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The map label for this gene is trpC

Identifier: 15673449

GI number: 15673449

Start: 1497553

End: 1498347

Strand: Reverse

Name: trpC

Synonym: L0051

Alternate gene names: 15673449

Gene position: 1498347-1497553 (Counterclockwise)

Preceding gene: 30024045

Following gene: 15673448

Centisome position: 63.34

GC content: 34.59

Gene sequence:

>795_bases
ATGAACATAAAAAAAGGAAAATTTCTAGAAACAATCCTAGCAGAAAAACGACTTGAAATTGCTAAAATGCCAGAAGAACA
AGTAGGAAAAGTTCGTCAAACATACAATTTTTATGATTACTTAAAAGAACATTCCGACCAGCTTCAAGTGATTGCCGAAG
TCAAAAAAGCTTCGCCCAGTCTAGGTGATATTAACTTAGAAGTGGATATCGTTGACCAAGCCAAAAATTACGAACAAGCC
GGTGCCGCTATGATTTCCGTCTTAACTGACCCTGTATTTTTTAAAGGAAATATTGAATATCTCTGTGAAATTTCAGAAAA
TGTCCAAATCCCCACCTTGAACAAGGATTTTATCATCGATAAAAAACAAATCAATCGGGCAGTTAATGCGGGAGCAACAG
TTATTTTACTCATTGTCGCAGTTTTTGAAAATCAATACCCCAAACTCCAAAACCTCTACAACTACGCACTTTCACTAGGA
CTTGAAGTTCTTGTTGAAACACATAATAAAGCAGAACTTGAGATTGCTCATCAGCTTGGAGCTAAAATTATTGGAGTTAA
TAATCGTAATTTAAAAACCTTTGAAGTGATCTTACAAAATTCAGTAGATTTGACACCCTACTTTAAAGAAGACAGTATCT
ACATTTCCGAATCAGGCATTTTTAGCGCAAACGAAGCCCAAAAAGTTTCCGATACTTTCAATGGAATATTGGTTGGAACA
GCACTCATGCAATCAGAAAATCTAGAAAAATCTTTGAAAGATTTAAAAGTCAAGAGGAAAACGAATGAAAATTAA

Upstream 100 bases:

>100_bases
ACAGGAGCAGCTCTTACCAAGTTGCATGAATTACAAGCAGAACAAATTGGTTAAAAATCTTGATGGCAAATTTTGAAATA
GCAGAAAATGAGAGAAAAAT

Downstream 100 bases:

>100_bases
AATCTGTGGCTTATCTACAAAAGAAGCTGTTGATACAGCTGTAGAATCTGGTGTCACACATCTCGGTTTTATTCTTAGTC
CCTCAAAACGCCAAGTTGCA

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS

Number of amino acids: Translated: 264; Mature: 264

Protein sequence:

>264_residues
MNIKKGKFLETILAEKRLEIAKMPEEQVGKVRQTYNFYDYLKEHSDQLQVIAEVKKASPSLGDINLEVDIVDQAKNYEQA
GAAMISVLTDPVFFKGNIEYLCEISENVQIPTLNKDFIIDKKQINRAVNAGATVILLIVAVFENQYPKLQNLYNYALSLG
LEVLVETHNKAELEIAHQLGAKIIGVNNRNLKTFEVILQNSVDLTPYFKEDSIYISESGIFSANEAQKVSDTFNGILVGT
ALMQSENLEKSLKDLKVKRKTNEN

Sequences:

>Translated_264_residues
MNIKKGKFLETILAEKRLEIAKMPEEQVGKVRQTYNFYDYLKEHSDQLQVIAEVKKASPSLGDINLEVDIVDQAKNYEQA
GAAMISVLTDPVFFKGNIEYLCEISENVQIPTLNKDFIIDKKQINRAVNAGATVILLIVAVFENQYPKLQNLYNYALSLG
LEVLVETHNKAELEIAHQLGAKIIGVNNRNLKTFEVILQNSVDLTPYFKEDSIYISESGIFSANEAQKVSDTFNGILVGT
ALMQSENLEKSLKDLKVKRKTNEN
>Mature_264_residues
MNIKKGKFLETILAEKRLEIAKMPEEQVGKVRQTYNFYDYLKEHSDQLQVIAEVKKASPSLGDINLEVDIVDQAKNYEQA
GAAMISVLTDPVFFKGNIEYLCEISENVQIPTLNKDFIIDKKQINRAVNAGATVILLIVAVFENQYPKLQNLYNYALSLG
LEVLVETHNKAELEIAHQLGAKIIGVNNRNLKTFEVILQNSVDLTPYFKEDSIYISESGIFSANEAQKVSDTFNGILVGT
ALMQSENLEKSLKDLKVKRKTNEN

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family

Homologues:

Organism=Escherichia coli, GI87081863, Length=221, Percent_Identity=38.0090497737557, Blast_Score=125, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6322638, Length=268, Percent_Identity=35.8208955223881, Blast_Score=146, Evalue=3e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRPC_LACLA (Q01999)

Other databases:

- EMBL:   M87483
- EMBL:   AE005176
- PIR:   S35127
- RefSeq:   NP_267623.1
- ProteinModelPortal:   Q01999
- SMR:   Q01999
- GeneID:   1115124
- GenomeReviews:   AE005176_GR
- KEGG:   lla:L0051
- NMPDR:   fig|272623.1.peg.1508
- HOGENOM:   HBG540956
- OMA:   VDLPLLC
- ProtClustDB:   PRK00278
- BioCyc:   LLAC272623:L0051-MONOMER
- BRENDA:   4.1.1.48
- HAMAP:   MF_00134_B
- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70

Pfam domain/function: PF00218 IGPS; SSF51366 RibP_bind_barrel

EC number: =4.1.1.48

Molecular weight: Translated: 29732; Mature: 29732

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKKGKFLETILAEKRLEIAKMPEEQVGKVRQTYNFYDYLKEHSDQLQVIAEVKKASPS
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LGDINLEVDIVDQAKNYEQAGAAMISVLTDPVFFKGNIEYLCEISENVQIPTLNKDFIID
CCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCCCCCEEE
KKQINRAVNAGATVILLIVAVFENQYPKLQNLYNYALSLGLEVLVETHNKAELEIAHQLG
HHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCC
AKIIGVNNRNLKTFEVILQNSVDLTPYFKEDSIYISESGIFSANEAQKVSDTFNGILVGT
CEEEECCCCCCHHHHHHHHCCCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHCHHHHHH
ALMQSENLEKSLKDLKVKRKTNEN
HHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNIKKGKFLETILAEKRLEIAKMPEEQVGKVRQTYNFYDYLKEHSDQLQVIAEVKKASPS
CCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LGDINLEVDIVDQAKNYEQAGAAMISVLTDPVFFKGNIEYLCEISENVQIPTLNKDFIID
CCCEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCCCCCCCCCCEEE
KKQINRAVNAGATVILLIVAVFENQYPKLQNLYNYALSLGLEVLVETHNKAELEIAHQLG
HHHHHHHHCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHCC
AKIIGVNNRNLKTFEVILQNSVDLTPYFKEDSIYISESGIFSANEAQKVSDTFNGILVGT
CEEEECCCCCCHHHHHHHHCCCCCCEEECCCEEEEECCCCCCCCHHHHHHHHHCHHHHHH
ALMQSENLEKSLKDLKVKRKTNEN
HHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1400208; 11337471