Definition | Akkermansia muciniphila ATCC BAA-835, complete genome. |
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Accession | NC_010655 |
Length | 2,664,102 |
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The map label for this gene is pdhC [H]
Identifier: 187735448
GI number: 187735448
Start: 1127732
End: 1128772
Strand: Reverse
Name: pdhC [H]
Synonym: Amuc_0947
Alternate gene names: 187735448
Gene position: 1128772-1127732 (Counterclockwise)
Preceding gene: 187735449
Following gene: 187735447
Centisome position: 42.37
GC content: 65.51
Gene sequence:
>1041_bases ATGGCTATTACCATTGAAATGCCCCGCCTGTCCGACTCCATGCACGAAGGCACCGTCCTGAGATGGCTCAAAAAAACAGG GGACTTCGTAAAAGTCGGCGACCATCTGGCCGACATTGAGACGGATAAGGCCCATGTGGAGCTCCAGGCCTGCGAGGACG GCACCCTAACGGAAATTCTGGTGCCGGAGGGAGGTTCCGCCGCGGCGGGAGCGCCCATTGCGCTGCTTCAGCCGGAATTC GGCGCAGCCGCCTGCGGCGGCCCCCCGCGCCCGTCCGCAACATGCAGCCCGCTGGCCGCCAGGCTGGCGGCGGAAGCCGG CCTGAACCCCGCCACGCTGCGCGGCACCGGCCCCCGGGGCAAAATCATGGCCGCGGATGTACGGGCCGCCCTGCGCCCCG CGGACGGCCCCGCCCGCCGGGTGCAGACCCCGCTGGCGCCCCGGGACACGCGCCACGCCACGCGCGTAGACAACTTTTAC CTGTATTCCCTGGAGGCGAACATGGCTTACCTGGCCGCCATCAGCACGCCCATCGCCGTCCAGTGCGAAAAACTCATCGG CGGCCGCTACAGCCTCTTTGACTACGTGGTGCGCGCGGCGGTGAAAGCATGCGCCAGCGAGCCGGAATGGCTGGCCGGAG ACGCCGCCGCAGAACTGCTCATGGTGCTGGACAAGGGGGAAAAATACGTCTTCATTGAAAACGCCTCCGGCAAGACGATT TACAACATCGCCATGGAACGCCTGGCCGCCCCCGCGGCAGGCCCTCTCCCCGCGGGCAGCGTCGCGCCCAACATCCTTCT TTGCGACAGCGGCGTGAACGTGGCAGCCCAGCGCGCCGTGCTGCCGGAAATGCCCCACAGCATCATCAGCATAGGAGGCA CCACGCCGAAAACGGGCATTGAAGCGGGGCGCCCCGTGTCCAAACTCATCCTGCCCGTCACCCTGTACGTGAACGCCGGA ATTCTGCCGGAATGCAAGGCTTCCAACATTGCCGCCGAATTCAAAACCCTGCTGGAAAACCCGGTTCTTCTCCTCCTGTA G
Upstream 100 bases:
>100_bases AAAATACAGCGCGTAACCGCGTTTCCGCGCGCCGGAAGGAGACGTCCCGCCCCTTCCGGCGCGCCTTCCTCCCTTTTACC ATATTTCAACATTCACCTCC
Downstream 100 bases:
>100_bases GGGTACCGGAACATGCTGCTCTTTTCCTTGAACGTTCCTCTTCCTCCCCCTGTCTTACCAACCATGAAAAAAGTCGCCAT ACTTGCCGCCCCCGGATTTG
Product: biotin/lipoyl attachment domain-containing protein
Products: NA
Alternate protein names: Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex; E2 [H]
Number of amino acids: Translated: 346; Mature: 345
Protein sequence:
>346_residues MAITIEMPRLSDSMHEGTVLRWLKKTGDFVKVGDHLADIETDKAHVELQACEDGTLTEILVPEGGSAAAGAPIALLQPEF GAAACGGPPRPSATCSPLAARLAAEAGLNPATLRGTGPRGKIMAADVRAALRPADGPARRVQTPLAPRDTRHATRVDNFY LYSLEANMAYLAAISTPIAVQCEKLIGGRYSLFDYVVRAAVKACASEPEWLAGDAAAELLMVLDKGEKYVFIENASGKTI YNIAMERLAAPAAGPLPAGSVAPNILLCDSGVNVAAQRAVLPEMPHSIISIGGTTPKTGIEAGRPVSKLILPVTLYVNAG ILPECKASNIAAEFKTLLENPVLLLL
Sequences:
>Translated_346_residues MAITIEMPRLSDSMHEGTVLRWLKKTGDFVKVGDHLADIETDKAHVELQACEDGTLTEILVPEGGSAAAGAPIALLQPEF GAAACGGPPRPSATCSPLAARLAAEAGLNPATLRGTGPRGKIMAADVRAALRPADGPARRVQTPLAPRDTRHATRVDNFY LYSLEANMAYLAAISTPIAVQCEKLIGGRYSLFDYVVRAAVKACASEPEWLAGDAAAELLMVLDKGEKYVFIENASGKTI YNIAMERLAAPAAGPLPAGSVAPNILLCDSGVNVAAQRAVLPEMPHSIISIGGTTPKTGIEAGRPVSKLILPVTLYVNAG ILPECKASNIAAEFKTLLENPVLLLL >Mature_345_residues AITIEMPRLSDSMHEGTVLRWLKKTGDFVKVGDHLADIETDKAHVELQACEDGTLTEILVPEGGSAAAGAPIALLQPEFG AAACGGPPRPSATCSPLAARLAAEAGLNPATLRGTGPRGKIMAADVRAALRPADGPARRVQTPLAPRDTRHATRVDNFYL YSLEANMAYLAAISTPIAVQCEKLIGGRYSLFDYVVRAAVKACASEPEWLAGDAAAELLMVLDKGEKYVFIENASGKTIY NIAMERLAAPAAGPLPAGSVAPNILLCDSGVNVAAQRAVLPEMPHSIISIGGTTPKTGIEAGRPVSKLILPVTLYVNAGI LPECKASNIAAEFKTLLENPVLLLL
Specific function: The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components:pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydroge
COG id: COG0508
COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 lipoyl-binding domain [H]
Homologues:
Organism=Homo sapiens, GI31711992, Length=439, Percent_Identity=24.8291571753986, Blast_Score=88, Evalue=1e-17, Organism=Homo sapiens, GI203098816, Length=62, Percent_Identity=54.8387096774194, Blast_Score=70, Evalue=3e-12, Organism=Homo sapiens, GI203098753, Length=62, Percent_Identity=54.8387096774194, Blast_Score=69, Evalue=5e-12, Organism=Caenorhabditis elegans, GI25146366, Length=95, Percent_Identity=37.8947368421053, Blast_Score=69, Evalue=3e-12,
Paralogues:
None
Copy number: 420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3096 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003016 - InterPro: IPR001078 - InterPro: IPR006257 - InterPro: IPR000089 - InterPro: IPR023213 - InterPro: IPR004167 - InterPro: IPR011053 [H]
Pfam domain/function: PF00198 2-oxoacid_dh; PF00364 Biotin_lipoyl; PF02817 E3_binding [H]
EC number: =2.3.1.12 [H]
Molecular weight: Translated: 36247; Mature: 36116
Theoretical pI: Translated: 6.05; Mature: 6.05
Prosite motif: PS50968 BIOTINYL_LIPOYL
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
2.0 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 4.3 %Cys+Met (Translated Protein) 2.0 %Cys (Mature Protein) 2.0 %Met (Mature Protein) 4.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MAITIEMPRLSDSMHEGTVLRWLKKTGDFVKVGDHLADIETDKAHVELQACEDGTLTEIL CEEEEECCCCCCCHHHHHHHHHHHHCCCEEEECCHHHCCCCCCEEEEEEECCCCCEEEEE VPEGGSAAAGAPIALLQPEFGAAACGGPPRPSATCSPLAARLAAEAGLNPATLRGTGPRG ECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCC KIMAADVRAALRPADGPARRVQTPLAPRDTRHATRVDNFYLYSLEANMAYLAAISTPIAV CEEEECHHHHHCCCCCCHHHCCCCCCCCCCCCHHCCCCEEEEEEECCEEEEEECCCCHHE QCEKLIGGRYSLFDYVVRAAVKACASEPEWLAGDAAAELLMVLDKGEKYVFIENASGKTI EHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEECCCEEEEEECCCCCCH YNIAMERLAAPAAGPLPAGSVAPNILLCDSGVNVAAQRAVLPEMPHSIISIGGTTPKTGI HHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHCCCCCHHHEEECCCCCCCCC EAGRPVSKLILPVTLYVNAGILPECKASNIAAEFKTLLENPVLLLL CCCCCHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEC >Mature Secondary Structure AITIEMPRLSDSMHEGTVLRWLKKTGDFVKVGDHLADIETDKAHVELQACEDGTLTEIL EEEEECCCCCCCHHHHHHHHHHHHCCCEEEECCHHHCCCCCCEEEEEEECCCCCEEEEE VPEGGSAAAGAPIALLQPEFGAAACGGPPRPSATCSPLAARLAAEAGLNPATLRGTGPRG ECCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEECCCCCC KIMAADVRAALRPADGPARRVQTPLAPRDTRHATRVDNFYLYSLEANMAYLAAISTPIAV CEEEECHHHHHCCCCCCHHHCCCCCCCCCCCCHHCCCCEEEEEEECCEEEEEECCCCHHE QCEKLIGGRYSLFDYVVRAAVKACASEPEWLAGDAAAELLMVLDKGEKYVFIENASGKTI EHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHEECCCEEEEEECCCCCCH YNIAMERLAAPAAGPLPAGSVAPNILLCDSGVNVAAQRAVLPEMPHSIISIGGTTPKTGI HHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHCCCCCHHHEEECCCCCCCCC EAGRPVSKLILPVTLYVNAGILPECKASNIAAEFKTLLENPVLLLL CCCCCHHHHHEEEEEEECCCCCCCCCCCHHHHHHHHHHCCCEEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 9823893 [H]