Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
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Accession | NC_010655 |
Length | 2,664,102 |
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The map label for this gene is mdh
Identifier: 187735927
GI number: 187735927
Start: 1722304
End: 1723293
Strand: Direct
Name: mdh
Synonym: Amuc_1436
Alternate gene names: 187735927
Gene position: 1722304-1723293 (Clockwise)
Preceding gene: 187735925
Following gene: 187735928
Centisome position: 64.65
GC content: 58.38
Gene sequence:
>990_bases ATGAAAACACCTATCACCGTTACCGTTACAGGAGCCGCCGGCCAAATTGCCTATTCCCTTCTGTTCCGTATTGCCTCCGG CAGCATGCTGGGGCCGGATCAGCCGATCAACCTGCGCCTGCTGGAAATTCCCCCGGCCATGAATGCTCTGGAAGGGGTGG TGATGGAGTTGCGTGACGCCGCGTTCCCGCTGGTTAATGAAATTGTCCCGACCAGCGATCCTGATGAAGCGTTCGCCGGC GCCAACTGGTGCCTGCTGGTAGGCTCCGTTCCCCGCAAGGCCGGTATGGAACGCAAGGACCTGCTGGATATCAACGGCAA GGTGTTCATCGGCCAGGGGCAGGCCATTGCCCGCAGCGCCGCCAAGGATGTGCGTGTGCTGGTGGTCGGCAACCCCTGCA ATACGAATGCCCTTATTGCCATGCACAATGCGAGCGGCGTTCCCTCCGACCGCTTTTTTGCCATGACTCGCCTGGATGAA AACCGTGCCAAGAGCCAGCTTGCGGAAAAGGCCGGCGTCCATGTGACGGAAGTGACCAACATGGCCATCTGGGGCAATCA TTCCTCCACCCAGTACCCTGATTTCACCAACGCCAGGATTGGCGGAAAGCCTGTGACGGAAGTCATCAAGGATACGGAAT GGCTTAAGGGCGATTTCATTACCACCGTGCAGCAGCGCGGTGCCGCCATTATCAAGGCACGCGGCGCTTCTTCCGCCGCT TCCGCCGCTTCCGCAGCCGTGGATACCGTCCGCAGCCTGGCTACCCAGACTCCGGAAGGCGACTGGTATTCCGTGGCCGT TTGCTCCGACGGTTCCTACGGCATTGAAAAAGGTCTTATCTGCTCCTTCCCGGTCCGCACCACCAAGGATGGCGGCTGGG AAATCGTGCAGGGGCTGCCGGTTGATGCGTTCTCCCGTGAAAAAATTGACGCTACCGTTAATGAACTGAAGGAAGAACGT GACGCTGTTTCCTCTTTGTTGAAGCATTAA
Upstream 100 bases:
>100_bases TTTTCTGTCAAAATAAAAAGTTCCTGATTGAGCGCCTCCTTTCCTTGTGGTATAACCGTGACCAGACAGGAAAATATCTG TTTATTTTAATTTGAACGTT
Downstream 100 bases:
>100_bases TGTTGATTTGCTCTTGCGCCGGGTTTCCCGTTTTCGGGAAGCCCGGTTTTTTATGTCCTGAAGATTCCATAAACCTCATT TTCTGCGGGACAGAAGTTTT
Product: malate dehydrogenase
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 329; Mature: 329
Protein sequence:
>329_residues MKTPITVTVTGAAGQIAYSLLFRIASGSMLGPDQPINLRLLEIPPAMNALEGVVMELRDAAFPLVNEIVPTSDPDEAFAG ANWCLLVGSVPRKAGMERKDLLDINGKVFIGQGQAIARSAAKDVRVLVVGNPCNTNALIAMHNASGVPSDRFFAMTRLDE NRAKSQLAEKAGVHVTEVTNMAIWGNHSSTQYPDFTNARIGGKPVTEVIKDTEWLKGDFITTVQQRGAAIIKARGASSAA SAASAAVDTVRSLATQTPEGDWYSVAVCSDGSYGIEKGLICSFPVRTTKDGGWEIVQGLPVDAFSREKIDATVNELKEER DAVSSLLKH
Sequences:
>Translated_329_residues MKTPITVTVTGAAGQIAYSLLFRIASGSMLGPDQPINLRLLEIPPAMNALEGVVMELRDAAFPLVNEIVPTSDPDEAFAG ANWCLLVGSVPRKAGMERKDLLDINGKVFIGQGQAIARSAAKDVRVLVVGNPCNTNALIAMHNASGVPSDRFFAMTRLDE NRAKSQLAEKAGVHVTEVTNMAIWGNHSSTQYPDFTNARIGGKPVTEVIKDTEWLKGDFITTVQQRGAAIIKARGASSAA SAASAAVDTVRSLATQTPEGDWYSVAVCSDGSYGIEKGLICSFPVRTTKDGGWEIVQGLPVDAFSREKIDATVNELKEER DAVSSLLKH >Mature_329_residues MKTPITVTVTGAAGQIAYSLLFRIASGSMLGPDQPINLRLLEIPPAMNALEGVVMELRDAAFPLVNEIVPTSDPDEAFAG ANWCLLVGSVPRKAGMERKDLLDINGKVFIGQGQAIARSAAKDVRVLVVGNPCNTNALIAMHNASGVPSDRFFAMTRLDE NRAKSQLAEKAGVHVTEVTNMAIWGNHSSTQYPDFTNARIGGKPVTEVIKDTEWLKGDFITTVQQRGAAIIKARGASSAA SAASAAVDTVRSLATQTPEGDWYSVAVCSDGSYGIEKGLICSFPVRTTKDGGWEIVQGLPVDAFSREKIDATVNELKEER DAVSSLLKH
Specific function: Catalyzes the reversible oxidation of malate to oxaloacetate
COG id: COG0039
COG function: function code C; Malate/lactate dehydrogenases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the LDH/MDH superfamily. MDH type 2 family
Homologues:
Organism=Homo sapiens, GI5174539, Length=332, Percent_Identity=53.9156626506024, Blast_Score=348, Evalue=3e-96, Organism=Homo sapiens, GI89886456, Length=330, Percent_Identity=24.8484848484848, Blast_Score=102, Evalue=5e-22, Organism=Escherichia coli, GI1789632, Length=326, Percent_Identity=26.9938650306748, Blast_Score=69, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17561064, Length=327, Percent_Identity=51.6819571865443, Blast_Score=303, Evalue=1e-82, Organism=Caenorhabditis elegans, GI32566798, Length=269, Percent_Identity=49.0706319702602, Blast_Score=236, Evalue=1e-62, Organism=Caenorhabditis elegans, GI32566800, Length=172, Percent_Identity=52.9069767441861, Blast_Score=146, Evalue=1e-35, Organism=Drosophila melanogaster, GI24583394, Length=331, Percent_Identity=53.4743202416918, Blast_Score=322, Evalue=3e-88, Organism=Drosophila melanogaster, GI24647881, Length=321, Percent_Identity=24.2990654205607, Blast_Score=65, Evalue=9e-11,
Paralogues:
None
Copy number: 2640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2380 Molecules/Cell In: Stationary-Phase, Rich-Media (Based on E. coli). 260 Molecules/Cell In: Stationary Phase
Swissprot (AC and ID): MDH_AKKM8 (B2UKY5)
Other databases:
- EMBL: CP001071 - RefSeq: YP_001878039.1 - ProteinModelPortal: B2UKY5 - SMR: B2UKY5 - GeneID: 6274593 - GenomeReviews: CP001071_GR - KEGG: amu:Amuc_1436 - HOGENOM: HBG289884 - OMA: MIIWGNH - ProtClustDB: PRK05442 - GO: GO:0005488 - GO: GO:0006096 - HAMAP: MF_01517 - InterPro: IPR001557 - InterPro: IPR022383 - InterPro: IPR001236 - InterPro: IPR015955 - InterPro: IPR001252 - InterPro: IPR010945 - InterPro: IPR016040 - Gene3D: G3DSA:3.90.110.10 - Gene3D: G3DSA:3.40.50.720 - PANTHER: PTHR23382 - PIRSF: PIRSF000102 - TIGRFAMs: TIGR01759
Pfam domain/function: PF02866 Ldh_1_C; PF00056 Ldh_1_N; SSF56327 Lactate_DH/Glyco_hydro_4_C
EC number: =1.1.1.37
Molecular weight: Translated: 35097; Mature: 35097
Theoretical pI: Translated: 5.77; Mature: 5.77
Prosite motif: PS00068 MDH
Important sites: ACT_SITE 187-187 BINDING 92-92 BINDING 98-98 BINDING 105-105 BINDING 112-112 BINDING 131-131 BINDING 162-162
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.2 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.6 %Cys+Met (Translated Protein) 1.2 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKTPITVTVTGAAGQIAYSLLFRIASGSMLGPDQPINLRLLEIPPAMNALEGVVMELRDA CCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH AFPLVNEIVPTSDPDEAFAGANWCLLVGSVPRKAGMERKDLLDINGKVFIGQGQAIARSA HHHHHHHHCCCCCCCHHHCCCCEEEEEECCCHHHCCCHHHEEECCCEEEEECCHHHHHHH AKDVRVLVVGNPCNTNALIAMHNASGVPSDRFFAMTRLDENRAKSQLAEKAGVHVTEVTN CCCEEEEEECCCCCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHCCEEEEEEE MAIWGNHSSTQYPDFTNARIGGKPVTEVIKDTEWLKGDFITTVQQRGAAIIKARGASSAA EEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCCHH SAASAAVDTVRSLATQTPEGDWYSVAVCSDGSYGIEKGLICSFPVRTTKDGGWEIVQGLP HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCEEECCCCCCCCCCEEEEECCC VDAFSREKIDATVNELKEERDAVSSLLKH CCCCCHHHHHHHHHHHHHHHHHHHHHHCC >Mature Secondary Structure MKTPITVTVTGAAGQIAYSLLFRIASGSMLGPDQPINLRLLEIPPAMNALEGVVMELRDA CCCCEEEEEECCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHH AFPLVNEIVPTSDPDEAFAGANWCLLVGSVPRKAGMERKDLLDINGKVFIGQGQAIARSA HHHHHHHHCCCCCCCHHHCCCCEEEEEECCCHHHCCCHHHEEECCCEEEEECCHHHHHHH AKDVRVLVVGNPCNTNALIAMHNASGVPSDRFFAMTRLDENRAKSQLAEKAGVHVTEVTN CCCEEEEEECCCCCCCEEEEEECCCCCCCCCEEEEECCCHHHHHHHHHHHHCCEEEEEEE MAIWGNHSSTQYPDFTNARIGGKPVTEVIKDTEWLKGDFITTVQQRGAAIIKARGASSAA EEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCEEEEECCCCCHH SAASAAVDTVRSLATQTPEGDWYSVAVCSDGSYGIEKGLICSFPVRTTKDGGWEIVQGLP HHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCEEECCCCCCCCCCEEEEECCC VDAFSREKIDATVNELKEERDAVSSLLKH CCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA