Definition Akkermansia muciniphila ATCC BAA-835, complete genome.
Accession NC_010655
Length 2,664,102

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The map label for this gene is rsbU [H]

Identifier: 187736006

GI number: 187736006

Start: 1810066

End: 1811703

Strand: Reverse

Name: rsbU [H]

Synonym: Amuc_1516

Alternate gene names: 187736006

Gene position: 1811703-1810066 (Counterclockwise)

Preceding gene: 187736007

Following gene: 187736000

Centisome position: 68.0

GC content: 56.17

Gene sequence:

>1638_bases
ATGCCGCCCTCACGCAACAGACATTCCGCCCAGAGAGTTTTTACCTGGGACAAAATCAAAATGGCCCTGGCGGCGGCGGA
AGAAGGATTTTATATCTGGAATATTAAAACGGGCGTCATTCATTACACGGACCGCTGCCTGACCATGATGGGGGCCAGCC
GCAAGGAGAAAGCCCCCAATATCTTCACCCAGCCGGAGCTTACCATACACGAGGAAGACCAGGCTTTTTTTTCCCAGGAA
GTGCGCCGTTATCTGGACGGCCACTCCCATGTGCCCATGCGCATTGAAATCCGGATGAAGAAGCTGAACTCCAAAAGCTG
GAGCTGGGTCCGCGTCAACGGACTCGCCCGCAGGGACAAGCAGCGCCGGCCCGTTATGCTGGTGGGCGTATGGGTCAATA
TTACCCGGCGGAAAACAGCGGAACTGCGTGCTGCGGAGGACAGGGACCTGTTTCATACCCTGATTGAACACATTCCCGAC
AGTATCTATTTCAAGAACCGGGAATCACGTTTCGTCCTGGCGAATACCGCCACAGCCAATAAGCTGGGCGTACCGACGCC
GGCAGACCTGACCGGACGCACGGACGATTACTTTTTTGACCAAACGATGTCCGATATTTCCCGCAAGGAGGAAATGGACA
TCATGGTTACCGGACGCCCCATCCGCGCCCGCCTTCATCATGAGACATGGCTCCACAAGGATGATTCCTGGAGCCAGATC
AGCAAGTTCCCGTGGTACGGACGCAACGGAGAGCTAAAGGGAATTGTAGGTATTTCCAGTGATGTCACCAAACTGGTGAA
GACTGAAATCAAGGCCACGGAAACGGCCCGCATCCTGGAGGAACGCAACAGAACTCTGGAAAAGGAAATAGATTTGGCCA
GGGAAATCCAGTTCGCCCTGCTTCCCTACGAAATTCCCTCCCGCTCCCATACGGAACACGGCCTGACCCGCCATGCGGAT
TTTCACCATATTTTCACTCCTTCGGAGGGGGTTGCAGGAGACTGGTTCGATGCTTTTCCCGTAGGCAGTTCCGGCGTCGG
CGCCATTGTCTGCGACGTGATGGGCCACGGCATCCGCGCCGCCCTGATCGCCTCCATGCTCCGCGGCCTGATGGAACAGT
TGTCCCACCTGGCGGATAACCCGGCGGCTTTCCTTACTTCCCTCAACCACCAGCTCGCCAAAATCCTGCAACGGGCGAAC
ACCACCATGTTTGCCTCTGCCGTTTATATTTACCTGGATCTGGAAACCGGGGTCATGACGGCTTCTACAGCCGGGCATCC
GCATCCCATCATTATGGGACCGGACGGAGTCGCCCGCAAAATGCCGCTGCCCAAAGGAATCGCCCTGGGGCTGCTGGATG
ACGCTACGTACCATAATGCCCAGTTTTCGCTCCTGGCGGGGTCCCGCATCCTGATGTACACGGACGGCCTGACGGAAGCA
GCCAACCAGGACGGGGAAGAAATGGGCGTGGAAAGGCTGATTGACTATTTCAATAATTCCTCCCCCCACAGCACCAAGGA
TTTTGTCCATCAGGCCCTTACCTGCGTAGCCAAATTTACCGGCTGCACCAATCAGGCCGACGATATCTGCATGCTGGGCA
TCAGCTATTCCGAACACGAGGCAGAAACGGACGGCTAA

Upstream 100 bases:

>100_bases
TCATACGCGTTCCCCCGGCCAGGCCTCCTTTCAGAAAGGATTCCTTTATTTTGCCTCTTGCCAAGACAGCGGTTTTATCG
TTAGATTAAGGGCAACTGCA

Downstream 100 bases:

>100_bases
CAGCCGGTTCCTGCTCCTGACGTTTCCCAAACCTGCTTCCTCTTCCCTGGCCGGCTGCATCCCGGAATTATCCGCGGGGG
GGAAACCCTACATGCACCCC

Product: PAS/PAC sensor protein

Products: NA

Alternate protein names: Sigma factor sigB regulation protein rsbU [H]

Number of amino acids: Translated: 545; Mature: 544

Protein sequence:

>545_residues
MPPSRNRHSAQRVFTWDKIKMALAAAEEGFYIWNIKTGVIHYTDRCLTMMGASRKEKAPNIFTQPELTIHEEDQAFFSQE
VRRYLDGHSHVPMRIEIRMKKLNSKSWSWVRVNGLARRDKQRRPVMLVGVWVNITRRKTAELRAAEDRDLFHTLIEHIPD
SIYFKNRESRFVLANTATANKLGVPTPADLTGRTDDYFFDQTMSDISRKEEMDIMVTGRPIRARLHHETWLHKDDSWSQI
SKFPWYGRNGELKGIVGISSDVTKLVKTEIKATETARILEERNRTLEKEIDLAREIQFALLPYEIPSRSHTEHGLTRHAD
FHHIFTPSEGVAGDWFDAFPVGSSGVGAIVCDVMGHGIRAALIASMLRGLMEQLSHLADNPAAFLTSLNHQLAKILQRAN
TTMFASAVYIYLDLETGVMTASTAGHPHPIIMGPDGVARKMPLPKGIALGLLDDATYHNAQFSLLAGSRILMYTDGLTEA
ANQDGEEMGVERLIDYFNNSSPHSTKDFVHQALTCVAKFTGCTNQADDICMLGISYSEHEAETDG

Sequences:

>Translated_545_residues
MPPSRNRHSAQRVFTWDKIKMALAAAEEGFYIWNIKTGVIHYTDRCLTMMGASRKEKAPNIFTQPELTIHEEDQAFFSQE
VRRYLDGHSHVPMRIEIRMKKLNSKSWSWVRVNGLARRDKQRRPVMLVGVWVNITRRKTAELRAAEDRDLFHTLIEHIPD
SIYFKNRESRFVLANTATANKLGVPTPADLTGRTDDYFFDQTMSDISRKEEMDIMVTGRPIRARLHHETWLHKDDSWSQI
SKFPWYGRNGELKGIVGISSDVTKLVKTEIKATETARILEERNRTLEKEIDLAREIQFALLPYEIPSRSHTEHGLTRHAD
FHHIFTPSEGVAGDWFDAFPVGSSGVGAIVCDVMGHGIRAALIASMLRGLMEQLSHLADNPAAFLTSLNHQLAKILQRAN
TTMFASAVYIYLDLETGVMTASTAGHPHPIIMGPDGVARKMPLPKGIALGLLDDATYHNAQFSLLAGSRILMYTDGLTEA
ANQDGEEMGVERLIDYFNNSSPHSTKDFVHQALTCVAKFTGCTNQADDICMLGISYSEHEAETDG
>Mature_544_residues
PPSRNRHSAQRVFTWDKIKMALAAAEEGFYIWNIKTGVIHYTDRCLTMMGASRKEKAPNIFTQPELTIHEEDQAFFSQEV
RRYLDGHSHVPMRIEIRMKKLNSKSWSWVRVNGLARRDKQRRPVMLVGVWVNITRRKTAELRAAEDRDLFHTLIEHIPDS
IYFKNRESRFVLANTATANKLGVPTPADLTGRTDDYFFDQTMSDISRKEEMDIMVTGRPIRARLHHETWLHKDDSWSQIS
KFPWYGRNGELKGIVGISSDVTKLVKTEIKATETARILEERNRTLEKEIDLAREIQFALLPYEIPSRSHTEHGLTRHADF
HHIFTPSEGVAGDWFDAFPVGSSGVGAIVCDVMGHGIRAALIASMLRGLMEQLSHLADNPAAFLTSLNHQLAKILQRANT
TMFASAVYIYLDLETGVMTASTAGHPHPIIMGPDGVARKMPLPKGIALGLLDDATYHNAQFSLLAGSRILMYTDGLTEAA
NQDGEEMGVERLIDYFNNSSPHSTKDFVHQALTCVAKFTGCTNQADDICMLGISYSEHEAETDG

Specific function: Positive regulator of sigma-B activity. Dephosphorylates rsbV in response to environmental stress conveyed from the rsbXST module [H]

COG id: COG2208

COG function: function code TK; Serine phosphatase RsbU, regulator of sigma subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PP2C-like domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017944
- InterPro:   IPR001932
- InterPro:   IPR014787
- InterPro:   IPR010822
- ProDom:   PD685490 [H]

Pfam domain/function: PF08673 RsbU_N; PF07228 SpoIIE [H]

EC number: =3.1.3.3 [H]

Molecular weight: Translated: 61438; Mature: 61306

Theoretical pI: Translated: 6.97; Mature: 6.97

Prosite motif: PS50113 PAC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPSRNRHSAQRVFTWDKIKMALAAAEEGFYIWNIKTGVIHYTDRCLTMMGASRKEKAPN
CCCCCCCCCHHHEEEHHHHHHHHHHHCCCEEEEEEECCEEEHHHHHHHHHCCCCHHCCCC
IFTQPELTIHEEDQAFFSQEVRRYLDGHSHVPMRIEIRMKKLNSKSWSWVRVNGLARRDK
CCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCEEEECCHHHHHC
QRRPVMLVGVWVNITRRKTAELRAAEDRDLFHTLIEHIPDSIYFKNRESRFVLANTATAN
CCCCEEEEEEEEEECCHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCCCEEEEEECCCCC
KLGVPTPADLTGRTDDYFFDQTMSDISRKEEMDIMVTGRPIRARLHHETWLHKDDSWSQI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCCHHHH
SKFPWYGRNGELKGIVGISSDVTKLVKTEIKATETARILEERNRTLEKEIDLAREIQFAL
HCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
LPYEIPSRSHTEHGLTRHADFHHIFTPSEGVAGDWFDAFPVGSSGVGAIVCDVMGHGIRA
ECEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHH
ALIASMLRGLMEQLSHLADNPAAFLTSLNHQLAKILQRANTTMFASAVYIYLDLETGVMT
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCEEE
ASTAGHPHPIIMGPDGVARKMPLPKGIALGLLDDATYHNAQFSLLAGSRILMYTDGLTEA
ECCCCCCCCEEECCCCCHHCCCCCCCCEEEEECCCCCCCCEEEEEECCEEEEEECCCHHH
ANQDGEEMGVERLIDYFNNSSPHSTKDFVHQALTCVAKFTGCTNQADDICMLGISYSEHE
HCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHCC
AETDG
CCCCC
>Mature Secondary Structure 
PPSRNRHSAQRVFTWDKIKMALAAAEEGFYIWNIKTGVIHYTDRCLTMMGASRKEKAPN
CCCCCCCCHHHEEEHHHHHHHHHHHCCCEEEEEEECCEEEHHHHHHHHHCCCCHHCCCC
IFTQPELTIHEEDQAFFSQEVRRYLDGHSHVPMRIEIRMKKLNSKSWSWVRVNGLARRDK
CCCCCCEEEECCHHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCCCEEEECCHHHHHC
QRRPVMLVGVWVNITRRKTAELRAAEDRDLFHTLIEHIPDSIYFKNRESRFVLANTATAN
CCCCEEEEEEEEEECCHHHHHHHCCCCHHHHHHHHHHCCCCEEEECCCCEEEEEECCCCC
KLGVPTPADLTGRTDDYFFDQTMSDISRKEEMDIMVTGRPIRARLHHETWLHKDDSWSQI
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHCCCCCCHHHH
SKFPWYGRNGELKGIVGISSDVTKLVKTEIKATETARILEERNRTLEKEIDLAREIQFAL
HCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEE
LPYEIPSRSHTEHGLTRHADFHHIFTPSEGVAGDWFDAFPVGSSGVGAIVCDVMGHGIRA
ECEECCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHH
ALIASMLRGLMEQLSHLADNPAAFLTSLNHQLAKILQRANTTMFASAVYIYLDLETGVMT
HHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEECCCEEE
ASTAGHPHPIIMGPDGVARKMPLPKGIALGLLDDATYHNAQFSLLAGSRILMYTDGLTEA
ECCCCCCCCEEECCCCCHHCCCCCCCCEEEEECCCCCCCCEEEEEECCEEEEEECCCHHH
ANQDGEEMGVERLIDYFNNSSPHSTKDFVHQALTCVAKFTGCTNQADDICMLGISYSEHE
HCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHCC
AETDG
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8002610; 8002609; 9384377; 8824586; 9786195; 12499568 [H]