Click here to switch to the map view.

The map label for this gene is pbuX

Identifier: 15926090

GI number: 15926090

Start: 431708

End: 432976

Strand: Direct

Name: pbuX

Synonym: SA0374

Alternate gene names: 15926090

Gene position: 431708-432976 (Clockwise)

Preceding gene: 15926089

Following gene: 15926091

Centisome position: 15.34

GC content: 35.54

Gene sequence:

>1269_bases
ATGAAAAATTTAATCCTAAGTGTTCAACATCTTTTAGCTATGTACGCAGGTGCCATCTTAGTTCCAATCATTGTTGGTAC
AAGTTTGAAGTTTACACCTGAACAAATCGCTTACTTAGTTACAGTAGATATATTTATGTGTGGGGTTGCCACATTTTTAC
AAGCCAATAAAGTAACAGGAACAGGATTACCAATCGTTCTTGGATGTACATTCACGGCTGTTGCGCCCATGATTTTAATT
GGTCAAACGAAAGGAATAGATGTACTTTACGGTTCGCTATTTTTATCAGGGATATTAGTTATTATCATCGCGCCTTTCTT
TTCACATCTTGTAAAATTCTTCCCACCAGTAGTAACGGGTAGTGTTGTTACTATCATTGGTATCAATTTAATGCCAGTAG
CAATGAATTACTTAGCTGGAGGTCAAGGTGCAAAGGACTATGGAGATGTTAAGAACATTTTGTTAGGTTTAATGACATTA
ATCATTATTCTTGTTTTACAAAGATTCACAACTGGATTTATTAAGAGTATTGCCATATTAATTGGACTCGTTTTAGGAAC
GATAGGTGCTGGCTTACTTGGGATGGTCGATATTAATCAAGTCAATCATGCCGGTTGGTTAGGCATCCCAGTGCCGTTTA
GATTCTCAGGATTTAGCTTTGATGTGACATCGACGTTAGTGTTCTTTATTTTAGCTATCGTTAGTTTAATTGAGTCGACA
GGTGTCTATCATGCGTTAAGTGAAATTACCGGTAAGAAGTTAGAAAGAAAAGATTTTCGTAAAGGTTATACTGCGGAAGG
TCTAGCGATAGTGTTAGGTTCTATATTCAATTCATTTCCGTATACAGCCTATTCGCAAAATGTAGGACTTGTTTCTTTAT
CCGGCGCTAAGAAAAATAATGTTATATACGGCATGGTCGTGTTATTACTTATATGTGGTTGTATACCTAAGCTTGGTGCA
TTAGCAAATATCATACCGCTACCTGTGTTAGGTGGTGCGATGATAGCTATGTTTGGCATGGTAATGGCATATGGTGTTAG
TATATTAGGACATATCGATTTTAAAAATCAAAACAATTTATTAATTATTGCTGTATCAGTAGGATTAGGTACTGGTATAA
GCGCTGTACCACAAGCATTTAAAGGTTTAGGTGAACAATTTGCATGGTTGACTCAAAACGGAATTGTTTTAGGCGCAATC
TCTGCAATTATTCTTAATTTCTTTTTTAATGGAATAAAGTATAAACAAACGGAAGAAAATGTGAAATAA

Upstream 100 bases:

>100_bases
ATGGGCATCAACGTTTAGAAGAAGCAGGTTTAACAGTTTCTTCTCTCTGCAAGGTTGCTTCACTAGAAGGAAACAAAGTG
ACATTGGTGGGAGAAGAATA

Downstream 100 bases:

>100_bases
TATAACTAATTAATTTGAAAAATGGAGGCTGTTTTTAATGTGGGAAAGTAAATTTGCAAAAGAATCATTAACGTTTGATG
ATGTGTTATTAATTCCAGCA

Product: xanthine permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 422; Mature: 422

Protein sequence:

>422_residues
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILI
GQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTL
IIILVLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFILAIVSLIEST
GVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLLICGCIPKLGA
LANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAI
SAIILNFFFNGIKYKQTEENVK

Sequences:

>Translated_422_residues
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILI
GQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTL
IIILVLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFILAIVSLIEST
GVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLLICGCIPKLGA
LANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAI
SAIILNFFFNGIKYKQTEENVK
>Mature_422_residues
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTGTGLPIVLGCTFTAVAPMILI
GQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTGSVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTL
IIILVLQRFTTGFIKSIAILIGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFILAIVSLIEST
GVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNNVIYGMVVLLLICGCIPKLGA
LANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNLLIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAI
SAIILNFFFNGIKYKQTEENVK

Specific function: Transport of xanthine in the cell [H]

COG id: COG2233

COG function: function code F; Xanthine/uracil permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine/uracil permease family. Nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) subfamily [H]

Homologues:

Organism=Homo sapiens, GI44680148, Length=438, Percent_Identity=23.0593607305936, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI40316845, Length=438, Percent_Identity=23.0593607305936, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI44680145, Length=169, Percent_Identity=26.6272189349112, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI44680143, Length=169, Percent_Identity=26.6272189349112, Blast_Score=67, Evalue=2e-11,
Organism=Escherichia coli, GI87082181, Length=427, Percent_Identity=37.7049180327869, Blast_Score=284, Evalue=7e-78,
Organism=Escherichia coli, GI87082178, Length=438, Percent_Identity=31.5068493150685, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1790087, Length=431, Percent_Identity=29.2343387470998, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1788843, Length=437, Percent_Identity=27.0022883295195, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI87081818, Length=391, Percent_Identity=27.6214833759591, Blast_Score=125, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17558856, Length=227, Percent_Identity=27.7533039647577, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI17542262, Length=173, Percent_Identity=26.5895953757225, Blast_Score=65, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21356175, Length=174, Percent_Identity=27.5862068965517, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017588
- InterPro:   IPR006042
- InterPro:   IPR006043 [H]

Pfam domain/function: PF00860 Xan_ur_permease [H]

EC number: NA

Molecular weight: Translated: 44804; Mature: 44804

Theoretical pI: Translated: 9.52; Mature: 9.52

Prosite motif: PS01116 XANTH_URACIL_PERMASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TGLPIVLGCTFTAVAPMILIGQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTG
CCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
SVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTLIIILVLQRFTTGFIKSIAIL
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFILAIVSLIEST
HHHHHHHHCCHHHHHEECCCCCCCCEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHC
GVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNN
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEECCCCCCC
VIYGMVVLLLICGCIPKLGALANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCE
LIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAISAIILNFFFNGIKYKQTEEN
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
VK
CC
>Mature Secondary Structure
MKNLILSVQHLLAMYAGAILVPIIVGTSLKFTPEQIAYLVTVDIFMCGVATFLQANKVTG
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TGLPIVLGCTFTAVAPMILIGQTKGIDVLYGSLFLSGILVIIIAPFFSHLVKFFPPVVTG
CCCCEEEHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
SVVTIIGINLMPVAMNYLAGGQGAKDYGDVKNILLGLMTLIIILVLQRFTTGFIKSIAIL
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IGLVLGTIGAGLLGMVDINQVNHAGWLGIPVPFRFSGFSFDVTSTLVFFILAIVSLIEST
HHHHHHHHCCHHHHHEECCCCCCCCEECCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHC
GVYHALSEITGKKLERKDFRKGYTAEGLAIVLGSIFNSFPYTAYSQNVGLVSLSGAKKNN
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEECCCCCCC
VIYGMVVLLLICGCIPKLGALANIIPLPVLGGAMIAMFGMVMAYGVSILGHIDFKNQNNL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCE
LIIAVSVGLGTGISAVPQAFKGLGEQFAWLTQNGIVLGAISAIILNFFFNGIKYKQTEEN
EEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCC
VK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9098051; 9384377 [H]