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The map label for this gene is guaB [H]

Identifier: 18311258

GI number: 18311258

Start: 2616682

End: 2618136

Strand: Reverse

Name: guaB [H]

Synonym: CPE2276

Alternate gene names: 18311258

Gene position: 2618136-2616682 (Counterclockwise)

Preceding gene: 18311259

Following gene: 18311257

Centisome position: 86.37

GC content: 33.75

Gene sequence:

>1455_bases
ATGGCAAGAATATTAAAAACAGCATATACATTTGATGATGTATTACTAGTACCAAACAAATCAGAGGTCCTACCTAATGA
GGTTTCTTTAAAAACTCAATTAACTAAAAAAATTCAATTAAATATTCCATTAATGAGTGCAAGTATGGATACAGTTACTG
AATCTAAAATGGCAATAGCTATGGCTAGAGAAGGTGGAATAGGAATAATCCATAAAAACATGACAATAGAAGATCAAGCA
AGAGAAGTTGATAGAGTAAAAAGACAAGAAAATGGAGTAATAACAGATCCAATATTCTTATCAGAAGATCACACAGTAAG
AGAAGCTTTAGATTTAATGGCTCAATACAGAATTTCAGGAGTTCCTGTAACAAGAGAAGGAAAACTAGTTGGAATCATAA
CAAACAGAGACATAGTATTTGAAACAAATTACGATAAAAAAGTTTCAGAGGTTATGACAAAAAGTCCATTAGTTACTGCG
AAAGAAGGAACTACATTAACTGAAGCATTAGAAATATTAAAGCAACATAAAATAGAAAAGCTTCCTTTAGTTGATGATGA
AAATAATCTAAAAGGACTTATAACTATAAAAGATATAGAAAAAGCTAAAGCTTTCCCAAATGCAGCTAAAGATGAAAAAG
GAAGACTTTTATGTGGAGCTTCAATTGGTGTAACTAATGACATGATGGAAAGAGTAGATGCAGTAGTTAAAGCAAAGGTT
GACGTTATTGTTTTAGATACAGCTCATGGTCATTCAAAAGGAGTTATTGAAGGAGTTAAGAGAATAAAAGCTAAATATCC
TGAACTTCAAGTAATAGCTGGTAACATAGCTACACCAGAGGCTGTAAGAGATTTAGCAGAAGCAGGTGCAGATTGTGTTA
AAGTAGGTATAGGACCTGGATCAATATGTACTACAAGAATAGTTGCAGGTGTTGGTGTTCCTCAATTAACAGCAGTTATG
GATTGTGCTGAAGAAGGTAAAAAATTAGGAATACCAGTAATAGCTGACGGTGGATTAAAATATTCAGGAGATATAGTTAA
GGCTTTAGCAGCTGGAGCTTGTGCAGCTATGATGGGATCAATCTTTGCAGGATGTGAAGAAGCACCAGGAGCTATAGAAA
TATATCAAGGTAGAAGCTATAAAGTTTACAGAGGAATGGGTTCACTTGGAGCTATGGCTAAAGGATCAAGTGATAGATAT
TTCCAAAATGGTACTAAGAAATTCGTTCCAGAAGGTGTAGAAGGAAGAATTGCTTACAAAGGACATTTAGCAGATACTAT
CTACCAACTAATAGGTGGAATAAAATCAGGAATGGGTTACTTAGGAGCACCAACTTTGGAAAATTTATATGAAAATGCTA
ATTTTGTTGTTCAAACTTCAGCAGGATTTAGAGAAAGTCACCCTCATGATATAAACATAACTAAGGAAGCACCAAACTAC
AGTGTTAACCAATAA

Upstream 100 bases:

>100_bases
GTTTGCTTTCAAAAAATAAGTAGAAGTTTAAAAGGTAGAAATACGGAAAAACATTTAATTGTACGTAAATAACTTAAAGA
TAGTGTGTGGAGGCGATAGT

Downstream 100 bases:

>100_bases
TTAGATTAAAAGCTTCAGCAAAATGTTAAAATATATATTAAGTTTTAACATTTTGTTGAATATATTTTATACATAAACGG
AAAATGAAATTGTGGAGGAA

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MARILKTAYTFDDVLLVPNKSEVLPNEVSLKTQLTKKIQLNIPLMSASMDTVTESKMAIAMAREGGIGIIHKNMTIEDQA
REVDRVKRQENGVITDPIFLSEDHTVREALDLMAQYRISGVPVTREGKLVGIITNRDIVFETNYDKKVSEVMTKSPLVTA
KEGTTLTEALEILKQHKIEKLPLVDDENNLKGLITIKDIEKAKAFPNAAKDEKGRLLCGASIGVTNDMMERVDAVVKAKV
DVIVLDTAHGHSKGVIEGVKRIKAKYPELQVIAGNIATPEAVRDLAEAGADCVKVGIGPGSICTTRIVAGVGVPQLTAVM
DCAEEGKKLGIPVIADGGLKYSGDIVKALAAGACAAMMGSIFAGCEEAPGAIEIYQGRSYKVYRGMGSLGAMAKGSSDRY
FQNGTKKFVPEGVEGRIAYKGHLADTIYQLIGGIKSGMGYLGAPTLENLYENANFVVQTSAGFRESHPHDINITKEAPNY
SVNQ

Sequences:

>Translated_484_residues
MARILKTAYTFDDVLLVPNKSEVLPNEVSLKTQLTKKIQLNIPLMSASMDTVTESKMAIAMAREGGIGIIHKNMTIEDQA
REVDRVKRQENGVITDPIFLSEDHTVREALDLMAQYRISGVPVTREGKLVGIITNRDIVFETNYDKKVSEVMTKSPLVTA
KEGTTLTEALEILKQHKIEKLPLVDDENNLKGLITIKDIEKAKAFPNAAKDEKGRLLCGASIGVTNDMMERVDAVVKAKV
DVIVLDTAHGHSKGVIEGVKRIKAKYPELQVIAGNIATPEAVRDLAEAGADCVKVGIGPGSICTTRIVAGVGVPQLTAVM
DCAEEGKKLGIPVIADGGLKYSGDIVKALAAGACAAMMGSIFAGCEEAPGAIEIYQGRSYKVYRGMGSLGAMAKGSSDRY
FQNGTKKFVPEGVEGRIAYKGHLADTIYQLIGGIKSGMGYLGAPTLENLYENANFVVQTSAGFRESHPHDINITKEAPNY
SVNQ
>Mature_483_residues
ARILKTAYTFDDVLLVPNKSEVLPNEVSLKTQLTKKIQLNIPLMSASMDTVTESKMAIAMAREGGIGIIHKNMTIEDQAR
EVDRVKRQENGVITDPIFLSEDHTVREALDLMAQYRISGVPVTREGKLVGIITNRDIVFETNYDKKVSEVMTKSPLVTAK
EGTTLTEALEILKQHKIEKLPLVDDENNLKGLITIKDIEKAKAFPNAAKDEKGRLLCGASIGVTNDMMERVDAVVKAKVD
VIVLDTAHGHSKGVIEGVKRIKAKYPELQVIAGNIATPEAVRDLAEAGADCVKVGIGPGSICTTRIVAGVGVPQLTAVMD
CAEEGKKLGIPVIADGGLKYSGDIVKALAAGACAAMMGSIFAGCEEAPGAIEIYQGRSYKVYRGMGSLGAMAKGSSDRYF
QNGTKKFVPEGVEGRIAYKGHLADTIYQLIGGIKSGMGYLGAPTLENLYENANFVVQTSAGFRESHPHDINITKEAPNYS
VNQ

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=480, Percent_Identity=45, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI34328928, Length=449, Percent_Identity=47.2160356347439, Blast_Score=371, Evalue=1e-102,
Organism=Homo sapiens, GI156616279, Length=449, Percent_Identity=47.2160356347439, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI34328930, Length=449, Percent_Identity=47.2160356347439, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI217035152, Length=446, Percent_Identity=47.3094170403587, Blast_Score=367, Evalue=1e-101,
Organism=Homo sapiens, GI66933016, Length=446, Percent_Identity=45.9641255605381, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI217035148, Length=480, Percent_Identity=44.375, Blast_Score=360, Evalue=1e-99,
Organism=Homo sapiens, GI217035150, Length=480, Percent_Identity=41.875, Blast_Score=332, Evalue=4e-91,
Organism=Homo sapiens, GI156104880, Length=239, Percent_Identity=39.3305439330544, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI50541954, Length=240, Percent_Identity=38.75, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI50541952, Length=240, Percent_Identity=38.75, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI50541948, Length=240, Percent_Identity=38.75, Blast_Score=166, Evalue=6e-41,
Organism=Homo sapiens, GI50541956, Length=240, Percent_Identity=38.75, Blast_Score=165, Evalue=7e-41,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=58.0246913580247, Blast_Score=517, Evalue=1e-148,
Organism=Escherichia coli, GI1786293, Length=261, Percent_Identity=32.5670498084291, Blast_Score=147, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=478, Percent_Identity=38.2845188284519, Blast_Score=293, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI71994389, Length=424, Percent_Identity=40.0943396226415, Blast_Score=281, Evalue=6e-76,
Organism=Caenorhabditis elegans, GI17560440, Length=276, Percent_Identity=37.3188405797101, Blast_Score=174, Evalue=1e-43,
Organism=Saccharomyces cerevisiae, GI6322012, Length=484, Percent_Identity=41.7355371900826, Blast_Score=346, Evalue=5e-96,
Organism=Saccharomyces cerevisiae, GI6323585, Length=488, Percent_Identity=41.1885245901639, Blast_Score=340, Evalue=4e-94,
Organism=Saccharomyces cerevisiae, GI6323464, Length=479, Percent_Identity=42.5887265135699, Blast_Score=338, Evalue=1e-93,
Organism=Saccharomyces cerevisiae, GI6319352, Length=379, Percent_Identity=42.4802110817942, Blast_Score=276, Evalue=5e-75,
Organism=Saccharomyces cerevisiae, GI6319353, Length=114, Percent_Identity=37.719298245614, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641071, Length=477, Percent_Identity=41.0901467505241, Blast_Score=331, Evalue=7e-91,
Organism=Drosophila melanogaster, GI24641073, Length=477, Percent_Identity=41.0901467505241, Blast_Score=331, Evalue=7e-91,
Organism=Drosophila melanogaster, GI28571163, Length=438, Percent_Identity=41.5525114155251, Blast_Score=302, Evalue=3e-82,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52094; Mature: 51963

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARILKTAYTFDDVLLVPNKSEVLPNEVSLKTQLTKKIQLNIPLMSASMDTVTESKMAIA
CCCHHHHHCCCCCEEECCCCCCCCCCCHHHHHHEEEEEEEECEEEECCHHHHHHHHEEEE
MAREGGIGIIHKNMTIEDQAREVDRVKRQENGVITDPIFLSEDHTVREALDLMAQYRISG
EECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEECCEEECCCCHHHHHHHHHHHHHHCC
VPVTREGKLVGIITNRDIVFETNYDKKVSEVMTKSPLVTAKEGTTLTEALEILKQHKIEK
CCEECCCCEEEEEECCEEEEECCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCC
LPLVDDENNLKGLITIKDIEKAKAFPNAAKDEKGRLLCGASIGVTNDMMERVDAVVKAKV
CCCCCCCCCCEEEEEEEECHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCEE
DVIVLDTAHGHSKGVIEGVKRIKAKYPELQVIAGNIATPEAVRDLAEAGADCVKVGIGPG
EEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCCC
SICTTRIVAGVGVPQLTAVMDCAEEGKKLGIPVIADGGLKYSGDIVKALAAGACAAMMGS
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEECCCCEECCHHHHHHHHHHHHHHHHH
IFAGCEEAPGAIEIYQGRSYKVYRGMGSLGAMAKGSSDRYFQNGTKKFVPEGVEGRIAYK
HHHCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHCCCHHCCCCCCCCEEEEE
GHLADTIYQLIGGIKSGMGYLGAPTLENLYENANFVVQTSAGFRESHPHDINITKEAPNY
CHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCEEEECCCCCC
SVNQ
CCCC
>Mature Secondary Structure 
ARILKTAYTFDDVLLVPNKSEVLPNEVSLKTQLTKKIQLNIPLMSASMDTVTESKMAIA
CCHHHHHCCCCCEEECCCCCCCCCCCHHHHHHEEEEEEEECEEEECCHHHHHHHHEEEE
MAREGGIGIIHKNMTIEDQAREVDRVKRQENGVITDPIFLSEDHTVREALDLMAQYRISG
EECCCCEEEEECCCCCCHHHHHHHHHHHHCCCCEECCEEECCCCHHHHHHHHHHHHHHCC
VPVTREGKLVGIITNRDIVFETNYDKKVSEVMTKSPLVTAKEGTTLTEALEILKQHKIEK
CCEECCCCEEEEEECCEEEEECCCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHCCCCC
LPLVDDENNLKGLITIKDIEKAKAFPNAAKDEKGRLLCGASIGVTNDMMERVDAVVKAKV
CCCCCCCCCCEEEEEEEECHHHHCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHCEE
DVIVLDTAHGHSKGVIEGVKRIKAKYPELQVIAGNIATPEAVRDLAEAGADCVKVGIGPG
EEEEEECCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHCCCCEEEECCCCC
SICTTRIVAGVGVPQLTAVMDCAEEGKKLGIPVIADGGLKYSGDIVKALAAGACAAMMGS
HHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEECCCCEECCHHHHHHHHHHHHHHHHH
IFAGCEEAPGAIEIYQGRSYKVYRGMGSLGAMAKGSSDRYFQNGTKKFVPEGVEGRIAYK
HHHCCCCCCCEEEEEECCCEEEEECCCCCCCCCCCCCCCHHHCCCHHCCCCCCCCEEEEE
GHLADTIYQLIGGIKSGMGYLGAPTLENLYENANFVVQTSAGFRESHPHDINITKEAPNY
CHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCCCCEEEECCCCCC
SVNQ
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]