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The map label for this gene is adk [H]

Identifier: 15674308

GI number: 15674308

Start: 75178

End: 75816

Strand: Direct

Name: adk [H]

Synonym: SPy_0074

Alternate gene names: 15674308

Gene position: 75178-75816 (Clockwise)

Preceding gene: 15674307

Following gene: 15674309

Centisome position: 4.06

GC content: 39.44

Gene sequence:

>639_bases
ATGAATCTTTTAATCATGGGTTTGCCGGGAGCTGGTAAAGGGACCCAAGCAGCTAAGATTGTTGAAGAATTTGGTATTGC
TCACATCTCAACAGGGGATATGTTCCGCGCCGCAATGGCTAATCAAACCGAAATGGGACGTTTAGCTAAAAGTTATATTG
ATAAAGGTGAATTGGTTCCTGATGAAGTCACAAACGGGATTGTAAAAGAGCGCTTAGCTGAGGATGATATCGCAGAAAAA
GGTTTTTTGCTTGATGGGTATCCACGTACTATTGAACAAGCACACGCCTTAGATGCAACACTTGAAGAACTAGGACTCCG
CTTAGATGGTGTTATTAATATTAAAGTGGATCCATCATGTCTTGTAGAGCGTTTGAGTGGTCGTATTATCAATCGTAAAA
CTGGTGAAACGTTCCATAAAGTGTTCAACCCACCAGTAGATTATAAAGAAGAAGATTACTATCAACGTGAAGATGATAAG
CCTGAAACTGTTAAACGTCGTTTGGACGTCAATATGGCTCAAGGAGAACCTATTCTTGAACACTATCGTAAGCTTGGTCT
TGTTACAGATATTGAAGGTAATCAAGAAATAACAGACGTTTTTGCAGATGTTGAAAAAGCGTTGCTAGAACTCAAATAA

Upstream 100 bases:

>100_bases
AGACTTGGTTATCATCAAACGATTTCTTGTTGCCATTTGAAAACAAAAACCAAGGAAAATAATTTCCTACTATGTATTTA
TTTTAAAAGAGGAGGAAAAG

Downstream 100 bases:

>100_bases
ATTATACAAATCTACTTGCATAAGTAGATTAGTAATGATATACTAGTTTAGTCTGACTTATAATTGTTACCTCTGTGCTC
AGAGGACATCAAATCGAAAT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MNLLIMGLPGAGKGTQAAKIVEEFGIAHISTGDMFRAAMANQTEMGRLAKSYIDKGELVPDEVTNGIVKERLAEDDIAEK
GFLLDGYPRTIEQAHALDATLEELGLRLDGVINIKVDPSCLVERLSGRIINRKTGETFHKVFNPPVDYKEEDYYQREDDK
PETVKRRLDVNMAQGEPILEHYRKLGLVTDIEGNQEITDVFADVEKALLELK

Sequences:

>Translated_212_residues
MNLLIMGLPGAGKGTQAAKIVEEFGIAHISTGDMFRAAMANQTEMGRLAKSYIDKGELVPDEVTNGIVKERLAEDDIAEK
GFLLDGYPRTIEQAHALDATLEELGLRLDGVINIKVDPSCLVERLSGRIINRKTGETFHKVFNPPVDYKEEDYYQREDDK
PETVKRRLDVNMAQGEPILEHYRKLGLVTDIEGNQEITDVFADVEKALLELK
>Mature_212_residues
MNLLIMGLPGAGKGTQAAKIVEEFGIAHISTGDMFRAAMANQTEMGRLAKSYIDKGELVPDEVTNGIVKERLAEDDIAEK
GFLLDGYPRTIEQAHALDATLEELGLRLDGVINIKVDPSCLVERLSGRIINRKTGETFHKVFNPPVDYKEEDYYQREDDK
PETVKRRLDVNMAQGEPILEHYRKLGLVTDIEGNQEITDVFADVEKALLELK

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=210, Percent_Identity=39.5238095238095, Blast_Score=164, Evalue=4e-41,
Organism=Homo sapiens, GI4502013, Length=210, Percent_Identity=39.5238095238095, Blast_Score=164, Evalue=4e-41,
Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=39.5, Blast_Score=149, Evalue=1e-36,
Organism=Homo sapiens, GI310110345, Length=200, Percent_Identity=36.5, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI53832003, Length=200, Percent_Identity=36.5, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI8051579, Length=200, Percent_Identity=36.5, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI53832001, Length=200, Percent_Identity=36.5, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI4502011, Length=210, Percent_Identity=30, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI22749187, Length=208, Percent_Identity=28.3653846153846, Blast_Score=100, Evalue=8e-22,
Organism=Homo sapiens, GI28144897, Length=211, Percent_Identity=30.8056872037915, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI28144899, Length=211, Percent_Identity=30.8056872037915, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI7706497, Length=206, Percent_Identity=27.1844660194175, Blast_Score=91, Evalue=9e-19,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=40.3669724770642, Blast_Score=156, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI17552384, Length=216, Percent_Identity=33.3333333333333, Blast_Score=136, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17533833, Length=209, Percent_Identity=32.0574162679426, Blast_Score=104, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17537943, Length=199, Percent_Identity=33.1658291457286, Blast_Score=100, Evalue=5e-22,
Organism=Caenorhabditis elegans, GI17567503, Length=203, Percent_Identity=31.0344827586207, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17550688, Length=207, Percent_Identity=28.0193236714976, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6320432, Length=209, Percent_Identity=41.1483253588517, Blast_Score=176, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321018, Length=203, Percent_Identity=32.0197044334975, Blast_Score=117, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6322828, Length=208, Percent_Identity=26.9230769230769, Blast_Score=95, Evalue=8e-21,
Organism=Drosophila melanogaster, GI22026816, Length=210, Percent_Identity=36.1904761904762, Blast_Score=152, Evalue=2e-37,
Organism=Drosophila melanogaster, GI17737899, Length=197, Percent_Identity=38.0710659898477, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24645822, Length=197, Percent_Identity=38.0710659898477, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI17647141, Length=208, Percent_Identity=28.3653846153846, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24663208, Length=206, Percent_Identity=28.1553398058252, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI221459597, Length=208, Percent_Identity=26.4423076923077, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21356893, Length=208, Percent_Identity=26.4423076923077, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 23700; Mature: 23700

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLLIMGLPGAGKGTQAAKIVEEFGIAHISTGDMFRAAMANQTEMGRLAKSYIDKGELVP
CCEEEEECCCCCCCHHHHHHHHHHCCEECCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCH
DEVTNGIVKERLAEDDIAEKGFLLDGYPRTIEQAHALDATLEELGLRLDGVINIKVDPSC
HHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHH
LVERLSGRIINRKTGETFHKVFNPPVDYKEEDYYQREDDKPETVKRRLDVNMAQGEPILE
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCHHCCCCCCHHHHHHHHCCCCCCCCHHHH
HYRKLGLVTDIEGNQEITDVFADVEKALLELK
HHHHCCCEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNLLIMGLPGAGKGTQAAKIVEEFGIAHISTGDMFRAAMANQTEMGRLAKSYIDKGELVP
CCEEEEECCCCCCCHHHHHHHHHHCCEECCCCHHHHHHHHCHHHHHHHHHHHHCCCCCCH
DEVTNGIVKERLAEDDIAEKGFLLDGYPRTIEQAHALDATLEELGLRLDGVINIKVDPSC
HHHHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHH
LVERLSGRIINRKTGETFHKVFNPPVDYKEEDYYQREDDKPETVKRRLDVNMAQGEPILE
HHHHHHCCCCCCCCHHHHHHHCCCCCCCCCCCHHCCCCCCHHHHHHHHCCCCCCCCHHHH
HYRKLGLVTDIEGNQEITDVFADVEKALLELK
HHHHCCCEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA