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The map label for this gene is trpG

Identifier: 15673451

GI number: 15673451

Start: 1499391

End: 1499987

Strand: Reverse

Name: trpG

Synonym: L0053

Alternate gene names: 15673451

Gene position: 1499987-1499391 (Counterclockwise)

Preceding gene: 15673452

Following gene: 30024045

Centisome position: 63.41

GC content: 37.02

Gene sequence:

>597_bases
TTGATTTTAATAATAGATAATTACGATAGTTTCACTTACAACTTAGTGCAGTATGTAGGTGTTTTGACTGATGTAGCAGT
TGTGAAAAATGACGATGATTCTTTGGGAAATATGGCAGAAAAAGCAGATGCCTTAATATTCTCACCAGGCCCTGGTTGGC
CTGCGGATGCTGGAAAAATGGAAACACTTATTCAGCAATTTGCAGGTCAAAAACCAATTTTAGGAATATGTCTAGGTTTT
CAAGCTATCGTTGAAGTTTTTGGTGGCAAACTTCGATTGGCACATCAAGTCATGCATGGCAAGAATTCACAAGTCCGTCA
GACCTCAGGAAATTTAATTTTCAATCATCTTCCCTCAAAATTTCTAGTTATGCGCTATCATTCAATTGTCATGGATGAGG
CAGTCGCTTTACCAGATTTTGCAATCACAGCAGTCGCGACAGATGATGGTGAAATTATGGCTATTGAAAATGAAAAAGAA
CAGATTTATGGATTACAATTTCACCCCGAATCCATTGGCACATTGGATGGTATGACCATGATTGAAAATTTTGTCAACCA
AGTAAATGAAAACAAGGAGTCATCAAATGAAAAATGA

Upstream 100 bases:

>100_bases
AAAAAATTTAACATCATCAGATAATTTTGTCAGTAATTTTTTACTGACAGAAAATAAAAAATTACTGACAGGCCTTGTCG
TTAAAAAATAGGAGACAAAA

Downstream 100 bases:

>100_bases
ACTTGAAAAAGTGATGTCAGGTCGTGACATGACCGAAAATGAAATGAATATGCTTGCTAATTCAATTATCCAAGGTGAAT
TAAGCGAGGTCCAAATTGCC

Product: anthranilate synthase component II

Products: NA

Alternate protein names: Glutamine amido-transferase

Number of amino acids: Translated: 198; Mature: 198

Protein sequence:

>198_residues
MILIIDNYDSFTYNLVQYVGVLTDVAVVKNDDDSLGNMAEKADALIFSPGPGWPADAGKMETLIQQFAGQKPILGICLGF
QAIVEVFGGKLRLAHQVMHGKNSQVRQTSGNLIFNHLPSKFLVMRYHSIVMDEAVALPDFAITAVATDDGEIMAIENEKE
QIYGLQFHPESIGTLDGMTMIENFVNQVNENKESSNEK

Sequences:

>Translated_198_residues
MILIIDNYDSFTYNLVQYVGVLTDVAVVKNDDDSLGNMAEKADALIFSPGPGWPADAGKMETLIQQFAGQKPILGICLGF
QAIVEVFGGKLRLAHQVMHGKNSQVRQTSGNLIFNHLPSKFLVMRYHSIVMDEAVALPDFAITAVATDDGEIMAIENEKE
QIYGLQFHPESIGTLDGMTMIENFVNQVNENKESSNEK
>Mature_198_residues
MILIIDNYDSFTYNLVQYVGVLTDVAVVKNDDDSLGNMAEKADALIFSPGPGWPADAGKMETLIQQFAGQKPILGICLGF
QAIVEVFGGKLRLAHQVMHGKNSQVRQTSGNLIFNHLPSKFLVMRYHSIVMDEAVALPDFAITAVATDDGEIMAIENEKE
QIYGLQFHPESIGTLDGMTMIENFVNQVNENKESSNEK

Specific function: Catalyzes The Biosynthesis Of 4-Amino-4-Deoxychorismate (Adc) From Chorismate And Glutamine. [C]

COG id: COG0512

COG function: function code EH; Anthranilate/para-aminobenzoate synthases component II

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Escherichia coli, GI1789760, Length=189, Percent_Identity=42.8571428571429, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1787517, Length=202, Percent_Identity=37.1287128712871, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786215, Length=159, Percent_Identity=26.4150943396226, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI133901714, Length=147, Percent_Identity=34.0136054421769, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71992710, Length=147, Percent_Identity=34.0136054421769, Blast_Score=68, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=147, Percent_Identity=34.0136054421769, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6322638, Length=202, Percent_Identity=38.1188118811881, Blast_Score=139, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324361, Length=214, Percent_Identity=28.9719626168224, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPG_LACLA (Q02003)

Other databases:

- EMBL:   M87483
- EMBL:   AE005176
- PIR:   S35125
- RefSeq:   NP_267625.1
- ProteinModelPortal:   Q02003
- SMR:   Q02003
- GeneID:   1115126
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0053
- NMPDR:   fig|272623.1.peg.1510
- HOGENOM:   HBG292341
- OMA:   HGKQSIL
- ProtClustDB:   PRK05670
- BioCyc:   LLAC272623:L0053-MONOMER
- BRENDA:   4.1.3.27
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR006221
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00566

Pfam domain/function: PF00117 GATase

EC number: =4.1.3.27

Molecular weight: Translated: 21825; Mature: 21825

Theoretical pI: Translated: 4.37; Mature: 4.37

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 77-77 ACT_SITE 168-168 ACT_SITE 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILIIDNYDSFTYNLVQYVGVLTDVAVVKNDDDSLGNMAEKADALIFSPGPGWPADAGKM
CEEEEECCCCHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHCCEEEECCCCCCCCCCHHH
ETLIQQFAGQKPILGICLGFQAIVEVFGGKLRLAHQVMHGKNSQVRQTSGNLIFNHLPSK
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEECCCCCEEEECCCHH
FLVMRYHSIVMDEAVALPDFAITAVATDDGEIMAIENEKEQIYGLQFHPESIGTLDGMTM
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCHHEEEEEECCCCCCCCCHHHH
IENFVNQVNENKESSNEK
HHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MILIIDNYDSFTYNLVQYVGVLTDVAVVKNDDDSLGNMAEKADALIFSPGPGWPADAGKM
CEEEEECCCCHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHCCEEEECCCCCCCCCCHHH
ETLIQQFAGQKPILGICLGFQAIVEVFGGKLRLAHQVMHGKNSQVRQTSGNLIFNHLPSK
HHHHHHHCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCEECCCCCEEEECCCHH
FLVMRYHSIVMDEAVALPDFAITAVATDDGEIMAIENEKEQIYGLQFHPESIGTLDGMTM
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEEEECCCHHEEEEEECCCCCCCCCHHHH
IENFVNQVNENKESSNEK
HHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400208; 11337471