Definition Streptococcus pyogenes M1 GAS chromosome, complete genome.
Accession NC_002737
Length 1,852,441

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The map label for this gene is infA

Identifier: 15674309

GI number: 15674309

Start: 75934

End: 76152

Strand: Direct

Name: infA

Synonym: SPy_0075

Alternate gene names: 15674309

Gene position: 75934-76152 (Clockwise)

Preceding gene: 15674308

Following gene: 15674310

Centisome position: 4.1

GC content: 36.99

Gene sequence:

>219_bases
GTGGCAAAAGAAGACGTGATTGAAATTGAAGGCAAAGTAGTAGAAACGATGCCAAATGCAATGTTTACTGTTGAATTGGA
AAATGGACATCAAATTCTAGCAACTGTATCAGGAAAAATCCGCAAAAATTACATTCGTATTTTAGTAGGTGACCGTGTTA
CAGTAGAAATGAGTCCTTATGACTTGACACGTGGACGCATCACATACCGCTTTAAATAA

Upstream 100 bases:

>100_bases
GCATAAGTAGATTAGTAATGATATACTAGTTTAGTCTGACTTATAATTGTTACCTCTGTGCTCAGAGGACATCAAATCGA
AATTTAGGGGGTACTTTTGC

Downstream 100 bases:

>100_bases
TCGAAATAATTGGAGGGATTAAAACATGAAGGTAAGACCATCGGTTAAACCAATTTGCGAATACTGTAAAGTTATTCGCC
GTAATGGTCGTGTTATGGTA

Product: translation initiation factor IF-1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 72; Mature: 71

Protein sequence:

>72_residues
MAKEDVIEIEGKVVETMPNAMFTVELENGHQILATVSGKIRKNYIRILVGDRVTVEMSPYDLTRGRITYRFK

Sequences:

>Translated_72_residues
MAKEDVIEIEGKVVETMPNAMFTVELENGHQILATVSGKIRKNYIRILVGDRVTVEMSPYDLTRGRITYRFK
>Mature_71_residues
AKEDVIEIEGKVVETMPNAMFTVELENGHQILATVSGKIRKNYIRILVGDRVTVEMSPYDLTRGRITYRFK

Specific function: No specific function has so far been attributed to this initiation factor; however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3

COG id: COG0361

COG function: function code J; Translation initiation factor 1 (IF-1)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1-like domain

Homologues:

Organism=Escherichia coli, GI1787110, Length=70, Percent_Identity=68.5714285714286, Blast_Score=108, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): IF1_STRA1 (Q3K3U7)

Other databases:

- EMBL:   CP000114
- RefSeq:   YP_328806.1
- ProteinModelPortal:   Q3K3U7
- SMR:   Q3K3U7
- EnsemblBacteria:   EBSTRT00000005260
- GeneID:   3685061
- GenomeReviews:   CP000114_GR
- KEGG:   sak:SAK_0113
- TIGR:   SAK_0113
- GeneTree:   EBGT00050000027175
- HOGENOM:   HBG286099
- OMA:   KMRMHFI
- ProtClustDB:   PRK00276
- BioCyc:   SAGA205921:SAK_0113-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00075
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR022967
- InterPro:   IPR006196
- InterPro:   IPR004368
- Gene3D:   G3DSA:2.40.50.140
- SMART:   SM00316
- TIGRFAMs:   TIGR00008

Pfam domain/function: PF01176 eIF-1a; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 8273; Mature: 8142

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS50832 S1_IF1_TYPE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKEDVIEIEGKVVETMPNAMFTVELENGHQILATVSGKIRKNYIRILVGDRVTVEMSPY
CCCCCEEEECCEEEECCCCEEEEEEECCCCEEEEEECCCEEEEEEEEEECCEEEEEECCC
DLTRGRITYRFK
CCCCCEEEEEEC
>Mature Secondary Structure 
AKEDVIEIEGKVVETMPNAMFTVELENGHQILATVSGKIRKNYIRILVGDRVTVEMSPY
CCCCEEEECCEEEECCCCEEEEEEECCCCEEEEEECCCEEEEEEEEEECCEEEEEECCC
DLTRGRITYRFK
CCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA