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The map label for this gene is nrdA [H]

Identifier: 15602582

GI number: 15602582

Start: 843244

End: 845514

Strand: Direct

Name: nrdA [H]

Synonym: PM0717

Alternate gene names: 15602582

Gene position: 843244-845514 (Clockwise)

Preceding gene: 15602581

Following gene: 15602583

Centisome position: 37.35

GC content: 41.66

Gene sequence:

>2271_bases
ATGAACAAAGCATTGATGGTCACCAAACGTGACGGACACCTTGAACCAATTGATCTGGATAAAATTCACCGTGTGATTAC
ATGGGCGGCAGAAGGCTTAGATAACGTTTCTGTTTCTCAAGTGGAATTACGTTCACATATTCAATTCTATGAAGGTATCC
GTACATCTGATATCCATGAAACCATCATTAAAGCTGCTGCAGACTTGATCAGTAAAGATAGCCCAGATTATCAATATCTT
GCTGCCCGTTTAGCCGTTTTCCATTTGCGTAAAAAAGCCTATGGTCATTTTGATCCCCCCCGTTTATACGATCACGTAAA
AAAATTGGTACGCATGGGAAAATACGATCCCGCCCTTTTAGTCGATTATACCCGTGAAGAATGGGATGAAATGGATTCTT
ATTTAGATCATTGGCGTGATATGACCTTTTCATACGCGGCGGTGAAGCAGTTAGAAGGGAAATACTTAGTACAAAATCGT
GTCACAGGTGAGATTTATGAATCCGCACAATTTCTTTATTTACTGGTAGCGGCGAGCTTATTTTCGAAATACCCCACTGA
AACCCGTTTAAGTTATATTCGTCGTTTCTATGATGCGACCTCAACTTTTAAAATCTCGCTGCCAACACCGATTATGGCAG
GGGTACGTACACCAACCCGTCAATTTAGCTCCTGTGTTTTAATTGAATGTGGCGACAGCTTAGACTCAATTAATGCAACC
GCCTCTGCTATTGTGAAATATGTTTCTCAACGCGCGGGGATTGGCGTCAATGCGGGTGCTATTCGTGCCTTAGGCAGTCC
AATTCGGGGCGGTGAGGCATTCCATACCGGTTGTATCCCGTTCTATAAATATTTCCAAACAGCCGTCAAATCTTGTTCAC
AAGGTGGGGTGCGTGGCGGTGCTGCCACGGTTTACTACCCGATTTGGCATTTAGAAGTGGAAAGTTTATTAGTATTAAAA
AATAACCGAGGTGTTGAAGATAACCGCGTACGCCACATGGATTACGGGGTGCAGCTAAATAAATTAATGTATCAACGTTT
AATTAAAGGCGGTGATATTACTTTATTTAGCCCGTCTGATGTGCCGGGATTGTATGAAGCCTTCTTTGCTGATCAAGATA
AATTTGAACAACTTTATTTGCAATATGAGCAAGATCCAACTATTCGTCAACGCAGCGTAAAAGCCGTTGAGCTGTTCTCA
TTATTGATGCAAGAACGCGCATCAACGGGACGAATCTATATTCAAAATGTGGACCACTGTAATACCCACTCCCCGTTTGA
TCCGAAAGTGGCGCCTGTCCGTCAATCTAACTTATGTTTAGAAATTGCGTTACCGACCAAGCCATTGCAACATTTCCATG
ATGAAAAAGGTGAAATTGCGTTATGTACCCTTTCTGCGTTCAATTTGGGTACCCTTGAAAATCTTGATGAGTTAGAAGGC
TTAGCTGATTTAGCAGTACGTGCGTTAGATGCCCTATTAGATTACCAAGACTACCCGGTGATCGCAGCGAAGAAAAGTTC
ACTTGCACGTCGCTCATTAGGCATTGGCGTAATCAACTATGCGTATTATTTAGCGAAGAATGGCGTGCGTTATTCTGACA
GCAGTGCCAACGATTTAACCCACCGCACTTTTGAAGCGATCCAATACTACTTATTGAAAGCATCAATGAACTTAGCCAAA
GAAATTGGTCCATGTGAATATTTCAATGAAACCACTTATTCACAAGGAATTTTACCAATCGATACCTATAAAAAAGACAT
TGATAACTTGACCAAAGAGCCACTGCACTACGATTGGGAGACCTTACGTAAAGAAATCCAAGAATTTGGTTTACGTAACT
CGACGTTAACAGCATTAATGCCTTCTGAAACCTCATCGCAAATTTCAAATGCAACAAATGGTATTGAACCACCACGTGGT
CATGTCAGTGTGAAAGCCTCAAAAGATGGTATCTTAAAACAAGTGGTGCCGGAATATGAAACCTTAGGTGAAAACTATGA
GTTGTTATGGGATCTCCCAAATAATGATGGTTATCTGCACTTAGTGGGGATTATGCAAAAATTCGTTGACCAAGCGATTT
CGGCAAACACCAACTATGACCCACAGCGTTTTGAAGACGGCAAGGTGCCAATGAAACGCTTACTGGGTGATTTATTAACT
GCCTATAAATACGGCTTAAAAACCTTGTACTACCAAAATACCCGCGATGGTGCTGAAGATGTGCAAGAAGATATTGATGA
TGGCTGTTCAGGTGGTGCATGTAAAATCTAA

Upstream 100 bases:

>100_bases
TTTACTACTTGAATTTTATCTACTAGCACATTATCTTGTATCAAATTTTCAATTCTACACAATATCTTGTGTTTTCATCA
TCTAACAACGGGTCTATAAC

Downstream 100 bases:

>100_bases
TATGAGTAATCACAACTAACGAGAATGCGTTTCATGGTAAAAAGTGAAGCGCATTTTTCGTTTTCTGGCTCTTTTTTTCG
GGAGTATTTTGTTCTAGCAC

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MNKALMVTKRDGHLEPIDLDKIHRVITWAAEGLDNVSVSQVELRSHIQFYEGIRTSDIHETIIKAAADLISKDSPDYQYL
AARLAVFHLRKKAYGHFDPPRLYDHVKKLVRMGKYDPALLVDYTREEWDEMDSYLDHWRDMTFSYAAVKQLEGKYLVQNR
VTGEIYESAQFLYLLVAASLFSKYPTETRLSYIRRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
ASAIVKYVSQRAGIGVNAGAIRALGSPIRGGEAFHTGCIPFYKYFQTAVKSCSQGGVRGGAATVYYPIWHLEVESLLVLK
NNRGVEDNRVRHMDYGVQLNKLMYQRLIKGGDITLFSPSDVPGLYEAFFADQDKFEQLYLQYEQDPTIRQRSVKAVELFS
LLMQERASTGRIYIQNVDHCNTHSPFDPKVAPVRQSNLCLEIALPTKPLQHFHDEKGEIALCTLSAFNLGTLENLDELEG
LADLAVRALDALLDYQDYPVIAAKKSSLARRSLGIGVINYAYYLAKNGVRYSDSSANDLTHRTFEAIQYYLLKASMNLAK
EIGPCEYFNETTYSQGILPIDTYKKDIDNLTKEPLHYDWETLRKEIQEFGLRNSTLTALMPSETSSQISNATNGIEPPRG
HVSVKASKDGILKQVVPEYETLGENYELLWDLPNNDGYLHLVGIMQKFVDQAISANTNYDPQRFEDGKVPMKRLLGDLLT
AYKYGLKTLYYQNTRDGAEDVQEDIDDGCSGGACKI

Sequences:

>Translated_756_residues
MNKALMVTKRDGHLEPIDLDKIHRVITWAAEGLDNVSVSQVELRSHIQFYEGIRTSDIHETIIKAAADLISKDSPDYQYL
AARLAVFHLRKKAYGHFDPPRLYDHVKKLVRMGKYDPALLVDYTREEWDEMDSYLDHWRDMTFSYAAVKQLEGKYLVQNR
VTGEIYESAQFLYLLVAASLFSKYPTETRLSYIRRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
ASAIVKYVSQRAGIGVNAGAIRALGSPIRGGEAFHTGCIPFYKYFQTAVKSCSQGGVRGGAATVYYPIWHLEVESLLVLK
NNRGVEDNRVRHMDYGVQLNKLMYQRLIKGGDITLFSPSDVPGLYEAFFADQDKFEQLYLQYEQDPTIRQRSVKAVELFS
LLMQERASTGRIYIQNVDHCNTHSPFDPKVAPVRQSNLCLEIALPTKPLQHFHDEKGEIALCTLSAFNLGTLENLDELEG
LADLAVRALDALLDYQDYPVIAAKKSSLARRSLGIGVINYAYYLAKNGVRYSDSSANDLTHRTFEAIQYYLLKASMNLAK
EIGPCEYFNETTYSQGILPIDTYKKDIDNLTKEPLHYDWETLRKEIQEFGLRNSTLTALMPSETSSQISNATNGIEPPRG
HVSVKASKDGILKQVVPEYETLGENYELLWDLPNNDGYLHLVGIMQKFVDQAISANTNYDPQRFEDGKVPMKRLLGDLLT
AYKYGLKTLYYQNTRDGAEDVQEDIDDGCSGGACKI
>Mature_756_residues
MNKALMVTKRDGHLEPIDLDKIHRVITWAAEGLDNVSVSQVELRSHIQFYEGIRTSDIHETIIKAAADLISKDSPDYQYL
AARLAVFHLRKKAYGHFDPPRLYDHVKKLVRMGKYDPALLVDYTREEWDEMDSYLDHWRDMTFSYAAVKQLEGKYLVQNR
VTGEIYESAQFLYLLVAASLFSKYPTETRLSYIRRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
ASAIVKYVSQRAGIGVNAGAIRALGSPIRGGEAFHTGCIPFYKYFQTAVKSCSQGGVRGGAATVYYPIWHLEVESLLVLK
NNRGVEDNRVRHMDYGVQLNKLMYQRLIKGGDITLFSPSDVPGLYEAFFADQDKFEQLYLQYEQDPTIRQRSVKAVELFS
LLMQERASTGRIYIQNVDHCNTHSPFDPKVAPVRQSNLCLEIALPTKPLQHFHDEKGEIALCTLSAFNLGTLENLDELEG
LADLAVRALDALLDYQDYPVIAAKKSSLARRSLGIGVINYAYYLAKNGVRYSDSSANDLTHRTFEAIQYYLLKASMNLAK
EIGPCEYFNETTYSQGILPIDTYKKDIDNLTKEPLHYDWETLRKEIQEFGLRNSTLTALMPSETSSQISNATNGIEPPRG
HVSVKASKDGILKQVVPEYETLGENYELLWDLPNNDGYLHLVGIMQKFVDQAISANTNYDPQRFEDGKVPMKRLLGDLLT
AYKYGLKTLYYQNTRDGAEDVQEDIDDGCSGGACKI

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=789, Percent_Identity=29.404309252218, Blast_Score=259, Evalue=6e-69,
Organism=Escherichia coli, GI2367133, Length=761, Percent_Identity=80.946123521682, Blast_Score=1305, Evalue=0.0,
Organism=Escherichia coli, GI1789030, Length=573, Percent_Identity=26.1780104712042, Blast_Score=153, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17555242, Length=790, Percent_Identity=27.2151898734177, Blast_Score=235, Evalue=6e-62,
Organism=Saccharomyces cerevisiae, GI6320914, Length=793, Percent_Identity=27.6166456494325, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6322123, Length=795, Percent_Identity=27.1698113207547, Blast_Score=251, Evalue=3e-67,
Organism=Drosophila melanogaster, GI17352481, Length=690, Percent_Identity=30.4347826086957, Blast_Score=257, Evalue=2e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85418; Mature: 85418

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKALMVTKRDGHLEPIDLDKIHRVITWAAEGLDNVSVSQVELRSHIQFYEGIRTSDIHE
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
TIIKAAADLISKDSPDYQYLAARLAVFHLRKKAYGHFDPPRLYDHVKKLVRMGKYDPALL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEE
VDYTREEWDEMDSYLDHWRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYLLVAASL
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHCCCHHHHHHHHHHHHHHHHHH
FSKYPTETRLSYIRRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
HHHCCCHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCHHHHCCEEEEEECCCHHHHHHH
ASAIVKYVSQRAGIGVNAGAIRALGSPIRGGEAFHTGCIPFYKYFQTAVKSCSQGGVRGG
HHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
AATVYYPIWHLEVESLLVLKNNRGVEDNRVRHMDYGVQLNKLMYQRLIKGGDITLFSPSD
CEEEEEEEEEEEEEEEEEEECCCCCCCCCEEHHHCCCHHHHHHHHHHHCCCCEEEECCCC
VPGLYEAFFADQDKFEQLYLQYEQDPTIRQRSVKAVELFSLLMQERASTGRIYIQNVDHC
CCHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
NTHSPFDPKVAPVRQSNLCLEIALPTKPLQHFHDEKGEIALCTLSAFNLGTLENLDELEG
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHH
LADLAVRALDALLDYQDYPVIAAKKSSLARRSLGIGVINYAYYLAKNGVRYSDSSANDLT
HHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHH
HRTFEAIQYYLLKASMNLAKEIGPCEYFNETTYSQGILPIDTYKKDIDNLTKEPLHYDWE
HHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCHH
TLRKEIQEFGLRNSTLTALMPSETSSQISNATNGIEPPRGHVSVKASKDGILKQVVPEYE
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHCCHHH
TLGENYELLWDLPNNDGYLHLVGIMQKFVDQAISANTNYDPQRFEDGKVPMKRLLGDLLT
HCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHH
AYKYGLKTLYYQNTRDGAEDVQEDIDDGCSGGACKI
HHHHHHHHEEECCCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNKALMVTKRDGHLEPIDLDKIHRVITWAAEGLDNVSVSQVELRSHIQFYEGIRTSDIHE
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCHHHH
TIIKAAADLISKDSPDYQYLAARLAVFHLRKKAYGHFDPPRLYDHVKKLVRMGKYDPALL
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEE
VDYTREEWDEMDSYLDHWRDMTFSYAAVKQLEGKYLVQNRVTGEIYESAQFLYLLVAASL
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHCCCHHHHHHHHHHHHHHHHHH
FSKYPTETRLSYIRRFYDATSTFKISLPTPIMAGVRTPTRQFSSCVLIECGDSLDSINAT
HHHCCCHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCHHHHCCEEEEEECCCHHHHHHH
ASAIVKYVSQRAGIGVNAGAIRALGSPIRGGEAFHTGCIPFYKYFQTAVKSCSQGGVRGG
HHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
AATVYYPIWHLEVESLLVLKNNRGVEDNRVRHMDYGVQLNKLMYQRLIKGGDITLFSPSD
CEEEEEEEEEEEEEEEEEEECCCCCCCCCEEHHHCCCHHHHHHHHHHHCCCCEEEECCCC
VPGLYEAFFADQDKFEQLYLQYEQDPTIRQRSVKAVELFSLLMQERASTGRIYIQNVDHC
CCHHHHHHHCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCC
NTHSPFDPKVAPVRQSNLCLEIALPTKPLQHFHDEKGEIALCTLSAFNLGTLENLDELEG
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHH
LADLAVRALDALLDYQDYPVIAAKKSSLARRSLGIGVINYAYYLAKNGVRYSDSSANDLT
HHHHHHHHHHHHHCCCCCCEEEECHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCHHH
HRTFEAIQYYLLKASMNLAKEIGPCEYFNETTYSQGILPIDTYKKDIDNLTKEPLHYDWE
HHHHHHHHHHHHHHHHHHHHHCCCHHHCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCHH
TLRKEIQEFGLRNSTLTALMPSETSSQISNATNGIEPPRGHVSVKASKDGILKQVVPEYE
HHHHHHHHHCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCCEEEEECCCCHHHHHCCHHH
TLGENYELLWDLPNNDGYLHLVGIMQKFVDQAISANTNYDPQRFEDGKVPMKRLLGDLLT
HCCCCCEEEEECCCCCCEEEHHHHHHHHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHH
AYKYGLKTLYYQNTRDGAEDVQEDIDDGCSGGACKI
HHHHHHHHEEECCCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]