Click here to switch to the map view.

The map label for this gene is pdhA

Identifier: 15672044

GI number: 15672044

Start: 63157

End: 64281

Strand: Reverse

Name: pdhA

Synonym: L0033

Alternate gene names: 15672044

Gene position: 64281-63157 (Counterclockwise)

Preceding gene: 15672045

Following gene: 15672043

Centisome position: 2.72

GC content: 41.33

Gene sequence:

>1125_bases
ATGTCAAATTCAGAACAAATCTTAGATTTCAAAGCGCAGCTAGAACTGCAAGACACTACATTTCCAATGCTTCAAATTCT
TAACGAAGAAGGAAAAATTGTTGACGAAGATGGTCTTAAACGTGCAGGACTTTCTGATGAAAAACTCGTTGAACTCTTTA
AAAGTATGCTTTTTGCACGTCAAGTTGACATTCGTTCAATGAAATTAGCTAAACAAGGACGTATGGGATTCTTTGGACCT
CACGCTGGTCAAGAAGCTTCTCAAATGGCCTCATCATTCGCTTTCACTGACGAAGACTGGCTCTTCCCAGGTTATCGTGA
CTTGCCACAAATTTACGCAAAAGGTTGGCCAATTTGGAAAGGTCTTCTTTGGTCTCGTGGACATCAACTTGGTAATGAGT
ATACTACCGATGATGGTAAACCTGTAAACTCATGGTTCCCACAAATTATCATTGGTGCTCAATACGTTGAAGCTGCTGGT
GTCGCGCTCGGACTCAAAAAACGTAAAAAAGATGCTGTAGCTTTCGTTTACACTGGTGATGGTGGTTCTTCACAAGGTGA
TACTTATGAAGGAATTAACTTTGCTGGAGCTTATAAAGCCCCACTTGTTGCCTTTATCCAAAATAACGGCTATGCAATTT
CGACGCCTCGTAGTCTCCAAAGTGCCGCTCCTCATTTAGCTGCTAAAGGTTGGGCCGCAGGTGCTCCTTCTATCGTAGTT
GATGGAATGGACGCGATTGCTATGTATCTTGCTTCTAAAGAAGCTCGTGCTTGGGCAGTAGCTGGAAATGGTCCAGTTGT
TATTGAAGCAATTACAAACCGTTTAGAACCACACTCAACAGCTGGTGATGACCCACTTCGCTATCGTACTAAAGAAGACA
TTGAAGCTTGGTGGAAAAAAGAACCTCTCGTTCGTATGCGTAATTTCCTGACTGAAAAAGGACTTTGGGATACAGAGAAA
GAGGAAGCTTATATTGCTGAACTTGATGCAGGTATTGATGCCGACATTAAGAAAGCCAACAATGTTGAAAAACAAAAAAT
TTCTAGCTTCATTAAAAATACACTTGAAGTGCCAAGCCAAGCAATGGCAGAACAAATTGCAAAATTTGAAAGCGAGGGCA
AATAA

Upstream 100 bases:

>100_bases
CGAACAGATTAAGTTATTTCACAAGCATAACCTTAGGAAATTTCTCCAAAAAATGATAAATTTCTAATTATAGACACATA
AAATAGAAAGGGAATCTATT

Downstream 100 bases:

>100_bases
GAATGGCAGTAAAAACTTATATTGCAGCAATTACAGAAGCGCTTGATTTGGCGCTCGAAAAAGATAAAGATGCACTCATT
TTTGGTGAAGACGTTGGACA

Product: PDH E1 component alpha subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 374; Mature: 373

Protein sequence:

>374_residues
MSNSEQILDFKAQLELQDTTFPMLQILNEEGKIVDEDGLKRAGLSDEKLVELFKSMLFARQVDIRSMKLAKQGRMGFFGP
HAGQEASQMASSFAFTDEDWLFPGYRDLPQIYAKGWPIWKGLLWSRGHQLGNEYTTDDGKPVNSWFPQIIIGAQYVEAAG
VALGLKKRKKDAVAFVYTGDGGSSQGDTYEGINFAGAYKAPLVAFIQNNGYAISTPRSLQSAAPHLAAKGWAAGAPSIVV
DGMDAIAMYLASKEARAWAVAGNGPVVIEAITNRLEPHSTAGDDPLRYRTKEDIEAWWKKEPLVRMRNFLTEKGLWDTEK
EEAYIAELDAGIDADIKKANNVEKQKISSFIKNTLEVPSQAMAEQIAKFESEGK

Sequences:

>Translated_374_residues
MSNSEQILDFKAQLELQDTTFPMLQILNEEGKIVDEDGLKRAGLSDEKLVELFKSMLFARQVDIRSMKLAKQGRMGFFGP
HAGQEASQMASSFAFTDEDWLFPGYRDLPQIYAKGWPIWKGLLWSRGHQLGNEYTTDDGKPVNSWFPQIIIGAQYVEAAG
VALGLKKRKKDAVAFVYTGDGGSSQGDTYEGINFAGAYKAPLVAFIQNNGYAISTPRSLQSAAPHLAAKGWAAGAPSIVV
DGMDAIAMYLASKEARAWAVAGNGPVVIEAITNRLEPHSTAGDDPLRYRTKEDIEAWWKKEPLVRMRNFLTEKGLWDTEK
EEAYIAELDAGIDADIKKANNVEKQKISSFIKNTLEVPSQAMAEQIAKFESEGK
>Mature_373_residues
SNSEQILDFKAQLELQDTTFPMLQILNEEGKIVDEDGLKRAGLSDEKLVELFKSMLFARQVDIRSMKLAKQGRMGFFGPH
AGQEASQMASSFAFTDEDWLFPGYRDLPQIYAKGWPIWKGLLWSRGHQLGNEYTTDDGKPVNSWFPQIIIGAQYVEAAGV
ALGLKKRKKDAVAFVYTGDGGSSQGDTYEGINFAGAYKAPLVAFIQNNGYAISTPRSLQSAAPHLAAKGWAAGAPSIVVD
GMDAIAMYLASKEARAWAVAGNGPVVIEAITNRLEPHSTAGDDPLRYRTKEDIEAWWKKEPLVRMRNFLTEKGLWDTEKE
EAYIAELDAGIDADIKKANNVEKQKISSFIKNTLEVPSQAMAEQIAKFESEGK

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG1071

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI11386135, Length=313, Percent_Identity=33.2268370607029, Blast_Score=172, Evalue=3e-43,
Organism=Homo sapiens, GI258645172, Length=355, Percent_Identity=30.7042253521127, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI4885543, Length=331, Percent_Identity=28.0966767371601, Blast_Score=112, Evalue=5e-25,
Organism=Homo sapiens, GI4505685, Length=301, Percent_Identity=27.5747508305648, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI291084742, Length=301, Percent_Identity=27.5747508305648, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI291084744, Length=308, Percent_Identity=26.9480519480519, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI291084757, Length=299, Percent_Identity=24.7491638795987, Blast_Score=76, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI86563357, Length=326, Percent_Identity=32.5153374233129, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI86563355, Length=326, Percent_Identity=32.5153374233129, Blast_Score=167, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17536047, Length=303, Percent_Identity=28.0528052805281, Blast_Score=112, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI32564172, Length=303, Percent_Identity=28.0528052805281, Blast_Score=112, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6321026, Length=303, Percent_Identity=29.042904290429, Blast_Score=121, Evalue=1e-28,
Organism=Drosophila melanogaster, GI21355903, Length=324, Percent_Identity=30.5555555555556, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24639744, Length=337, Percent_Identity=27.5964391691395, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI28571106, Length=337, Percent_Identity=27.5964391691395, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24639740, Length=337, Percent_Identity=27.5964391691395, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24639746, Length=294, Percent_Identity=29.2517006802721, Blast_Score=99, Evalue=6e-21,
Organism=Drosophila melanogaster, GI24639748, Length=313, Percent_Identity=25.8785942492013, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001017
- InterPro:   IPR017596 [H]

Pfam domain/function: PF00676 E1_dh [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 41325; Mature: 41194

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNSEQILDFKAQLELQDTTFPMLQILNEEGKIVDEDGLKRAGLSDEKLVELFKSMLFAR
CCCCHHHHHHHEEEEECCCHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHH
QVDIRSMKLAKQGRMGFFGPHAGQEASQMASSFAFTDEDWLFPGYRDLPQIYAKGWPIWK
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHH
GLLWSRGHQLGNEYTTDDGKPVNSWFPQIIIGAQYVEAAGVALGLKKRKKDAVAFVYTGD
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
GGSSQGDTYEGINFAGAYKAPLVAFIQNNGYAISTPRSLQSAAPHLAAKGWAAGAPSIVV
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCHHHHHHCCHHHHCCCCCCCCCEEE
DGMDAIAMYLASKEARAWAVAGNGPVVIEAITNRLEPHSTAGDDPLRYRTKEDIEAWWKK
CCHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCC
EPLVRMRNFLTEKGLWDTEKEEAYIAELDAGIDADIKKANNVEKQKISSFIKNTLEVPSQ
CHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCHH
AMAEQIAKFESEGK
HHHHHHHHHHCCCC
>Mature Secondary Structure 
SNSEQILDFKAQLELQDTTFPMLQILNEEGKIVDEDGLKRAGLSDEKLVELFKSMLFAR
CCCHHHHHHHEEEEECCCHHHHHHHHCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHHH
QVDIRSMKLAKQGRMGFFGPHAGQEASQMASSFAFTDEDWLFPGYRDLPQIYAKGWPIWK
HHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCHHH
GLLWSRGHQLGNEYTTDDGKPVNSWFPQIIIGAQYVEAAGVALGLKKRKKDAVAFVYTGD
HHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
GGSSQGDTYEGINFAGAYKAPLVAFIQNNGYAISTPRSLQSAAPHLAAKGWAAGAPSIVV
CCCCCCCCCCCCCCCCCCCCCEEEEEECCCEEEECCHHHHHHCCHHHHCCCCCCCCCEEE
DGMDAIAMYLASKEARAWAVAGNGPVVIEAITNRLEPHSTAGDDPLRYRTKEDIEAWWKK
CCHHHHHHHHHCCCCCEEEEECCCCEEEHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCC
EPLVRMRNFLTEKGLWDTEKEEAYIAELDAGIDADIKKANNVEKQKISSFIKNTLEVPSQ
CHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHCCHH
AMAEQIAKFESEGK
HHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA