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The map label for this gene is cysJ [H]

Identifier: 170748716

GI number: 170748716

Start: 2429517

End: 2431121

Strand: Reverse

Name: cysJ [H]

Synonym: Mrad2831_2298

Alternate gene names: 170748716

Gene position: 2431121-2429517 (Counterclockwise)

Preceding gene: 170748717

Following gene: 170748715

Centisome position: 40.0

GC content: 70.78

Gene sequence:

>1605_bases
ATGACCCAGCACGTCTCGCCCCCCCTCGTCCTGATCCCCGAGACCGCGCCCTTCAACGAGGACCAGCGCGCCTGGCTCTC
GGGCTACTTCGCGGCCCTGCTCGGCCCCTCCGCCGCGGGTGCCACGGCGCTGGCGCCGGGCGATGCTCCCGCGAGCGGCC
CGAAGCTCGCCGACAACGACGACGCCCCCTGGCACGACCCCTCCGTGCCGATCGGCGAGCGGATGGAGATGGCCAAGGAT
CGGCCCGAGCCGCAGAAGCTGATGGCCGCCATGGCCCAGCAGGATTGCGGCCAGTGCGGCTACAACTGCGCCGACTACGC
CAACGCGATCTTCCTGAAGAACGAGGCGCGCCTGAACCTTTGCCAGCCCGGCGGCAAAGAGACCCTGCGCATGCTCAAGA
AGCTCGACGAGGAGTTCGGCGCCGCCGGAGGCGCCCCGGCTGCCCCGAAGGTGGACGACGACGCCCCGAAGGCGGCGGCC
GATCTGGGCCCGCTCGGCTACTGCCGCGAGAACCCGGTCGAGGCGCTGTTCCTGTCCCGCCGCCGCCTCAACGATCCGGG
CGGCGAGAAGGAGACGTGGCACATCGAGATCGGCCTGGACGGCACGCCGATCCAGTACGAGGTCGGCGACTCCCTCGGCC
TGTTCCCCGCCAACGCCCCGGCGCTGGTGGACGCCGTGATCGCGGAGCTCGGCGCCCGGCCCGAGCGGGTGATCGGCGAG
AAGACCCTGCGCGAGCACCTGCTGATGAACTACGCGCTCGGCGCGGCGCCCGACAACCTCTACCAGCTCCTGTCGCTGCT
CACCTCCGGAGCGGCGCGCAAGAAGGCGCAGGCGCTCGCCTCCGGCGAGGATCCGGACGGCGACGCCGCCTATCTCGACG
TGCTCGGCGCGCTCCACAAGTTCCCGGGCGCGCGGCCCGACGCCGAGGTCTTCCTCGAGGCCCTGGACGAGCTCCAGCCG
CGGCTCTACTCGATCTCGTCCTCGCCGAAAATGGATGTCGGCCGGGTGTCGCTGACGGTGGACGCGGTGCGCTACAATCA
CCGCTCGCGGCTGCGGCTCGGCGTCGCTTCGACCCATCTCGGCGAGCGCCTGCCCGAGCAGACCAAGGTGAAGGTCTATC
TGCAGAAGGCGCACGGCTTCGGCCTGCCGGCCGACCTGGCGAAGGACGTGATCATGTGCGGTCCCGGCACCGGCATCGCG
CCGTTCCGGGCCTTCCTGCGCGAGCGCGCCGCCACGCGGGCGCCGGGCCGCAACTGGCTGTTCTACGGCCACCAGCGGCA
GGCCAGCGACTTCTTCTACAAGGACGAGCTGAACAGCCTGAAGGACGACAAGGTGCTCACCCGCCTGTCCCTGGCGTGGT
CGCGCGACGGCACGGAGAAGACCTACGTCCAGGACCGGATGCGCGAGAACGGCGCCGAGCTGTGGAAGTGGCTCGAGGGC
GGCGCGCATTTCTACGTCTGCGGCGACGCCAAGCGCATGGCCAAGGACGTCGAGCGGGCGATCATCGACGTGGCGGCGCA
GTTCGGCGGCAAGAGCCCCGAGGACGCGGTGGCCTACCTCGCGGCGCTCAAGAAGGCCGGGCGGTATCAGGCTGACGTCT
ACTGA

Upstream 100 bases:

>100_bases
GCCAGGGCCCCGAGGAGAGCTTCCAGGCCTTCACCAGCCGCACCGGCGCGGAGGCGCTCCGCGACGCCGCCGAGGACCAG
CCCGCCCTGAAGGCCGCCGC

Downstream 100 bases:

>100_bases
GCACCGGTAACCCTCCCCCCTGTGCCGGGGGAGGGCGATGCGGCGCGGCGCTTGCTCCCGCCCAGGACGACCCTTCGAGG
ATCCAGCCATGACCCAGCCA

Product: sulfite reductase

Products: NA

Alternate protein names: SiR-FP [H]

Number of amino acids: Translated: 534; Mature: 533

Protein sequence:

>534_residues
MTQHVSPPLVLIPETAPFNEDQRAWLSGYFAALLGPSAAGATALAPGDAPASGPKLADNDDAPWHDPSVPIGERMEMAKD
RPEPQKLMAAMAQQDCGQCGYNCADYANAIFLKNEARLNLCQPGGKETLRMLKKLDEEFGAAGGAPAAPKVDDDAPKAAA
DLGPLGYCRENPVEALFLSRRRLNDPGGEKETWHIEIGLDGTPIQYEVGDSLGLFPANAPALVDAVIAELGARPERVIGE
KTLREHLLMNYALGAAPDNLYQLLSLLTSGAARKKAQALASGEDPDGDAAYLDVLGALHKFPGARPDAEVFLEALDELQP
RLYSISSSPKMDVGRVSLTVDAVRYNHRSRLRLGVASTHLGERLPEQTKVKVYLQKAHGFGLPADLAKDVIMCGPGTGIA
PFRAFLRERAATRAPGRNWLFYGHQRQASDFFYKDELNSLKDDKVLTRLSLAWSRDGTEKTYVQDRMRENGAELWKWLEG
GAHFYVCGDAKRMAKDVERAIIDVAAQFGGKSPEDAVAYLAALKKAGRYQADVY

Sequences:

>Translated_534_residues
MTQHVSPPLVLIPETAPFNEDQRAWLSGYFAALLGPSAAGATALAPGDAPASGPKLADNDDAPWHDPSVPIGERMEMAKD
RPEPQKLMAAMAQQDCGQCGYNCADYANAIFLKNEARLNLCQPGGKETLRMLKKLDEEFGAAGGAPAAPKVDDDAPKAAA
DLGPLGYCRENPVEALFLSRRRLNDPGGEKETWHIEIGLDGTPIQYEVGDSLGLFPANAPALVDAVIAELGARPERVIGE
KTLREHLLMNYALGAAPDNLYQLLSLLTSGAARKKAQALASGEDPDGDAAYLDVLGALHKFPGARPDAEVFLEALDELQP
RLYSISSSPKMDVGRVSLTVDAVRYNHRSRLRLGVASTHLGERLPEQTKVKVYLQKAHGFGLPADLAKDVIMCGPGTGIA
PFRAFLRERAATRAPGRNWLFYGHQRQASDFFYKDELNSLKDDKVLTRLSLAWSRDGTEKTYVQDRMRENGAELWKWLEG
GAHFYVCGDAKRMAKDVERAIIDVAAQFGGKSPEDAVAYLAALKKAGRYQADVY
>Mature_533_residues
TQHVSPPLVLIPETAPFNEDQRAWLSGYFAALLGPSAAGATALAPGDAPASGPKLADNDDAPWHDPSVPIGERMEMAKDR
PEPQKLMAAMAQQDCGQCGYNCADYANAIFLKNEARLNLCQPGGKETLRMLKKLDEEFGAAGGAPAAPKVDDDAPKAAAD
LGPLGYCRENPVEALFLSRRRLNDPGGEKETWHIEIGLDGTPIQYEVGDSLGLFPANAPALVDAVIAELGARPERVIGEK
TLREHLLMNYALGAAPDNLYQLLSLLTSGAARKKAQALASGEDPDGDAAYLDVLGALHKFPGARPDAEVFLEALDELQPR
LYSISSSPKMDVGRVSLTVDAVRYNHRSRLRLGVASTHLGERLPEQTKVKVYLQKAHGFGLPADLAKDVIMCGPGTGIAP
FRAFLRERAATRAPGRNWLFYGHQRQASDFFYKDELNSLKDDKVLTRLSLAWSRDGTEKTYVQDRMRENGAELWKWLEGG
AHFYVCGDAKRMAKDVERAIIDVAAQFGGKSPEDAVAYLAALKKAGRYQADVY

Specific function: Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow f

COG id: COG0369

COG function: function code P; Sulfite reductase, alpha subunit (flavoprotein)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 flavodoxin-like domain [H]

Homologues:

Organism=Homo sapiens, GI127139033, Length=401, Percent_Identity=33.1670822942643, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI7657393, Length=392, Percent_Identity=30.1020408163265, Blast_Score=157, Evalue=3e-38,
Organism=Homo sapiens, GI10835173, Length=406, Percent_Identity=32.2660098522167, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI221316709, Length=392, Percent_Identity=29.8469387755102, Blast_Score=150, Evalue=4e-36,
Organism=Homo sapiens, GI221316705, Length=401, Percent_Identity=29.426433915212, Blast_Score=149, Evalue=6e-36,
Organism=Homo sapiens, GI24041029, Length=395, Percent_Identity=31.3924050632911, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI169790958, Length=410, Percent_Identity=28.0487804878049, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI169790956, Length=410, Percent_Identity=28.0487804878049, Blast_Score=135, Evalue=7e-32,
Organism=Homo sapiens, GI40254422, Length=375, Percent_Identity=31.4666666666667, Blast_Score=122, Evalue=6e-28,
Organism=Homo sapiens, GI221316707, Length=437, Percent_Identity=26.7734553775744, Blast_Score=120, Evalue=3e-27,
Organism=Escherichia coli, GI1789123, Length=400, Percent_Identity=41.25, Blast_Score=281, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17554134, Length=394, Percent_Identity=32.48730964467, Blast_Score=200, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17531441, Length=416, Percent_Identity=25, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17566446, Length=374, Percent_Identity=27.2727272727273, Blast_Score=87, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321832, Length=438, Percent_Identity=28.310502283105, Blast_Score=134, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6321143, Length=385, Percent_Identity=27.2727272727273, Blast_Score=127, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6325305, Length=382, Percent_Identity=24.3455497382199, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24582192, Length=400, Percent_Identity=31.5, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI17137192, Length=400, Percent_Identity=31.5, Blast_Score=182, Evalue=6e-46,
Organism=Drosophila melanogaster, GI24583543, Length=389, Percent_Identity=33.1619537275064, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI78706876, Length=389, Percent_Identity=33.1619537275064, Blast_Score=164, Evalue=2e-40,
Organism=Drosophila melanogaster, GI78706872, Length=389, Percent_Identity=33.1619537275064, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI24660907, Length=277, Percent_Identity=28.158844765343, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24660903, Length=277, Percent_Identity=28.158844765343, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24647438, Length=384, Percent_Identity=24.21875, Blast_Score=83, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010199
- InterPro:   IPR003097
- InterPro:   IPR017927
- InterPro:   IPR001094
- InterPro:   IPR008254
- InterPro:   IPR001709
- InterPro:   IPR023173
- InterPro:   IPR001433
- InterPro:   IPR017938 [H]

Pfam domain/function: PF00667 FAD_binding_1; PF00258 Flavodoxin_1; PF00175 NAD_binding_1 [H]

EC number: =1.8.1.2 [H]

Molecular weight: Translated: 58011; Mature: 57880

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHVSPPLVLIPETAPFNEDQRAWLSGYFAALLGPSAAGATALAPGDAPASGPKLADND
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCC
DAPWHDPSVPIGERMEMAKDRPEPQKLMAAMAQQDCGQCGYNCADYANAIFLKNEARLNL
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECCCCEEE
CQPGGKETLRMLKKLDEEFGAAGGAPAAPKVDDDAPKAAADLGPLGYCRENPVEALFLSR
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHH
RRLNDPGGEKETWHIEIGLDGTPIQYEVGDSLGLFPANAPALVDAVIAELGARPERVIGE
HHCCCCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
KTLREHLLMNYALGAAPDNLYQLLSLLTSGAARKKAQALASGEDPDGDAAYLDVLGALHK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FPGARPDAEVFLEALDELQPRLYSISSSPKMDVGRVSLTVDAVRYNHRSRLRLGVASTHL
CCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEEEHHHHCCCHHEEECHHHHHH
GERLPEQTKVKVYLQKAHGFGLPADLAKDVIMCGPGTGIAPFRAFLRERAATRAPGRNWL
HHHCCCCHHEEEEEEHHCCCCCCHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEE
FYGHQRQASDFFYKDELNSLKDDKVLTRLSLAWSRDGTEKTYVQDRMRENGAELWKWLEG
EECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
GAHFYVCGDAKRMAKDVERAIIDVAAQFGGKSPEDAVAYLAALKKAGRYQADVY
CCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TQHVSPPLVLIPETAPFNEDQRAWLSGYFAALLGPSAAGATALAPGDAPASGPKLADND
CCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCCCCC
DAPWHDPSVPIGERMEMAKDRPEPQKLMAAMAQQDCGQCGYNCADYANAIFLKNEARLNL
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHCCEEEEECCCCEEE
CQPGGKETLRMLKKLDEEFGAAGGAPAAPKVDDDAPKAAADLGPLGYCRENPVEALFLSR
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHH
RRLNDPGGEKETWHIEIGLDGTPIQYEVGDSLGLFPANAPALVDAVIAELGARPERVIGE
HHCCCCCCCCEEEEEEECCCCCCEEEECCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHH
KTLREHLLMNYALGAAPDNLYQLLSLLTSGAARKKAQALASGEDPDGDAAYLDVLGALHK
HHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHH
FPGARPDAEVFLEALDELQPRLYSISSSPKMDVGRVSLTVDAVRYNHRSRLRLGVASTHL
CCCCCCCHHHHHHHHHHHHHHHEECCCCCCCCCCEEEEEEEHHHHCCCHHEEECHHHHHH
GERLPEQTKVKVYLQKAHGFGLPADLAKDVIMCGPGTGIAPFRAFLRERAATRAPGRNWL
HHHCCCCHHEEEEEEHHCCCCCCHHHHCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCEE
FYGHQRQASDFFYKDELNSLKDDKVLTRLSLAWSRDGTEKTYVQDRMRENGAELWKWLEG
EECCCCCCCCCHHHHHHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHC
GAHFYVCGDAKRMAKDVERAIIDVAAQFGGKSPEDAVAYLAALKKAGRYQADVY
CCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA