortal:   Q6NGX3
- SMR:   Q6NGX3
- GeneID:   2649908
- GenomeReviews:   BX248353_GR
- KEGG:   cdi:DIP1377
- NMPDR:   fig|257309.1.peg.1320
- HOGENOM:   HBG437552
- OMA:   RTGWGVI
- PhylomeDB:   Q6NGX3
- ProtClustDB:   PRK00039
- BioCyc:   CDIP257309:DIP1377-MONOMER
- BRENDA:   3.1.22.4
- HAMAP:   MF_00034
- InterPro:   IPR012337
- InterPro:   IPR020563
- InterPro:   IPR002176
- PRINTS:   PR00696
- TIGRFAMs:   TIGR00228

Pfam domain/function: PF02075 RuvC; SSF53098 RNaseH_fold

EC number: =3.1.22.4

Molecular weight: Translated: 17379; Mature: 17248

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS01321 RUVC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIDPGLTRCGLSVVQAGKGRSVIPVAVGVVRTPPHAELSQRLLELSEAVNSWIDEYQPD
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
VVAIERIFERGNVSTVMNTAHGVGVLVLAAAQRGLPVHMYTPSEVKKAISGNGRADKKQM
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCCCHHHHH
TAMITRILGLVEAPKPADAADALALAVCHCWRAPMLAIHNSQR
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCC
>Mature Secondary Structure 
GIDPGLTRCGLSVVQAGKGRSVIPVAVGVVRTPPHAELSQRLLELSEAVNSWIDEYQPD
CCCCCHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCH
VVAIERIFERGNVSTVMNTAHGVGVLVLAAAQRGLPVHMYTPSEVKKAISGNGRADKKQM
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCCCHHHHH
TAMITRILGLVEAPKPADAADALALAVCHCWRAPMLAIHNSQR
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14602910