Click here to switch to the map view.

The map label for this gene is lplL

Identifier: 15672045

GI number: 15672045

Start: 64370

End: 65371

Strand: Reverse

Name: lplL

Synonym: L64373

Alternate gene names: 15672045

Gene position: 65371-64370 (Counterclockwise)

Preceding gene: 15672046

Following gene: 15672044

Centisome position: 2.76

GC content: 37.92

Gene sequence:

>1002_bases
ATGCAATTTATTAACTATCTAGGTCAAGACGCTTACACAAATATCGCGATGGACAGCTGGCTACTTTATCACCTAAAACC
AACTGAGCCTGTTTTTGCTTTATGGCAAAATAAACGTGCAGTTATTGTGGGGCGCAACCAAAACACTTTTGCTGAAGTGA
ATCAAGACTACATTGACAGTCATGATGTTCAAGTTGTTCGTCGAGTATCTGGCGGTGGTGCAGTTTATCATGATGAAGGA
AACATCTGTTTCACATTTTTTGTTCCTGTCGAAAATTCTGGCTCTGTCAACTTTAAAAAATTTGTTCAACCGATGTATGA
AGCACTCCATGCTGTTGGAATCAAAGCTGAAATCACTGGACGCAATGACCTTGAAGTTGAGGGTAAAAAGATTTCGGGAA
ATGCCCAACGCTATGCTGGAGGTTATTTGATGCATCACGGAACCCTCCTTTGGGACACTGATGTTGAAGCAATGATTCGT
TCTCTCAATGTTTCTGATGAAAAATTTGTCAGTAAAGCGGCTAAATCAGTTCGCGCTCGTGTGGGAAATATCAAAGATTT
TGCCCCTGAGGACTTAACCTTAGATAGTTTTATTGACGCATTAAAATACTATCTCACAGACGAAGGAAAAGATGGTGAAT
TAGTTTTAACTGATGACCAACTTAGCTCAATCAAAAAAATACGAGATGAGCAATTTGCAACTTGGGATTGGAATTATGGC
GAATCACCAAAATTCTCCTTCCAAAATCACGCTAAATTTACTGGCGGAGCCATTGATATTCAAGTCAATGTTGAAAATGG
TAAAATCACTGAAATTAATTTCCAAGGAGATTTCTTAGGCGTTCGAGATTGGCGAGATATCAAAGAGCAATTTATTGGTC
TTGAATTTGAACCTTCAGCAATTCTTGAAGTCCTTGAAACAAATAAAGAAGGACAATATTTTGGAACAATTCAAAATACT
GAACTTTCTGAAATGTTCAAAGCTGACTATCGAACAGATTAA

Upstream 100 bases:

>100_bases
TTACATTTTGTTTCACAAAGGGTATAATTAAACCGTGCGTGTTATTTTGTCAAACTTGTTTGACAAAATAAGCACAAGTA
TTTGGAAGGGATGCATAAAC

Downstream 100 bases:

>100_bases
GTTATTTCACAAGCATAACCTTAGGAAATTTCTCCAAAAAATGATAAATTTCTAATTATAGACACATAAAATAGAAAGGG
AATCTATTATGTCAAATTCA

Product: lipoate-protein ligase

Products: NA

Alternate protein names: Lipoate--protein ligase [H]

Number of amino acids: Translated: 333; Mature: 333

Protein sequence:

>333_residues
MQFINYLGQDAYTNIAMDSWLLYHLKPTEPVFALWQNKRAVIVGRNQNTFAEVNQDYIDSHDVQVVRRVSGGGAVYHDEG
NICFTFFVPVENSGSVNFKKFVQPMYEALHAVGIKAEITGRNDLEVEGKKISGNAQRYAGGYLMHHGTLLWDTDVEAMIR
SLNVSDEKFVSKAAKSVRARVGNIKDFAPEDLTLDSFIDALKYYLTDEGKDGELVLTDDQLSSIKKIRDEQFATWDWNYG
ESPKFSFQNHAKFTGGAIDIQVNVENGKITEINFQGDFLGVRDWRDIKEQFIGLEFEPSAILEVLETNKEGQYFGTIQNT
ELSEMFKADYRTD

Sequences:

>Translated_333_residues
MQFINYLGQDAYTNIAMDSWLLYHLKPTEPVFALWQNKRAVIVGRNQNTFAEVNQDYIDSHDVQVVRRVSGGGAVYHDEG
NICFTFFVPVENSGSVNFKKFVQPMYEALHAVGIKAEITGRNDLEVEGKKISGNAQRYAGGYLMHHGTLLWDTDVEAMIR
SLNVSDEKFVSKAAKSVRARVGNIKDFAPEDLTLDSFIDALKYYLTDEGKDGELVLTDDQLSSIKKIRDEQFATWDWNYG
ESPKFSFQNHAKFTGGAIDIQVNVENGKITEINFQGDFLGVRDWRDIKEQFIGLEFEPSAILEVLETNKEGQYFGTIQNT
ELSEMFKADYRTD
>Mature_333_residues
MQFINYLGQDAYTNIAMDSWLLYHLKPTEPVFALWQNKRAVIVGRNQNTFAEVNQDYIDSHDVQVVRRVSGGGAVYHDEG
NICFTFFVPVENSGSVNFKKFVQPMYEALHAVGIKAEITGRNDLEVEGKKISGNAQRYAGGYLMHHGTLLWDTDVEAMIR
SLNVSDEKFVSKAAKSVRARVGNIKDFAPEDLTLDSFIDALKYYLTDEGKDGELVLTDDQLSSIKKIRDEQFATWDWNYG
ESPKFSFQNHAKFTGGAIDIQVNVENGKITEINFQGDFLGVRDWRDIKEQFIGLEFEPSAILEVLETNKEGQYFGTIQNT
ELSEMFKADYRTD

Specific function: Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes [H]

COG id: COG0095

COG function: function code H; Lipoate-protein ligase A

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lplA family [H]

Homologues:

Organism=Homo sapiens, GI7706252, Length=310, Percent_Identity=30.9677419354839, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI21729884, Length=310, Percent_Identity=30.9677419354839, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI21729882, Length=310, Percent_Identity=30.9677419354839, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI21729880, Length=310, Percent_Identity=30.9677419354839, Blast_Score=131, Evalue=7e-31,
Organism=Homo sapiens, GI21729878, Length=310, Percent_Identity=30.9677419354839, Blast_Score=131, Evalue=7e-31,
Organism=Escherichia coli, GI1790846, Length=281, Percent_Identity=33.8078291814947, Blast_Score=159, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI71981909, Length=230, Percent_Identity=33.4782608695652, Blast_Score=107, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322415, Length=291, Percent_Identity=26.8041237113402, Blast_Score=99, Evalue=9e-22,
Organism=Drosophila melanogaster, GI28573464, Length=288, Percent_Identity=31.9444444444444, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004143
- InterPro:   IPR005107
- InterPro:   IPR019491
- InterPro:   IPR004562 [H]

Pfam domain/function: PF03099 BPL_LipA_LipB; PF10437 Lip_prot_lig_C [H]

EC number: =2.7.7.63 [H]

Molecular weight: Translated: 37856; Mature: 37856

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFINYLGQDAYTNIAMDSWLLYHLKPTEPVFALWQNKRAVIVGRNQNTFAEVNQDYIDS
CCHHHHHCCCHHHHHEECCEEEEEECCCCCEEEEECCCEEEEEECCCCCHHHCCHHHCCC
HDVQVVRRVSGGGAVYHDEGNICFTFFVPVENSGSVNFKKFVQPMYEALHAVGIKAEITG
CCHHEEEEECCCCEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECC
RNDLEVEGKKISGNAQRYAGGYLMHHGTLLWDTDVEAMIRSLNVSDEKFVSKAAKSVRAR
CCCCEEECEEECCCCHHHCCCEEEECCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHH
VGNIKDFAPEDLTLDSFIDALKYYLTDEGKDGELVLTDDQLSSIKKIRDEQFATWDWNYG
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHCCCEEECCCCC
ESPKFSFQNHAKFTGGAIDIQVNVENGKITEINFQGDFLGVRDWRDIKEQFIGLEFEPSA
CCCCCCCCCCCEECCCEEEEEEEECCCEEEEEEECCCEEECCHHHHHHHHHCCCCCCHHH
ILEVLETNKEGQYFGTIQNTELSEMFKADYRTD
HHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCC
>Mature Secondary Structure
MQFINYLGQDAYTNIAMDSWLLYHLKPTEPVFALWQNKRAVIVGRNQNTFAEVNQDYIDS
CCHHHHHCCCHHHHHEECCEEEEEECCCCCEEEEECCCEEEEEECCCCCHHHCCHHHCCC
HDVQVVRRVSGGGAVYHDEGNICFTFFVPVENSGSVNFKKFVQPMYEALHAVGIKAEITG
CCHHEEEEECCCCEEEECCCCEEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCEEEECC
RNDLEVEGKKISGNAQRYAGGYLMHHGTLLWDTDVEAMIRSLNVSDEKFVSKAAKSVRAR
CCCCEEECEEECCCCHHHCCCEEEECCEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHHH
VGNIKDFAPEDLTLDSFIDALKYYLTDEGKDGELVLTDDQLSSIKKIRDEQFATWDWNYG
HCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHCCCEEECCCCC
ESPKFSFQNHAKFTGGAIDIQVNVENGKITEINFQGDFLGVRDWRDIKEQFIGLEFEPSA
CCCCCCCCCCCEECCCEEEEEEEECCCEEEEEEECCCEEECCHHHHHHHHHCCCCCCHHH
ILEVLETNKEGQYFGTIQNTELSEMFKADYRTD
HHHHHHCCCCCCEEEEECCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]