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The map label for this gene is ftsI [H]

Identifier: 68535819

GI number: 68535819

Start: 887263

End: 889155

Strand: Direct

Name: ftsI [H]

Synonym: jk0744

Alternate gene names: 68535819

Gene position: 887263-889155 (Clockwise)

Preceding gene: 68535818

Following gene: 68535820

Centisome position: 36.03

GC content: 60.12

Gene sequence:

>1893_bases
GTGTCTACCCCTAACGACCGCCGCTCCCCGCGGACGGTTGAATCCAACTCGTGGTTGATCCTGGATACCTCCTTCGCGCG
TTTCAGTAAGCGCGTCCGCCTTGTATTCCTGGTCGTCTTCTTGACGGTCCTCGCTTTGCTGTTGCGCCTGGTCTGGGTTC
AGCTGGTGGCTAGCCCGTCGTTGTCTACTCAAGCTCAGATGCAGCGCACTTCCGTGATTACCGAACCAGCCCTGCGCGGC
GGCATCACCGACCGTAACGGTCAGGTGTTGGCCTACACAATGGATGCACGGAGCCTGTCGGTGCATCCAAAGAAGCTTGA
GGAGTTCATGCAAGAGCGTCATGAACTAGATCCCGAAGGTGTGCCCGAGCCCAAGCAGCGCATCGAAGACATCGCCAAGC
GTCTGCCCGAGATGATCAATAAAGAAGGCGACGATATCGAGGAAGACGATATCCGCAAGAAGCTGACCAGCGACAAAGAC
TATGAGGTGCTGGTGCGCAACGTCGACCCGGACGTAGCGGAGAAGGTCGCTGAGGAATTCCCCGAGATTACCGCTGAGCG
CCAGGATCTGCGTCAATACCCCAACGGCGCGGTGGCTCAGAACATGATCGGCAAGATCAGTACCGATAACCAGGGACAAT
TCGGCCTGGAGCTTTCCCAGGATGCGCGCCTGCAGGGCATCAACGGTTCCCGCACCGTGGATGTTGCCGGCGATGGCTAC
CTGATCCCGGGCTCCACCCGCGACGTGCACCCAGCCGTCAATGGTGATTCCTACGAGCTGACCATCGACCTGGACGCGCA
GACGTATGTGCAGCAGGCGCTGCAGCAGGCGCGGGAGAAGTCGGGCGCAAAGTCCGCCTCGGCCGTCGTGCTGGATTCGA
AGACTGGCGAGATCATCGCCATGGGCTCCAGTGATTCGATCGACCCTAACGGGGACATTGAAAAGCAGCTGAAGCGCAAG
AAGGTCTTTGGCGACCGCGCAACGGCCGATTCCTTTGAACCCGGCTCCGTGGCCAAGATCATGACCGCCGCCGCGGCTAT
CCAGGAAGGCAAAACCACCCCGGATGAGATTTTGAAGGTTCCCGGCAGCATCGATATGTCCGGCGTGACCGTTAAGGATG
CGTGGGAGCATGGTGAGGTTCCGTACACCACCACGGGCGTTTTTGGTAAGTCCTCGAACGTTGGCACCCTGATGCTCGCG
CAGCGCGTGGGCGAGGACAAGATGTACGACTACTTCCGCAAGTTCGGCGTGGGTCAAGCCGCGGGCGTGGGCCTGCCCTA
TGAGGTATCCGGCTACATGCCAGAGCTAAGCCAGTGGTCTGGCGGCACCTTCGCGAACCTGCCGATCGGTCAGGGTATGT
CCATGAGTTTGCTGCAGATGACCAGCATTTACCAGGCGCTGGCCAATGATGGCGTGCGCGTGGAGCCCAGGTTGATCAAC
AAGATCACCAGCTCCGACGGAGCGGAGCTGGCCGCCGACCCAGCGAAAGAGACTCGTGTGGTTTCCCCGGAGACAGCCCG
CACAACCGTGGACATGTTCCGCGCAGTCACGCAGAAGGATGAGACAGGTGTGCAGCAGGGCAGTGGTGCACCGGCTGCGA
TCGACGGCTACCAGGTTTCCGGCAAGACGGGTACAGCCCAGCAGGTCGATCCGGATACCGGAGCTTATTCTAACTCCGCC
TACTGGATTAACTTCGCTGGCATTGCGCCCGCCGACAAGCCCCGCTTCGTCGTGGGCATCATGCTGGACAATCCCCAGCG
TGGAACTGACGGGGGCGCGGGTGGCAGTGCTGCACCTTTGTTCCACGACATCATGGCGTGGATGCTCGACCACTACAATG
TGCCGCTGTCTGAGAAGGCAGGGCCAAAGCTGATGCTGGAGGCAAATCAATGA

Upstream 100 bases:

>100_bases
ACAGCCAATCGAAAACTTCAGACACGCCGGGGCCAACCCCGGCTTGTTTTCGTAATTGCGAGGACAATAACCAAGAGTGA
ATAGAAAGGAGGGCAACCAC

Downstream 100 bases:

>100_bases
CATCGTTGAAGCAGCTCGCTGAAATCTGCGGAGGCACCCTCACTGGGCCTTGGGAAGGCGTTGAGGTGACCTCCGCCGCG
ATTGGTTCTCAAGATGTGGA

Product: penicillin-binding protein

Products: NA

Alternate protein names: Penicillin-binding protein 3; PBP-3; Peptidoglycan glycosyltransferase 3 [H]

Number of amino acids: Translated: 630; Mature: 629

Protein sequence:

>630_residues
MSTPNDRRSPRTVESNSWLILDTSFARFSKRVRLVFLVVFLTVLALLLRLVWVQLVASPSLSTQAQMQRTSVITEPALRG
GITDRNGQVLAYTMDARSLSVHPKKLEEFMQERHELDPEGVPEPKQRIEDIAKRLPEMINKEGDDIEEDDIRKKLTSDKD
YEVLVRNVDPDVAEKVAEEFPEITAERQDLRQYPNGAVAQNMIGKISTDNQGQFGLELSQDARLQGINGSRTVDVAGDGY
LIPGSTRDVHPAVNGDSYELTIDLDAQTYVQQALQQAREKSGAKSASAVVLDSKTGEIIAMGSSDSIDPNGDIEKQLKRK
KVFGDRATADSFEPGSVAKIMTAAAAIQEGKTTPDEILKVPGSIDMSGVTVKDAWEHGEVPYTTTGVFGKSSNVGTLMLA
QRVGEDKMYDYFRKFGVGQAAGVGLPYEVSGYMPELSQWSGGTFANLPIGQGMSMSLLQMTSIYQALANDGVRVEPRLIN
KITSSDGAELAADPAKETRVVSPETARTTVDMFRAVTQKDETGVQQGSGAPAAIDGYQVSGKTGTAQQVDPDTGAYSNSA
YWINFAGIAPADKPRFVVGIMLDNPQRGTDGGAGGSAAPLFHDIMAWMLDHYNVPLSEKAGPKLMLEANQ

Sequences:

>Translated_630_residues
MSTPNDRRSPRTVESNSWLILDTSFARFSKRVRLVFLVVFLTVLALLLRLVWVQLVASPSLSTQAQMQRTSVITEPALRG
GITDRNGQVLAYTMDARSLSVHPKKLEEFMQERHELDPEGVPEPKQRIEDIAKRLPEMINKEGDDIEEDDIRKKLTSDKD
YEVLVRNVDPDVAEKVAEEFPEITAERQDLRQYPNGAVAQNMIGKISTDNQGQFGLELSQDARLQGINGSRTVDVAGDGY
LIPGSTRDVHPAVNGDSYELTIDLDAQTYVQQALQQAREKSGAKSASAVVLDSKTGEIIAMGSSDSIDPNGDIEKQLKRK
KVFGDRATADSFEPGSVAKIMTAAAAIQEGKTTPDEILKVPGSIDMSGVTVKDAWEHGEVPYTTTGVFGKSSNVGTLMLA
QRVGEDKMYDYFRKFGVGQAAGVGLPYEVSGYMPELSQWSGGTFANLPIGQGMSMSLLQMTSIYQALANDGVRVEPRLIN
KITSSDGAELAADPAKETRVVSPETARTTVDMFRAVTQKDETGVQQGSGAPAAIDGYQVSGKTGTAQQVDPDTGAYSNSA
YWINFAGIAPADKPRFVVGIMLDNPQRGTDGGAGGSAAPLFHDIMAWMLDHYNVPLSEKAGPKLMLEANQ
>Mature_629_residues
STPNDRRSPRTVESNSWLILDTSFARFSKRVRLVFLVVFLTVLALLLRLVWVQLVASPSLSTQAQMQRTSVITEPALRGG
ITDRNGQVLAYTMDARSLSVHPKKLEEFMQERHELDPEGVPEPKQRIEDIAKRLPEMINKEGDDIEEDDIRKKLTSDKDY
EVLVRNVDPDVAEKVAEEFPEITAERQDLRQYPNGAVAQNMIGKISTDNQGQFGLELSQDARLQGINGSRTVDVAGDGYL
IPGSTRDVHPAVNGDSYELTIDLDAQTYVQQALQQAREKSGAKSASAVVLDSKTGEIIAMGSSDSIDPNGDIEKQLKRKK
VFGDRATADSFEPGSVAKIMTAAAAIQEGKTTPDEILKVPGSIDMSGVTVKDAWEHGEVPYTTTGVFGKSSNVGTLMLAQ
RVGEDKMYDYFRKFGVGQAAGVGLPYEVSGYMPELSQWSGGTFANLPIGQGMSMSLLQMTSIYQALANDGVRVEPRLINK
ITSSDGAELAADPAKETRVVSPETARTTVDMFRAVTQKDETGVQQGSGAPAAIDGYQVSGKTGTAQQVDPDTGAYSNSAY
WINFAGIAPADKPRFVVGIMLDNPQRGTDGGAGGSAAPLFHDIMAWMLDHYNVPLSEKAGPKLMLEANQ

Specific function: Cell wall formation. Essential for the formation of a septum of the murein sacculus. Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein; Periplasmic side. Note=The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein (By similarity) [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=591, Percent_Identity=31.6412859560068, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1786854, Length=651, Percent_Identity=24.7311827956989, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: =2.4.1.129 [H]

Molecular weight: Translated: 68360; Mature: 68228

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPNDRRSPRTVESNSWLILDTSFARFSKRVRLVFLVVFLTVLALLLRLVWVQLVASPS
CCCCCCCCCCCEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LSTQAQMQRTSVITEPALRGGITDRNGQVLAYTMDARSLSVHPKKLEEFMQERHELDPEG
CCHHHHHHHHHHHHCHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCC
VPEPKQRIEDIAKRLPEMINKEGDDIEEDDIRKKLTSDKDYEVLVRNVDPDVAEKVAEEF
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHH
PEITAERQDLRQYPNGAVAQNMIGKISTDNQGQFGLELSQDARLQGINGSRTVDVAGDGY
HHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEECCCCEEECCCCCEEEEECCCCE
LIPGSTRDVHPAVNGDSYELTIDLDAQTYVQQALQQAREKSGAKSASAVVLDSKTGEIIA
ECCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEE
MGSSDSIDPNGDIEKQLKRKKVFGDRATADSFEPGSVAKIMTAAAAIQEGKTTPDEILKV
ECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCC
PGSIDMSGVTVKDAWEHGEVPYTTTGVFGKSSNVGTLMLAQRVGEDKMYDYFRKFGVGQA
CCCCCCCCEEEECCCCCCCCCEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCC
AGVGLPYEVSGYMPELSQWSGGTFANLPIGQGMSMSLLQMTSIYQALANDGVRVEPRLIN
CCCCCCEECCCCCCCHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCEECHHHHH
KITSSDGAELAADPAKETRVVSPETARTTVDMFRAVTQKDETGVQQGSGAPAAIDGYQVS
HHHCCCCCCCCCCCCHHCEECCCCHHHHHHHHHHHHHHCHHHCCCCCCCCCCEECCEEEC
GKTGTAQQVDPDTGAYSNSAYWINFAGIAPADKPRFVVGIMLDNPQRGTDGGAGGSAAPL
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHH
FHDIMAWMLDHYNVPLSEKAGPKLMLEANQ
HHHHHHHHHHHCCCCCCCCCCCEEEEECCC
>Mature Secondary Structure 
STPNDRRSPRTVESNSWLILDTSFARFSKRVRLVFLVVFLTVLALLLRLVWVQLVASPS
CCCCCCCCCCEECCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
LSTQAQMQRTSVITEPALRGGITDRNGQVLAYTMDARSLSVHPKKLEEFMQERHELDPEG
CCHHHHHHHHHHHHCHHHHCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCC
VPEPKQRIEDIAKRLPEMINKEGDDIEEDDIRKKLTSDKDYEVLVRNVDPDVAEKVAEEF
CCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHH
PEITAERQDLRQYPNGAVAQNMIGKISTDNQGQFGLELSQDARLQGINGSRTVDVAGDGY
HHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCCCCEECCCCEEECCCCCEEEEECCCCE
LIPGSTRDVHPAVNGDSYELTIDLDAQTYVQQALQQAREKSGAKSASAVVLDSKTGEIIA
ECCCCCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCEEE
MGSSDSIDPNGDIEKQLKRKKVFGDRATADSFEPGSVAKIMTAAAAIQEGKTTPDEILKV
ECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHCC
PGSIDMSGVTVKDAWEHGEVPYTTTGVFGKSSNVGTLMLAQRVGEDKMYDYFRKFGVGQA
CCCCCCCCEEEECCCCCCCCCEEECCCCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCCCC
AGVGLPYEVSGYMPELSQWSGGTFANLPIGQGMSMSLLQMTSIYQALANDGVRVEPRLIN
CCCCCCEECCCCCCCHHCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCEECHHHHH
KITSSDGAELAADPAKETRVVSPETARTTVDMFRAVTQKDETGVQQGSGAPAAIDGYQVS
HHHCCCCCCCCCCCCHHCEECCCCHHHHHHHHHHHHHHCHHHCCCCCCCCCCEECCEEEC
GKTGTAQQVDPDTGAYSNSAYWINFAGIAPADKPRFVVGIMLDNPQRGTDGGAGGSAAPL
CCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHH
FHDIMAWMLDHYNVPLSEKAGPKLMLEANQ
HHHHHHHHHHHCCCCCCCCCCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]