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The map label for this gene is lip2 [H]

Identifier: 21241149

GI number: 21241149

Start: 445592

End: 446560

Strand: Direct

Name: lip2 [H]

Synonym: XAC0375

Alternate gene names: 21241149

Gene position: 445592-446560 (Clockwise)

Preceding gene: 21241148

Following gene: 21241153

Centisome position: 8.61

GC content: 68.21

Gene sequence:

>969_bases
ATGTCGTTTGATCCTGATGTCGTGCGCCTGTTCGCCCAGCTTCAAGAGGCGGCGCAGCCGCCCATGGACACCCTGCCGAT
CGAAGGCGCGCGCGCGATGATGCGCGCGGTGGGCGCGCAGTTCGGTTTCCAGCGCCTCGAGATGGCCGAGGTACGCGATC
TGCAGGCCGATGCCGCTACCGGTGCAGTGCCTTTGCGCGTGTATCGCCCTACGGGGCTCGCAACCGGCCCAGCCCCGACC
TGCCTATACGTGCACGGCGGCGGCGGTCTGGTCGGCGATCTGGAGTCCCATGACGATGTGTGTCGGCAATTGGCAGCGCG
CGCTGGCTGTCAGGTGCTGGCGATCCATTACCGTCTGGCCCCCGAGCACCCGGCGCCGGCCGGTGTGGAAGATGTCATCG
CGACCTTGCATTGGCTGGTTGCGCACCCGGACACGGTCGGCGCCGATGTGCAGCGCCTTGCCGTCTGCGGCGACAGTATC
GGCGGCGCCATGGCCGCGGTTGCCGCACTGGCCGCGCGCGATGCCGGAATCGCCTTGCGTTGCCAGCTGCTGGTCTATCC
GCTGACCGACGCGCGCCAGGACAGCGGCTTGTATCCATCGCGCTCGCTCAACGCCGGCCTGCCGCCGTTGACTGCGGCAG
CGGTGGAATTCTTCAACCGCCATCTGCTGCCGGATATGGCGGTGGCCAACGACTGGCGTGTCTCGCCGATGCTGGCGCCG
GATGTCGCCGGCGTTGCGCCTGCGCTGGTCGTGGTCTGCGACCGCGACATGCTCTACGACGAAGGCCGCGCCTATGCCGA
GCGCCTGCGTGCGGCAGGAGTGGAAGTCACCCTGCATAGCTTCCCGGGCATGATCCACGGCTTCATCAACATGGGCAGCG
TCTTGCGTGCCGCCGGTGAAACGCTGGACCTGGCGGCACTGACGCTACGCCAGCGCCTGCTGCCGGCGATCGAACGCAGG
GCCGCCTGA

Upstream 100 bases:

>100_bases
CCGGCCAGCAGGTCAATCCGTTAACACTAGTTAACGATGTGAATAGTGACGATTCATAACAATCTGGCAAGCTCGACAAC
TGCTTATCGGAGAGTTCGTC

Downstream 100 bases:

>100_bases
CGACCTGCGGCAGCCGTGCCGAGGCTCGCGCTGCCGCAACCCTGGCGGTATCGCTGCAGCTTCGGTGCGTGTGGCACCGC
ATGCCTGTGCGCCCTGCGAC

Product: lipase

Products: NA

Alternate protein names: Triacylglycerol lipase [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MSFDPDVVRLFAQLQEAAQPPMDTLPIEGARAMMRAVGAQFGFQRLEMAEVRDLQADAATGAVPLRVYRPTGLATGPAPT
CLYVHGGGGLVGDLESHDDVCRQLAARAGCQVLAIHYRLAPEHPAPAGVEDVIATLHWLVAHPDTVGADVQRLAVCGDSI
GGAMAAVAALAARDAGIALRCQLLVYPLTDARQDSGLYPSRSLNAGLPPLTAAAVEFFNRHLLPDMAVANDWRVSPMLAP
DVAGVAPALVVVCDRDMLYDEGRAYAERLRAAGVEVTLHSFPGMIHGFINMGSVLRAAGETLDLAALTLRQRLLPAIERR
AA

Sequences:

>Translated_322_residues
MSFDPDVVRLFAQLQEAAQPPMDTLPIEGARAMMRAVGAQFGFQRLEMAEVRDLQADAATGAVPLRVYRPTGLATGPAPT
CLYVHGGGGLVGDLESHDDVCRQLAARAGCQVLAIHYRLAPEHPAPAGVEDVIATLHWLVAHPDTVGADVQRLAVCGDSI
GGAMAAVAALAARDAGIALRCQLLVYPLTDARQDSGLYPSRSLNAGLPPLTAAAVEFFNRHLLPDMAVANDWRVSPMLAP
DVAGVAPALVVVCDRDMLYDEGRAYAERLRAAGVEVTLHSFPGMIHGFINMGSVLRAAGETLDLAALTLRQRLLPAIERR
AA
>Mature_321_residues
SFDPDVVRLFAQLQEAAQPPMDTLPIEGARAMMRAVGAQFGFQRLEMAEVRDLQADAATGAVPLRVYRPTGLATGPAPTC
LYVHGGGGLVGDLESHDDVCRQLAARAGCQVLAIHYRLAPEHPAPAGVEDVIATLHWLVAHPDTVGADVQRLAVCGDSIG
GAMAAVAALAARDAGIALRCQLLVYPLTDARQDSGLYPSRSLNAGLPPLTAAAVEFFNRHLLPDMAVANDWRVSPMLAPD
VAGVAPALVVVCDRDMLYDEGRAYAERLRAAGVEVTLHSFPGMIHGFINMGSVLRAAGETLDLAALTLRQRLLPAIERRA
A

Specific function: Has An Esterase Activity. Triacetyl Glycerol (Triacetin) Is A Substrate Of The Enzyme. [C]

COG id: COG0657

COG function: function code I; Esterase/lipase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'GDXG' lipolytic enzyme family [H]

Homologues:

Organism=Homo sapiens, GI157041239, Length=324, Percent_Identity=28.0864197530864, Blast_Score=104, Evalue=9e-23,
Organism=Homo sapiens, GI68299767, Length=293, Percent_Identity=27.3037542662116, Blast_Score=92, Evalue=5e-19,
Organism=Homo sapiens, GI61966717, Length=181, Percent_Identity=32.0441988950276, Blast_Score=89, Evalue=7e-18,
Organism=Homo sapiens, GI157041237, Length=286, Percent_Identity=27.6223776223776, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786682, Length=263, Percent_Identity=28.1368821292776, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17540028, Length=327, Percent_Identity=25.3822629969419, Blast_Score=112, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17567059, Length=270, Percent_Identity=29.6296296296296, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI72001146, Length=317, Percent_Identity=23.9747634069401, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71996133, Length=139, Percent_Identity=33.8129496402878, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI115533410, Length=97, Percent_Identity=32.9896907216495, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI115533412, Length=97, Percent_Identity=32.9896907216495, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656084, Length=128, Percent_Identity=30.46875, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24656076, Length=128, Percent_Identity=30.46875, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI20130169, Length=128, Percent_Identity=30.46875, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013094
- InterPro:   IPR002168 [H]

Pfam domain/function: PF07859 Abhydrolase_3 [H]

EC number: =3.1.1.3 [H]

Molecular weight: Translated: 34120; Mature: 33989

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFDPDVVRLFAQLQEAAQPPMDTLPIEGARAMMRAVGAQFGFQRLEMAEVRDLQADAAT
CCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GAVPLRVYRPTGLATGPAPTCLYVHGGGGLVGDLESHDDVCRQLAARAGCQVLAIHYRLA
CCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEC
PEHPAPAGVEDVIATLHWLVAHPDTVGADVQRLAVCGDSIGGAMAAVAALAARDAGIALR
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEE
CQLLVYPLTDARQDSGLYPSRSLNAGLPPLTAAAVEFFNRHLLPDMAVANDWRVSPMLAP
EEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCC
DVAGVAPALVVVCDRDMLYDEGRAYAERLRAAGVEVTLHSFPGMIHGFINMGSVLRAAGE
CHHHHHHHEEEEECCHHHHHHHHHHHHHHHHCCCEEEHHHCCHHHHHHHHHHHHHHHCCC
TLDLAALTLRQRLLPAIERRAA
HHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFDPDVVRLFAQLQEAAQPPMDTLPIEGARAMMRAVGAQFGFQRLEMAEVRDLQADAAT
CCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
GAVPLRVYRPTGLATGPAPTCLYVHGGGGLVGDLESHDDVCRQLAARAGCQVLAIHYRLA
CCEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEC
PEHPAPAGVEDVIATLHWLVAHPDTVGADVQRLAVCGDSIGGAMAAVAALAARDAGIALR
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEE
CQLLVYPLTDARQDSGLYPSRSLNAGLPPLTAAAVEFFNRHLLPDMAVANDWRVSPMLAP
EEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCC
DVAGVAPALVVVCDRDMLYDEGRAYAERLRAAGVEVTLHSFPGMIHGFINMGSVLRAAGE
CHHHHHHHEEEEECCHHHHHHHHHHHHHHHHCCCEEEHHHCCHHHHHHHHHHHHHHHCCC
TLDLAALTLRQRLLPAIERRAA
HHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1907455 [H]