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The map label for this gene is hemL1 [H]

Identifier: 57650539

GI number: 57650539

Start: 1744721

End: 1746007

Strand: Reverse

Name: hemL1 [H]

Synonym: SACOL1714

Alternate gene names: 57650539

Gene position: 1746007-1744721 (Counterclockwise)

Preceding gene: 57650540

Following gene: 57650538

Centisome position: 62.15

GC content: 36.44

Gene sequence:

>1287_bases
ATGAGATATACGAAATCAGAAGAAGCAATGAAGGTTGCTGAAACTTTAATGCCTGGTGGTGTAAATAGTCCAGTACGCGC
ATTTAAATCAGTAGATACACCAGCAATTTTTATGGATCACGGTAAAGGTTCAAAAATTTATGATATCGATGGTAACGAGT
ATATCGACTATGTACTAAGTTGGGGACCACTTATTTTAGGACATAGAGACCCTCAAGTTATTAGTCATTTACATGAAGCA
ATTGATAAAGGTACAAGTTTTGGTGCATCAACATTACTTGAAAATAAATTGGCGCAGCTCGTTATTGACCGAGTACCTTC
AATAGAAAAAGTGCGTATGGTGTCATCTGGTACAGAAGCTACATTGGATACTTTAAGATTAGCACGTGGTTATACTGGCA
GAAATAAAATTGTGAAATTTGAAGGTTGCTATCATGGTCATAGTGATTCGTTATTAATCAAAGCTGGTTCTGGGGTGGCA
ACATTAGGATTGCCGGATTCTCCTGGTGTGCCTGAAGGTATTGCTAAAAATACAATTACAGTTCCATACAATGATTTAGA
TGCACTTAAAATCGCTTTCGAAAAATTTGGAAACGATATTGCTGGTGTAATCGTAGAACCTGTTGCTGGTAATATGGGTG
TCGTACCGCCGATTGAAGGTTTTTTACAGGGATTAAGAGATATTACGACTGAATACGGCGCATTGCTAATTTTCGATGAA
GTAATGACTGGTTTCAGAGTCGGTTATCATTGTGCACAAGGTTACTTTGGTGTGACACCAGATTTAACTTGCTTAGGAAA
AGTTATCGGTGGAGGACTACCTGTAGGTGCATTTGGTGGTAAAAAAGAAATCATGGATCATATAGCACCATTAGGAAATA
TTTATCAAGCGGGTACGTTATCAGGAAATCCTCTTGCAATGACAAGTGGTTATGAAACGTTAAGCCAATTAACGCCAGAG
ACATATGAGTATTTTAATATGTTAGGCGATATACTTGAAGACGGTTTAAAACGTGTATTTGCTAAACACAATGTACCAAT
AACTGTAAATAGAGCAGGTTCAATGATTGGTTATTTCTTAAATGAAGGACCTGTAACTAATTTTGAACAAGCGAATAAAA
GTGATTTGAAATTATTTGCAGAAATGTATCGAGAAATGGCAAAAGAAGGTGTGTTTTTACCACCATCTCAATTTGAAGGT
ACATTCTTATCTACGGCACACACGAAAGAAGATATTGAAAAAACGATTCAAGCATTTGATACGGCTTTAAGTCGTATTGT
AAAATAA

Upstream 100 bases:

>100_bases
ATATGATTATTACGTATTTTGCAAAGGACATTTGTCGCTATTTAGATAAATAAGGTTTTATATTTATGATTTTCCATAAA
CTGTAGGAGGAATTTACTTT

Downstream 100 bases:

>100_bases
ATATACGGACAAATTGAGAGCCTGAACTTTGTTCAGGCTCTTTTTAAATGTATATAAGGCATGGGCGGCGACTTGATAGT
GAAAGTCCATATATGCTTTG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA 1; Glutamate-1-semialdehyde aminotransferase 1; GSA-AT 1 [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MRYTKSEEAMKVAETLMPGGVNSPVRAFKSVDTPAIFMDHGKGSKIYDIDGNEYIDYVLSWGPLILGHRDPQVISHLHEA
IDKGTSFGASTLLENKLAQLVIDRVPSIEKVRMVSSGTEATLDTLRLARGYTGRNKIVKFEGCYHGHSDSLLIKAGSGVA
TLGLPDSPGVPEGIAKNTITVPYNDLDALKIAFEKFGNDIAGVIVEPVAGNMGVVPPIEGFLQGLRDITTEYGALLIFDE
VMTGFRVGYHCAQGYFGVTPDLTCLGKVIGGGLPVGAFGGKKEIMDHIAPLGNIYQAGTLSGNPLAMTSGYETLSQLTPE
TYEYFNMLGDILEDGLKRVFAKHNVPITVNRAGSMIGYFLNEGPVTNFEQANKSDLKLFAEMYREMAKEGVFLPPSQFEG
TFLSTAHTKEDIEKTIQAFDTALSRIVK

Sequences:

>Translated_428_residues
MRYTKSEEAMKVAETLMPGGVNSPVRAFKSVDTPAIFMDHGKGSKIYDIDGNEYIDYVLSWGPLILGHRDPQVISHLHEA
IDKGTSFGASTLLENKLAQLVIDRVPSIEKVRMVSSGTEATLDTLRLARGYTGRNKIVKFEGCYHGHSDSLLIKAGSGVA
TLGLPDSPGVPEGIAKNTITVPYNDLDALKIAFEKFGNDIAGVIVEPVAGNMGVVPPIEGFLQGLRDITTEYGALLIFDE
VMTGFRVGYHCAQGYFGVTPDLTCLGKVIGGGLPVGAFGGKKEIMDHIAPLGNIYQAGTLSGNPLAMTSGYETLSQLTPE
TYEYFNMLGDILEDGLKRVFAKHNVPITVNRAGSMIGYFLNEGPVTNFEQANKSDLKLFAEMYREMAKEGVFLPPSQFEG
TFLSTAHTKEDIEKTIQAFDTALSRIVK
>Mature_428_residues
MRYTKSEEAMKVAETLMPGGVNSPVRAFKSVDTPAIFMDHGKGSKIYDIDGNEYIDYVLSWGPLILGHRDPQVISHLHEA
IDKGTSFGASTLLENKLAQLVIDRVPSIEKVRMVSSGTEATLDTLRLARGYTGRNKIVKFEGCYHGHSDSLLIKAGSGVA
TLGLPDSPGVPEGIAKNTITVPYNDLDALKIAFEKFGNDIAGVIVEPVAGNMGVVPPIEGFLQGLRDITTEYGALLIFDE
VMTGFRVGYHCAQGYFGVTPDLTCLGKVIGGGLPVGAFGGKKEIMDHIAPLGNIYQAGTLSGNPLAMTSGYETLSQLTPE
TYEYFNMLGDILEDGLKRVFAKHNVPITVNRAGSMIGYFLNEGPVTNFEQANKSDLKLFAEMYREMAKEGVFLPPSQFEG
TFLSTAHTKEDIEKTIQAFDTALSRIVK

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=318, Percent_Identity=32.0754716981132, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI284507298, Length=238, Percent_Identity=34.453781512605, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI13994255, Length=328, Percent_Identity=25.3048780487805, Blast_Score=88, Evalue=2e-17,
Organism=Homo sapiens, GI24119277, Length=357, Percent_Identity=27.1708683473389, Blast_Score=86, Evalue=5e-17,
Organism=Escherichia coli, GI1786349, Length=425, Percent_Identity=52.2352941176471, Blast_Score=462, Evalue=1e-131,
Organism=Escherichia coli, GI1789016, Length=378, Percent_Identity=31.2169312169312, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1788044, Length=344, Percent_Identity=32.2674418604651, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI145693181, Length=321, Percent_Identity=30.8411214953271, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1789759, Length=338, Percent_Identity=30.7692307692308, Blast_Score=131, Evalue=8e-32,
Organism=Escherichia coli, GI1787560, Length=352, Percent_Identity=29.8295454545455, Blast_Score=116, Evalue=3e-27,
Organism=Escherichia coli, GI1786991, Length=286, Percent_Identity=26.5734265734266, Blast_Score=76, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI25144271, Length=313, Percent_Identity=29.3929712460064, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71992977, Length=339, Percent_Identity=27.7286135693215, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25144274, Length=161, Percent_Identity=37.888198757764, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324432, Length=360, Percent_Identity=27.2222222222222, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6323470, Length=329, Percent_Identity=27.9635258358663, Blast_Score=87, Evalue=5e-18,
Organism=Drosophila melanogaster, GI21357415, Length=317, Percent_Identity=26.813880126183, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 46389; Mature: 46389

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYTKSEEAMKVAETLMPGGVNSPVRAFKSVDTPAIFMDHGKGSKIYDIDGNEYIDYVLS
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEECCCCCEEEECCCCHHHHHHHH
WGPLILGHRDPQVISHLHEAIDKGTSFGASTLLENKLAQLVIDRVPSIEKVRMVSSGTEA
CCCEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHH
TLDTLRLARGYTGRNKIVKFEGCYHGHSDSLLIKAGSGVATLGLPDSPGVPEGIAKNTIT
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCEEE
VPYNDLDALKIAFEKFGNDIAGVIVEPVAGNMGVVPPIEGFLQGLRDITTEYGALLIFDE
ECCCCHHHHHHHHHHHCCCEEHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VMTGFRVGYHCAQGYFGVTPDLTCLGKVIGGGLPVGAFGGKKEIMDHIAPLGNIYQAGTL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHCHHCCCCC
SGNPLAMTSGYETLSQLTPETYEYFNMLGDILEDGLKRVFAKHNVPITVNRAGSMIGYFL
CCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHH
NEGPVTNFEQANKSDLKLFAEMYREMAKEGVFLPPSQFEGTFLSTAHTKEDIEKTIQAFD
CCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
TALSRIVK
HHHHHHCC
>Mature Secondary Structure
MRYTKSEEAMKVAETLMPGGVNSPVRAFKSVDTPAIFMDHGKGSKIYDIDGNEYIDYVLS
CCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCCEEEEECCCCCEEEECCCCHHHHHHHH
WGPLILGHRDPQVISHLHEAIDKGTSFGASTLLENKLAQLVIDRVPSIEKVRMVSSGTEA
CCCEEECCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHH
TLDTLRLARGYTGRNKIVKFEGCYHGHSDSLLIKAGSGVATLGLPDSPGVPEGIAKNTIT
HHHHHHHHHCCCCCCCEEEEECCCCCCCCCEEEEECCCEEEECCCCCCCCCCCCCCCEEE
VPYNDLDALKIAFEKFGNDIAGVIVEPVAGNMGVVPPIEGFLQGLRDITTEYGALLIFDE
ECCCCHHHHHHHHHHHCCCEEHHEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
VMTGFRVGYHCAQGYFGVTPDLTCLGKVIGGGLPVGAFGGKKEIMDHIAPLGNIYQAGTL
HHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHCHHCHHCCCCC
SGNPLAMTSGYETLSQLTPETYEYFNMLGDILEDGLKRVFAKHNVPITVNRAGSMIGYFL
CCCCEEEECCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHH
NEGPVTNFEQANKSDLKLFAEMYREMAKEGVFLPPSQFEGTFLSTAHTKEDIEKTIQAFD
CCCCCCCHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHH
TALSRIVK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA