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The map label for this gene is prsA [H]

Identifier: 85859367

GI number: 85859367

Start: 1565345

End: 1566439

Strand: Direct

Name: prsA [H]

Synonym: SYN_03141

Alternate gene names: 85859367

Gene position: 1565345-1566439 (Clockwise)

Preceding gene: 85859366

Following gene: 85859370

Centisome position: 49.24

GC content: 47.67

Gene sequence:

>1095_bases
ATGGCATCACCGAAAAACAGTTGGGTCCTAAAGGGCTTTTTTTCAACATTATTTGTTCTGATCTGTCTGCTTGCATTCCT
TCTGACAGCATGTCAAAAAAATGATCAACAGGGTACGGCTTCCAAAGAAGAAACCGCTCCGACAGCCTCTGTTCCCCAGA
CGGCAACGCCCGCGGAAGGGGCCGAAAAGGCCTTGGGTCCTGGCGATCCGGTCATTGAGGTTGACGGGGTAAAAATGACC
AAGGGGCAATTGGATACGGAAGTGAACCGCAAACTGGAGTCTATCAGAAAGAGGGTTCCAGCCGAAAAGTTGCCTCAGGT
AAAAACAAATATCCAGAAACGCCTCATCGATGATTTTGTGGTGAAAACCCTGCTGAACAACGAGGTCAATCGTCTTAAAA
TCACCGCAACAGAACAGGAAGTCAATGAAGCGGTTGAAAAACTGAAATCATCTCTTCCCGCAAATGTAAGTTTGGAGAAT
CTACTTAAAAAGAATCAGATGACCAGAGAAAAAATGCGTGAAGAGATCCGGCTGGGCATACAGATCAACAAGCTCATGGT
CTCACGGACAAAGAACTTGCCCAAACCTACCGAAAAGGAAATAACCTCTTTTTACAAAAAAAATCAGGATCGGTTTAAAC
TGCCCGAGGCAGTGCATGTCCGTCATATCCTGATTGCCAGGGCGCCAGATGACGGAGAGAAGGTTATTGCCGAGAAGAAG
GCCAAAGCTGAAGGGCTGCGGAAGAAGATCCTGGCAGGTGCTGATTTCGCTGAACTTGCGAAAAGCAATTCCGACTGTCC
AAGTAAAAGTGCGGGGGGCGACCTCGGGATCGTTTCGAGGGGACAAATGGTCAAACCCTTTGAAGACGCGATCTTCTCTT
TGAAAAAGAATCAAATCGGTCCAGTGGTGCAGACGGAATACGGCTTTCATGTGGTCCAGGTTCTGGATGTGCGGCAGCCC
AAGACTGTGGCGTTGGATGAAAGAACAAAGGGCATGATTTCTTCATTTCTCTTGCAGCAGAAACAGCAGGAAGCGTTCAG
AAAAATGGTCGCGTCCCTGAAAGAAAAGGCGAACATTATCGCCTACATGCCTTAG

Upstream 100 bases:

>100_bases
CCCCGCCACTCGCTTGAATCAATCTGACAGTATGATTTCCCTGCAGTCTGAGGAGGGAAAGACAGATCCAGGAGCAAAAG
TAATTTAAAGAGGAGAATTT

Downstream 100 bases:

>100_bases
AACAATAAAGAAGGGTAAACAACGGGATATCAAAGTCCAGGCGGCGGCGATGTCCCGTTGTTGTTTTTCCCGGAACCCTT
CCTCCTTCCCTGCCGATTCA

Product: peptidylprolyl isomerase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 364; Mature: 363

Protein sequence:

>364_residues
MASPKNSWVLKGFFSTLFVLICLLAFLLTACQKNDQQGTASKEETAPTASVPQTATPAEGAEKALGPGDPVIEVDGVKMT
KGQLDTEVNRKLESIRKRVPAEKLPQVKTNIQKRLIDDFVVKTLLNNEVNRLKITATEQEVNEAVEKLKSSLPANVSLEN
LLKKNQMTREKMREEIRLGIQINKLMVSRTKNLPKPTEKEITSFYKKNQDRFKLPEAVHVRHILIARAPDDGEKVIAEKK
AKAEGLRKKILAGADFAELAKSNSDCPSKSAGGDLGIVSRGQMVKPFEDAIFSLKKNQIGPVVQTEYGFHVVQVLDVRQP
KTVALDERTKGMISSFLLQQKQQEAFRKMVASLKEKANIIAYMP

Sequences:

>Translated_364_residues
MASPKNSWVLKGFFSTLFVLICLLAFLLTACQKNDQQGTASKEETAPTASVPQTATPAEGAEKALGPGDPVIEVDGVKMT
KGQLDTEVNRKLESIRKRVPAEKLPQVKTNIQKRLIDDFVVKTLLNNEVNRLKITATEQEVNEAVEKLKSSLPANVSLEN
LLKKNQMTREKMREEIRLGIQINKLMVSRTKNLPKPTEKEITSFYKKNQDRFKLPEAVHVRHILIARAPDDGEKVIAEKK
AKAEGLRKKILAGADFAELAKSNSDCPSKSAGGDLGIVSRGQMVKPFEDAIFSLKKNQIGPVVQTEYGFHVVQVLDVRQP
KTVALDERTKGMISSFLLQQKQQEAFRKMVASLKEKANIIAYMP
>Mature_363_residues
ASPKNSWVLKGFFSTLFVLICLLAFLLTACQKNDQQGTASKEETAPTASVPQTATPAEGAEKALGPGDPVIEVDGVKMTK
GQLDTEVNRKLESIRKRVPAEKLPQVKTNIQKRLIDDFVVKTLLNNEVNRLKITATEQEVNEAVEKLKSSLPANVSLENL
LKKNQMTREKMREEIRLGIQINKLMVSRTKNLPKPTEKEITSFYKKNQDRFKLPEAVHVRHILIARAPDDGEKVIAEKKA
KAEGLRKKILAGADFAELAKSNSDCPSKSAGGDLGIVSRGQMVKPFEDAIFSLKKNQIGPVVQTEYGFHVVQVLDVRQPK
TVALDERTKGMISSFLLQQKQQEAFRKMVASLKEKANIIAYMP

Specific function: Plays a major role in protein secretion by helping the post-translocational extracellular folding of several secreted proteins [H]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cell membrane; Lipid-anchor (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

Organism=Homo sapiens, GI5453898, Length=108, Percent_Identity=40.7407407407407, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1790211, Length=70, Percent_Identity=42.8571428571429, Blast_Score=64, Evalue=2e-11,
Organism=Drosophila melanogaster, GI17647355, Length=108, Percent_Identity=41.6666666666667, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023059
- InterPro:   IPR000297
- InterPro:   IPR023058
- InterPro:   IPR015391
- InterPro:   IPR008880 [H]

Pfam domain/function: PF00639 Rotamase; PF09312 SurA_N [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 40490; Mature: 40358

Theoretical pI: Translated: 10.29; Mature: 10.29

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPKNSWVLKGFFSTLFVLICLLAFLLTACQKNDQQGTASKEETAPTASVPQTATPAEG
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCH
AEKALGPGDPVIEVDGVKMTKGQLDTEVNRKLESIRKRVPAEKLPQVKTNIQKRLIDDFV
HHHCCCCCCCEEEECCCEECCCHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHH
VKTLLNNEVNRLKITATEQEVNEAVEKLKSSLPANVSLENLLKKNQMTREKMREEIRLGI
HHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCH
QINKLMVSRTKNLPKPTEKEITSFYKKNQDRFKLPEAVHVRHILIARAPDDGEKVIAEKK
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHCCCHHHHHHHHEEEECCCCHHHHHHHHH
AKAEGLRKKILAGADFAELAKSNSDCPSKSAGGDLGIVSRGQMVKPFEDAIFSLKKNQIG
HHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
PVVQTEYGFHVVQVLDVRQPKTVALDERTKGMISSFLLQQKQQEAFRKMVASLKEKANII
CEEECCCCCEEEHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
AYMP
EECC
>Mature Secondary Structure 
ASPKNSWVLKGFFSTLFVLICLLAFLLTACQKNDQQGTASKEETAPTASVPQTATPAEG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHCCCCCCCCCCCCCCCH
AEKALGPGDPVIEVDGVKMTKGQLDTEVNRKLESIRKRVPAEKLPQVKTNIQKRLIDDFV
HHHCCCCCCCEEEECCCEECCCHHHHHHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHHH
VKTLLNNEVNRLKITATEQEVNEAVEKLKSSLPANVSLENLLKKNQMTREKMREEIRLGI
HHHHHCCCCCEEEEEECHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCH
QINKLMVSRTKNLPKPTEKEITSFYKKNQDRFKLPEAVHVRHILIARAPDDGEKVIAEKK
HHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHCCCHHHHHHHHEEEECCCCHHHHHHHHH
AKAEGLRKKILAGADFAELAKSNSDCPSKSAGGDLGIVSRGQMVKPFEDAIFSLKKNQIG
HHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
PVVQTEYGFHVVQVLDVRQPKTVALDERTKGMISSFLLQQKQQEAFRKMVASLKEKANII
CEEECCCCCEEEHHHHCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEE
AYMP
EECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]