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The map label for this gene is adk

Identifier: 167623529

GI number: 167623529

Start: 1916716

End: 1917360

Strand: Direct

Name: adk

Synonym: Shal_1598

Alternate gene names: 167623529

Gene position: 1916716-1917360 (Clockwise)

Preceding gene: 167623528

Following gene: 167623530

Centisome position: 36.67

GC content: 45.74

Gene sequence:

>645_bases
ATGCGCATTATGCTATTAGGTGCCCCAGGTGCCGGTAAAGGTACTCAAGCCCAATTCATCATGGAAAAGTACGGTGTTCC
TCAAATTTCTACAGGCGACATGCTACGTGCAGCGGTAAAAGCAGGCACACCACTAGGCTTAGAAGCTAAGAAAGTCATGG
ATGCTGGTCAGTTGGTTTCTGATGAGCTAATTATTGGCCTAGTAAAAGAGCGTGTTGCACAAGATGATTGCGCTGCAGGT
TTCCTATTAGACGGTTTCCCTCGTACTATTCCACAAGCAGATGCTATGGCTTCAAGCGGTATTGCACTTGATCACGTGAT
TGAAATTGATGTGCCAGACGAAGAGATCGTTAAGCGTATGAGCGGTCGTCGTGTTCACCCTGGTTCTGGCCGTGTTTACC
ACATTGTCTTTAACCAACCAAAAGTTGAAGGTAAAGATGACGTGACCGGTGAAGACCTAGCTATTCGTCCTGATGATGAA
GAATCAACAGTACGTAAGCGTCTTGATATTTATCATGAACAAACTAAGCCACTAGTAGAATACTACGGCGCGGTTGCAGC
TAAAGGTGACGTGACGTATAACAAGTTTGACGGCACTCAGTCAGTTGCTACCGTTAGCGATGAGATCGTTGCAGTACTAA
GCTAA

Upstream 100 bases:

>100_bases
ATCGCCGCACTAAATATAATAATACCCATCGACTAGACAGCTTTTTGCTTATTCTAGGCGGATGTCGGTATCACAGTGCG
AAATTAAGAGGAAGATTCAG

Downstream 100 bases:

>100_bases
ACTGATACTCAATTAACTTGGTACACGTTTATTTGGCAGTAAGCTAAATAAAGCTTAACTAACAATGTGTTTATGAGCTA
GTTCTCATATTTTAAAAAGC

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 214; Mature: 214

Protein sequence:

>214_residues
MRIMLLGAPGAGKGTQAQFIMEKYGVPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGLVKERVAQDDCAAG
FLLDGFPRTIPQADAMASSGIALDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHIVFNQPKVEGKDDVTGEDLAIRPDDE
ESTVRKRLDIYHEQTKPLVEYYGAVAAKGDVTYNKFDGTQSVATVSDEIVAVLS

Sequences:

>Translated_214_residues
MRIMLLGAPGAGKGTQAQFIMEKYGVPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGLVKERVAQDDCAAG
FLLDGFPRTIPQADAMASSGIALDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHIVFNQPKVEGKDDVTGEDLAIRPDDE
ESTVRKRLDIYHEQTKPLVEYYGAVAAKGDVTYNKFDGTQSVATVSDEIVAVLS
>Mature_214_residues
MRIMLLGAPGAGKGTQAQFIMEKYGVPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVSDELIIGLVKERVAQDDCAAG
FLLDGFPRTIPQADAMASSGIALDHVIEIDVPDEEIVKRMSGRRVHPGSGRVYHIVFNQPKVEGKDDVTGEDLAIRPDDE
ESTVRKRLDIYHEQTKPLVEYYGAVAAKGDVTYNKFDGTQSVATVSDEIVAVLS

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI7524346, Length=218, Percent_Identity=46.3302752293578, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI4502013, Length=218, Percent_Identity=46.3302752293578, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI19923437, Length=182, Percent_Identity=44.5054945054945, Blast_Score=161, Evalue=4e-40,
Organism=Homo sapiens, GI310110345, Length=201, Percent_Identity=39.3034825870647, Blast_Score=141, Evalue=3e-34,
Organism=Homo sapiens, GI53832003, Length=201, Percent_Identity=39.3034825870647, Blast_Score=141, Evalue=3e-34,
Organism=Homo sapiens, GI8051579, Length=201, Percent_Identity=39.3034825870647, Blast_Score=141, Evalue=3e-34,
Organism=Homo sapiens, GI53832001, Length=201, Percent_Identity=39.3034825870647, Blast_Score=141, Evalue=3e-34,
Organism=Homo sapiens, GI4502011, Length=181, Percent_Identity=31.4917127071823, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI22749187, Length=206, Percent_Identity=28.6407766990291, Blast_Score=101, Evalue=6e-22,
Organism=Homo sapiens, GI7706497, Length=222, Percent_Identity=28.3783783783784, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI28144897, Length=181, Percent_Identity=27.6243093922652, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI28144899, Length=181, Percent_Identity=27.6243093922652, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI21450759, Length=139, Percent_Identity=26.6187050359712, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI237858799, Length=138, Percent_Identity=26.8115942028986, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1786680, Length=213, Percent_Identity=68.5446009389671, Blast_Score=301, Evalue=2e-83,
Organism=Caenorhabditis elegans, GI17552384, Length=186, Percent_Identity=47.3118279569892, Blast_Score=180, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17537943, Length=184, Percent_Identity=33.695652173913, Blast_Score=119, Evalue=9e-28,
Organism=Caenorhabditis elegans, GI17567503, Length=182, Percent_Identity=34.0659340659341, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6320432, Length=218, Percent_Identity=46.3302752293578, Blast_Score=200, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6321018, Length=196, Percent_Identity=41.3265306122449, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6322828, Length=184, Percent_Identity=28.2608695652174, Blast_Score=87, Evalue=2e-18,
Organism=Drosophila melanogaster, GI22026816, Length=184, Percent_Identity=51.0869565217391, Blast_Score=191, Evalue=3e-49,
Organism=Drosophila melanogaster, GI17737899, Length=182, Percent_Identity=43.4065934065934, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24645822, Length=182, Percent_Identity=43.4065934065934, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI17647141, Length=181, Percent_Identity=29.2817679558011, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24663208, Length=181, Percent_Identity=29.2817679558011, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI221459597, Length=184, Percent_Identity=26.6304347826087, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356893, Length=184, Percent_Identity=26.6304347826087, Blast_Score=71, Evalue=5e-13,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_SHEHH (B0TP07)

Other databases:

- EMBL:   CP000931
- RefSeq:   YP_001673823.1
- ProteinModelPortal:   B0TP07
- SMR:   B0TP07
- GeneID:   5906506
- GenomeReviews:   CP000931_GR
- KEGG:   shl:Shal_1598
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- ProtClustDB:   PRK00279
- BioCyc:   SHAL458817:SHAL_1598-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23070; Mature: 23070

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIMLLGAPGAGKGTQAQFIMEKYGVPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DELIIGLVKERVAQDDCAAGFLLDGFPRTIPQADAMASSGIALDHVIEIDVPDEEIVKRM
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHCCCCEEEEEEEEECCHHHHHHHH
SGRRVHPGSGRVYHIVFNQPKVEGKDDVTGEDLAIRPDDEESTVRKRLDIYHEQTKPLVE
HCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCHHHHH
YYGAVAAKGDVTYNKFDGTQSVATVSDEIVAVLS
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHEECC
>Mature Secondary Structure
MRIMLLGAPGAGKGTQAQFIMEKYGVPQISTGDMLRAAVKAGTPLGLEAKKVMDAGQLVS
CEEEEEECCCCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHH
DELIIGLVKERVAQDDCAAGFLLDGFPRTIPQADAMASSGIALDHVIEIDVPDEEIVKRM
HHHHHHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHCCCCEEEEEEEEECCHHHHHHHH
SGRRVHPGSGRVYHIVFNQPKVEGKDDVTGEDLAIRPDDEESTVRKRLDIYHEQTKPLVE
HCCEECCCCCCEEEEEECCCCCCCCCCCCCCCEEECCCCHHHHHHHHHHHHHHHCHHHHH
YYGAVAAKGDVTYNKFDGTQSVATVSDEIVAVLS
HHHHHCCCCCCEEEECCCCCHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA