| Definition | Corynebacterium jeikeium K411, complete genome. |
|---|---|
| Accession | NC_007164 |
| Length | 2,462,499 |
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The map label for this gene is murE [H]
Identifier: 68535820
GI number: 68535820
Start: 889152
End: 890762
Strand: Direct
Name: murE [H]
Synonym: jk0745
Alternate gene names: 68535820
Gene position: 889152-890762 (Clockwise)
Preceding gene: 68535819
Following gene: 68535821
Centisome position: 36.11
GC content: 62.57
Gene sequence:
>1611_bases ATGACATCGTTGAAGCAGCTCGCTGAAATCTGCGGAGGCACCCTCACTGGGCCTTGGGAAGGCGTTGAGGTGACCTCCGC CGCGATTGGTTCTCAAGATGTGGAGCAGGGTGGTTTGTTCTGCGCCGTTCCCGGACAGAAGGTCCACGGCGCGACCTTCG CCGCGGATAGCAAAGCCGCCGCTGTTCTGACCGATGCCGCAGGCCAGCGCATTATTGATGACGCCACCACGCCGCTACCG TGCATCGTTGTCGACAACGTTCGCAAGTGGATGGGGCCGGTAGCTGCAGAGGTTTATGGCCACCCGGCGCGTCAGTTGAA GACCATCGGGATTACCGGTACGTCGGGCAAGACCACCACCAGCTACTTGGTGGAAAAGGCTCTTCTGGAATCCGGACTGC GGGTGGGCCTGATCGGCACCACGGGTACACGCATCAACGGCCAGCCCATCCCTACCTCACTGACTACTCCCGAGGCACCC ACGCTGCAGGCCTTGCTGGCACGAATGGTGGCCGAGGGAGTCACGCACCTCGTGATGGAGGTTTCCAGCCACGCATTGCA GCTAGGCCGCGTGCACGGCGTGCACTTTGACGTGGTGGCGTTTACGAACCTGAGCCAGGACCACCTGGATTTTCATCCGA CGATGGAGGACTACTTCCAGGCGAAAGCGCTGCTGTTCGAACGCGCGGAGGATGGTGGTGTTCCGGGCACCGCTGTGGTC TGTTGTGAGGACGAGTGGGGCGAGCGCATGCGCGCCATCGCCGCGAAGTACTCGTCGACCGTGGCGCTGTACCCCCAGGG CGGCAACCACGAGGCCGAAACCGGCAGCCCCGTGTGGTCTATTGCTTCCGCCGAGGTGGCTCCCAACGGCCGCCAGCACA TTCGCCTGTCTATCGCGGGCGGCTCCGAACCGCGAGAGTTGGATTACAGCATCGGCATGGCGGGTTCCTTTAACCAGGCC AACAGCCTGGTGGCTCTGGCCTGCATCGAGGCAGTCACTGGAGAACCGCTGTCTAGCGATAGCACAGCCGTACAGGCTCT GGCGGACGTGCAGGTTCCCGGCCGGATGCAGCTGGTCGAGGAAGGCCAAGACTTCCTGGCCATGGTTGACTATGCGCACA AGCCGGGCGCGGTGCAGGCCGTGCTGGGCAGCTTGCACGACTATCTGCCGGATCCGGCAGCCCGCATTGGCATCGTCCTC GGAGCCGGTGGAAACCGCGATCACGACAAGCGCGCGATCATGGGCCGTATCGCCGCGGAGTTGGCGGATGCGGTGTTCGT CACGGATGACAATCCCCGGGATGAGGAACCTTCCGTGATTAGGGAAGCTATTTACGCCGGGGCGCGAGAGGGCGTCCAAA AGAAAGAACAAGAACAATCAACCAACGCCGAGACCGTGTGCGAGATCGTGCCCGACCGTGCGGAGGCCATCGCCGCAGCC GTAACCTGGGCACGGCCCGGCGATGCGGTGGTCGTCGCCGGTAAGGGGCATGAAAAGGGGCAACTTGTGGCAGGAAAGAT GCATCCCTTCGACGATGTGGAGGAGTTGGCGACGGCTTTGAAGAACCGGGTACGGCAAGAGCGTGAGGCAGATAATGGTG AAGGTAGGTAG
Upstream 100 bases:
>100_bases CTGCACCTTTGTTCCACGACATCATGGCGTGGATGCTCGACCACTACAATGTGCCGCTGTCTGAGAAGGCAGGGCCAAAG CTGATGCTGGAGGCAAATCA
Downstream 100 bases:
>100_bases CAGCGATGATTGAGTTAACGACACAGAAGATCGCCGAGGTATCCGGCAGCACGCTGATTAACGACGTGGATCCGCAGGCC GTAGTGACCGGCCCGGTGGA
Product: UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase
Products: NA
Alternate protein names: Meso-A2pm-adding enzyme; Meso-diaminopimelate-adding enzyme; UDP-MurNAc-L-Ala-D-Glu:meso-diaminopimelate ligase; UDP-MurNAc-tripeptide synthetase; UDP-N-acetylmuramyl-tripeptide synthetase [H]
Number of amino acids: Translated: 536; Mature: 535
Protein sequence:
>536_residues MTSLKQLAEICGGTLTGPWEGVEVTSAAIGSQDVEQGGLFCAVPGQKVHGATFAADSKAAAVLTDAAGQRIIDDATTPLP CIVVDNVRKWMGPVAAEVYGHPARQLKTIGITGTSGKTTTSYLVEKALLESGLRVGLIGTTGTRINGQPIPTSLTTPEAP TLQALLARMVAEGVTHLVMEVSSHALQLGRVHGVHFDVVAFTNLSQDHLDFHPTMEDYFQAKALLFERAEDGGVPGTAVV CCEDEWGERMRAIAAKYSSTVALYPQGGNHEAETGSPVWSIASAEVAPNGRQHIRLSIAGGSEPRELDYSIGMAGSFNQA NSLVALACIEAVTGEPLSSDSTAVQALADVQVPGRMQLVEEGQDFLAMVDYAHKPGAVQAVLGSLHDYLPDPAARIGIVL GAGGNRDHDKRAIMGRIAAELADAVFVTDDNPRDEEPSVIREAIYAGAREGVQKKEQEQSTNAETVCEIVPDRAEAIAAA VTWARPGDAVVVAGKGHEKGQLVAGKMHPFDDVEELATALKNRVRQEREADNGEGR
Sequences:
>Translated_536_residues MTSLKQLAEICGGTLTGPWEGVEVTSAAIGSQDVEQGGLFCAVPGQKVHGATFAADSKAAAVLTDAAGQRIIDDATTPLP CIVVDNVRKWMGPVAAEVYGHPARQLKTIGITGTSGKTTTSYLVEKALLESGLRVGLIGTTGTRINGQPIPTSLTTPEAP TLQALLARMVAEGVTHLVMEVSSHALQLGRVHGVHFDVVAFTNLSQDHLDFHPTMEDYFQAKALLFERAEDGGVPGTAVV CCEDEWGERMRAIAAKYSSTVALYPQGGNHEAETGSPVWSIASAEVAPNGRQHIRLSIAGGSEPRELDYSIGMAGSFNQA NSLVALACIEAVTGEPLSSDSTAVQALADVQVPGRMQLVEEGQDFLAMVDYAHKPGAVQAVLGSLHDYLPDPAARIGIVL GAGGNRDHDKRAIMGRIAAELADAVFVTDDNPRDEEPSVIREAIYAGAREGVQKKEQEQSTNAETVCEIVPDRAEAIAAA VTWARPGDAVVVAGKGHEKGQLVAGKMHPFDDVEELATALKNRVRQEREADNGEGR >Mature_535_residues TSLKQLAEICGGTLTGPWEGVEVTSAAIGSQDVEQGGLFCAVPGQKVHGATFAADSKAAAVLTDAAGQRIIDDATTPLPC IVVDNVRKWMGPVAAEVYGHPARQLKTIGITGTSGKTTTSYLVEKALLESGLRVGLIGTTGTRINGQPIPTSLTTPEAPT LQALLARMVAEGVTHLVMEVSSHALQLGRVHGVHFDVVAFTNLSQDHLDFHPTMEDYFQAKALLFERAEDGGVPGTAVVC CEDEWGERMRAIAAKYSSTVALYPQGGNHEAETGSPVWSIASAEVAPNGRQHIRLSIAGGSEPRELDYSIGMAGSFNQAN SLVALACIEAVTGEPLSSDSTAVQALADVQVPGRMQLVEEGQDFLAMVDYAHKPGAVQAVLGSLHDYLPDPAARIGIVLG AGGNRDHDKRAIMGRIAAELADAVFVTDDNPRDEEPSVIREAIYAGAREGVQKKEQEQSTNAETVCEIVPDRAEAIAAAV TWARPGDAVVVAGKGHEKGQLVAGKMHPFDDVEELATALKNRVRQEREADNGEGR
Specific function: Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan [H]
COG id: COG0769
COG function: function code M; UDP-N-acetylmuramyl tripeptide synthase
Gene ontology:
Cell location: Cytoplasm [H]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the MurCDEF family. MurE subfamily [H]
Homologues:
Organism=Escherichia coli, GI1786273, Length=489, Percent_Identity=34.560327198364, Blast_Score=177, Evalue=1e-45,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR004101 - InterPro: IPR013221 - InterPro: IPR000713 - InterPro: IPR005761 [H]
Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]
EC number: =6.3.2.13 [H]
Molecular weight: Translated: 56557; Mature: 56426
Theoretical pI: Translated: 4.71; Mature: 4.71
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 2.1 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MTSLKQLAEICGGTLTGPWEGVEVTSAAIGSQDVEQGGLFCAVPGQKVHGATFAADSKAA CCCHHHHHHHHCCCCCCCCCCCEEHHHHHCCCHHHHCCEEEECCCCCCCCCEEECCCCCC AVLTDAAGQRIIDDATTPLPCIVVDNVRKWMGPVAAEVYGHPARQLKTIGITGTSGKTTT EEEEHHCCCHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCHH SYLVEKALLESGLRVGLIGTTGTRINGQPIPTSLTTPEAPTLQALLARMVAEGVTHLVME HHHHHHHHHHCCCEEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH VSSHALQLGRVHGVHFDVVAFTNLSQDHLDFHPTMEDYFQAKALLFERAEDGGVPGTAVV HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEE CCEDEWGERMRAIAAKYSSTVALYPQGGNHEAETGSPVWSIASAEVAPNGRQHIRLSIAG EECHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEC GSEPRELDYSIGMAGSFNQANSLVALACIEAVTGEPLSSDSTAVQALADVQVPGRMQLVE CCCCCEECEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHH EGQDFLAMVDYAHKPGAVQAVLGSLHDYLPDPAARIGIVLGAGGNRDHDKRAIMGRIAAE CCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHEEEEEECCCCCCHHHHHHHHHHHHH LADAVFVTDDNPRDEEPSVIREAIYAGAREGVQKKEQEQSTNAETVCEIVPDRAEAIAAA HHCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHH VTWARPGDAVVVAGKGHEKGQLVAGKMHPFDDVEELATALKNRVRQEREADNGEGR HEECCCCCEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC >Mature Secondary Structure TSLKQLAEICGGTLTGPWEGVEVTSAAIGSQDVEQGGLFCAVPGQKVHGATFAADSKAA CCHHHHHHHHCCCCCCCCCCCEEHHHHHCCCHHHHCCEEEECCCCCCCCCEEECCCCCC AVLTDAAGQRIIDDATTPLPCIVVDNVRKWMGPVAAEVYGHPARQLKTIGITGTSGKTTT EEEEHHCCCHHHHCCCCCCCEEEEHHHHHHHHHHHHHHHCCCHHHEEEEEEECCCCCCHH SYLVEKALLESGLRVGLIGTTGTRINGQPIPTSLTTPEAPTLQALLARMVAEGVTHLVME HHHHHHHHHHCCCEEEEEECCCCEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH VSSHALQLGRVHGVHFDVVAFTNLSQDHLDFHPTMEDYFQAKALLFERAEDGGVPGTAVV HHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCEEE CCEDEWGERMRAIAAKYSSTVALYPQGGNHEAETGSPVWSIASAEVAPNGRQHIRLSIAG EECHHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCEEEEEECCCCCCCCEEEEEEEEC GSEPRELDYSIGMAGSFNQANSLVALACIEAVTGEPLSSDSTAVQALADVQVPGRMQLVE CCCCCEECEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCHHHHHH EGQDFLAMVDYAHKPGAVQAVLGSLHDYLPDPAARIGIVLGAGGNRDHDKRAIMGRIAAE CCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCHHEEEEEECCCCCCHHHHHHHHHHHHH LADAVFVTDDNPRDEEPSVIREAIYAGAREGVQKKEQEQSTNAETVCEIVPDRAEAIAAA HHCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHHHHH VTWARPGDAVVVAGKGHEKGQLVAGKMHPFDDVEELATALKNRVRQEREADNGEGR HEECCCCCEEEEECCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 12948626 [H]