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The map label for this gene is dhaT [H]

Identifier: 91788389

GI number: 91788389

Start: 2641670

End: 2642806

Strand: Direct

Name: dhaT [H]

Synonym: Bpro_2526

Alternate gene names: 91788389

Gene position: 2641670-2642806 (Clockwise)

Preceding gene: 91788385

Following gene: 91788396

Centisome position: 50.8

GC content: 64.56

Gene sequence:

>1137_bases
ATGGCCTTCATTTACTACGTGACCCAGATCCAGTTTGAATTTGGCGCGGTCAAACTGCTCAAGCAGGAGTGCGAGCGTGT
GGGCATCACCCGGCCCCTGATCGTGACTGATCCGGGTGTCAAGGCGGCAGGTATTTTGCAAAAAGCGCTCGATGCCCTGC
CCGGCATCGCCGTCACGGTATTCGACCAGACGCCCTCCAATCCCACCGAAGCGGCGGTGCGCGCGGCAGCCGCGCTCTAC
AAGGCCGGCGGCTGCGATGGCCTGATCGCCGTGGGCGGCGGCTCGGCCATTGACTGCGCCAAGGGCGTGGCCATTGCGGC
CACACACGAGGGCCCCCTGACCACTTACGCCACCATTGAAGGCGGTTCCCCAAAGATTTCGGATCGCGTCGCTCCGCTGA
TCGCCGTGCCCACCACCAGCGGCACCGGCAGCGAGGTGGCACGCGGCGCGATCATCATCGTCGACGATCACCGCAAGCTC
GGTTTTCATTCCTGGCACCTGGTGCCCAAGACAGCCATTTGCGATCCCGAACTCACGCTGGGCCTGCCCGCCATGCTGAC
CGCCGCCACCGGCATGGACGCGATTGCGCACTGCATGGAAACCTTCATGTCGCCGGCCTTCAATCCGCCGGCCGACGGCA
TCGGGCTGGACGGCCTGGAACGGGGCTGGTCGCATATTGAGCGTGCCACGCGCGACGGCAGCGACCGCGAGGCGCGCCTG
AACCTGATGAGCGCCTCCATGCAGGGTGCGATGGCTTTTCAGAAAGGCCTGGGCTGCGTCCATTCCCTCAGCCACAGCCT
GGGCGGCGTCGATCCCCGGCTGCACCATGGCACGCTCAATGCCATGTTCCTGCCGGCGGTGGTGCGTTTCAATGCCAGCG
CCGAGTCAGTTCAAAAAGAGCGCCGACTAGACCGCATGGCCCGCGCCATGGGCTTGCGTTCGGGCAGTGACATTCCAGAT
GCCATCAAGGACATGAATGCCCGCCTCGGCCTGCCTACGGGCCTGGCCGCCATGGGCGTGCAGCGCGACTGGTTTGACCG
CATCATCGTGGGTGCGCTGGCCGATCACTGTCACAAGACAAATCCGCGCCTGGCAAGTCCCGAGGAATACCGGGAGATGC
TGGAAACCTCGCTCTAA

Upstream 100 bases:

>100_bases
GGTTTGCTTGCGGCCCATGCGCGCGTCCAGCCAGTAAAGTAAAGTCAATCCGTTTCGATAGATCACACCCGCATCGTACA
ACGCAGAAAGACAGCAAATC

Downstream 100 bases:

>100_bases
TGCCGCCGCTCAGGGGGCGTTGCAGCCTCCGATTCAATCAGGCGCAGCATGAAGGCTTCACATTGCGCAATTTGTTCGAG
GGTGGCGAATTCATTCGGGC

Product: iron-containing alcohol dehydrogenase

Products: NA

Alternate protein names: 1,3-propanediol oxidoreductase; 3-hydroxypropionaldehyde reductase [H]

Number of amino acids: Translated: 378; Mature: 377

Protein sequence:

>378_residues
MAFIYYVTQIQFEFGAVKLLKQECERVGITRPLIVTDPGVKAAGILQKALDALPGIAVTVFDQTPSNPTEAAVRAAAALY
KAGGCDGLIAVGGGSAIDCAKGVAIAATHEGPLTTYATIEGGSPKISDRVAPLIAVPTTSGTGSEVARGAIIIVDDHRKL
GFHSWHLVPKTAICDPELTLGLPAMLTAATGMDAIAHCMETFMSPAFNPPADGIGLDGLERGWSHIERATRDGSDREARL
NLMSASMQGAMAFQKGLGCVHSLSHSLGGVDPRLHHGTLNAMFLPAVVRFNASAESVQKERRLDRMARAMGLRSGSDIPD
AIKDMNARLGLPTGLAAMGVQRDWFDRIIVGALADHCHKTNPRLASPEEYREMLETSL

Sequences:

>Translated_378_residues
MAFIYYVTQIQFEFGAVKLLKQECERVGITRPLIVTDPGVKAAGILQKALDALPGIAVTVFDQTPSNPTEAAVRAAAALY
KAGGCDGLIAVGGGSAIDCAKGVAIAATHEGPLTTYATIEGGSPKISDRVAPLIAVPTTSGTGSEVARGAIIIVDDHRKL
GFHSWHLVPKTAICDPELTLGLPAMLTAATGMDAIAHCMETFMSPAFNPPADGIGLDGLERGWSHIERATRDGSDREARL
NLMSASMQGAMAFQKGLGCVHSLSHSLGGVDPRLHHGTLNAMFLPAVVRFNASAESVQKERRLDRMARAMGLRSGSDIPD
AIKDMNARLGLPTGLAAMGVQRDWFDRIIVGALADHCHKTNPRLASPEEYREMLETSL
>Mature_377_residues
AFIYYVTQIQFEFGAVKLLKQECERVGITRPLIVTDPGVKAAGILQKALDALPGIAVTVFDQTPSNPTEAAVRAAAALYK
AGGCDGLIAVGGGSAIDCAKGVAIAATHEGPLTTYATIEGGSPKISDRVAPLIAVPTTSGTGSEVARGAIIIVDDHRKLG
FHSWHLVPKTAICDPELTLGLPAMLTAATGMDAIAHCMETFMSPAFNPPADGIGLDGLERGWSHIERATRDGSDREARLN
LMSASMQGAMAFQKGLGCVHSLSHSLGGVDPRLHHGTLNAMFLPAVVRFNASAESVQKERRLDRMARAMGLRSGSDIPDA
IKDMNARLGLPTGLAAMGVQRDWFDRIIVGALADHCHKTNPRLASPEEYREMLETSL

Specific function: Most active with substrates containing two primary alcohol groups separated by one or two carbon atoms. In the physiological direction, 3-hydroxypropionaldehyde is the preferred substrate [H]

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=423, Percent_Identity=27.4231678486998, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI48994951, Length=356, Percent_Identity=36.2359550561798, Blast_Score=188, Evalue=5e-49,
Organism=Escherichia coli, GI87082107, Length=368, Percent_Identity=33.1521739130435, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1789163, Length=380, Percent_Identity=31.3157894736842, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1787493, Length=404, Percent_Identity=30.1980198019802, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1789386, Length=351, Percent_Identity=30.4843304843305, Blast_Score=104, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI17537053, Length=291, Percent_Identity=29.2096219931272, Blast_Score=108, Evalue=5e-24,
Organism=Saccharomyces cerevisiae, GI6321181, Length=375, Percent_Identity=34.4, Blast_Score=191, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24657991, Length=419, Percent_Identity=26.9689737470167, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.202 [H]

Molecular weight: Translated: 40013; Mature: 39882

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00913 ADH_IRON_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAFIYYVTQIQFEFGAVKLLKQECERVGITRPLIVTDPGVKAAGILQKALDALPGIAVTV
CEEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEE
FDQTPSNPTEAAVRAAAALYKAGGCDGLIAVGGGSAIDCAKGVAIAATHEGPLTTYATIE
ECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCEEEEEECCCCCEEEEEEC
GGSPKISDRVAPLIAVPTTSGTGSEVARGAIIIVDDHRKLGFHSWHLVPKTAICDPELTL
CCCCCCHHCCCCEEEEECCCCCCHHHHCCEEEEEECCCCCCCCEEECCCCCCCCCCCHHC
GLPAMLTAATGMDAIAHCMETFMSPAFNPPADGIGLDGLERGWSHIERATRDGSDREARL
CCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
NLMSASMQGAMAFQKGLGCVHSLSHSLGGVDPRLHHGTLNAMFLPAVVRFNASAESVQKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
RRLDRMARAMGLRSGSDIPDAIKDMNARLGLPTGLAAMGVQRDWFDRIIVGALADHCHKT
HHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCC
NPRLASPEEYREMLETSL
CCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AFIYYVTQIQFEFGAVKLLKQECERVGITRPLIVTDPGVKAAGILQKALDALPGIAVTV
EEEEEEEEEEHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHCCCEEEEE
FDQTPSNPTEAAVRAAAALYKAGGCDGLIAVGGGSAIDCAKGVAIAATHEGPLTTYATIE
ECCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHCCEEEEEECCCCCEEEEEEC
GGSPKISDRVAPLIAVPTTSGTGSEVARGAIIIVDDHRKLGFHSWHLVPKTAICDPELTL
CCCCCCHHCCCCEEEEECCCCCCHHHHCCEEEEEECCCCCCCCEEECCCCCCCCCCCHHC
GLPAMLTAATGMDAIAHCMETFMSPAFNPPADGIGLDGLERGWSHIERATRDGSDREARL
CCHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHH
NLMSASMQGAMAFQKGLGCVHSLSHSLGGVDPRLHHGTLNAMFLPAVVRFNASAESVQKE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHH
RRLDRMARAMGLRSGSDIPDAIKDMNARLGLPTGLAAMGVQRDWFDRIIVGALADHCHKT
HHHHHHHHHHCCCCCCCCHHHHHHCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCC
NPRLASPEEYREMLETSL
CCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7721705 [H]