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The map label for this gene is guaB

Identifier: 15926091

GI number: 15926091

Start: 433014

End: 434480

Strand: Direct

Name: guaB

Synonym: SA0375

Alternate gene names: 15926091

Gene position: 433014-434480 (Clockwise)

Preceding gene: 15926090

Following gene: 15926092

Centisome position: 15.38

GC content: 37.29

Gene sequence:

>1467_bases
ATGTGGGAAAGTAAATTTGCAAAAGAATCATTAACGTTTGATGATGTGTTATTAATTCCAGCACAATCTGATATTTTACC
GAAAGACGTTGATTTAAGCGTACAATTATCAGACAAAGTTAAATTAAATATTCCAGTTATTTCTGCTGGTATGGATACAG
TAACTGAATCTAAAATGGCGATTGCTATGGCTCGTCAAGGTGGTTTAGGTGTTATTCATAAAAATATGGGCGTTGAAGAA
CAAGCGGACGAAGTTCAAAAAGTAAAACGCTCAGAAAATGGTGTCATTTCAAACCCATTTTTCTTAACACCAGAAGAAAG
TGTTTATGAAGCGGAAGCATTAATGGGTAAATACCGTATTTCAGGTGTACCAATTGTTGATAATAAAGAAGATCGCAACT
TAGTAGGTATTTTAACAAACCGCGACTTACGTTTTATTGAAGACTTCTCAATTAAAATTGTAGATGTAATGACGCAAGAA
AATTTAATTACAGCTCCAGTGAATACAACACTTGAAGAAGCAGAAAAAATTCTCCAAAAACATAAGATTGAAAAGTTACC
ATTAGTTAAAGACGGACGTCTAGAAGGTCTTATTACTATTAAAGATATTGAAAAAGTTATCGAATTCCCTAATGCAGCAA
AAGATGAACATGGTCGTCTACTTGTAGCCGCAGCAATTGGTATTTCAAAAGATACTGATATTCGTGCTCAAAAATTAGTC
GAAGCAGGTGTGGATGTCTTAGTTATCGATACAGCACATGGTCACTCTAAAGGCGTTATCGATCAAGTGAAACATATTAA
GAAGACTTACCCAGAAATCACATTAGTAGCTGGTAACGTAGCAACTGCAGAAGCAACAAAAGATTTATTTGAAGCGGGTG
CAGATATTGTTAAAGTTGGTATTGGCCCAGGTTCAATTTGTACGACGCGTGTTGTAGCAGGTGTTGGTGTACCACAAATT
ACAGCAATTTATGATTGTGCAACTGAAGCACGCAAACATGGTAAAGCTATCATTGCTGATGGTGGTATTAAATTCTCAGG
AGATATCATTAAAGCATTAGCTGCTGGTGGACATGCGGTTATGTTAGGTAGCTTATTAGCAGGTACTGAAGAAAGTCCAG
GTGCTACAGAAATTTTCCAAGGTAGACAATATAAAGTATACCGTGGTATGGGCTCTTTAGGTGCGATGGAAAAAGGTTCA
AACGACCGTTACTTCCAAGAGGACAAAGCGCCTAAGAAATTTGTTCCTGAAGGTATCGAAGGACGTACGGCTTATAAAGG
TGCGTTACAAGATACAATTTACCAATTAATGGGCGGTGTGCGTGCTGGTATGGGTTATACTGGTTCACACGATTTAAGAG
AATTACGCGAAGAAGCACAATTTACACGTATGGGTCCTGCTGGTTTAGCAGAAAGCCATCCACATAATATTCAAATTACG
AAAGAATCACCGAACTACTCATTCTAA

Upstream 100 bases:

>100_bases
ATTATTCTTAATTTCTTTTTTAATGGAATAAAGTATAAACAAACGGAAGAAAATGTGAAATAATATAACTAATTAATTTG
AAAAATGGAGGCTGTTTTTA

Downstream 100 bases:

>100_bases
TTAAGATAAAGGAGAACGACAAATATGGAAATGGCAAAAGAACAAGAGTTAATCCTTGTCTTAGACTTTGGTAGCCAATA
CAACCAATTAATTACACGCC

Product: inositol-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH

Number of amino acids: Translated: 488; Mature: 488

Protein sequence:

>488_residues
MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEE
QADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQE
NLITAPVNTTLEEAEKILQKHKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLV
EAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQI
TAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGS
NDRYFQEDKAPKKFVPEGIEGRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQIT
KESPNYSF

Sequences:

>Translated_488_residues
MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEE
QADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQE
NLITAPVNTTLEEAEKILQKHKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLV
EAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQI
TAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGS
NDRYFQEDKAPKKFVPEGIEGRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQIT
KESPNYSF
>Mature_488_residues
MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMAIAMARQGGLGVIHKNMGVEE
QADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRISGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQE
NLITAPVNTTLEEAEKILQKHKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLV
EAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVGIGPGSICTTRVVAGVGVPQI
TAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAVMLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGS
NDRYFQEDKAPKKFVPEGIEGRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQIT
KESPNYSF

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains

Homologues:

Organism=Homo sapiens, GI217035146, Length=458, Percent_Identity=42.5764192139738, Blast_Score=339, Evalue=4e-93,
Organism=Homo sapiens, GI34328928, Length=457, Percent_Identity=42.6695842450766, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI34328930, Length=457, Percent_Identity=42.6695842450766, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI156616279, Length=457, Percent_Identity=42.6695842450766, Blast_Score=338, Evalue=8e-93,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=40.4564315352697, Blast_Score=338, Evalue=8e-93,
Organism=Homo sapiens, GI217035152, Length=449, Percent_Identity=42.9844097995546, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI217035148, Length=458, Percent_Identity=41.703056768559, Blast_Score=325, Evalue=5e-89,
Organism=Homo sapiens, GI217035150, Length=458, Percent_Identity=39.5196506550218, Blast_Score=299, Evalue=5e-81,
Organism=Homo sapiens, GI50541956, Length=245, Percent_Identity=38.7755102040816, Blast_Score=163, Evalue=4e-40,
Organism=Homo sapiens, GI50541954, Length=245, Percent_Identity=38.7755102040816, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI50541952, Length=245, Percent_Identity=38.7755102040816, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI50541948, Length=245, Percent_Identity=38.7755102040816, Blast_Score=162, Evalue=5e-40,
Organism=Homo sapiens, GI156104880, Length=223, Percent_Identity=40.3587443946188, Blast_Score=162, Evalue=7e-40,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=53.0864197530864, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1786293, Length=239, Percent_Identity=35.9832635983264, Blast_Score=154, Evalue=9e-39,
Organism=Caenorhabditis elegans, GI71994385, Length=477, Percent_Identity=37.7358490566038, Blast_Score=286, Evalue=2e-77,
Organism=Caenorhabditis elegans, GI71994389, Length=424, Percent_Identity=38.9150943396226, Blast_Score=270, Evalue=1e-72,
Organism=Caenorhabditis elegans, GI17560440, Length=259, Percent_Identity=35.5212355212355, Blast_Score=165, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6322012, Length=459, Percent_Identity=39.4335511982571, Blast_Score=320, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6323585, Length=459, Percent_Identity=40.0871459694989, Blast_Score=317, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6323464, Length=459, Percent_Identity=40.958605664488, Blast_Score=315, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6319352, Length=337, Percent_Identity=40.0593471810089, Blast_Score=249, Evalue=6e-67,
Organism=Saccharomyces cerevisiae, GI6319353, Length=118, Percent_Identity=38.9830508474576, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24641071, Length=457, Percent_Identity=41.3566739606127, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI24641073, Length=457, Percent_Identity=41.3566739606127, Blast_Score=331, Evalue=6e-91,
Organism=Drosophila melanogaster, GI28571163, Length=415, Percent_Identity=41.9277108433735, Blast_Score=299, Evalue=3e-81,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): IMDH_STAA3 (Q2FJM6)

Other databases:

- EMBL:   CP000255
- RefSeq:   YP_493102.1
- ProteinModelPortal:   Q2FJM6
- SMR:   Q2FJM6
- STRING:   Q2FJM6
- EnsemblBacteria:   EBSTAT00000037927
- GeneID:   3912908
- GenomeReviews:   CP000255_GR
- KEGG:   saa:SAUSA300_0388
- eggNOG:   COG0516
- GeneTree:   EBGT00050000024354
- HOGENOM:   HBG298985
- OMA:   CVGLITV
- ProtClustDB:   CLSK884611
- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093
- Gene3D:   G3DSA:3.20.20.70
- PIRSF:   PIRSF000130
- SMART:   SM00116
- TIGRFAMs:   TIGR01302

Pfam domain/function: PF00571 CBS; PF00478 IMPDH

EC number: =1.1.1.205

Molecular weight: Translated: 52851; Mature: 52851

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS51371 CBS; PS00487 IMP_DH_GMP_RED

Important sites: ACT_SITE 307-307 BINDING 340-340 BINDING 387-387

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMA
CCCCHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEEEEECCCHHHHHHHHH
IAMARQGGLGVIHKNMGVEEQADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRI
EEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHEE
SGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQENLITAPVNTTLEEAEKILQK
CCEEEECCCCCCCEEEEEECCCEEEEECCCEEEEEEEECCCEEECCCCCHHHHHHHHHHH
HKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLV
HCHHCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHH
EAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVG
HCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEEEC
IGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAV
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECHHHHHHHHCCCHHH
MLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIE
HHHHHHCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCC
GRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQIT
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
KESPNYSF
ECCCCCCC
>Mature Secondary Structure
MWESKFAKESLTFDDVLLIPAQSDILPKDVDLSVQLSDKVKLNIPVISAGMDTVTESKMA
CCCCHHHHCCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEEEEECCCHHHHHHHHH
IAMARQGGLGVIHKNMGVEEQADEVQKVKRSENGVISNPFFLTPEESVYEAEALMGKYRI
EEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHEE
SGVPIVDNKEDRNLVGILTNRDLRFIEDFSIKIVDVMTQENLITAPVNTTLEEAEKILQK
CCEEEECCCCCCCEEEEEECCCEEEEECCCEEEEEEEECCCEEECCCCCHHHHHHHHHHH
HKIEKLPLVKDGRLEGLITIKDIEKVIEFPNAAKDEHGRLLVAAAIGISKDTDIRAQKLV
HCHHCCCCCCCCCCCEEEEHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCCCCHHHHHHH
EAGVDVLVIDTAHGHSKGVIDQVKHIKKTYPEITLVAGNVATAEATKDLFEAGADIVKVG
HCCCCEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCEEEEC
IGPGSICTTRVVAGVGVPQITAIYDCATEARKHGKAIIADGGIKFSGDIIKALAAGGHAV
CCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCEEECHHHHHHHHCCCHHH
MLGSLLAGTEESPGATEIFQGRQYKVYRGMGSLGAMEKGSNDRYFQEDKAPKKFVPEGIE
HHHHHHCCCCCCCCHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCC
GRTAYKGALQDTIYQLMGGVRAGMGYTGSHDLRELREEAQFTRMGPAGLAESHPHNIQIT
CCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEE
KESPNYSF
ECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA