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The map label for this gene is trpD

Identifier: 30024045

GI number: 30024045

Start: 1498394

End: 1499401

Strand: Reverse

Name: trpD

Synonym: L0052

Alternate gene names: 30024045

Gene position: 1499401-1498394 (Counterclockwise)

Preceding gene: 15673451

Following gene: 15673449

Centisome position: 63.38

GC content: 40.18

Gene sequence:

>1008_bases
ATGAAAAATGAACTTGAAAAAGTGATGTCAGGTCGTGACATGACCGAAAATGAAATGAATATGCTTGCTAATTCAATTAT
CCAAGGTGAATTAAGCGAGGTCCAAATTGCCAGCTTTTTAGTAGCATTAAAAATGAAAGGTGAAGCAGCAAGCGAATTGA
CTGGTTTGGCTCGAGCTTTACAAAAAGCAGCGATTCCCATTCCAACAAATTTGACAAATGCGATGGACAATTGTGGAACA
GGAGGCGACCGCTCATTCAGTTTTAATATTTCAACCACAGCCGCTTTTGTTTTAGCAGCTGGTGGAGTCAATATGGCAAA
ACACGGAAATCGCTCCATTACCAGTAAATCTGGCTCGGCAGACGTTCTTGAGGCCTTAGGAATCAATCTTTATTTACCAG
CAGAAAAGTTAGCTCAAGTTTTTGACAAAGTTGGTTTAGTTTTCCTTTTTGCTCAAAATCTCCACCCAGCGATGAAATAC
TTCACGCCAGTCCGCAGACAACTCGAAATTCCAACAATTATGAACTTGACTGGGCCACTAATCAATCCAATTCCACTTGA
TACGCAACTTCTTGGTACCTCACGTCCAGATTTACTTGAATTAACAGCAAATGTTTTGAAAGGCTTGGGCCGTAAGCGAG
CATTAGTCATCACAGGTGAAGGCGGAATGGACGAAGCAACTCCCTTTGGACTTAATCATTACGCACTTTTAGAAAATGAC
AAAGTGACTTTGCATGAATTTAGAGCCTCAGAAGTTGGTATTTCAGAAGTTCAACTCAATGATATTCGTGGAGGTGAAGC
CCCAGAAAATGCTGAAATTTTAAAAAATGTCCTTGAAAATCAACCGTCAGCCTTTTTAGAAACGACCGTTTTAAATGCCG
GACTTGGATTTTATGCCAATGGAAAAGTTGATTCCATCAAATCCGGAGTTGACCTTGCAAGAGAAGTAATTAGTACAGGA
GCAGCTCTTACCAAGTTGCATGAATTACAAGCAGAACAAATTGGTTAA

Upstream 100 bases:

>100_bases
TATGGATTACAATTTCACCCCGAATCCATTGGCACATTGGATGGTATGACCATGATTGAAAATTTTGTCAACCAAGTAAA
TGAAAACAAGGAGTCATCAA

Downstream 100 bases:

>100_bases
AAATCTTGATGGCAAATTTTGAAATAGCAGAAAATGAGAGAAAAATATGAACATAAAAAAAGGAAAATTTCTAGAAACAA
TCCTAGCAGAAAAACGACTT

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKNELEKVMSGRDMTENEMNMLANSIIQGELSEVQIASFLVALKMKGEAASELTGLARALQKAAIPIPTNLTNAMDNCGT
GGDRSFSFNISTTAAFVLAAGGVNMAKHGNRSITSKSGSADVLEALGINLYLPAEKLAQVFDKVGLVFLFAQNLHPAMKY
FTPVRRQLEIPTIMNLTGPLINPIPLDTQLLGTSRPDLLELTANVLKGLGRKRALVITGEGGMDEATPFGLNHYALLEND
KVTLHEFRASEVGISEVQLNDIRGGEAPENAEILKNVLENQPSAFLETTVLNAGLGFYANGKVDSIKSGVDLAREVISTG
AALTKLHELQAEQIG

Sequences:

>Translated_335_residues
MKNELEKVMSGRDMTENEMNMLANSIIQGELSEVQIASFLVALKMKGEAASELTGLARALQKAAIPIPTNLTNAMDNCGT
GGDRSFSFNISTTAAFVLAAGGVNMAKHGNRSITSKSGSADVLEALGINLYLPAEKLAQVFDKVGLVFLFAQNLHPAMKY
FTPVRRQLEIPTIMNLTGPLINPIPLDTQLLGTSRPDLLELTANVLKGLGRKRALVITGEGGMDEATPFGLNHYALLEND
KVTLHEFRASEVGISEVQLNDIRGGEAPENAEILKNVLENQPSAFLETTVLNAGLGFYANGKVDSIKSGVDLAREVISTG
AALTKLHELQAEQIG
>Mature_335_residues
MKNELEKVMSGRDMTENEMNMLANSIIQGELSEVQIASFLVALKMKGEAASELTGLARALQKAAIPIPTNLTNAMDNCGT
GGDRSFSFNISTTAAFVLAAGGVNMAKHGNRSITSKSGSADVLEALGINLYLPAEKLAQVFDKVGLVFLFAQNLHPAMKY
FTPVRRQLEIPTIMNLTGPLINPIPLDTQLLGTSRPDLLELTANVLKGLGRKRALVITGEGGMDEATPFGLNHYALLEND
KVTLHEFRASEVGISEVQLNDIRGGEAPENAEILKNVLENQPSAFLETTVLNAGLGFYANGKVDSIKSGVDLAREVISTG
AALTKLHELQAEQIG

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=277, Percent_Identity=39.7111913357401, Blast_Score=183, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320561, Length=325, Percent_Identity=26.7692307692308, Blast_Score=101, Evalue=2e-22,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_LACLA (Q02000)

Other databases:

- EMBL:   M87483
- EMBL:   AE005176
- PIR:   D86808
- PIR:   S35126
- RefSeq:   NP_267624.2
- ProteinModelPortal:   Q02000
- SMR:   Q02000
- GeneID:   1115125
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0052
- NMPDR:   fig|272623.1.peg.1509
- HOGENOM:   HBG559996
- OMA:   LGVYSPE
- ProtClustDB:   PRK00188
- BioCyc:   LLAC272623:L0052-MONOMER
- BRENDA:   2.4.2.18
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 35846; Mature: 35846

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNELEKVMSGRDMTENEMNMLANSIIQGELSEVQIASFLVALKMKGEAASELTGLARAL
CCHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QKAAIPIPTNLTNAMDNCGTGGDRSFSFNISTTAAFVLAAGGVNMAKHGNRSITSKSGSA
HHCCCCCCCCHHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCCHHHCCCCCCCCCCCCH
DVLEALGINLYLPAEKLAQVFDKVGLVFLFAQNLHPAMKYFTPVRRQLEIPTIMNLTGPL
HHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHCCCCCC
INPIPLDTQLLGTSRPDLLELTANVLKGLGRKRALVITGEGGMDEATPFGLNHYALLEND
CCCCCCCHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCC
KVTLHEFRASEVGISEVQLNDIRGGEAPENAEILKNVLENQPSAFLETTVLNAGLGFYAN
CEEHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEC
GKVDSIKSGVDLAREVISTGAALTKLHELQAEQIG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNELEKVMSGRDMTENEMNMLANSIIQGELSEVQIASFLVALKMKGEAASELTGLARAL
CCHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
QKAAIPIPTNLTNAMDNCGTGGDRSFSFNISTTAAFVLAAGGVNMAKHGNRSITSKSGSA
HHCCCCCCCCHHHHHHHCCCCCCCEEEEECHHHHHHHHHCCCCCHHHCCCCCCCCCCCCH
DVLEALGINLYLPAEKLAQVFDKVGLVFLFAQNLHPAMKYFTPVRRQLEIPTIMNLTGPL
HHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHHHCCCCCC
INPIPLDTQLLGTSRPDLLELTANVLKGLGRKRALVITGEGGMDEATPFGLNHYALLEND
CCCCCCCHHCCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEECCC
KVTLHEFRASEVGISEVQLNDIRGGEAPENAEILKNVLENQPSAFLETTVLNAGLGFYAN
CEEHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCCEEEC
GKVDSIKSGVDLAREVISTGAALTKLHELQAEQIG
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400208; 11337471