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The map label for this gene is ilvA [H]

Identifier: 21241153

GI number: 21241153

Start: 450882

End: 451841

Strand: Direct

Name: ilvA [H]

Synonym: XAC0379

Alternate gene names: 21241153

Gene position: 450882-451841 (Clockwise)

Preceding gene: 21241149

Following gene: 21241154

Centisome position: 8.71

GC content: 70.52

Gene sequence:

>960_bases
ATGATCGAGACGGTCCCCCTTGCCCATTCCGACGTCCTGCAAGCCGCTGCGCGGATCGCGCCGCACTGCGCGCCGACACC
GTTGCTGACATCGCACAGCCTAGATGCGCTCAGCAGTGCGCAGTTGTTCTTCAAGGCCGAGCATCTGCAGCGCAGTGGCG
CATTCAAGTTCCGGGGTGCCTGCAATGCCGTATGGTCGCTGCCGGACGCGCTGGCTGCGCGCGGTGTGGTCACGCATTCC
TCCGGCAATCACGGCGCGGCGCTGGCGCTTGCCGCACGCACGCGCGGCATCGGCTGCCACGTGGTGGTGCCCGAGGGCGC
GGTGGCGGCCAAGCTCGCCAATATCTCCCGGAACGGCGCCACGTTGTGGCGTTGCGCGCCGACCATCGCGGCGCGGGAAC
AGATGTGCGCTGAGGTGCAGGCCGGCAGCGGCGCCACGCTGGTGCACCCGTATACCGATCGTGCAGTGATCGCCGGGCAG
GGCACCGCCACGCTGGAGTTGCTGCACCAGAGCGGCGTGCTGGATGTGCTGGTGGCGCCTGTCGGCGGTGGTGGGCTGGC
GGCCGGTGCCGCACTGGCGCTGCAGGCTTCGCCGGACTGCGAGCTGGTGCTGGCCGAGCCTGCCGGCGCAGCCGACACCG
CGCGTTCGCTGGCGGCCGGGCAGCGGCTGGTCGATTTCGTGCCGGACACCATTTGCGACGGCCTGCGCGGCACCTTGGGC
GCGCCCAACTTCGCCGTGCTGCAGCGCGCCGGTGCGCAGGTGATCACGGTGGACGATGCCGCGGTGGTGCAGGCCATGCG
GCTGGTCTGGCAGTTGCTCAAGCAAGTGGTCGAGCCGTCTTCGGCGATCGCCCTGGCTGCGGTCCTGGCCCAGCCGGCAC
GGTTTGCCGGGCGGCGAGTGGGGCTGATCCTGTCCGGCGGCAATGTCGATCTGGACGCCTTGCCTTGGGTCGCGGCGTGA

Upstream 100 bases:

>100_bases
CCTTAATTGTGCGGCATTGCGACGCTTTGTCATCGATCCAGCATGCGCGGCGGTAGGCGTGCGACCCGTGAAGAGGAGGC
GATACGTTAATCTTGCAGGC

Downstream 100 bases:

>100_bases
GCAGGCGCTCACGCGGGCTCGGCCTGTGGGGCTGGGGCTGGCGGTTGTGCATGCTGGCGCTGATCTGGCTGGTGGCCGTG
GCAGGCTGGATCGTGTGGAT

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 319; Mature: 319

Protein sequence:

>319_residues
MIETVPLAHSDVLQAAARIAPHCAPTPLLTSHSLDALSSAQLFFKAEHLQRSGAFKFRGACNAVWSLPDALAARGVVTHS
SGNHGAALALAARTRGIGCHVVVPEGAVAAKLANISRNGATLWRCAPTIAAREQMCAEVQAGSGATLVHPYTDRAVIAGQ
GTATLELLHQSGVLDVLVAPVGGGGLAAGAALALQASPDCELVLAEPAGAADTARSLAAGQRLVDFVPDTICDGLRGTLG
APNFAVLQRAGAQVITVDDAAVVQAMRLVWQLLKQVVEPSSAIALAAVLAQPARFAGRRVGLILSGGNVDLDALPWVAA

Sequences:

>Translated_319_residues
MIETVPLAHSDVLQAAARIAPHCAPTPLLTSHSLDALSSAQLFFKAEHLQRSGAFKFRGACNAVWSLPDALAARGVVTHS
SGNHGAALALAARTRGIGCHVVVPEGAVAAKLANISRNGATLWRCAPTIAAREQMCAEVQAGSGATLVHPYTDRAVIAGQ
GTATLELLHQSGVLDVLVAPVGGGGLAAGAALALQASPDCELVLAEPAGAADTARSLAAGQRLVDFVPDTICDGLRGTLG
APNFAVLQRAGAQVITVDDAAVVQAMRLVWQLLKQVVEPSSAIALAAVLAQPARFAGRRVGLILSGGNVDLDALPWVAA
>Mature_319_residues
MIETVPLAHSDVLQAAARIAPHCAPTPLLTSHSLDALSSAQLFFKAEHLQRSGAFKFRGACNAVWSLPDALAARGVVTHS
SGNHGAALALAARTRGIGCHVVVPEGAVAAKLANISRNGATLWRCAPTIAAREQMCAEVQAGSGATLVHPYTDRAVIAGQ
GTATLELLHQSGVLDVLVAPVGGGGLAAGAALALQASPDCELVLAEPAGAADTARSLAAGQRLVDFVPDTICDGLRGTLG
APNFAVLQRAGAQVITVDDAAVVQAMRLVWQLLKQVVEPSSAIALAAVLAQPARFAGRRVGLILSGGNVDLDALPWVAA

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=320, Percent_Identity=39.6875, Blast_Score=222, Evalue=4e-58,
Organism=Escherichia coli, GI1789505, Length=318, Percent_Identity=29.559748427673, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1790207, Length=299, Percent_Identity=32.4414715719064, Blast_Score=99, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17508781, Length=321, Percent_Identity=35.5140186915888, Blast_Score=179, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI71991565, Length=311, Percent_Identity=31.5112540192926, Blast_Score=111, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI17537387, Length=315, Percent_Identity=31.4285714285714, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6322631, Length=305, Percent_Identity=40.9836065573771, Blast_Score=203, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320930, Length=291, Percent_Identity=29.8969072164948, Blast_Score=100, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6319788, Length=283, Percent_Identity=27.208480565371, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21355833, Length=312, Percent_Identity=29.4871794871795, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 32454; Mature: 32454

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIETVPLAHSDVLQAAARIAPHCAPTPLLTSHSLDALSSAQLFFKAEHLQRSGAFKFRGA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCC
CNAVWSLPDALAARGVVTHSSGNHGAALALAARTRGIGCHVVVPEGAVAAKLANISRNGA
CHHHHCCHHHHHHCCEEEECCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHCCCCCC
TLWRCAPTIAAREQMCAEVQAGSGATLVHPYTDRAVIAGQGTATLELLHQSGVLDVLVAP
EEEEECHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCHHHHHHHHCCCEEEEEEC
VGGGGLAAGAALALQASPDCELVLAEPAGAADTARSLAAGQRLVDFVPDTICDGLRGTLG
CCCCCHHHCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCC
APNFAVLQRAGAQVITVDDAAVVQAMRLVWQLLKQVVEPSSAIALAAVLAQPARFAGRRV
CCCHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEE
GLILSGGNVDLDALPWVAA
EEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MIETVPLAHSDVLQAAARIAPHCAPTPLLTSHSLDALSSAQLFFKAEHLQRSGAFKFRGA
CCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEECCC
CNAVWSLPDALAARGVVTHSSGNHGAALALAARTRGIGCHVVVPEGAVAAKLANISRNGA
CHHHHCCHHHHHHCCEEEECCCCCCEEEEEEECCCCCEEEEECCCCHHHHHHHHCCCCCC
TLWRCAPTIAAREQMCAEVQAGSGATLVHPYTDRAVIAGQGTATLELLHQSGVLDVLVAP
EEEEECHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEECCCCHHHHHHHHCCCEEEEEEC
VGGGGLAAGAALALQASPDCELVLAEPAGAADTARSLAAGQRLVDFVPDTICDGLRGTLG
CCCCCHHHCEEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHHHHHCCCCC
APNFAVLQRAGAQVITVDDAAVVQAMRLVWQLLKQVVEPSSAIALAAVLAQPARFAGRRV
CCCHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCEE
GLILSGGNVDLDALPWVAA
EEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA