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The map label for this gene is neuA [H]

Identifier: 15602052

GI number: 15602052

Start: 209243

End: 209914

Strand: Reverse

Name: neuA [H]

Synonym: PM0187

Alternate gene names: 15602052

Gene position: 209914-209243 (Counterclockwise)

Preceding gene: 15602053

Following gene: 15602051

Centisome position: 9.3

GC content: 40.77

Gene sequence:

>672_bases
ATGACAAATATTGCGATCATTCCTGCACGAGCCGGCTCAAAAGGGATTCCAGATAAAAACCTGCAGCCCGTGGGTGGGCA
TTCTCTGATTGGACGTGCTATTTTAGCGGCAAAAAATGCTGACGTTTTCGATATGATTGTCGTAACCTCTGATGGTGATA
ATATCTTACGTGAAGCAGAAAAATATGGGGCATTAGCGCTGAAAAGACCCGCTGAGTTGGCCCAAGACAATTCAAGAACC
ATTGATGCCATTTTACATGCACTAGAGAGCTTAAATATTCGCGAAGGCACTTGTACCCTATTACAACCGACTAGCCCATT
ACGTGATCATTTAGATATCAAAAATGCGATGGATATGTATGTCAATGGCGGAGTACATTCTGTGGTGTCGGCGTGCGAGT
GTGAACATCATCCCTATAAAGCTTTTGCATTAAGCAAAGATCATGAAGTTTTGCCTGTACGTGAAATTGCTGATTTTGAA
GCCGCACGCCAAACTTTACCGAAAATGTATCGTGCAAATGGTGCCATTTATATTAATGACATTGCACAATTGCTAAAAGA
AAAATATTTCTTCATTCCGCCTCTCAAATTCTACTTAATGCCAACTTATCGTTCTGTGGATATTGATGTGAAGCAGGATT
TAGAACTCGCGGAAATTTTATCCAATAAATGA

Upstream 100 bases:

>100_bases
CCGTATGTTAAGGTCATGCGTCGTTTAGGTATAATTGACGAATCACAAGTCATCTTTTGGGACAGTTTAAAACAGTTGTA
ATCCAAGATAGGAGCTTATT

Downstream 100 bases:

>100_bases
CCGCACTTTTGTCGTCAGTAGGTCTTGGTTAAGCCAGTTAGCAGTAAAACGACGTTTAAACAAGCCTACTGTTTCTTTTC
ATAGTGGTTCGTAACCCTCC

Product: NeuA

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase [H]

Number of amino acids: Translated: 223; Mature: 222

Protein sequence:

>223_residues
MTNIAIIPARAGSKGIPDKNLQPVGGHSLIGRAILAAKNADVFDMIVVTSDGDNILREAEKYGALALKRPAELAQDNSRT
IDAILHALESLNIREGTCTLLQPTSPLRDHLDIKNAMDMYVNGGVHSVVSACECEHHPYKAFALSKDHEVLPVREIADFE
AARQTLPKMYRANGAIYINDIAQLLKEKYFFIPPLKFYLMPTYRSVDIDVKQDLELAEILSNK

Sequences:

>Translated_223_residues
MTNIAIIPARAGSKGIPDKNLQPVGGHSLIGRAILAAKNADVFDMIVVTSDGDNILREAEKYGALALKRPAELAQDNSRT
IDAILHALESLNIREGTCTLLQPTSPLRDHLDIKNAMDMYVNGGVHSVVSACECEHHPYKAFALSKDHEVLPVREIADFE
AARQTLPKMYRANGAIYINDIAQLLKEKYFFIPPLKFYLMPTYRSVDIDVKQDLELAEILSNK
>Mature_222_residues
TNIAIIPARAGSKGIPDKNLQPVGGHSLIGRAILAAKNADVFDMIVVTSDGDNILREAEKYGALALKRPAELAQDNSRTI
DAILHALESLNIREGTCTLLQPTSPLRDHLDIKNAMDMYVNGGVHSVVSACECEHHPYKAFALSKDHEVLPVREIADFEA
ARQTLPKMYRANGAIYINDIAQLLKEKYFFIPPLKFYLMPTYRSVDIDVKQDLELAEILSNK

Specific function: Unknown

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family [H]

Homologues:

Organism=Homo sapiens, GI8923900, Length=219, Percent_Identity=31.0502283105023, Blast_Score=87, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003329 [H]

Pfam domain/function: PF02348 CTP_transf_3 [H]

EC number: =2.7.7.43 [H]

Molecular weight: Translated: 24712; Mature: 24581

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNIAIIPARAGSKGIPDKNLQPVGGHSLIGRAILAAKNADVFDMIVVTSDGDNILREAE
CCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHH
KYGALALKRPAELAQDNSRTIDAILHALESLNIREGTCTLLQPTSPLRDHLDIKNAMDMY
HHCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
VNGGVHSVVSACECEHHPYKAFALSKDHEVLPVREIADFEAARQTLPKMYRANGAIYIND
CCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHH
IAQLLKEKYFFIPPLKFYLMPTYRSVDIDVKQDLELAEILSNK
HHHHHHHCCCCCCCHHHEEECCCCEECCCHHHCCHHHHHHCCC
>Mature Secondary Structure 
TNIAIIPARAGSKGIPDKNLQPVGGHSLIGRAILAAKNADVFDMIVVTSDGDNILREAE
CCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEEECCCHHHHHHHH
KYGALALKRPAELAQDNSRTIDAILHALESLNIREGTCTLLQPTSPLRDHLDIKNAMDMY
HHCCCCCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
VNGGVHSVVSACECEHHPYKAFALSKDHEVLPVREIADFEAARQTLPKMYRANGAIYIND
CCCCHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEHHH
IAQLLKEKYFFIPPLKFYLMPTYRSVDIDVKQDLELAEILSNK
HHHHHHHCCCCCCCHHHEEECCCCEECCCHHHCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]