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The map label for this gene is coaBC [H]

Identifier: 182680682

GI number: 182680682

Start: 150219

End: 151448

Strand: Direct

Name: coaBC [H]

Synonym: XfasM23_0111

Alternate gene names: 182680682

Gene position: 150219-151448 (Clockwise)

Preceding gene: 182680677

Following gene: 182680683

Centisome position: 5.92

GC content: 55.45

Gene sequence:

>1230_bases
GTGACTGGATCTCATCAGCCACGGTCATTGAACGGACAGCGTTTGCTGTTGTGTGTCAGTGGTGGTATTGCTGCTTATAA
ATCGCTTGAGCTTGTGCGCCGCCTTTGTGGTGCGGGTGCTCAGGTCCAGGTTGCGATGACTGCTAGTGCGCAGCAGTTTG
TCACGCCACTTAGTTTCCAGGCATTGTCTGGCCAATCGACCCGTACCACGCTGTGGGATGGTAACGCTGAACAGGCGATG
GGGCATATTGAGTTGGCGCGTTGGGCCGAGCGTGTTTTGATTGCTCCTGCTAGTGCTGATGTGATCGCGCGGTTGGCGCA
TGGTTTGGCGGATGATTTGGTGACGACTCTGTGTTTGGCGACAACGGCGCCGCTGATCATATGCCCAGCGATGAACCACA
ATATGTGGCTGCATCCAGCGACTCAGGCGAATGTTGCGATGTTGTTGGGGCGTGGTGTGCAGGTCATCGGACCAGAGGAT
GGTCCGTTGGCAGAAGGTGTGTCTGGGTTGGGCCGTATGAGCGAACCAGAGGCGATTGTTGTTGCGTTGGTTCAGGGGGT
GTCTCCAGCTCCAGTTCACGGTGGTTTGTTCCATGGGCAGCGCATTGTGATTAGTGCTGGACCCACATTCGAAGATTTGG
ATCCGGTGCGTTACCTTGGCAATCGCAGCAGTGGCAAGATGGGTTTTGCTTTGGCTAGTGCGGCGGTGTCCCATGGGGCT
GAGGTGGTGTTGGTGGCTGGTCCGGTGTATCAGCCAACTCCACCTGGGGTGATTCGGGTGGATGTACGTTCGGCGGCACA
GATGCGCGATGCAGTCCTCAGCGCGTTCCCCGCGGATGTTTACATCGGTGCAGCTGCGGTGGCTGATTACGCACCTAAAT
CGGTGTTGCCACAAAAGATCAAGAAGTCTGGCCAGACGCTGATCCTGGAGTTGGTGCGTACCCAAGACATCTTGTCAGAG
GTGGCAGCGCAGACGGCTAACCTGAAATTTGTGGTTGGTTTCGCTGCAGAGACGCATGATGTTGCGTGCTACGCACGCGG
TAAATTGGCTGCCAAGCACTTGGATTTGATTATCGCCAACCAGGTTGGGATTGTTGGAAACGGTTTTGAAAGTGATGACA
ATGCTGTCACTGCGTATTGGCAGGGTGGCGAACGCGTTTTCGCTAGTTGCAGTAAGGTGGAGTTGGCTGAGCGCCTGCTG
GCACTGATTGCTGAAAGGATGCAGACATGA

Upstream 100 bases:

>100_bases
CATCTGTGTAGGATGCCTAGTCTCATGCTTCTCTGATATCAGACTGGAATGGATCATCGGCTAATCTAGTCGTCCTAATT
AACTGTAGGAATCAACTGAG

Downstream 100 bases:

>100_bases
GTGCTGCTGTAAAACCACTGCAGATCAAGATTCTGGATCCTCGTCTCGGTACCGTTTGGCCGCTGCCGACCTATGCGACG
GAAGCAAGTGCTGGGCTTGA

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 409; Mature: 408

Protein sequence:

>409_residues
MTGSHQPRSLNGQRLLLCVSGGIAAYKSLELVRRLCGAGAQVQVAMTASAQQFVTPLSFQALSGQSTRTTLWDGNAEQAM
GHIELARWAERVLIAPASADVIARLAHGLADDLVTTLCLATTAPLIICPAMNHNMWLHPATQANVAMLLGRGVQVIGPED
GPLAEGVSGLGRMSEPEAIVVALVQGVSPAPVHGGLFHGQRIVISAGPTFEDLDPVRYLGNRSSGKMGFALASAAVSHGA
EVVLVAGPVYQPTPPGVIRVDVRSAAQMRDAVLSAFPADVYIGAAAVADYAPKSVLPQKIKKSGQTLILELVRTQDILSE
VAAQTANLKFVVGFAAETHDVACYARGKLAAKHLDLIIANQVGIVGNGFESDDNAVTAYWQGGERVFASCSKVELAERLL
ALIAERMQT

Sequences:

>Translated_409_residues
MTGSHQPRSLNGQRLLLCVSGGIAAYKSLELVRRLCGAGAQVQVAMTASAQQFVTPLSFQALSGQSTRTTLWDGNAEQAM
GHIELARWAERVLIAPASADVIARLAHGLADDLVTTLCLATTAPLIICPAMNHNMWLHPATQANVAMLLGRGVQVIGPED
GPLAEGVSGLGRMSEPEAIVVALVQGVSPAPVHGGLFHGQRIVISAGPTFEDLDPVRYLGNRSSGKMGFALASAAVSHGA
EVVLVAGPVYQPTPPGVIRVDVRSAAQMRDAVLSAFPADVYIGAAAVADYAPKSVLPQKIKKSGQTLILELVRTQDILSE
VAAQTANLKFVVGFAAETHDVACYARGKLAAKHLDLIIANQVGIVGNGFESDDNAVTAYWQGGERVFASCSKVELAERLL
ALIAERMQT
>Mature_408_residues
TGSHQPRSLNGQRLLLCVSGGIAAYKSLELVRRLCGAGAQVQVAMTASAQQFVTPLSFQALSGQSTRTTLWDGNAEQAMG
HIELARWAERVLIAPASADVIARLAHGLADDLVTTLCLATTAPLIICPAMNHNMWLHPATQANVAMLLGRGVQVIGPEDG
PLAEGVSGLGRMSEPEAIVVALVQGVSPAPVHGGLFHGQRIVISAGPTFEDLDPVRYLGNRSSGKMGFALASAAVSHGAE
VVLVAGPVYQPTPPGVIRVDVRSAAQMRDAVLSAFPADVYIGAAAVADYAPKSVLPQKIKKSGQTLILELVRTQDILSEV
AAQTANLKFVVGFAAETHDVACYARGKLAAKHLDLIIANQVGIVGNGFESDDNAVTAYWQGGERVFASCSKVELAERLLA
LIAERMQT

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=171, Percent_Identity=34.5029239766082, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87082301, Length=402, Percent_Identity=51.2437810945274, Blast_Score=347, Evalue=8e-97,
Organism=Caenorhabditis elegans, GI17560194, Length=192, Percent_Identity=30.7291666666667, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322762, Length=189, Percent_Identity=27.5132275132275, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24657262, Length=187, Percent_Identity=27.2727272727273, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 42934; Mature: 42803

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSHQPRSLNGQRLLLCVSGGIAAYKSLELVRRLCGAGAQVQVAMTASAQQFVTPLSFQ
CCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHCCCHHH
ALSGQSTRTTLWDGNAEQAMGHIELARWAERVLIAPASADVIARLAHGLADDLVTTLCLA
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHH
TTAPLIICPAMNHNMWLHPATQANVAMLLGRGVQVIGPEDGPLAEGVSGLGRMSEPEAIV
HCCCEEEEECCCCCEEECCCCCCCHHHHHCCCEEEECCCCCCHHHHHHHCCCCCCCHHEE
VALVQGVSPAPVHGGLFHGQRIVISAGPTFEDLDPVRYLGNRSSGKMGFALASAAVSHGA
HHHHHCCCCCCCCCCEECCCEEEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCC
EVVLVAGPVYQPTPPGVIRVDVRSAAQMRDAVLSAFPADVYIGAAAVADYAPKSVLPQKI
EEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHH
KKSGQTLILELVRTQDILSEVAAQTANLKFVVGFAAETHDVACYARGKLAAKHLDLIIAN
HHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEECCCHHHHHHCEEEEC
QVGIVGNGFESDDNAVTAYWQGGERVFASCSKVELAERLLALIAERMQT
CCCEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TGSHQPRSLNGQRLLLCVSGGIAAYKSLELVRRLCGAGAQVQVAMTASAQQFVTPLSFQ
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHCCCHHH
ALSGQSTRTTLWDGNAEQAMGHIELARWAERVLIAPASADVIARLAHGLADDLVTTLCLA
CCCCCCCEEEEECCCHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHHHHHH
TTAPLIICPAMNHNMWLHPATQANVAMLLGRGVQVIGPEDGPLAEGVSGLGRMSEPEAIV
HCCCEEEEECCCCCEEECCCCCCCHHHHHCCCEEEECCCCCCHHHHHHHCCCCCCCHHEE
VALVQGVSPAPVHGGLFHGQRIVISAGPTFEDLDPVRYLGNRSSGKMGFALASAAVSHGA
HHHHHCCCCCCCCCCEECCCEEEEECCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHCCC
EVVLVAGPVYQPTPPGVIRVDVRSAAQMRDAVLSAFPADVYIGAAAVADYAPKSVLPQKI
EEEEEECCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHH
KKSGQTLILELVRTQDILSEVAAQTANLKFVVGFAAETHDVACYARGKLAAKHLDLIIAN
HHCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCEEEEECCCHHHHHHCEEEEC
QVGIVGNGFESDDNAVTAYWQGGERVFASCSKVELAERLLALIAERMQT
CCCEEECCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]