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The map label for this gene is engA

Identifier: 99080832

GI number: 99080832

Start: 1062663

End: 1064141

Strand: Direct

Name: engA

Synonym: TM1040_0991

Alternate gene names: 99080832

Gene position: 1062663-1064141 (Clockwise)

Preceding gene: 99080831

Following gene: 99080833

Centisome position: 33.2

GC content: 61.8

Gene sequence:

>1479_bases
ATGTCGTTTACGCTCGCCATCGTGGGGCGCCCAAATGTGGGCAAGTCCACTTTGTTCAACCGCCTTGTCGGCAAGAAACT
CGCGCTGGTTGATGACCAGCCCGGAGTCACGCGCGACCTGCGCGAGGGCGAGGCACGGCTGGGCGATCTGCGCTTTACGG
TGATCGACAGCGCCGGTCTGGAAGATGCAACCGACAACAGCCTCGAGGGCCGCATGCGCCGCCTCACCGAACGTGCGGTG
GAAATGGCCGATGTGTGCCTGTTCCTGATCGATGCGCGCGCAGGCGTGACACCCACCGATGAGGTTTTTGCCGAGATCCT
GCGCAAGAAATCCGCGCATGTCATTCTGGCGGCGAATAAATCCGAAGGGTCTGCGGCGGATGCGGGCGTGCTGGAGGCCT
ATGGCCTCGGGCTGGGGGAGCCGATCCGCATGTCCGGTGAGCATGGCGAAGGGCTGAATGATCTCTATTCCGAACTGCTG
CCGGTTTCGGAAAAGTTCGAAAAACTCGCCGAGGAGACCGCGCCCGAAACGGATGTGGTCCTCGACGAGGATGAAAACGA
GGCGTTCAACGCGGGCGAAGAGATCGCGGCCACGCCGGTTCCGACACTTGAAAAGCCGCTTCAGGTGGCCGTTGTCGGGC
GCCCGAATGCCGGGAAATCCACGCTGATCAACAAGATCCTTGGCGAGGACCGTCTCTTGACCGGTCCCGAAGCCGGGATC
ACCCGCGATGCCATCAGCCTCAAGATCGACTGGTCCGGCACGCCGATGCGAATCTTTGACACCGCCGGCATGCGCAAGAA
GGCCAAGGTGCAGGAAAAGCTCGAGAAACTCTCGGTCTCTGATGGCCTGCGCGCGGTCAAATTTGCCGAGGTCGTGGTGG
TTTTGCTTGATGCGGCGATCCCGTTTGAACAGCAGGATCTGCGGATTGCGGACCTTGCCGAGCGCGAGGGGCGCGCGGTG
GTGATCGCGGTCAACAAATGGGACATCGAGGACGAAAAGCAGGAAAAGCTCAAAGCGCTGAAAGAAGCCTTCGAGCGCCT
GTTGCCGCAGCTGCGCGGCGCGCCTCTGGTCACGGTTTCGGCCAAGACGGGCCGGGGGCTAGACCGGCTGCATGCCGCAA
TCATGAAAGCCCATGACGTGTGGAACCGTCGGGTGCCGACGGCTGCGCTCAACCGTTGGCTTGCGGGGATGCTGGAACAG
CACCCGCCGCCCGCACCGCAGGGCAAGCGCATCAAGCTGCGCTACATGACCCAAGCCAAGACCCGTCCGCCGGGCTTTGT
GGTGATGTGCTCGCATCCCGACAAAATGCCCGCGAGTTACAACCGCTATCTGGTGAACGGGCTGCGGGAAGATTTTGATA
TGCCGGGCACGCCCATTCGTCTGACTTTGCGCGGTCAGGGGGACAAGAACCCCTATAAGGGCAAGAAAAAGTCGACGCCC
TCGCGTCTGCGCAAACACCTTGAAGGCCGCAAGAGCTGA

Upstream 100 bases:

>100_bases
GCAAATTTCTCTGCCATGGGCGCGTTTGAATTTATTTACTGGCGTGTGCAGCAAAGATACGCTATGCGCGCGGTTCACCC
ATCACGGAAAGTTCTGTTCC

Downstream 100 bases:

>100_bases
GCGACCCGATCTGAACGGGGTGCGGCGTGCAAACAGGCGTGCCGCGCCAGATCCTGCCTTTCCTCTGCCGTGACCCTGAT
CCCCCCAGCCGGTTGTTGCA

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MSFTLAIVGRPNVGKSTLFNRLVGKKLALVDDQPGVTRDLREGEARLGDLRFTVIDSAGLEDATDNSLEGRMRRLTERAV
EMADVCLFLIDARAGVTPTDEVFAEILRKKSAHVILAANKSEGSAADAGVLEAYGLGLGEPIRMSGEHGEGLNDLYSELL
PVSEKFEKLAEETAPETDVVLDEDENEAFNAGEEIAATPVPTLEKPLQVAVVGRPNAGKSTLINKILGEDRLLTGPEAGI
TRDAISLKIDWSGTPMRIFDTAGMRKKAKVQEKLEKLSVSDGLRAVKFAEVVVVLLDAAIPFEQQDLRIADLAEREGRAV
VIAVNKWDIEDEKQEKLKALKEAFERLLPQLRGAPLVTVSAKTGRGLDRLHAAIMKAHDVWNRRVPTAALNRWLAGMLEQ
HPPPAPQGKRIKLRYMTQAKTRPPGFVVMCSHPDKMPASYNRYLVNGLREDFDMPGTPIRLTLRGQGDKNPYKGKKKSTP
SRLRKHLEGRKS

Sequences:

>Translated_492_residues
MSFTLAIVGRPNVGKSTLFNRLVGKKLALVDDQPGVTRDLREGEARLGDLRFTVIDSAGLEDATDNSLEGRMRRLTERAV
EMADVCLFLIDARAGVTPTDEVFAEILRKKSAHVILAANKSEGSAADAGVLEAYGLGLGEPIRMSGEHGEGLNDLYSELL
PVSEKFEKLAEETAPETDVVLDEDENEAFNAGEEIAATPVPTLEKPLQVAVVGRPNAGKSTLINKILGEDRLLTGPEAGI
TRDAISLKIDWSGTPMRIFDTAGMRKKAKVQEKLEKLSVSDGLRAVKFAEVVVVLLDAAIPFEQQDLRIADLAEREGRAV
VIAVNKWDIEDEKQEKLKALKEAFERLLPQLRGAPLVTVSAKTGRGLDRLHAAIMKAHDVWNRRVPTAALNRWLAGMLEQ
HPPPAPQGKRIKLRYMTQAKTRPPGFVVMCSHPDKMPASYNRYLVNGLREDFDMPGTPIRLTLRGQGDKNPYKGKKKSTP
SRLRKHLEGRKS
>Mature_491_residues
SFTLAIVGRPNVGKSTLFNRLVGKKLALVDDQPGVTRDLREGEARLGDLRFTVIDSAGLEDATDNSLEGRMRRLTERAVE
MADVCLFLIDARAGVTPTDEVFAEILRKKSAHVILAANKSEGSAADAGVLEAYGLGLGEPIRMSGEHGEGLNDLYSELLP
VSEKFEKLAEETAPETDVVLDEDENEAFNAGEEIAATPVPTLEKPLQVAVVGRPNAGKSTLINKILGEDRLLTGPEAGIT
RDAISLKIDWSGTPMRIFDTAGMRKKAKVQEKLEKLSVSDGLRAVKFAEVVVVLLDAAIPFEQQDLRIADLAEREGRAVV
IAVNKWDIEDEKQEKLKALKEAFERLLPQLRGAPLVTVSAKTGRGLDRLHAAIMKAHDVWNRRVPTAALNRWLAGMLEQH
PPPAPQGKRIKLRYMTQAKTRPPGFVVMCSHPDKMPASYNRYLVNGLREDFDMPGTPIRLTLRGQGDKNPYKGKKKSTPS
RLRKHLEGRKS

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain

Homologues:

Organism=Escherichia coli, GI87082120, Length=487, Percent_Identity=38.8090349075975, Blast_Score=312, Evalue=3e-86,
Organism=Escherichia coli, GI2367268, Length=162, Percent_Identity=32.7160493827161, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1788919, Length=127, Percent_Identity=32.2834645669291, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17507259, Length=125, Percent_Identity=32, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=192, Percent_Identity=29.1666666666667, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DER_SILST (Q1GHZ2)

Other databases:

- EMBL:   CP000377
- RefSeq:   YP_612986.1
- ProteinModelPortal:   Q1GHZ2
- SMR:   Q1GHZ2
- STRING:   Q1GHZ2
- GeneID:   4078153
- GenomeReviews:   CP000377_GR
- KEGG:   sit:TM1040_0991
- NMPDR:   fig|292414.1.peg.3066
- eggNOG:   COG1160
- HOGENOM:   HBG592135
- OMA:   TRDRTYQ
- PhylomeDB:   Q1GHZ2
- ProtClustDB:   PRK00093
- BioCyc:   SSP292414:TM1040_0991-MONOMER
- GO:   GO:0005622
- HAMAP:   MF_00195
- InterPro:   IPR016484
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR001806
- InterPro:   IPR005225
- Gene3D:   G3DSA:3.30.300.20
- PIRSF:   PIRSF006485
- PRINTS:   PR00449
- TIGRFAMs:   TIGR03594
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01926 MMR_HSR1

EC number: NA

Molecular weight: Translated: 54108; Mature: 53977

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFTLAIVGRPNVGKSTLFNRLVGKKLALVDDQPGVTRDLREGEARLGDLRFTVIDSAGL
CCEEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCEEEEEEECCCC
EDATDNSLEGRMRRLTERAVEMADVCLFLIDARAGVTPTDEVFAEILRKKSAHVILAANK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECC
SEGSAADAGVLEAYGLGLGEPIRMSGEHGEGLNDLYSELLPVSEKFEKLAEETAPETDVV
CCCCCCCCHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEE
LDEDENEAFNAGEEIAATPVPTLEKPLQVAVVGRPNAGKSTLINKILGEDRLLTGPEAGI
EECCCCCHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEECCCCCCC
TRDAISLKIDWSGTPMRIFDTAGMRKKAKVQEKLEKLSVSDGLRAVKFAEVVVVLLDAAI
CCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
PFEQQDLRIADLAEREGRAVVIAVNKWDIEDEKQEKLKALKEAFERLLPQLRGAPLVTVS
CCCCCCCCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AKTGRGLDRLHAAIMKAHDVWNRRVPTAALNRWLAGMLEQHPPPAPQGKRIKLRYMTQAK
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCC
TRPPGFVVMCSHPDKMPASYNRYLVNGLREDFDMPGTPIRLTLRGQGDKNPYKGKKKSTP
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCH
SRLRKHLEGRKS
HHHHHHHCCCCC
>Mature Secondary Structure 
SFTLAIVGRPNVGKSTLFNRLVGKKLALVDDQPGVTRDLREGEARLGDLRFTVIDSAGL
CEEEEEEECCCCCHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHHCCEEEEEEECCCC
EDATDNSLEGRMRRLTERAVEMADVCLFLIDARAGVTPTDEVFAEILRKKSAHVILAANK
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEECC
SEGSAADAGVLEAYGLGLGEPIRMSGEHGEGLNDLYSELLPVSEKFEKLAEETAPETDVV
CCCCCCCCHHHHHHCCCCCCCEEECCCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCEE
LDEDENEAFNAGEEIAATPVPTLEKPLQVAVVGRPNAGKSTLINKILGEDRLLTGPEAGI
EECCCCCHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCEECCCCCCC
TRDAISLKIDWSGTPMRIFDTAGMRKKAKVQEKLEKLSVSDGLRAVKFAEVVVVLLDAAI
CCCEEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCC
PFEQQDLRIADLAEREGRAVVIAVNKWDIEDEKQEKLKALKEAFERLLPQLRGAPLVTVS
CCCCCCCCHHHHHCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
AKTGRGLDRLHAAIMKAHDVWNRRVPTAALNRWLAGMLEQHPPPAPQGKRIKLRYMTQAK
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEEEEECCC
TRPPGFVVMCSHPDKMPASYNRYLVNGLREDFDMPGTPIRLTLRGQGDKNPYKGKKKSTP
CCCCCEEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCH
SRLRKHLEGRKS
HHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA