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The map label for this gene is pdhB

Identifier: 15672043

GI number: 15672043

Start: 62174

End: 63154

Strand: Reverse

Name: pdhB

Synonym: L0034

Alternate gene names: 15672043

Gene position: 63154-62174 (Counterclockwise)

Preceding gene: 15672044

Following gene: 15672042

Centisome position: 2.67

GC content: 40.98

Gene sequence:

>981_bases
ATGGCAGTAAAAACTTATATTGCAGCAATTACAGAAGCGCTTGATTTGGCGCTCGAAAAAGATAAAGATGCACTCATTTT
TGGTGAAGACGTTGGACAAAATGGTGGGGTTTTCCGTGCTACTGATGGTCTGCAAGCAAAATATGGAGAAGAACGTGTTT
TCAATACTCCACTTGCTGAATCAGGAATTGGTGGAATGGCAATTGGTCTTGCAACACAAGGTTTCCACCCAATTATGGAA
ATCCAATTCGGAACCTTTATCTTTGAAGTTTTCGACTCAATTGCTGGACAAATGAGCCGGACACGTTACCGTTTTAATAA
CACACGTTCAAATAATATTGTCGTGCGTACACCTTATGGAATCGGAACTAAAACGCCTGAAATGCACGCGGATTCAATTG
AAGGGCTATTTTCACAAATCCCCGGAATTCGTGTTGTAATGCCTTCAAATCCAGCTGATGCTAAAGGATTATTGCTGGCT
TCAATTGAAAATAACGACCCTGTTATTTTCCTTGAAAACCTTCACCTTTATCGCTCACTTAAAGGTGAAGTTCCTGAAGG
TTACTATACTACACCACTTGATACTGCTGCAGTCGCTAAAGAAGGATCTGATGTTTCAATCATTGCTTATGGTGGAACAG
TTCCACTTGCTCTTAAAGCTGCTGAACAACTCGAAAAAGATGGAATTAAAGCTGAAGTCCTTGACCTCAGAACAGTTGCT
CCTCTTGATATTGAGTCAATTGGTAAAACAGTTGAAAAAACTGGGCGTGTGGTCGTTGTTCAAGAAGCTCAACGTACAGC
CGGTATCGCAGCGAATGTCATGGCCGAAATTTCAGAACGTTTTGTTTTGAACCTTAAAGCGCCAATTGGACGTGTTAGTG
GTCCTGACTCAATTTTCCCATTTGCACAAGCAGAAAATGACTGGGCAGTTAAAGCTGAAGATATTGTGAATAAAGTTAAA
GAGGTGGTTGACTATGACTGA

Upstream 100 bases:

>100_bases
AAAAACAAAAAATTTCTAGCTTCATTAAAAATACACTTGAAGTGCCAAGCCAAGCAATGGCAGAACAAATTGCAAAATTT
GAAAGCGAGGGCAAATAAGA

Downstream 100 bases:

>100_bases
GATTTTTAAAATGCCTGATATTGGCGAAGGAATGCACGAAGGAGACATTGCCAACTGGTTAGTTAAAGTTGGAGATGTTG
TTAAAGAAGATGACCCAATT

Product: PDH E1 component beta subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 326; Mature: 325

Protein sequence:

>326_residues
MAVKTYIAAITEALDLALEKDKDALIFGEDVGQNGGVFRATDGLQAKYGEERVFNTPLAESGIGGMAIGLATQGFHPIME
IQFGTFIFEVFDSIAGQMSRTRYRFNNTRSNNIVVRTPYGIGTKTPEMHADSIEGLFSQIPGIRVVMPSNPADAKGLLLA
SIENNDPVIFLENLHLYRSLKGEVPEGYYTTPLDTAAVAKEGSDVSIIAYGGTVPLALKAAEQLEKDGIKAEVLDLRTVA
PLDIESIGKTVEKTGRVVVVQEAQRTAGIAANVMAEISERFVLNLKAPIGRVSGPDSIFPFAQAENDWAVKAEDIVNKVK
EVVDYD

Sequences:

>Translated_326_residues
MAVKTYIAAITEALDLALEKDKDALIFGEDVGQNGGVFRATDGLQAKYGEERVFNTPLAESGIGGMAIGLATQGFHPIME
IQFGTFIFEVFDSIAGQMSRTRYRFNNTRSNNIVVRTPYGIGTKTPEMHADSIEGLFSQIPGIRVVMPSNPADAKGLLLA
SIENNDPVIFLENLHLYRSLKGEVPEGYYTTPLDTAAVAKEGSDVSIIAYGGTVPLALKAAEQLEKDGIKAEVLDLRTVA
PLDIESIGKTVEKTGRVVVVQEAQRTAGIAANVMAEISERFVLNLKAPIGRVSGPDSIFPFAQAENDWAVKAEDIVNKVK
EVVDYD
>Mature_325_residues
AVKTYIAAITEALDLALEKDKDALIFGEDVGQNGGVFRATDGLQAKYGEERVFNTPLAESGIGGMAIGLATQGFHPIMEI
QFGTFIFEVFDSIAGQMSRTRYRFNNTRSNNIVVRTPYGIGTKTPEMHADSIEGLFSQIPGIRVVMPSNPADAKGLLLAS
IENNDPVIFLENLHLYRSLKGEVPEGYYTTPLDTAAVAKEGSDVSIIAYGGTVPLALKAAEQLEKDGIKAEVLDLRTVAP
LDIESIGKTVEKTGRVVVVQEAQRTAGIAANVMAEISERFVLNLKAPIGRVSGPDSIFPFAQAENDWAVKAEDIVNKVKE
VVDYD

Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=294, Percent_Identity=45.9183673469388, Blast_Score=258, Evalue=4e-69,
Organism=Homo sapiens, GI34101272, Length=294, Percent_Identity=45.9183673469388, Blast_Score=258, Evalue=4e-69,
Organism=Homo sapiens, GI156564403, Length=321, Percent_Identity=31.7757009345794, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI291084858, Length=321, Percent_Identity=30.5295950155763, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17506935, Length=322, Percent_Identity=40.0621118012422, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17538422, Length=321, Percent_Identity=34.5794392523364, Blast_Score=195, Evalue=2e-50,
Organism=Saccharomyces cerevisiae, GI6319698, Length=321, Percent_Identity=35.5140186915888, Blast_Score=200, Evalue=2e-52,
Organism=Drosophila melanogaster, GI160714828, Length=317, Percent_Identity=41.9558359621451, Blast_Score=236, Evalue=2e-62,
Organism=Drosophila melanogaster, GI160714832, Length=294, Percent_Identity=43.1972789115646, Blast_Score=235, Evalue=2e-62,
Organism=Drosophila melanogaster, GI21358145, Length=320, Percent_Identity=32.8125, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24650940, Length=320, Percent_Identity=32.8125, Blast_Score=190, Evalue=1e-48,
Organism=Drosophila melanogaster, GI160714826, Length=60, Percent_Identity=61.6666666666667, Blast_Score=78, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24645119, Length=289, Percent_Identity=27.3356401384083, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45551847, Length=289, Percent_Identity=27.3356401384083, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI45550715, Length=289, Percent_Identity=27.3356401384083, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24650943, Length=84, Percent_Identity=38.0952380952381, Blast_Score=72, Evalue=6e-13,
Organism=Drosophila melanogaster, GI24650945, Length=84, Percent_Identity=38.0952380952381, Blast_Score=72, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.1 [H]

Molecular weight: Translated: 35210; Mature: 35079

Theoretical pI: Translated: 4.52; Mature: 4.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKTYIAAITEALDLALEKDKDALIFGEDVGQNGGVFRATDGLQAKYGEERVFNTPLAE
CCHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCHHCCCCCCC
SGIGGMAIGLATQGFHPIMEIQFGTFIFEVFDSIAGQMSRTRYRFNNTRSNNIVVRTPYG
CCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCC
IGTKTPEMHADSIEGLFSQIPGIRVVMPSNPADAKGLLLASIENNDPVIFLENLHLYRSL
CCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCHHHHHH
KGEVPEGYYTTPLDTAAVAKEGSDVSIIAYGGTVPLALKAAEQLEKDGIKAEVLDLRTVA
CCCCCCCEEECCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEECC
PLDIESIGKTVEKTGRVVVVQEAQRTAGIAANVMAEISERFVLNLKAPIGRVSGPDSIFP
CCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCC
FAQAENDWAVKAEDIVNKVKEVVDYD
CCCCCCCCEEEHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AVKTYIAAITEALDLALEKDKDALIFGEDVGQNGGVFRATDGLQAKYGEERVFNTPLAE
CHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCCHHCCCCCCC
SGIGGMAIGLATQGFHPIMEIQFGTFIFEVFDSIAGQMSRTRYRFNNTRSNNIVVRTPYG
CCCCCEEEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEECCCC
IGTKTPEMHADSIEGLFSQIPGIRVVMPSNPADAKGLLLASIENNDPVIFLENLHLYRSL
CCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCEEEEEECCCCCEEEEECCHHHHHH
KGEVPEGYYTTPLDTAAVAKEGSDVSIIAYGGTVPLALKAAEQLEKDGIKAEVLDLRTVA
CCCCCCCEEECCCCHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCEEEEEEEEECC
PLDIESIGKTVEKTGRVVVVQEAQRTAGIAANVMAEISERFVLNLKAPIGRVSGPDSIFP
CCCHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCC
FAQAENDWAVKAEDIVNKVKEVVDYD
CCCCCCCCEEEHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2200674; 2253629 [H]