Click here to switch to the map view.

The map label for this gene is hemH [H]

Identifier: 167623530

GI number: 167623530

Start: 1917536

End: 1918531

Strand: Direct

Name: hemH [H]

Synonym: Shal_1599

Alternate gene names: 167623530

Gene position: 1917536-1918531 (Clockwise)

Preceding gene: 167623529

Following gene: 167623531

Centisome position: 36.69

GC content: 47.59

Gene sequence:

>996_bases
TTGAGTGACTCAGTCCCCCCATTTGGCGTGTTACTAGTAAACTTAGGTACGCCTGATTCACCAACCGCTCCCGATGTTAA
AAAGTTTCTTAAGCAGTTTTTGAGCGACCCACGAGTAGTCGATCTGTCTCCTTGGATATGGAAGCCGATTTTAAACGGTA
TCATTCTTAATACCCGCCCGGCTAAAGTGGCCAAGCTCTATCAGTCTATCTGGTGGGATGAAGGCTCGCCTTTGATGGTC
ATCAGCCAAAAACAGCGTGATAAACTCAAACAGACGCTGCATGAGTCGTTTGGCCAGACCATTCCTGTTGAACTAGGGAT
GAGTTATGGCAACCCGTCATTGCAATCGGGGATCGATAGCCTTAAGTCTCAAGGGGCTGAAAAGATCTTCGTCCTACCAC
TTTACGCTCAATACTCTTGCTCAACCGTCGCCCCTGTTTATGATGCGATTGCCCAGTTACTTAAAGCTGAGCGCAACATC
CCTGAAATGCGCATCAATAAGCAGTATTTCGATCATCCTGCTTATATTCAAGCACTCGCCGAGTCGGTTAAGACCCACTG
GAATAGCAAAGGTCAGGCCGATGTGTTGATGATGTCGTTTCATGGCGTGCCACTGCGCTATATTACTGAGGGGGATCCTT
ATCAGGCGCAGTGCCAAGCGACTGCAGAGTTATTGGCCAAGGCGCTGGAGTTAACGCCTGAACAGTGGCGAGTCTGCTAC
CAATCTCAATTCGGTAAAGAGGAGTGGATAAAACCTGCAACCGATGAGCTGCTAGGATCATTGCCTAAGCAAGGGGTTAA
GTCGGTCGATATTATGTGTCCTGCGTTTTCATCTGACTGCTTGGAAACACTCGAGGAGATCTCTCAAGAGGGCAAAGCGG
AGTTCTTATCGGCTGGTGGTGAACGATATGAATTTATCGATTGCCTTAATGATGCACCAGCTCATATAGCGTTGTTAGCT
GAGCTTGTTCAAGAGCAAACAAAAGGTTGGTATTAA

Upstream 100 bases:

>100_bases
AGCTAGTTCTCATATTTTAAAAAGCCCATGAAAATGGGCTTTTTTTATGCTTTTCGCAATGATAGCCTGAGGTGAATATC
TTGCTAAAAAGAGAATTCAT

Downstream 100 bases:

>100_bases
ATTTTCTGAGTTCTATAGTGATTTCAGCTAGCGAAAGAGGTGTGGTGTGGTAAAATCCCCCACCTTTTCGCGCATCTAGC
CCTTTAAATTCACTATTTTT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase 1; Protoheme ferro-lyase 1 [H]

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MSDSVPPFGVLLVNLGTPDSPTAPDVKKFLKQFLSDPRVVDLSPWIWKPILNGIILNTRPAKVAKLYQSIWWDEGSPLMV
ISQKQRDKLKQTLHESFGQTIPVELGMSYGNPSLQSGIDSLKSQGAEKIFVLPLYAQYSCSTVAPVYDAIAQLLKAERNI
PEMRINKQYFDHPAYIQALAESVKTHWNSKGQADVLMMSFHGVPLRYITEGDPYQAQCQATAELLAKALELTPEQWRVCY
QSQFGKEEWIKPATDELLGSLPKQGVKSVDIMCPAFSSDCLETLEEISQEGKAEFLSAGGERYEFIDCLNDAPAHIALLA
ELVQEQTKGWY

Sequences:

>Translated_331_residues
MSDSVPPFGVLLVNLGTPDSPTAPDVKKFLKQFLSDPRVVDLSPWIWKPILNGIILNTRPAKVAKLYQSIWWDEGSPLMV
ISQKQRDKLKQTLHESFGQTIPVELGMSYGNPSLQSGIDSLKSQGAEKIFVLPLYAQYSCSTVAPVYDAIAQLLKAERNI
PEMRINKQYFDHPAYIQALAESVKTHWNSKGQADVLMMSFHGVPLRYITEGDPYQAQCQATAELLAKALELTPEQWRVCY
QSQFGKEEWIKPATDELLGSLPKQGVKSVDIMCPAFSSDCLETLEEISQEGKAEFLSAGGERYEFIDCLNDAPAHIALLA
ELVQEQTKGWY
>Mature_330_residues
SDSVPPFGVLLVNLGTPDSPTAPDVKKFLKQFLSDPRVVDLSPWIWKPILNGIILNTRPAKVAKLYQSIWWDEGSPLMVI
SQKQRDKLKQTLHESFGQTIPVELGMSYGNPSLQSGIDSLKSQGAEKIFVLPLYAQYSCSTVAPVYDAIAQLLKAERNIP
EMRINKQYFDHPAYIQALAESVKTHWNSKGQADVLMMSFHGVPLRYITEGDPYQAQCQATAELLAKALELTPEQWRVCYQ
SQFGKEEWIKPATDELLGSLPKQGVKSVDIMCPAFSSDCLETLEEISQEGKAEFLSAGGERYEFIDCLNDAPAHIALLAE
LVQEQTKGWY

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=335, Percent_Identity=28.0597014925373, Blast_Score=110, Evalue=1e-24,
Organism=Homo sapiens, GI60499025, Length=335, Percent_Identity=28.0597014925373, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786681, Length=315, Percent_Identity=49.8412698412698, Blast_Score=317, Evalue=5e-88,
Organism=Saccharomyces cerevisiae, GI6324750, Length=332, Percent_Identity=25.9036144578313, Blast_Score=83, Evalue=6e-17,
Organism=Drosophila melanogaster, GI17864156, Length=345, Percent_Identity=24.9275362318841, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24651774, Length=274, Percent_Identity=23.7226277372263, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI45552018, Length=163, Percent_Identity=26.9938650306748, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 37015; Mature: 36883

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSVPPFGVLLVNLGTPDSPTAPDVKKFLKQFLSDPRVVDLSPWIWKPILNGIILNTRP
CCCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHCCEEECCCH
AKVAKLYQSIWWDEGSPLMVISQKQRDKLKQTLHESFGQTIPVELGMSYGNPSLQSGIDS
HHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCEECCEECCCCCCHHHHHHHHH
LKSQGAEKIFVLPLYAQYSCSTVAPVYDAIAQLLKAERNIPEMRINKQYFDHPAYIQALA
HHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHCCCHHHHHHHH
ESVKTHWNSKGQADVLMMSFHGVPLRYITEGDPYQAQCQATAELLAKALELTPEQWRVCY
HHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
QSQFGKEEWIKPATDELLGSLPKQGVKSVDIMCPAFSSDCLETLEEISQEGKAEFLSAGG
HHHCCHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
ERYEFIDCLNDAPAHIALLAELVQEQTKGWY
CHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SDSVPPFGVLLVNLGTPDSPTAPDVKKFLKQFLSDPRVVDLSPWIWKPILNGIILNTRP
CCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCEEECCHHHHHHHHCCEEECCCH
AKVAKLYQSIWWDEGSPLMVISQKQRDKLKQTLHESFGQTIPVELGMSYGNPSLQSGIDS
HHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHCCEECCEECCCCCCHHHHHHHHH
LKSQGAEKIFVLPLYAQYSCSTVAPVYDAIAQLLKAERNIPEMRINKQYFDHPAYIQALA
HHHCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHCHHHCCCHHHHHHHH
ESVKTHWNSKGQADVLMMSFHGVPLRYITEGDPYQAQCQATAELLAKALELTPEQWRVCY
HHHHHHCCCCCCCEEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHH
QSQFGKEEWIKPATDELLGSLPKQGVKSVDIMCPAFSSDCLETLEEISQEGKAEFLSAGG
HHHCCHHHCCCCCHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCC
ERYEFIDCLNDAPAHIALLAELVQEQTKGWY
CHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]