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The map label for this gene is pyrG

Identifier: 62185186

GI number: 62185186

Start: 645667

End: 647280

Strand: Direct

Name: pyrG

Synonym: CAB570

Alternate gene names: 62185186

Gene position: 645667-647280 (Clockwise)

Preceding gene: 62185185

Following gene: 62185187

Centisome position: 56.42

GC content: 41.95

Gene sequence:

>1614_bases
ATGTCATTCAAGTGCATCTTTTTAACAGGAGGAGTCGTATCCTCCTTAGGCAAGGGATTAACTGCTGCCTCACTTGCTCT
ACTACTAGAGCGACAAGGACTTAAAGTTGCTATGTTAAAACTGGATCCTTATCTTAACGTCGATCCAGGAACAATGAATC
CTTATGAACACGGTGAGGTTTACGTTACCAATGACGGTATAGAGACAGATCTCGACCTTGGTCATTATCATCGCTTTTCT
TCAGTAAACCTATCTAGGTATTCTACAGCGACTTCAGGGCAAATCTATGCCCGAGTAATTAAAAAAGAACGCGATGGGTT
GTATCTAGGAAGTACAGTTCAAGTTATCCCGCACATCACTAACGAAATCATCGAAGTTATCTTAGAGTGTGCTAGGGAAA
ATCATCCCGATGTATTAATCGTAGAAATCGGTGGTACCGTTGGAGATATAGAATCCCTACCTTTCTTAGAAGCTATCCGA
CAATTCCGTTATGAGCATGCTGAAGACTGCTTCAGCATTCATATGACCTACGTACCTTATTTACAAGCCGCAGGAGAGGT
AAAAACCAAACCTACGCAGCACTCCGTCCAAAGTTTGCGAAGCATTGGCATTATTCCTGATGCGATTCTCTGCAGATCTG
AAGCTCCTTTAAGCTCAGAAGTAAAAAAGAAAATCAGCCTATTTTGCAATGTTCCTAGTACCGCGGTTTTTAACGTTGTC
GATGTGGAACATTCCATATACGAAATGCCCTTAATGTTATCTCAAGAAAAGATCTCTACGTTTATCACAGAAAAATTAGG
ACTGTTTACTAAAAAAGAAGATCTAAGTGATTGGGAAATGTTAGTAGAACGTTTGCGCCATCCTCTTCCTAATAAGATAC
GCTTAGGTTTAGTCGGTAAATACGTACAACATAAAGACGCGTATAAATCTGTTTTTGAGTCTATCACCCACGCCGCTTTA
AGCTTGAATTGCTCAGTAGAGTTATTCCCTTTAGACTCTGATGATCCGCATTTCCTTGAAACCTTAGAACTCTGTGACGG
CTGCCTGGTCCCCGGAGGTTTTGGGTCTCGAGGTTGGGAAGGGAAAATTATTGCCGCCAAGCTGTGCAGAGAAAGAGGGA
TCCCTTATTTTGGAATCTGCTTAGGTATGCAGGTTCTCGTTGTTGAATATGCTCGTCACGTCCTCCATCTAGAACACGCA
AACTCTACAGAAATGGACAAAGATACACCTGATCCTGTGATTTGTATGTTGGATTGGCAAGCTTCATTAATCGCTACAGG
CGGTACGATGCGTCTTGGAGCCTATCCCTGTGCATTATCACCAGGAAGTAAAGTATACGCGATGTATGGGCAACCTGAAA
TTATGGAACGCCATCGCCATCGCTATGAAGTGAATTTCAACTATATACAACAATTAAAAGATCACGGATTGGATATTGTG
GGTACGTGCCCAGAACAAGGACTTTGCGAAATCGTAGAAATCAAAGATCACCCTTGGATGATAGGAGTACAATTCCACCC
AGAATTCCTTTCAAAATTGATCAAGCCTCACCCACTCTTTGTAGGCTTTATCGAGGCAGCACTTCTTCACTCTAGGAATA
AAACTTATGTCTAA

Upstream 100 bases:

>100_bases
TACTAGAACACGGTGGATCCATTCATGTATGTGTAGTGGAAGCTAAGAGCCCTTCGGTGGATTATCCAGAAGATATCAGT
AAGGTGGAAGAATACTTAAC

Downstream 100 bases:

>100_bases
TCCTCAGGTAGCAAAAGTTTTCCTTGGTGTAGATTATGGAGAGAGGCGGATAGGTCTAGCCTACGCGGCCTACCCCCTGG
GCATTAGTTTGCCCATAGGG

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 537; Mature: 536

Protein sequence:

>537_residues
MSFKCIFLTGGVVSSLGKGLTAASLALLLERQGLKVAMLKLDPYLNVDPGTMNPYEHGEVYVTNDGIETDLDLGHYHRFS
SVNLSRYSTATSGQIYARVIKKERDGLYLGSTVQVIPHITNEIIEVILECARENHPDVLIVEIGGTVGDIESLPFLEAIR
QFRYEHAEDCFSIHMTYVPYLQAAGEVKTKPTQHSVQSLRSIGIIPDAILCRSEAPLSSEVKKKISLFCNVPSTAVFNVV
DVEHSIYEMPLMLSQEKISTFITEKLGLFTKKEDLSDWEMLVERLRHPLPNKIRLGLVGKYVQHKDAYKSVFESITHAAL
SLNCSVELFPLDSDDPHFLETLELCDGCLVPGGFGSRGWEGKIIAAKLCRERGIPYFGICLGMQVLVVEYARHVLHLEHA
NSTEMDKDTPDPVICMLDWQASLIATGGTMRLGAYPCALSPGSKVYAMYGQPEIMERHRHRYEVNFNYIQQLKDHGLDIV
GTCPEQGLCEIVEIKDHPWMIGVQFHPEFLSKLIKPHPLFVGFIEAALLHSRNKTYV

Sequences:

>Translated_537_residues
MSFKCIFLTGGVVSSLGKGLTAASLALLLERQGLKVAMLKLDPYLNVDPGTMNPYEHGEVYVTNDGIETDLDLGHYHRFS
SVNLSRYSTATSGQIYARVIKKERDGLYLGSTVQVIPHITNEIIEVILECARENHPDVLIVEIGGTVGDIESLPFLEAIR
QFRYEHAEDCFSIHMTYVPYLQAAGEVKTKPTQHSVQSLRSIGIIPDAILCRSEAPLSSEVKKKISLFCNVPSTAVFNVV
DVEHSIYEMPLMLSQEKISTFITEKLGLFTKKEDLSDWEMLVERLRHPLPNKIRLGLVGKYVQHKDAYKSVFESITHAAL
SLNCSVELFPLDSDDPHFLETLELCDGCLVPGGFGSRGWEGKIIAAKLCRERGIPYFGICLGMQVLVVEYARHVLHLEHA
NSTEMDKDTPDPVICMLDWQASLIATGGTMRLGAYPCALSPGSKVYAMYGQPEIMERHRHRYEVNFNYIQQLKDHGLDIV
GTCPEQGLCEIVEIKDHPWMIGVQFHPEFLSKLIKPHPLFVGFIEAALLHSRNKTYV
>Mature_536_residues
SFKCIFLTGGVVSSLGKGLTAASLALLLERQGLKVAMLKLDPYLNVDPGTMNPYEHGEVYVTNDGIETDLDLGHYHRFSS
VNLSRYSTATSGQIYARVIKKERDGLYLGSTVQVIPHITNEIIEVILECARENHPDVLIVEIGGTVGDIESLPFLEAIRQ
FRYEHAEDCFSIHMTYVPYLQAAGEVKTKPTQHSVQSLRSIGIIPDAILCRSEAPLSSEVKKKISLFCNVPSTAVFNVVD
VEHSIYEMPLMLSQEKISTFITEKLGLFTKKEDLSDWEMLVERLRHPLPNKIRLGLVGKYVQHKDAYKSVFESITHAALS
LNCSVELFPLDSDDPHFLETLELCDGCLVPGGFGSRGWEGKIIAAKLCRERGIPYFGICLGMQVLVVEYARHVLHLEHAN
STEMDKDTPDPVICMLDWQASLIATGGTMRLGAYPCALSPGSKVYAMYGQPEIMERHRHRYEVNFNYIQQLKDHGLDIVG
TCPEQGLCEIVEIKDHPWMIGVQFHPEFLSKLIKPHPLFVGFIEAALLHSRNKTYV

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI28559085, Length=551, Percent_Identity=44.1016333938294, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI28559083, Length=551, Percent_Identity=44.1016333938294, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI221316689, Length=551, Percent_Identity=44.1016333938294, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI148491070, Length=551, Percent_Identity=43.7386569872958, Blast_Score=436, Evalue=1e-122,
Organism=Escherichia coli, GI1789142, Length=540, Percent_Identity=51.4814814814815, Blast_Score=525, Evalue=1e-150,
Organism=Caenorhabditis elegans, GI25148299, Length=602, Percent_Identity=37.7076411960133, Blast_Score=389, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6322563, Length=565, Percent_Identity=41.2389380530973, Blast_Score=425, Evalue=1e-119,
Organism=Saccharomyces cerevisiae, GI6319432, Length=561, Percent_Identity=39.572192513369, Blast_Score=410, Evalue=1e-115,
Organism=Drosophila melanogaster, GI24664469, Length=552, Percent_Identity=45.2898550724638, Blast_Score=450, Evalue=1e-126,
Organism=Drosophila melanogaster, GI21357815, Length=496, Percent_Identity=44.3548387096774, Blast_Score=385, Evalue=1e-107,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_CHLAB (Q5L5S1)

Other databases:

- EMBL:   CR848038
- RefSeq:   YP_219971.1
- HSSP:   P0A7E5
- ProteinModelPortal:   Q5L5S1
- SMR:   Q5L5S1
- GeneID:   3337638
- GenomeReviews:   CR848038_GR
- KEGG:   cab:CAB570
- HOGENOM:   HBG597806
- OMA:   NIKIDPY
- ProtClustDB:   PRK05380
- BioCyc:   CABO218497:CAB570-MONOMER
- BRENDA:   6.3.4.2
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 60163; Mature: 60032

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 380-380 ACT_SITE 506-506 ACT_SITE 508-508

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFKCIFLTGGVVSSLGKGLTAASLALLLERQGLKVAMLKLDPYLNVDPGTMNPYEHGEV
CCEEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEE
YVTNDGIETDLDLGHYHRFSSVNLSRYSTATSGQIYARVIKKERDGLYLGSTVQVIPHIT
EEECCCCCCCCCCCHHHCCCCCCCHHCCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHH
NEIIEVILECARENHPDVLIVEIGGTVGDIESLPFLEAIRQFRYEHAEDCFSIHMTYVPY
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQAAGEVKTKPTQHSVQSLRSIGIIPDAILCRSEAPLSSEVKKKISLFCNVPSTAVFNVV
HHHCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHEEECCCCCCEEEEE
DVEHSIYEMPLMLSQEKISTFITEKLGLFTKKEDLSDWEMLVERLRHPLPNKIRLGLVGK
ECCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEHHHHH
YVQHKDAYKSVFESITHAALSLNCSVELFPLDSDDPHFLETLELCDGCLVPGGFGSRGWE
HHHHHHHHHHHHHHHHHHHEEEECEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
GKIIAAKLCRERGIPYFGICLGMQVLVVEYARHVLHLEHANSTEMDKDTPDPVICMLDWQ
CCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEEEECC
ASLIATGGTMRLGAYPCALSPGSKVYAMYGQPEIMERHRHRYEVNFNYIQQLKDHGLDIV
EEEEECCCEEEECCCCEECCCCCCEEEEECCHHHHHHHCCEEEECHHHHHHHHHCCCEEE
GTCPEQGLCEIVEIKDHPWMIGVQFHPEFLSKLIKPHPLFVGFIEAALLHSRNKTYV
ECCCCCCCEEEEEECCCCEEEEEEECHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SFKCIFLTGGVVSSLGKGLTAASLALLLERQGLKVAMLKLDPYLNVDPGTMNPYEHGEV
CEEEEEEECHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCEE
YVTNDGIETDLDLGHYHRFSSVNLSRYSTATSGQIYARVIKKERDGLYLGSTVQVIPHIT
EEECCCCCCCCCCCHHHCCCCCCCHHCCCCCCCHHHHHHHHHCCCCEEECCHHHHHHHHH
NEIIEVILECARENHPDVLIVEIGGTVGDIESLPFLEAIRQFRYEHAEDCFSIHMTYVPY
HHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LQAAGEVKTKPTQHSVQSLRSIGIIPDAILCRSEAPLSSEVKKKISLFCNVPSTAVFNVV
HHHCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHHHHEEECCCCCCEEEEE
DVEHSIYEMPLMLSQEKISTFITEKLGLFTKKEDLSDWEMLVERLRHPLPNKIRLGLVGK
ECCHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEHHHHH
YVQHKDAYKSVFESITHAALSLNCSVELFPLDSDDPHFLETLELCDGCLVPGGFGSRGWE
HHHHHHHHHHHHHHHHHHHEEEECEEEEEECCCCCHHHHHHHHHHCCCCCCCCCCCCCCC
GKIIAAKLCRERGIPYFGICLGMQVLVVEYARHVLHLEHANSTEMDKDTPDPVICMLDWQ
CCHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCEEEEEECC
ASLIATGGTMRLGAYPCALSPGSKVYAMYGQPEIMERHRHRYEVNFNYIQQLKDHGLDIV
EEEEECCCEEEECCCCEECCCCCCEEEEECCHHHHHHHCCEEEECHHHHHHHHHCCCEEE
GTCPEQGLCEIVEIKDHPWMIGVQFHPEFLSKLIKPHPLFVGFIEAALLHSRNKTYV
ECCCCCCCEEEEEECCCCEEEEEEECHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA