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The map label for this gene is guaA

Identifier: 18311257

GI number: 18311257

Start: 2615047

End: 2616576

Strand: Reverse

Name: guaA

Synonym: CPE2275

Alternate gene names: 18311257

Gene position: 2616576-2615047 (Counterclockwise)

Preceding gene: 18311258

Following gene: 18311255

Centisome position: 86.31

GC content: 34.58

Gene sequence:

>1530_bases
ATGAGAGATTTAGTTTTAGTTGTCGACTTTGGTGGGCAATATAATCAATTAATAGCTAGAAGAGTTAGAGAATGTGGAGT
TTATTGTGAAATAATACCTTACACATACAGCATAGAAAAAATAAAAGAAAAGAATCCAAAGGGAATAATATTCACTGGTG
GACCAAACTCAGTTTATGGAGAAAACACTCCTACATTAGATAAAGAAATATTTAACTTAAACGTTCCTGTATTAGGAATA
TGTTATGGAGATCAATTAATGGCACACCTTTTAGGTGGAAAAGTTGATACTGCTCCAGTAAGAGAATATGGAAAAACTAA
TGTAACTTTAGACAATTCATCAAAATTATTTGCTGGAATAGAAGCAGATGAAACTTGTTGGATGAGTCACACTGATTACA
TAGCAGAAGCACCAGAAGGATTCAAAATAATAGCTCATACAGATGTTTGTCCAGTAGCGGCTATGGAAAACGAAGAAAGA
AGACTTTATGGAGTTCAATTCCATCCAGAAGTTGAGCACACTCCATTTGGTCAAAACATGATGAGAAATTTCCTTTACAA
TATATGTGGATTAGAAAATTCTTGGTCAATGGCTTCTTTCGCAGAAGAAAAAATAGCTGAAATCAAGAAAATAGTTGGAG
ATAAAAAATTAATATGTGCATTATCAGGTGGAGTTGATTCATCAGTTGCAGCTGTTATGGTTCACAAGGCTGTAGGTAAG
CAATTAACTTGTATCTTTGTTGACCACGGTCTATTAAGAAAAGATGAGGGAGATCAAGTAGAAAAAATCTTCAAAGAAGG
TTTTGATATGAACCTTATCAGAGTTAATGCTCAAGATAGATTCTTAGGTAAATTAAAAGGAGTTTCAGATCCAGAAACTA
AGAGAAAGATAATCGGAGAAGAATTCATAAGAGTATTTGAAGAAGAAGCTGGAAAATTAGGAGACATTAAATTCTTAGTT
CAAGGAACAATTTATCCAGACGTTGTTGAAAGTGGAACAGATACTTCAGCAGTAATTAAGAGTCACCATAACGTTGGAGG
ACTTCCAGAAGATATGGAATTCTCATTAATAGAGCCATTAAGAGAATTATTCAAAGATGAAGTAAGAGCTGTAGGAGAAG
AATTAGGAATTCCTCACCACTTAGTATGGAGACAGCCATTCCCAGGACCAGGATTAGCTATAAGAGTTCTAGGAGAAGTA
ACTGAAGATAAATTAGAAGTTGTTAGAGAAGCTGATGCTATATTCAGAGAAGAAATAGCTTTAGCAGGTCTTGAAAGTGA
AATATGGCAATACTTCGCAGTATTACCTAACATTCAATCAGTTGGTGTTATGGGAGACGAAAGAACTTACTGCCACACTG
TAGGATTAAGAGCAGTTACATCATCAGACGGAATGACTTCAAACTGGGCTCATATACCATATGAAGTTATAGATAAAGTA
TCAAGAAGAATTGTAAATGAAGTTAAGGGAGTTAACAGAATTGTTTACGATGTAACTTCAAAACCACCAGCAACTATCGA
GTGGGAATAA

Upstream 100 bases:

>100_bases
TTAAAAGCTTCAGCAAAATGTTAAAATATATATTAAGTTTTAACATTTTGTTGAATATATTTTATACATAAACGGAAAAT
GAAATTGTGGAGGAAAGCAA

Downstream 100 bases:

>100_bases
TATAAATAATTGATTCAGATAGGTATTAATCCTATCTGAATTTTAATATAATTTATCTGATTATAAATTATTAGGTCTAA
ATCAGATAAAATTTAAGTAT

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 509; Mature: 509

Protein sequence:

>509_residues
MRDLVLVVDFGGQYNQLIARRVRECGVYCEIIPYTYSIEKIKEKNPKGIIFTGGPNSVYGENTPTLDKEIFNLNVPVLGI
CYGDQLMAHLLGGKVDTAPVREYGKTNVTLDNSSKLFAGIEADETCWMSHTDYIAEAPEGFKIIAHTDVCPVAAMENEER
RLYGVQFHPEVEHTPFGQNMMRNFLYNICGLENSWSMASFAEEKIAEIKKIVGDKKLICALSGGVDSSVAAVMVHKAVGK
QLTCIFVDHGLLRKDEGDQVEKIFKEGFDMNLIRVNAQDRFLGKLKGVSDPETKRKIIGEEFIRVFEEEAGKLGDIKFLV
QGTIYPDVVESGTDTSAVIKSHHNVGGLPEDMEFSLIEPLRELFKDEVRAVGEELGIPHHLVWRQPFPGPGLAIRVLGEV
TEDKLEVVREADAIFREEIALAGLESEIWQYFAVLPNIQSVGVMGDERTYCHTVGLRAVTSSDGMTSNWAHIPYEVIDKV
SRRIVNEVKGVNRIVYDVTSKPPATIEWE

Sequences:

>Translated_509_residues
MRDLVLVVDFGGQYNQLIARRVRECGVYCEIIPYTYSIEKIKEKNPKGIIFTGGPNSVYGENTPTLDKEIFNLNVPVLGI
CYGDQLMAHLLGGKVDTAPVREYGKTNVTLDNSSKLFAGIEADETCWMSHTDYIAEAPEGFKIIAHTDVCPVAAMENEER
RLYGVQFHPEVEHTPFGQNMMRNFLYNICGLENSWSMASFAEEKIAEIKKIVGDKKLICALSGGVDSSVAAVMVHKAVGK
QLTCIFVDHGLLRKDEGDQVEKIFKEGFDMNLIRVNAQDRFLGKLKGVSDPETKRKIIGEEFIRVFEEEAGKLGDIKFLV
QGTIYPDVVESGTDTSAVIKSHHNVGGLPEDMEFSLIEPLRELFKDEVRAVGEELGIPHHLVWRQPFPGPGLAIRVLGEV
TEDKLEVVREADAIFREEIALAGLESEIWQYFAVLPNIQSVGVMGDERTYCHTVGLRAVTSSDGMTSNWAHIPYEVIDKV
SRRIVNEVKGVNRIVYDVTSKPPATIEWE
>Mature_509_residues
MRDLVLVVDFGGQYNQLIARRVRECGVYCEIIPYTYSIEKIKEKNPKGIIFTGGPNSVYGENTPTLDKEIFNLNVPVLGI
CYGDQLMAHLLGGKVDTAPVREYGKTNVTLDNSSKLFAGIEADETCWMSHTDYIAEAPEGFKIIAHTDVCPVAAMENEER
RLYGVQFHPEVEHTPFGQNMMRNFLYNICGLENSWSMASFAEEKIAEIKKIVGDKKLICALSGGVDSSVAAVMVHKAVGK
QLTCIFVDHGLLRKDEGDQVEKIFKEGFDMNLIRVNAQDRFLGKLKGVSDPETKRKIIGEEFIRVFEEEAGKLGDIKFLV
QGTIYPDVVESGTDTSAVIKSHHNVGGLPEDMEFSLIEPLRELFKDEVRAVGEELGIPHHLVWRQPFPGPGLAIRVLGEV
TEDKLEVVREADAIFREEIALAGLESEIWQYFAVLPNIQSVGVMGDERTYCHTVGLRAVTSSDGMTSNWAHIPYEVIDKV
SRRIVNEVKGVNRIVYDVTSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=547, Percent_Identity=35.6489945155393, Blast_Score=313, Evalue=2e-85,
Organism=Escherichia coli, GI1788854, Length=516, Percent_Identity=52.3255813953488, Blast_Score=558, Evalue=1e-160,
Organism=Escherichia coli, GI1789760, Length=153, Percent_Identity=28.7581699346405, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI133901714, Length=566, Percent_Identity=36.3957597173145, Blast_Score=315, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI71992710, Length=566, Percent_Identity=36.3957597173145, Blast_Score=315, Evalue=4e-86,
Organism=Caenorhabditis elegans, GI71992717, Length=566, Percent_Identity=36.3957597173145, Blast_Score=315, Evalue=4e-86,
Organism=Saccharomyces cerevisiae, GI6323873, Length=518, Percent_Identity=51.1583011583012, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI281365319, Length=545, Percent_Identity=35.7798165137615, Blast_Score=307, Evalue=1e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_CLOPE (Q8XI46)

Other databases:

- EMBL:   BA000016
- EMBL:   AY082069
- RefSeq:   NP_563191.1
- ProteinModelPortal:   Q8XI46
- SMR:   Q8XI46
- GeneID:   990628
- GenomeReviews:   BA000016_GR
- KEGG:   cpe:CPE2275
- NMPDR:   fig|195102.1.peg.2338
- HOGENOM:   HBG391775
- OMA:   YENAICL
- PhylomeDB:   Q8XI46
- ProtClustDB:   PRK00074
- BioCyc:   CPER195102:CPE2275-MONOMER
- BRENDA:   6.3.5.2
- HAMAP:   MF_00344
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 56844; Mature: 56844

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I ; PS00228 TUBULIN_B_AUTOREG

Important sites: ACT_SITE 81-81 ACT_SITE 168-168 ACT_SITE 170-170

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDLVLVVDFGGQYNQLIARRVRECGVYCEIIPYTYSIEKIKEKNPKGIIFTGGPNSVYG
CCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCEEEHHHHHCCCCCEEEEECCCCCCCC
ENTPTLDKEIFNLNVPVLGICYGDQLMAHLLGGKVDTAPVREYGKTNVTLDNSSKLFAGI
CCCCCCCHHHEECCCCEEEEEEHHHHHHHHHCCCCCCHHHHHCCCCEEEECCCCCEEEEC
EADETCWMSHTDYIAEAPEGFKIIAHTDVCPVAAMENEERRLYGVQFHPEVEHTPFGQNM
CCCCCEECCCCCHHHCCCCCCEEEEECCCCCCHHCCCCCCEEEEEEECCCCCCCCCCHHH
MRNFLYNICGLENSWSMASFAEEKIAEIKKIVGDKKLICALSGGVDSSVAAVMVHKAVGK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCC
QLTCIFVDHGLLRKDEGDQVEKIFKEGFDMNLIRVNAQDRFLGKLKGVSDPETKRKIIGE
EEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHH
EFIRVFEEEAGKLGDIKFLVQGTIYPDVVESGTDTSAVIKSHHNVGGLPEDMEFSLIEPL
HHHHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHH
RELFKDEVRAVGEELGIPHHLVWRQPFPGPGLAIRVLGEVTEDKLEVVREADAIFREEIA
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
LAGLESEIWQYFAVLPNIQSVGVMGDERTYCHTVGLRAVTSSDGMTSNWAHIPYEVIDKV
HHCHHHHHHHHHHHCCCCHHCCCCCCCCCEEEEECCEEEECCCCCCCCCCCCCHHHHHHH
SRRIVNEVKGVNRIVYDVTSKPPATIEWE
HHHHHHHHHHCCEEEEEECCCCCCEEECC
>Mature Secondary Structure
MRDLVLVVDFGGQYNQLIARRVRECGVYCEIIPYTYSIEKIKEKNPKGIIFTGGPNSVYG
CCCEEEEEECCCCHHHHHHHHHHHCCCEEEEECCEEEHHHHHCCCCCEEEEECCCCCCCC
ENTPTLDKEIFNLNVPVLGICYGDQLMAHLLGGKVDTAPVREYGKTNVTLDNSSKLFAGI
CCCCCCCHHHEECCCCEEEEEEHHHHHHHHHCCCCCCHHHHHCCCCEEEECCCCCEEEEC
EADETCWMSHTDYIAEAPEGFKIIAHTDVCPVAAMENEERRLYGVQFHPEVEHTPFGQNM
CCCCCEECCCCCHHHCCCCCCEEEEECCCCCCHHCCCCCCEEEEEEECCCCCCCCCCHHH
MRNFLYNICGLENSWSMASFAEEKIAEIKKIVGDKKLICALSGGVDSSVAAVMVHKAVGK
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHCC
QLTCIFVDHGLLRKDEGDQVEKIFKEGFDMNLIRVNAQDRFLGKLKGVSDPETKRKIIGE
EEEEEEECCCCCCCCCCHHHHHHHHCCCCEEEEEECCCHHHHHHHCCCCCCHHHHHHHHH
EFIRVFEEEAGKLGDIKFLVQGTIYPDVVESGTDTSAVIKSHHNVGGLPEDMEFSLIEPL
HHHHHHHHHCCCCCCEEEEEECCCCHHHHCCCCCHHHHHHCCCCCCCCCCCCCHHHHHHH
RELFKDEVRAVGEELGIPHHLVWRQPFPGPGLAIRVLGEVTEDKLEVVREADAIFREEIA
HHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHH
LAGLESEIWQYFAVLPNIQSVGVMGDERTYCHTVGLRAVTSSDGMTSNWAHIPYEVIDKV
HHCHHHHHHHHHHHCCCCHHCCCCCCCCCEEEEECCEEEECCCCCCCCCCCCCHHHHHHH
SRRIVNEVKGVNRIVYDVTSKPPATIEWE
HHHHHHHHHHCCEEEEEECCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11792842