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The map label for this gene is thiD1

Identifier: 15673245

GI number: 15673245

Start: 1294247

End: 1295050

Strand: Reverse

Name: thiD1

Synonym: L0200

Alternate gene names: 15673245

Gene position: 1295050-1294247 (Counterclockwise)

Preceding gene: 15673246

Following gene: 15673244

Centisome position: 54.75

GC content: 36.69

Gene sequence:

>804_bases
ATGATTGATGTTTCTAAAGTTGTGACAATCGCTGGAATTGATTCTTCTGGTGGGGCTGGTATTAATGCTGACCTAAAAAC
TTTTCATAATCAAAAAGTATATTCGGCAACGATTGTGACAGGGTTGACAGCGCAAAATACCTATGGAGTACAAGAAATTT
TACCGACAAATAAAGCTTTTATTTTGGCTCAATTTGACTCAGTATTTTCTGATTTGGAAATTTCGGCAGCTAAAACGGGG
GCACTTTTTGATACTGCTCAAGTTGAAGCGGTAATTCAAGGCTTGAAAAAATATAAACCGAAGCATTTGCTGGTGGATCC
GGTAATGGTGGCTAAAGGCGGGGCAATTCTTTTGACAAGAGAAGCCATTGATTTGATAAAAAATGAATTGTTACCTTTAG
CAGAATTGGTCACTCCCAATTTGGAAGAGGCAGAGGTTATGTGTGGCTATAAAATTACTGACGAAAAGGAAATTTTAAAA
GCCCTTCATGATATTCAAAAGTTAGGTACTAAAAATGTGCTGATTAAAGGGGGACATGGCAATGGAGAACTGGTCAGAGA
TTATTTATTGATGACAGATGGTTCTGTCAGTACTTATGACTCTAAAAGATTACTGACAGAAAGAACACACGGAACCGGAG
ATACACTTTCTTCTTATATTACAGCTCATTTAGCTTTAGGAGAAGATTTAAAAGAAGTGATGCCAAAAGCTAAATTGTTT
ATTACTGAAGCTATTTCACAAACAATCAATGTTGGTCACGGTCACGGACCGTTAAACCATTGGGTGACAATTAATGAAAA
ATAA

Upstream 100 bases:

>100_bases
GCTACTGAGCAAGTAGAAAATCTACCAGGAAATTTTGTGAATCGTTTTCTTGATAAAATTTATCAAGCGACGCAAGAGGT
TATATAAGGGAGAAAAAGAA

Downstream 100 bases:

>100_bases
AATTTTAGACCTGAGGGCATATTTTATTGCTGGCCCACAAGATTTTCCAAAACTTTCAATTGATGATGCAATCGATAAAA
TTTCTGTAATCATAAAAAGT

Product: phosphomethylpyrimidine kinase

Products: NA

Alternate protein names: Hydroxymethylpyrimidine kinase; HMP kinase; Hydroxymethylpyrimidine phosphate kinase; HMP-P kinase; HMP-phosphate kinase; HMPP kinase [H]

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MIDVSKVVTIAGIDSSGGAGINADLKTFHNQKVYSATIVTGLTAQNTYGVQEILPTNKAFILAQFDSVFSDLEISAAKTG
ALFDTAQVEAVIQGLKKYKPKHLLVDPVMVAKGGAILLTREAIDLIKNELLPLAELVTPNLEEAEVMCGYKITDEKEILK
ALHDIQKLGTKNVLIKGGHGNGELVRDYLLMTDGSVSTYDSKRLLTERTHGTGDTLSSYITAHLALGEDLKEVMPKAKLF
ITEAISQTINVGHGHGPLNHWVTINEK

Sequences:

>Translated_267_residues
MIDVSKVVTIAGIDSSGGAGINADLKTFHNQKVYSATIVTGLTAQNTYGVQEILPTNKAFILAQFDSVFSDLEISAAKTG
ALFDTAQVEAVIQGLKKYKPKHLLVDPVMVAKGGAILLTREAIDLIKNELLPLAELVTPNLEEAEVMCGYKITDEKEILK
ALHDIQKLGTKNVLIKGGHGNGELVRDYLLMTDGSVSTYDSKRLLTERTHGTGDTLSSYITAHLALGEDLKEVMPKAKLF
ITEAISQTINVGHGHGPLNHWVTINEK
>Mature_267_residues
MIDVSKVVTIAGIDSSGGAGINADLKTFHNQKVYSATIVTGLTAQNTYGVQEILPTNKAFILAQFDSVFSDLEISAAKTG
ALFDTAQVEAVIQGLKKYKPKHLLVDPVMVAKGGAILLTREAIDLIKNELLPLAELVTPNLEEAEVMCGYKITDEKEILK
ALHDIQKLGTKNVLIKGGHGNGELVRDYLLMTDGSVSTYDSKRLLTERTHGTGDTLSSYITAHLALGEDLKEVMPKAKLF
ITEAISQTINVGHGHGPLNHWVTINEK

Specific function: Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P [H]

COG id: COG0351

COG function: function code H; Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiD family [H]

Homologues:

Organism=Escherichia coli, GI1788420, Length=256, Percent_Identity=40.234375, Blast_Score=187, Evalue=8e-49,
Organism=Saccharomyces cerevisiae, GI6325378, Length=272, Percent_Identity=31.6176470588235, Blast_Score=115, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324997, Length=270, Percent_Identity=32.5925925925926, Blast_Score=106, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324517, Length=275, Percent_Identity=32.3636363636364, Blast_Score=104, Evalue=2e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004399 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.49; =2.7.4.7 [H]

Molecular weight: Translated: 28863; Mature: 28863

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDVSKVVTIAGIDSSGGAGINADLKTFHNQKVYSATIVTGLTAQNTYGVQEILPTNKAF
CCCHHHEEEEEECCCCCCCCCCHHHHHHCCCCEEEEEEEECEECCCCCCHHHHCCCCCEE
ILAQFDSVFSDLEISAAKTGALFDTAQVEAVIQGLKKYKPKHLLVDPVMVAKGGAILLTR
EEEEHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCEEEEEH
EAIDLIKNELLPLAELVTPNLEEAEVMCGYKITDEKEILKALHDIQKLGTKNVLIKGGHG
HHHHHHHHHCCCHHHHHCCCCCHHHEEECEEECCHHHHHHHHHHHHHCCCCCEEEECCCC
NGELVRDYLLMTDGSVSTYDSKRLLTERTHGTGDTLSSYITAHLALGEDLKEVMPKAKLF
CHHHHHHHHEEECCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ITEAISQTINVGHGHGPLNHWVTINEK
HHHHHHHHHCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MIDVSKVVTIAGIDSSGGAGINADLKTFHNQKVYSATIVTGLTAQNTYGVQEILPTNKAF
CCCHHHEEEEEECCCCCCCCCCHHHHHHCCCCEEEEEEEECEECCCCCCHHHHCCCCCEE
ILAQFDSVFSDLEISAAKTGALFDTAQVEAVIQGLKKYKPKHLLVDPVMVAKGGAILLTR
EEEEHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCEEEECCCEEEEEH
EAIDLIKNELLPLAELVTPNLEEAEVMCGYKITDEKEILKALHDIQKLGTKNVLIKGGHG
HHHHHHHHHCCCHHHHHCCCCCHHHEEECEEECCHHHHHHHHHHHHHCCCCCEEEECCCC
NGELVRDYLLMTDGSVSTYDSKRLLTERTHGTGDTLSSYITAHLALGEDLKEVMPKAKLF
CHHHHHHHHEEECCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHH
ITEAISQTINVGHGHGPLNHWVTINEK
HHHHHHHHHCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]