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The map label for this gene is pyrG

Identifier: 182681124

GI number: 182681124

Start: 674637

End: 676301

Strand: Direct

Name: pyrG

Synonym: XfasM23_0566

Alternate gene names: 182681124

Gene position: 674637-676301 (Clockwise)

Preceding gene: 182681123

Following gene: 182681125

Centisome position: 26.61

GC content: 53.27

Gene sequence:

>1665_bases
ATGACTCCTCTTATTTTTGTTACTGGCGGTGTTGTTTCTTCCCTTGGCAAGGGCATCGCGGCGGCTTCCCTTGCGTCCAT
CCTTGAAGCACGTGGTTTGAAGGTGACGATGGTGAAGTTGGATCCTTACATCAACGTGGATCCTGGGACGATGAGTCCGT
TCCAACATGGTGAGGTTTATGTCACTGACGATGGTGCTGAGACTGATCTGGATTTGGGCCATTACGAGCGTTTTGTACGC
ACGCGGTTGTCGCGTAAAAATTCGGTCACTACTGGTAGGATTTACCAGAATGTGATTTGCAAGGAGCGCCGCGGTGACTA
TCTCGGTGCGACCGTACAGGTGATCCCTCACATTACCGACGAGATTCGCCGCTGCATTGATGAGGCTACAGCAAGCTTTG
ATGTGGCGTTGGTGGAGATTGGCGGTACTGTCGGGGATATTGAATCGCTCCCTTTCTTGGAGGCGATCCGTCAAGTGCGG
ATTGAGCGTGGTGCGGAGAGGACGATGTTCATGCACTTGACGCTGGTGCCGTATATTGCCGCTGCTGGGGAACTCAAGAC
AAAACCGACGCAGCATTCTGTCAAAGAGCTGCGTTCGATCGGTATTCAGCCGGATGTGTTGTTGTGTCGTTCCGAGCAGG
TGATTCCGGATTCAGAGCGTCGCAAAATTGCATTGTTTACCAACGTTTCCGAGCGGGCAGTGATTGGCTGTCCTGATATT
GACGTGTTGTATGGGATGCCTTTGGAGCTGCGTCGCCAGGGTCTTGATGAAATTGTGATTGATCAGTTCAAACTAAGCGG
AACAGCGAGTTTGGCTGATTTGTCCGAATGGGAGGATGTGGTCGACGCGATTAAGCATCCTCTGGATGAAGTCACTATCG
CTGTTGTCGGCAAGTACGTCGATTATCAGGATGCCTATAAGTCCGTGGGTGAGGCACTCAAGCATGGTGGCCTGCGTCAA
CGTACTAAGGTCAATCTGAAGTGGGTTGAGGCTCAGGACTTGGAGGGGAGCGATATGGCTGCTCTTAAAGACATTGACGG
TATTTTGGTGCCGGGGGGATTCGGTGATCGTGGTTTTGAGGGGAAGGTGCTCGCCTCCAGGTACGCGCGTGAGCAGCGGG
TGCCGTATTTCGGCATTTGCTATGGTATGCAGGCGGCGGTGGTGGATTACGCGCGCCATGTTGCCGGGCTTGAGGGTGCC
AATAGTACTGAGAATGATCGCCAGTCGTCTCACCCTGTCATTGCTTTGATTACCGAGTGGCGGACCACAACAGGTGAGGT
CGAGCGTCGTGATGAGAAGTCCGATCTAGGCGGTACGATGCGTCTTGGTTTGCAGGAGCAACGTCTCAAGGCAGGGACAC
TGGCGCGCGAGTTGTATGGAAGGGATGTGGTTGGTGAGCGTCATCGGCATCGTTACGAATTTAATAATCGCTACCGGACT
CAGTTGGAGGATGCTGGTTTGGTGATCGCTGCTAAATCAATGGACGACACCTTGGTGGAGATGATCGAGTTACCACGTGA
GATGCATCCTTGGTTTCTGGCGTGCCAGGCGCATCCTGAGTTCTTGTCGACTCCACGGGATGGTCATCCGCTCTTTATTG
GTTTTGTGAAGGCGTCGCGCGCGCGCAAGGCTGGAGGCAAATTGCTCAGGGAAGTCTGCGTTTGA

Upstream 100 bases:

>100_bases
TTAGTTTTGTGCCCCAATACATTTGTCGTTCTTAGTGGTGATGCTTGGGCATCGGAGAAGTGCCCGTTAGACTATTGTTT
TACCTGAGCCATGTGGTCCC

Downstream 100 bases:

>100_bases
ACCTATGTCTGTTTTTGATCTGATGTTTGATTTTTGATGAAGATGTGTTTCGGATCGGAATCAAGATATCTTCAGGGAGG
TTGAGGGAGGGACATGTCCT

Product: CTP synthetase

Products: NA

Alternate protein names: CTP synthetase; UTP--ammonia ligase

Number of amino acids: Translated: 554; Mature: 553

Protein sequence:

>554_residues
MTPLIFVTGGVVSSLGKGIAAASLASILEARGLKVTMVKLDPYINVDPGTMSPFQHGEVYVTDDGAETDLDLGHYERFVR
TRLSRKNSVTTGRIYQNVICKERRGDYLGATVQVIPHITDEIRRCIDEATASFDVALVEIGGTVGDIESLPFLEAIRQVR
IERGAERTMFMHLTLVPYIAAAGELKTKPTQHSVKELRSIGIQPDVLLCRSEQVIPDSERRKIALFTNVSERAVIGCPDI
DVLYGMPLELRRQGLDEIVIDQFKLSGTASLADLSEWEDVVDAIKHPLDEVTIAVVGKYVDYQDAYKSVGEALKHGGLRQ
RTKVNLKWVEAQDLEGSDMAALKDIDGILVPGGFGDRGFEGKVLASRYAREQRVPYFGICYGMQAAVVDYARHVAGLEGA
NSTENDRQSSHPVIALITEWRTTTGEVERRDEKSDLGGTMRLGLQEQRLKAGTLARELYGRDVVGERHRHRYEFNNRYRT
QLEDAGLVIAAKSMDDTLVEMIELPREMHPWFLACQAHPEFLSTPRDGHPLFIGFVKASRARKAGGKLLREVCV

Sequences:

>Translated_554_residues
MTPLIFVTGGVVSSLGKGIAAASLASILEARGLKVTMVKLDPYINVDPGTMSPFQHGEVYVTDDGAETDLDLGHYERFVR
TRLSRKNSVTTGRIYQNVICKERRGDYLGATVQVIPHITDEIRRCIDEATASFDVALVEIGGTVGDIESLPFLEAIRQVR
IERGAERTMFMHLTLVPYIAAAGELKTKPTQHSVKELRSIGIQPDVLLCRSEQVIPDSERRKIALFTNVSERAVIGCPDI
DVLYGMPLELRRQGLDEIVIDQFKLSGTASLADLSEWEDVVDAIKHPLDEVTIAVVGKYVDYQDAYKSVGEALKHGGLRQ
RTKVNLKWVEAQDLEGSDMAALKDIDGILVPGGFGDRGFEGKVLASRYAREQRVPYFGICYGMQAAVVDYARHVAGLEGA
NSTENDRQSSHPVIALITEWRTTTGEVERRDEKSDLGGTMRLGLQEQRLKAGTLARELYGRDVVGERHRHRYEFNNRYRT
QLEDAGLVIAAKSMDDTLVEMIELPREMHPWFLACQAHPEFLSTPRDGHPLFIGFVKASRARKAGGKLLREVCV
>Mature_553_residues
TPLIFVTGGVVSSLGKGIAAASLASILEARGLKVTMVKLDPYINVDPGTMSPFQHGEVYVTDDGAETDLDLGHYERFVRT
RLSRKNSVTTGRIYQNVICKERRGDYLGATVQVIPHITDEIRRCIDEATASFDVALVEIGGTVGDIESLPFLEAIRQVRI
ERGAERTMFMHLTLVPYIAAAGELKTKPTQHSVKELRSIGIQPDVLLCRSEQVIPDSERRKIALFTNVSERAVIGCPDID
VLYGMPLELRRQGLDEIVIDQFKLSGTASLADLSEWEDVVDAIKHPLDEVTIAVVGKYVDYQDAYKSVGEALKHGGLRQR
TKVNLKWVEAQDLEGSDMAALKDIDGILVPGGFGDRGFEGKVLASRYAREQRVPYFGICYGMQAAVVDYARHVAGLEGAN
STENDRQSSHPVIALITEWRTTTGEVERRDEKSDLGGTMRLGLQEQRLKAGTLARELYGRDVVGERHRHRYEFNNRYRTQ
LEDAGLVIAAKSMDDTLVEMIELPREMHPWFLACQAHPEFLSTPRDGHPLFIGFVKASRARKAGGKLLREVCV

Specific function: Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen

COG id: COG0504

COG function: function code F; CTP synthase (UTP-ammonia lyase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain

Homologues:

Organism=Homo sapiens, GI148491070, Length=560, Percent_Identity=43.2142857142857, Blast_Score=455, Evalue=1e-128,
Organism=Homo sapiens, GI28559085, Length=558, Percent_Identity=41.3978494623656, Blast_Score=431, Evalue=1e-120,
Organism=Homo sapiens, GI28559083, Length=558, Percent_Identity=41.3978494623656, Blast_Score=431, Evalue=1e-120,
Organism=Homo sapiens, GI221316689, Length=558, Percent_Identity=41.3978494623656, Blast_Score=431, Evalue=1e-120,
Organism=Escherichia coli, GI1789142, Length=538, Percent_Identity=65.2416356877323, Blast_Score=700, Evalue=0.0,
Organism=Caenorhabditis elegans, GI25148299, Length=605, Percent_Identity=36.3636363636364, Blast_Score=392, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6319432, Length=569, Percent_Identity=40.9490333919156, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322563, Length=569, Percent_Identity=40.7732864674868, Blast_Score=422, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24664469, Length=560, Percent_Identity=44.1071428571429, Blast_Score=451, Evalue=1e-127,
Organism=Drosophila melanogaster, GI21357815, Length=507, Percent_Identity=42.8007889546351, Blast_Score=382, Evalue=1e-106,

Paralogues:

None

Copy number: 480 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PYRG_XYLF2 (B2I935)

Other databases:

- EMBL:   CP001011
- RefSeq:   YP_001829284.1
- ProteinModelPortal:   B2I935
- SMR:   B2I935
- GeneID:   6203725
- GenomeReviews:   CP001011_GR
- KEGG:   xfn:XfasM23_0566
- HOGENOM:   HBG597806
- OMA:   RVTMQKL
- ProtClustDB:   PRK05380
- HAMAP:   MF_01227
- InterPro:   IPR004468
- InterPro:   IPR017456
- InterPro:   IPR017926
- InterPro:   IPR000991
- TIGRFAMs:   TIGR00337

Pfam domain/function: PF06418 CTP_synth_N; PF00117 GATase

EC number: =6.3.4.2

Molecular weight: Translated: 61565; Mature: 61434

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 380-380 ACT_SITE 518-518 ACT_SITE 520-520

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPLIFVTGGVVSSLGKGIAAASLASILEARGLKVTMVKLDPYINVDPGTMSPFQHGEVY
CCCEEEECCHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFVRTRLSRKNSVTTGRIYQNVICKERRGDYLGATVQVIPHITD
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EIRRCIDEATASFDVALVEIGGTVGDIESLPFLEAIRQVRIERGAERTMFMHLTLVPYIA
HHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHH
AAGELKTKPTQHSVKELRSIGIQPDVLLCRSEQVIPDSERRKIALFTNVSERAVIGCPDI
HCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEECCCCC
DVLYGMPLELRRQGLDEIVIDQFKLSGTASLADLSEWEDVVDAIKHPLDEVTIAVVGKYV
HHHCCCCHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
DYQDAYKSVGEALKHGGLRQRTKVNLKWVEAQDLEGSDMAALKDIDGILVPGGFGDRGFE
CHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCHHHHHCCCCEEECCCCCCCCCC
GKVLASRYAREQRVPYFGICYGMQAAVVDYARHVAGLEGANSTENDRQSSHPVIALITEW
CHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECC
RTTTGEVERRDEKSDLGGTMRLGLQEQRLKAGTLARELYGRDVVGERHRHRYEFNNRYRT
CCCCCHHHHCCCHHCCCCEEECCCHHHHHHHHHHHHHHHCCCHHCHHHHHHCCCCCCHHH
QLEDAGLVIAAKSMDDTLVEMIELPREMHPWFLACQAHPEFLSTPRDGHPLFIGFVKASR
HHCCCCEEEEECCCCHHHHHHHHCHHHCCCEEEEEECCHHHHCCCCCCCCEEEEEEEHHH
ARKAGGKLLREVCV
HHHHHHHHHHHHCC
>Mature Secondary Structure 
TPLIFVTGGVVSSLGKGIAAASLASILEARGLKVTMVKLDPYINVDPGTMSPFQHGEVY
CCEEEECCHHHHHHCCHHHHHHHHHHHHHCCCEEEEEEECCEEECCCCCCCCCCCCEEE
VTDDGAETDLDLGHYERFVRTRLSRKNSVTTGRIYQNVICKERRGDYLGATVQVIPHITD
EECCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
EIRRCIDEATASFDVALVEIGGTVGDIESLPFLEAIRQVRIERGAERTMFMHLTLVPYIA
HHHHHHHHHCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHH
AAGELKTKPTQHSVKELRSIGIQPDVLLCRSEQVIPDSERRKIALFTNVSERAVIGCPDI
HCCCCCCCCCHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEECCCCC
DVLYGMPLELRRQGLDEIVIDQFKLSGTASLADLSEWEDVVDAIKHPLDEVTIAVVGKYV
HHHCCCCHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
DYQDAYKSVGEALKHGGLRQRTKVNLKWVEAQDLEGSDMAALKDIDGILVPGGFGDRGFE
CHHHHHHHHHHHHHHCCCCCCEEEEEEEEEECCCCCCCHHHHHCCCCEEECCCCCCCCCC
GKVLASRYAREQRVPYFGICYGMQAAVVDYARHVAGLEGANSTENDRQSSHPVIALITEW
CHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECC
RTTTGEVERRDEKSDLGGTMRLGLQEQRLKAGTLARELYGRDVVGERHRHRYEFNNRYRT
CCCCCHHHHCCCHHCCCCEEECCCHHHHHHHHHHHHHHHCCCHHCHHHHHHCCCCCCHHH
QLEDAGLVIAAKSMDDTLVEMIELPREMHPWFLACQAHPEFLSTPRDGHPLFIGFVKASR
HHCCCCEEEEECCCCHHHHHHHHCHHHCCCEEEEEECCHHHHCCCCCCCCEEEEEEEHHH
ARKAGGKLLREVCV
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA