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The map label for this gene is parC/gyrA

Identifier: 13358030

GI number: 13358030

Start: 531447

End: 533999

Strand: Direct

Name: parC/gyrA

Synonym: UU467

Alternate gene names: 13358030

Gene position: 531447-533999 (Clockwise)

Preceding gene: 13358029

Following gene: 13358031

Centisome position: 70.7

GC content: 26.44

Gene sequence:

>2553_bases
ATGAGTGTAAATCATCAAAAAATTATTAATACACCTTTAGACAACATTGTTGGTGAAAGTTATGCAAAATATGCAAAATA
CATTATTCAAGATCGTGCTTTACCTGATATTCGTGATGGTTTAAAACCTGTTCAACGACGAATTTTATACGCAATGAGTG
AATTAGGAATCTTTTATGATAAACCTTATAAAAAATCTGCACGTACAGTAGGAGAAGTAATTGGTAAATATCATCCACAT
GGAGATTCATCAATTTATGAAGCAATGGTGAGAATGAGTCAAGATTGAAAAAATAATCTATGTTTATTAGATATGCATGG
TAATAAAGGTTCAATTGATGGTGATAATGCTGCTGCAATGCGTTATACAGAAGCTCGATTATCAAAAATTGCTAGTGTAA
TGTTAGCCAACTTAAAAAAAGATGTTGTTAAATTTAGTCCAAACTTTGATGATAGTGAAAAAGAGCCATCAATTTTACCA
TCTCTTTTTCCTAATTTGTTAATCAATGGAGCAACAGGAATTGCTTCTGGTTATGCAACAAATATTCCTCCTCATAACCC
TAATGAAGTTTTTGATGCTTTAATTTATCGTATTGATCATCCAGATTGTAGTGTAGAAAAACTAATTGAAATCTGTCCTG
CGCCAGATTTTCCCACAGGTGGGGAAATCCACGATTTAAATGGATGTGCTAATGCTCACAAAACTGGTGAAGGTAAATTT
ATAATTCGTGCTTGCATTGATTTTAAAATCAATGATAATAAGATTAATCAAATTATTATTAGTTCAATCCCTTATGAAAC
AAACAAGGCTTTAATCATTAAAGAAATTGAAGATATTATTTATAATAAAGAAGTTGCTGGATTAATCGAAGTTCGTGATG
AATCTGATGCTAAGGGAATTAGTATAATTATTGATACTAAAAAAGATATTAATTTAGAAAATGTTAAAAACTATTTATAT
AAAAAAACCAACTTGGAAATCAGCTATAATACAAAATTTATTGCAATTGTTCACCGAACTCCTACACTTGTAAATCTATC
TACATATTTAGATGCTCAAATTAATCATAGTTTAGATGTAATTAATAAAGTCGATTTATATGATCTAAACAAAATTTTGT
TACGTATTGAAATTGTTGAAGGCTTAATTAAATGCGTTGATTTAATTGATGAAATTATTAAAATTATTCGTGCTAGTGAA
TCGCGTCAAGATGCAAAAAATACTTTAATTCAAGTTTTTAATTTTACAAATAATCAAGCTGAAGCGATTATTATGATGCG
TTTACATAATTTGACACGTACTGATATATTTGATTTAAAAAATGAATGACAAACGCTACAAGACGAAGCTAAAACGCTAC
AAGAACGAATAAATTCACTTCAAGTTCGCAAAAATTATTTAAAACAAAAAATGATTGAATTTAAAAAAACTTTTGGTTTT
GAACGCAAAACAAAATTATTTGATGAATTAGTAAAAGTTGAAATAAACGAAGATCAAATGATCGAAAAACAAAATTTGAA
TTTAGTAATAAGTCGTGATGGATACATTAAAACTGTTTCTAAAAAGTCATTTGAGTCATCTAAATATGATGAATTAGGAT
TAAAAACTAATGATATTCTTTTTTATCATAATATCATTAATTCTCATGATAAAATCCTAATCATTACATCAAAAGCTAAA
TTAATTAATTTAGTTGCTCATAAAATCACTTCTATGCGGTGAAAAGATGTTGGTGAACACTTAAATAATTATGTGAAATT
TGATGCTAATGAAAAAGTTATAGCTGTTTATATATGGAACGAACAATTTAAAATTGATGAATATCAATTAGTTTTGGCTT
CTAGATTAAATCTAATTAAAAGAATTGAATTAAGCGAGTTGGATATAAATAAAAATAGTAAACAAATTAGCATTATGAAA
TTAAATGATAATGATAATTTAATCAGTGCTAATTTAATCAAAAAAGGTCATAATCAATTTATTATTGCAATTTCTAAATT
AGGATTAGCCCTGCTATTTTTAGTTCATGAAATTAATTGCTTAAATCGTTTAGCTAAAGGAATTAAAATTATGAAATTAA
AACCAAATGATGAGGTTAGTGCTATTTTAATTACTCCTAATAATGGTTATAATGTTCAACTTTTTTTAGAACGGGGAAGT
AAGTGTTTTAATATTAGTGAATTAAAATTATCAAAACGTGCGGCCACACCAACAAATTTATATCCAATAACAAAAAAAGT
GCAAAATGTTTTAGCAGCTTTTTTAGTTGCTCATGAAAATGTTTTTTATCTTTTAGATCAACAACAAAAAATAAATCCAT
ATTACTTATCAAACCCCAAACCAACAAAACTAGATACTAAAATTAGTATCTATGAAAACGATCAAATGATCACTGATGTA
GTTAAAGATTGCTTTTTAAGTGATGAAGCAATTAGTGATTTTAAAAAAATTAATATGTACGCAAATGAATTTGATAATGA
AATGCTAAAAATTAATAAAAATCACGATGATTCACAATTAGAATTAATTGATGAAGAGGAAGAAAAAAAATAA

Upstream 100 bases:

>100_bases
GTAATGACGTAAGTATTCGAAAGCAGTGAATTGATAATAATATTGATTTTAGTGTCATTGACGAATTACAAATCAATAAT
GAGGAGTCTAAATAAAAAAT

Downstream 100 bases:

>100_bases
TGATAACAAATAAAAAATGTAAAGGCTGTGGAGCTTTTTTGAATGATCAAATCAATACAATTGGATATACCCCAAAAATA
AATGAAACAAAAACCAATTT

Product: topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 850; Mature: 849

Protein sequence:

>850_residues
MSVNHQKIINTPLDNIVGESYAKYAKYIIQDRALPDIRDGLKPVQRRILYAMSELGIFYDKPYKKSARTVGEVIGKYHPH
GDSSIYEAMVRMSQDWKNNLCLLDMHGNKGSIDGDNAAAMRYTEARLSKIASVMLANLKKDVVKFSPNFDDSEKEPSILP
SLFPNLLINGATGIASGYATNIPPHNPNEVFDALIYRIDHPDCSVEKLIEICPAPDFPTGGEIHDLNGCANAHKTGEGKF
IIRACIDFKINDNKINQIIISSIPYETNKALIIKEIEDIIYNKEVAGLIEVRDESDAKGISIIIDTKKDINLENVKNYLY
KKTNLEISYNTKFIAIVHRTPTLVNLSTYLDAQINHSLDVINKVDLYDLNKILLRIEIVEGLIKCVDLIDEIIKIIRASE
SRQDAKNTLIQVFNFTNNQAEAIIMMRLHNLTRTDIFDLKNEWQTLQDEAKTLQERINSLQVRKNYLKQKMIEFKKTFGF
ERKTKLFDELVKVEINEDQMIEKQNLNLVISRDGYIKTVSKKSFESSKYDELGLKTNDILFYHNIINSHDKILIITSKAK
LINLVAHKITSMRWKDVGEHLNNYVKFDANEKVIAVYIWNEQFKIDEYQLVLASRLNLIKRIELSELDINKNSKQISIMK
LNDNDNLISANLIKKGHNQFIIAISKLGLALLFLVHEINCLNRLAKGIKIMKLKPNDEVSAILITPNNGYNVQLFLERGS
KCFNISELKLSKRAATPTNLYPITKKVQNVLAAFLVAHENVFYLLDQQQKINPYYLSNPKPTKLDTKISIYENDQMITDV
VKDCFLSDEAISDFKKINMYANEFDNEMLKINKNHDDSQLELIDEEEEKK

Sequences:

>Translated_850_residues
MSVNHQKIINTPLDNIVGESYAKYAKYIIQDRALPDIRDGLKPVQRRILYAMSELGIFYDKPYKKSARTVGEVIGKYHPH
GDSSIYEAMVRMSQD*KNNLCLLDMHGNKGSIDGDNAAAMRYTEARLSKIASVMLANLKKDVVKFSPNFDDSEKEPSILP
SLFPNLLINGATGIASGYATNIPPHNPNEVFDALIYRIDHPDCSVEKLIEICPAPDFPTGGEIHDLNGCANAHKTGEGKF
IIRACIDFKINDNKINQIIISSIPYETNKALIIKEIEDIIYNKEVAGLIEVRDESDAKGISIIIDTKKDINLENVKNYLY
KKTNLEISYNTKFIAIVHRTPTLVNLSTYLDAQINHSLDVINKVDLYDLNKILLRIEIVEGLIKCVDLIDEIIKIIRASE
SRQDAKNTLIQVFNFTNNQAEAIIMMRLHNLTRTDIFDLKNE*QTLQDEAKTLQERINSLQVRKNYLKQKMIEFKKTFGF
ERKTKLFDELVKVEINEDQMIEKQNLNLVISRDGYIKTVSKKSFESSKYDELGLKTNDILFYHNIINSHDKILIITSKAK
LINLVAHKITSMR*KDVGEHLNNYVKFDANEKVIAVYIWNEQFKIDEYQLVLASRLNLIKRIELSELDINKNSKQISIMK
LNDNDNLISANLIKKGHNQFIIAISKLGLALLFLVHEINCLNRLAKGIKIMKLKPNDEVSAILITPNNGYNVQLFLERGS
KCFNISELKLSKRAATPTNLYPITKKVQNVLAAFLVAHENVFYLLDQQQKINPYYLSNPKPTKLDTKISIYENDQMITDV
VKDCFLSDEAISDFKKINMYANEFDNEMLKINKNHDDSQLELIDEEEEKK
>Mature_849_residues
SVNHQKIINTPLDNIVGESYAKYAKYIIQDRALPDIRDGLKPVQRRILYAMSELGIFYDKPYKKSARTVGEVIGKYHPHG
DSSIYEAMVRMSQD*KNNLCLLDMHGNKGSIDGDNAAAMRYTEARLSKIASVMLANLKKDVVKFSPNFDDSEKEPSILPS
LFPNLLINGATGIASGYATNIPPHNPNEVFDALIYRIDHPDCSVEKLIEICPAPDFPTGGEIHDLNGCANAHKTGEGKFI
IRACIDFKINDNKINQIIISSIPYETNKALIIKEIEDIIYNKEVAGLIEVRDESDAKGISIIIDTKKDINLENVKNYLYK
KTNLEISYNTKFIAIVHRTPTLVNLSTYLDAQINHSLDVINKVDLYDLNKILLRIEIVEGLIKCVDLIDEIIKIIRASES
RQDAKNTLIQVFNFTNNQAEAIIMMRLHNLTRTDIFDLKNE*QTLQDEAKTLQERINSLQVRKNYLKQKMIEFKKTFGFE
RKTKLFDELVKVEINEDQMIEKQNLNLVISRDGYIKTVSKKSFESSKYDELGLKTNDILFYHNIINSHDKILIITSKAKL
INLVAHKITSMR*KDVGEHLNNYVKFDANEKVIAVYIWNEQFKIDEYQLVLASRLNLIKRIELSELDINKNSKQISIMKL
NDNDNLISANLIKKGHNQFIIAISKLGLALLFLVHEINCLNRLAKGIKIMKLKPNDEVSAILITPNNGYNVQLFLERGSK
CFNISELKLSKRAATPTNLYPITKKVQNVLAAFLVAHENVFYLLDQQQKINPYYLSNPKPTKLDTKISIYENDQMITDVV
KDCFLSDEAISDFKKINMYANEFDNEMLKINKNHDDSQLELIDEEEEKK

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm. Note=Bipolarly localized [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=182, Percent_Identity=30.7692307692308, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI19913406, Length=198, Percent_Identity=30.3030303030303, Blast_Score=79, Evalue=2e-14,
Organism=Escherichia coli, GI1788562, Length=742, Percent_Identity=33.9622641509434, Blast_Score=414, Evalue=1e-116,
Organism=Escherichia coli, GI1789396, Length=688, Percent_Identity=32.8488372093023, Blast_Score=340, Evalue=2e-94,
Organism=Caenorhabditis elegans, GI17535065, Length=167, Percent_Identity=33.5329341317365, Blast_Score=87, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI212645657, Length=165, Percent_Identity=32.1212121212121, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI212645845, Length=189, Percent_Identity=31.2169312169312, Blast_Score=80, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI115534553, Length=162, Percent_Identity=30.2469135802469, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=169, Percent_Identity=33.1360946745562, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI17136538, Length=182, Percent_Identity=30.7692307692308, Blast_Score=77, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013760
- InterPro:   IPR005741 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 96822; Mature: 96691

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVNHQKIINTPLDNIVGESYAKYAKYIIQDRALPDIRDGLKPVQRRILYAMSELGIFYD
CCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEC
KPYKKSARTVGEVIGKYHPHGDSSIYEAMVRMSQDKNNLCLLDMHGNKGSIDGDNAAAMR
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHH
YTEARLSKIASVMLANLKKDVVKFSPNFDDSEKEPSILPSLFPNLLINGATGIASGYATN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCCC
IPPHNPNEVFDALIYRIDHPDCSVEKLIEICPAPDFPTGGEIHDLNGCANAHKTGEGKFI
CCCCCHHHHHHHHHHEECCCCCCHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCEE
IRACIDFKINDNKINQIIISSIPYETNKALIIKEIEDIIYNKEVAGLIEVRDESDAKGIS
EEEEEEEEECCCCCCEEEEECCCCCCCCEEEHHHHHHHHHCCCCCEEEEECCCCCCCCEE
IIIDTKKDINLENVKNYLYKKTNLEISYNTKFIAIVHRTPTLVNLSTYLDAQINHSLDVI
EEEECCCCCCHHHHHHHHHHHCCEEEEECCEEEEEEECCCCEEEEHHHHCHHCCCCHHHH
NKVDLYDLNKILLRIEIVEGLIKCVDLIDEIIKIIRASESRQDAKNTLIQVFNFTNNQAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEEECCCCCHH
AIIMMRLHNLTRTDIFDLKNEQTLQDEAKTLQERINSLQVRKNYLKQKMIEFKKTFGFER
EEEEEHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
KTKLFDELVKVEINEDQMIEKQNLNLVISRDGYIKTVSKKSFESSKYDELGLKTNDILFY
HHHHHHHHHEEECCHHHHHHHCCCEEEEECCCCEEECCHHCCCCCCCHHCCCCCCCEEEE
HNIINSHDKILIITSKAKLINLVAHKITSMRKDVGEHLNNYVKFDANEKVIAVYIWNEQF
EHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCEEEEEEECCCE
KIDEYQLVLASRLNLIKRIELSELDINKNSKQISIMKLNDNDNLISANLIKKGHNQFIIA
ECCHHHHHHHHHHHHHHHCCHHEECCCCCCCEEEEEEECCCCCEEEHHHHHCCCCEEEEE
ISKLGLALLFLVHEINCLNRLAKGIKIMKLKPNDEVSAILITPNNGYNVQLFLERGSKCF
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCCCEEEEEEECCCCEE
NISELKLSKRAATPTNLYPITKKVQNVLAAFLVAHENVFYLLDQQQKINPYYLSNPKPTK
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEECCCCCCC
LDTKISIYENDQMITDVVKDCFLSDEAISDFKKINMYANEFDNEMLKINKNHDDSQLELI
CCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEE
DEEEEKK
CCHHCCC
>Mature Secondary Structure 
SVNHQKIINTPLDNIVGESYAKYAKYIIQDRALPDIRDGLKPVQRRILYAMSELGIFYD
CCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCEEC
KPYKKSARTVGEVIGKYHPHGDSSIYEAMVRMSQDKNNLCLLDMHGNKGSIDGDNAAAMR
CCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCCHHHH
YTEARLSKIASVMLANLKKDVVKFSPNFDDSEKEPSILPSLFPNLLINGATGIASGYATN
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCCC
IPPHNPNEVFDALIYRIDHPDCSVEKLIEICPAPDFPTGGEIHDLNGCANAHKTGEGKFI
CCCCCHHHHHHHHHHEECCCCCCHHHHHHHCCCCCCCCCCCEECCCCCCCCCCCCCCCEE
IRACIDFKINDNKINQIIISSIPYETNKALIIKEIEDIIYNKEVAGLIEVRDESDAKGIS
EEEEEEEEECCCCCCEEEEECCCCCCCCEEEHHHHHHHHHCCCCCEEEEECCCCCCCCEE
IIIDTKKDINLENVKNYLYKKTNLEISYNTKFIAIVHRTPTLVNLSTYLDAQINHSLDVI
EEEECCCCCCHHHHHHHHHHHCCEEEEECCEEEEEEECCCCEEEEHHHHCHHCCCCHHHH
NKVDLYDLNKILLRIEIVEGLIKCVDLIDEIIKIIRASESRQDAKNTLIQVFNFTNNQAE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHEEEEECCCCCHH
AIIMMRLHNLTRTDIFDLKNEQTLQDEAKTLQERINSLQVRKNYLKQKMIEFKKTFGFER
EEEEEHHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
KTKLFDELVKVEINEDQMIEKQNLNLVISRDGYIKTVSKKSFESSKYDELGLKTNDILFY
HHHHHHHHHEEECCHHHHHHHCCCEEEEECCCCEEECCHHCCCCCCCHHCCCCCCCEEEE
HNIINSHDKILIITSKAKLINLVAHKITSMRKDVGEHLNNYVKFDANEKVIAVYIWNEQF
EHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCEEECCCCCEEEEEEECCCE
KIDEYQLVLASRLNLIKRIELSELDINKNSKQISIMKLNDNDNLISANLIKKGHNQFIIA
ECCHHHHHHHHHHHHHHHCCHHEECCCCCCCEEEEEEECCCCCEEEHHHHHCCCCEEEEE
ISKLGLALLFLVHEINCLNRLAKGIKIMKLKPNDEVSAILITPNNGYNVQLFLERGSKCF
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEECCCCCEEEEEEECCCCEE
NISELKLSKRAATPTNLYPITKKVQNVLAAFLVAHENVFYLLDQQQKINPYYLSNPKPTK
CCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCEEECCCCCCC
LDTKISIYENDQMITDVVKDCFLSDEAISDFKKINMYANEFDNEMLKINKNHDDSQLELI
CCCEEEEEECCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCEEEE
DEEEEKK
CCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969507; 9539793; 9384377 [H]