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The map label for this gene is msrA2 [H]

Identifier: 238024896

GI number: 238024896

Start: 1948953

End: 1949717

Strand: Direct

Name: msrA2 [H]

Synonym: bglu_2g15390

Alternate gene names: 238024896

Gene position: 1948953-1949717 (Clockwise)

Preceding gene: 238024895

Following gene: 238024899

Centisome position: 68.93

GC content: 72.55

Gene sequence:

>765_bases
ATGAAGCCGATTCGACACGATCTTGCCCCCTGCCCGCGCCGCCGCGCGTCGCGCGCCGGCCTGCTCATGCGCCTGGCCGG
CGGCGCCGCCGCGCTCGGCGCGCTCGCCGCGGTGCTGCTCGGCTGGCAGCCGGCCGCGCTGGCCGACGCGGCCAGGCCGC
TGCCCGCGCCCGTGCTCGACGAAACACCGGGCGCCACGCGCACCGAGACGGCCGTGTTCTCGGGCGGCTGCTTCTGGGGC
GTGCAGGGCGTGTTCGAGCACGTGGCCGGCGTCGAGCAGGTCGCCGCCGGCTACGCGGGCGGCGCGGCCTCGACGGCGCA
GTACGAGGCCGTCAGCGAGGGCGACACCGGCCACGCGGAATCGGTGCGGGTGGTCTACGATCCGAGCCGGATCACCTACG
GGCGGCTGCTGCAGATCTTCTTCTCGGTCGCGCACGATCCGACCGAACTGAACCGCCAGGGCCCCGACACCGGCACCCAG
TACCGCTCGGCGATCTTCCCCGTCGACGCGCAGCAGAAGGCGATCGCGCTCGCCTACATCCGGCAGTTGACCGACGCCCA
CGCGTTCCCGGCGCCGATCGTGACGAGCATCGAAGCCGGCCAGCGCTTCTATCCGGCCGAGGCCTACCATCAGGATTTCC
TGGTGCGCCACCCCGCCTACCCGTACATCGTGATCAACGACCTGCCGAAGGTGGCCGCGCTGAAGGCCGGCTACCCGAAG
CTGTACGTCGACACGCCGGTGCGGTACGCGCCGGACGGCAACTGA

Upstream 100 bases:

>100_bases
TTCTCGATCGAATTCCTCGACCCCGGCGTGCAGGCATTCGCGTTCACGTTCGGTTGAACCCGCATCATCCGATCTCCGAC
TTGCGCAAGGAACCCACATC

Downstream 100 bases:

>100_bases
GGCGCGCGGCGGCCGCGCCCGTCGCGCGATCGATCGGCCCCCGCCGCCGCGGCACGCCGCGTTGCGCGCGCCGGCGGTTC
GAGGGCGCGGCGCCTGCCGT

Product: peptide methionine sulfoxide reductase

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 2; Peptide-methionine (S)-S-oxide reductase 2; Peptide Met(O) reductase 2 [H]

Number of amino acids: Translated: 254; Mature: 254

Protein sequence:

>254_residues
MKPIRHDLAPCPRRRASRAGLLMRLAGGAAALGALAAVLLGWQPAALADAARPLPAPVLDETPGATRTETAVFSGGCFWG
VQGVFEHVAGVEQVAAGYAGGAASTAQYEAVSEGDTGHAESVRVVYDPSRITYGRLLQIFFSVAHDPTELNRQGPDTGTQ
YRSAIFPVDAQQKAIALAYIRQLTDAHAFPAPIVTSIEAGQRFYPAEAYHQDFLVRHPAYPYIVINDLPKVAALKAGYPK
LYVDTPVRYAPDGN

Sequences:

>Translated_254_residues
MKPIRHDLAPCPRRRASRAGLLMRLAGGAAALGALAAVLLGWQPAALADAARPLPAPVLDETPGATRTETAVFSGGCFWG
VQGVFEHVAGVEQVAAGYAGGAASTAQYEAVSEGDTGHAESVRVVYDPSRITYGRLLQIFFSVAHDPTELNRQGPDTGTQ
YRSAIFPVDAQQKAIALAYIRQLTDAHAFPAPIVTSIEAGQRFYPAEAYHQDFLVRHPAYPYIVINDLPKVAALKAGYPK
LYVDTPVRYAPDGN
>Mature_254_residues
MKPIRHDLAPCPRRRASRAGLLMRLAGGAAALGALAAVLLGWQPAALADAARPLPAPVLDETPGATRTETAVFSGGCFWG
VQGVFEHVAGVEQVAAGYAGGAASTAQYEAVSEGDTGHAESVRVVYDPSRITYGRLLQIFFSVAHDPTELNRQGPDTGTQ
YRSAIFPVDAQQKAIALAYIRQLTDAHAFPAPIVTSIEAGQRFYPAEAYHQDFLVRHPAYPYIVINDLPKVAALKAGYPK
LYVDTPVRYAPDGN

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=155, Percent_Identity=47.0967741935484, Blast_Score=135, Evalue=3e-32,
Organism=Homo sapiens, GI208609995, Length=155, Percent_Identity=47.0967741935484, Blast_Score=134, Evalue=5e-32,
Organism=Homo sapiens, GI208609993, Length=108, Percent_Identity=50, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1790665, Length=187, Percent_Identity=42.7807486631016, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17533973, Length=160, Percent_Identity=32.5, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6320881, Length=161, Percent_Identity=37.2670807453416, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24664627, Length=150, Percent_Identity=35.3333333333333, Blast_Score=84, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24664631, Length=150, Percent_Identity=34.6666666666667, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45553131, Length=144, Percent_Identity=34.7222222222222, Blast_Score=78, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 27126; Mature: 27126

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPIRHDLAPCPRRRASRAGLLMRLAGGAAALGALAAVLLGWQPAALADAARPLPAPVLD
CCCHHHHCCCCCHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC
ETPGATRTETAVFSGGCFWGVQGVFEHVAGVEQVAAGYAGGAASTAQYEAVSEGDTGHAE
CCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCC
SVRVVYDPSRITYGRLLQIFFSVAHDPTELNRQGPDTGTQYRSAIFPVDAQQKAIALAYI
CEEEEECCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHEECCCCCHHHHHHHHHH
RQLTDAHAFPAPIVTSIEAGQRFYPAEAYHQDFLVRHPAYPYIVINDLPKVAALKAGYPK
HHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHCCCCE
LYVDTPVRYAPDGN
EEEECCEEECCCCC
>Mature Secondary Structure
MKPIRHDLAPCPRRRASRAGLLMRLAGGAAALGALAAVLLGWQPAALADAARPLPAPVLD
CCCHHHHCCCCCHHHHHHHCCHHHCCCCHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCC
ETPGATRTETAVFSGGCFWGVQGVFEHVAGVEQVAAGYAGGAASTAQYEAVSEGDTGHAE
CCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCC
SVRVVYDPSRITYGRLLQIFFSVAHDPTELNRQGPDTGTQYRSAIFPVDAQQKAIALAYI
CEEEEECCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCHHHHHEECCCCCHHHHHHHHHH
RQLTDAHAFPAPIVTSIEAGQRFYPAEAYHQDFLVRHPAYPYIVINDLPKVAALKAGYPK
HHHHHCCCCCCHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCEEEECCCCHHHHHHCCCCE
LYVDTPVRYAPDGN
EEEECCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]